An NCI-designated Comprehensive Cancer Center

Jianjun Chen Lab

Jianjun Chen Lab Group Photo 500px
The ultimate goal of the lab is to translate the laboratory discoveries into the development of effective novel therapeutic strategies to treat cancers, especially acute leukemia, in the clinic.
Jianjun Chen Lab Group Photo 500px
 
Jianjun Chen received his Ph.D. degree from Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, China, and then conducted postdoctorate training with Dr. Janet D. Rowley at University of Chicago, where he launched his independent laboratory in 2009 in the Department of Medicine. Before joining Beckman Research Institute of City of Hope as a full professor and Simms/Mann Family Foundation Chair in Systems Biology in 2017, Chen had been serving as an associate professor of Cancer Biology at the University of Cincinnati College of Medicine after moving from University of Chicago. Chen is a Scholar of The Leukemia and Lymphoma Society (2017) and Researcher of the Year, The Pamela B. Katten Memorial Leukemia Research Foundation Award (2014). Chen is a permanent member of the National Institutes of Health Developmental Therapeutics study section, and his research program is currently supported by four R01 grants from the National Cancer Institute.
 
The Chen laboratory is interested in discovering novel genetic/epigenetic regulations and the associated molecular mechanisms of both protein-coding genes and noncoding RNAs (e.g., microRNAs) in normal developmental processes (e.g., hematopoiesis) and tumorigenesis (e.g., leukemogenesis). In recent years, Chen and colleagues have been focusing on both basic and translational research associated with RNA/DNA epigenetics, especially RNA methylation/demethylation related to the N6 methyladenosine (m6A) machinery and DNA demethylation related to the TET1/2/3 family, and have developed several small-molecule compound inhibitors to selectively target cancer-related RNA/DNA epigenetic modifiers that hold therapeutic potential. The ultimate goal of the lab is to translate the laboratory discoveries into the development of effective novel therapeutic strategies to treat cancers, especially acute leukemia, in the clinic.
 
To view all research highlights, please visit Jianjun Chen's Research Highlights.

Principal Investigator

Jianjun Chen, Ph.D.
Simms/Mann Family Foundation Chair in Systems Biology,Professor and Vice Chair, Department of Systems Biology
Role: Principal Investigator

Principal Investigator

Jianjun Chen, Ph.D.
Simms/Mann Family Foundation Chair in Systems Biology,Professor and Vice Chair, Department of Systems Biology
Role:Principal Investigator

Lab Members

Postdoctoral Fellow
Staff Scientist
Staff Scientist
Postdoctoral Fellow
Visiting Graduate Student
Assistant Research Professor
Postdoctoral Fellow
Research Associate II
Assistant Research Professor
Postdoctoral Fellow
Assistant Research Professor
Visiting Scholar

Lab Publications

Default publication image
Jianjun Chen's Publications
To view a complete list of publications, please click the link below.

Lab Location & Contact

Jianjun Chen Lab
1500 East Duarte Road,
Duarte, CA 91010
Ample Free Parking