Key Publications

Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe J, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C, Yang J, Chen J. Recognition of RNA N6-methyadenosine by IGF2BP proteins Enhances mRNA Stability and Translation. Nature Cell Biology. 2018. In Press.
 
Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore L, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy J, Yang J, Qian Z, Wei M, He C, Chen J. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell. December 28, 2017 Epub.
https://www.ncbi.nlm.nih.gov/pubmed/29290617
 
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas D, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy J, Jin J, He C, Chen J. R-2HG exhibits anti-tumor activity by targeting FTO/m6A/MYC/CEBPA signaling. Cell. 2018 Jan 11;172(1-2):90-105. PMCID: PMC5766423.
*Highlighted (Research Watch) by Cancer Discovery (2017 Dec 21. doi: 10.1158/2159-8290.CD-RW2017-240. [Epub ahead of print])
https://www.ncbi.nlm.nih.gov/pubmed/29249359
 
Jiang X, Hu C, Ferchen K, Nie J, Cui X, Chen CH, Cheng L, Zuo Z, Seibel W, He C, Tang Y, Skibbe JR, Wunderlich M, Reinhold WC, Dong L, Shen C, Arnovitz S, Ulrich B, Lu J, Weng H, Su R, Huang H, Wang Y, Li C, Qin X, Mulloy J, Zheng Y, Diao J, Jin J, Li C, Liu PP, He C, Chen Y, Chen J. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature Communications. 2017 January 13; 8:2099. PMCID: PMC5727390.
https://www.ncbi.nlm.nih.gov/pubmed/29235481
 
Li Z, Weng H, Su R, Weng X, Zuo Z, Li C, Huang H, Nachtergaele S, Dong L, Hu C, Qin X, Tang L, Wang Y, Hong GM, Huang H, Wang X, Chen P, Gurbuxani S, Arnovitz S, Li Y, Li S, Strong J, Neilly MB, Larson RA, Jiang X, Zhang P, Jin J, He C, Chen J. FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. PMCID: PMC5234852.
https://www.ncbi.nlm.nih.gov/pubmed/28017614
                       **Cover Story: http://www.cell.com/cancer-cell/issue?pii=S1535-6108(16)X0002-5
                       **Highlighted at: http://cancerdiscovery.aacrjournals.org/content/7/2/OF9
 
Li Z, Chen P, Su R, Hu C, Li Y, Elkahloun AG, Zuo Z, Gurbuxani S, Arnovitz S, Weng H, Wang Y, Li S, Huang H, Neilly MB, Wang GG, Jiang X, Liu PP, Jin J, Chen J. PBX3 and MEIS1 cooperate in hematopoietic cells to drive acute myeloid leukemias characterized by a core transcriptome of the MLL-rearranged disease. Cancer Research. 2016 Feb 1. 76(3):619-29. PMCID: PMC4810030.
https://www.ncbi.nlm.nih.gov/pubmed/26747896
 
Huang H, Jiang X, Wang J, Li Y, Song CX, Chen P, Li S, Gurbuxani S, Arnovitz S, Wang Y, Weng H, Neilly MB, He C, Li Z, and Chen J. Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia. Cancer Letters. 2016. 372(2):157-65. PMCID: PMC4809417.
https://www.ncbi.nlm.nih.gov/pubmed/26791235
 
Jiang X, Hu C, Arnovitz S, Bugno J, Yu M, Zuo Z, Chen P, Huang H, Ulrich B, Gurbuxani S, Weng H, Strong J, Wang Y, Li Y, Salat J, Li S, Elkahloun AG, Yang Y, Neilly MB, Larson RA, Le Beau MM, Herold T, Bohlander SK,  Liu PP, Zhang J, Li Z, He C, Jin J, Hong S, Chen J. miR-22 has a potent anti-tumor role with therapeutic potential in acute myeloid leukemia. Nature Communications. 2016 Apr 26; 7:11452. PMCID: Pending. (**Featured article)
https://www.ncbi.nlm.nih.gov/pubmed/27116251
 
Jiang X, Bugno J, Hu C, Yang Y, Herold T, Qi J, Chen P, Gurbuxani S, Arnovitz S, Strong J, Ferchen K, Ulrich B, Weng H, Wang Y, Huang H, Li S, Neilly MB, Larson RA, Le Beau MM, Bohlander SK, Jin J, Li Z, Bradner JE, Hong S, Chen J. Eradication of acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles. Cancer Research. 2016 Aug 1;76(15):4470-80. PMCID: PMC4970973.
https://www.ncbi.nlm.nih.gov/pubmed/27280396
 
Li Z, Chen P, Su R, Li Y, Hu C, Wang Y, Arnovitz S, He M, Gurbuxani S, Zuo Z, Elkahloun AG, Li S, Weng H, Huang H, Neilly MB, Wang S, Olson EN, Larson RA, Le Beau MM, Zhang J, Jiang X, Wei M, Jin J, Liu PP, Chen J. Overexpression and knockout of miR-126 both promote leukemogenesis. Blood. 2015. 126(17):2005-15. PMCID: PMC4616234.    
https://www.ncbi.nlm.nih.gov/pubmed/26361793
 
Zhao L, Sun MA, Li Z, Bai X, Yu M, Wang M, Liang L, Shao X, Arnovitz S, Wang Q, He C, Lu X*, Chen J*, Xie H* (*co-senior/corresponding authors). The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation. Genome Res. 2014. 24(8):1296-307. PMCID: PMC4120083.
https://www.ncbi.nlm.nih.gov/pubmed/24835587
 
Li Z, Zhang Z, Li Y, Arnovitz S, Chen P, Huang H, Jiang X, Hong GM, Kunjamma RB, Ren H, He C, Wang CZ, Elkahloun AG, Valk PJM, Dohner K, Neilly MB, Bullinger L, Delwel R, Lowenberg B, Paul P. Liu, Morgan R, Rowley JD, Yuan CS,  Chen J. PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood. 2013. 121(8):1422-31. PMCID: PMC3578957.
https://www.ncbi.nlm.nih.gov/pubmed/23264595
 
Li Z, Herold T, He C, Valk PJM, Chen P, Jurinovic V, Mansmann U, Radmacher M, Maharry K, Sun M, Yang X, Huang H, Jiang X, Sauerland MC, Büchner T, Hiddemann W, Elkahloun A, Neilly MB, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, Dohner K, Bullinger L, Liu PP, Delwel R, Marcucci G, Lowenberg B, Bloomfield CD, Rowley JD, Bohlander SK, Chen J. Identification of a 24-Gene Prognostic Signature That Improves the European LeukemiaNet Risk Classification of Acute Myeloid Leukemia: An International Collaborative Study of 1,324 Patients. Journal of Clinical Oncology. 2013. 31(9):1172-81. PMCID: PMC3595425.
https://www.ncbi.nlm.nih.gov/pubmed/23382473
 
Chen P, Price C, Li Z, Li Y, Cao D, Wiley A, He C, Gurbuxani S, Kunjamma RB, Huang H, Jiang X, Arnovitz S, Xu M, Hong GM, Elkahloun AG, Neilly MB, Wunderlich M, Larson RA, Le Beau MM, Mulloy JC, Liu PP, Rowley JD, Chen J. miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia–rearranged leukemia. Proc Natl Acad Sci USA. 2013. 110(28):11511-6. PMCID: PMC3710804.
https://www.ncbi.nlm.nih.gov/pubmed/23798388
 
Huang H, Jiang X, Li Z, Li Y, Song CX, He C, Sun M, Chen P, Gurbuxani S, Wang J, Hong GM, Elkahloun AG, Arnovitz S, Wang J, Szulwach K, Lin L, Street C, Wunderlich M, Dawlaty M, Neilly MB, Jaenisch R, Yang FC, Mulloy JC, Jin P, Liu PP, Rowley JD, Xu M, He C, Chen J. TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proc Natl Acad Sci USA. 2013. 110(29):11994-9. PMCID: PMC3718141.
https://www.ncbi.nlm.nih.gov/pubmed/23818607
 
Jiang X, Huang H, Li Z,  Li Y, Wang X, Gurbuxani S, Chen P, He C, You D, Zhang S, Wang J, Arnovitz S, Elkahloun A, Price C, Hong GM, Ren H, Kunjamma RB, Neilly MB, Matthews J, Xu M, Larson RA, Le Beau MM, Slany RK, Liu PP, Lu J, Zhang J, He C, Chen J. Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell. 2012. 22: 524-535. PMCID: PMC3480215.
https://www.ncbi.nlm.nih.gov/pubmed/23079661
 
Li Z, Huang H, Chen P, He M, Li Y, Arnovitz S, Zhang J, Hyjek E, Elkahloun A, Jiang X, Zhang Z, He C, Cao D, Shen C, Vardiman J, Wunderlich M, Wang Y, Neilly MB, Jin J, Wei M, Lu J, Molly JC, Zeleznik-Le NJ, Liu PP, Zhang J, Chen J. miR-196b Directly Targets Both HOXA9/MEIS1 Oncogenes and FAS Tumor Suppressor in MLL-rearranged Leukemia. Nature Communications. 2012. 2:688. PMCID: PMC3514459. (**Featured article)
https://www.ncbi.nlm.nih.gov/pubmed/22353710