Vu Nguyen Ngo Lab
The research program in the Ngo laboratory is focused on pathogenetic mechanisms and identification of molecular targets in aggressive lymphoid malignancies. Dr. Ngo completed his Ph.D. degree in the laboratory of Jason Cyster at the University of California, San Francisco, where he studied the molecular basis of lymphoid tissue organization through interactions of lymphocytes with stromal cells and the chemokines and cytokines they secret. He then joined the laboratory of Louis Staudt at the National Institute of Health, National Cancer Institute for postdoctoral training, where he developed an expertise in large-scale functional genomics research using RNA interference technology to identify functionally important pathways that harbor oncogenic mutations driving lymphomagenesis in diffuse large B-cell lymphomas.
In 2010, Dr. Ngo was recruited to start his independent laboratory in the division of Stem Cell and Leukemia Research at the Beckman Research Institute at City of Hope. His laboratory has discovered an important role for recurrent mutations of cyclin D1, which results in deregulated protein turnover and therapy resistance in mantle cell lymphoma. In 2017, Dr. Ngo joined the Department of Systems Biology where he will use innovative functional genomics tools and powerful animal modeling using relevant patient-derived lymphoma samples to gain new insights into critical signaling pathways that are important in lymphomagenesis and resistance to therapy. Dr. Ngo is a recipient of the American Society of Hematology Scholar Award, the Gabrielle’s Angel Foundation For Cancer Research Award and the Department of Defense’s Career Development Award.