An NCI-designated Comprehensive Cancer Center
Sonia Rodriguez-Rodriguez

Sonia Rodriguez-Rodriguez, Ph.D.

Assistant Research Professor, Gehr Family Center for Leukemia Research
Research Focus
  • Leukemia
  • Role of SKP2 in hematopoiesis and T cell leukemia

Locations

City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

  • Nieto JM, Madrid C, Miquelay E, Parra JL, Rodriguez S, Juarez A. Evidence for Direct Protein-Protein Interaction between Members of the Enterobacterial Hha/YmoA and H-NS Families of Proteins. Journal of Bacteriology 184: 629-635. (2002).
  • Pons JI, Rodriguez S, Madrid C, Juarez A, Nieto JM. In vivo increase of solubility of overexpressed Hha protein by tandem expression with interacting protein H-NS. Protein expression & purification 35: 293-297. (2004).
  • Rodriguez S, Nieto JM, Madrid C, Juarez A. Functional replacement of the oligomerization domain of H-NS by the Hha protein of Escherichia coli. Journal of Bacteriology 187: 5452-5459. (2005).
  • Abella M, Rodriguez S, Paytubi S, Campoy S, White MF, Barbé J. The Sulfolobus solfataricus radA paralogue sso0777 is DNA damage inducible and positively regulated by the Sta1 protein. Nucleic acid research 35: 6788-6797. (2007).
  • Fernandez L, Rodriguez S, Huang H, Chora A, Mumaw C, Cruz E, Pollok K, Cristina F, Krause DS, Price JE, Ferkowicz MJ, Scadden DT, Clauss M, Cardoso AA, Carlesso N. TNF and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation. Experimental hematology 36(5):545-558. (2008).
  • Rodriguez S, Chora A, Goumnerov B, Mumaw C, Goebel S, Fernandez L, Baydoun H, HogenEsch H, Dombkowski DM, Karlewicz CA, Rice S, Rahme LG, Carlesso N. Dysfunctional expansion of  hematopoietic stem cells and block of myeloid differentiation in lethal sepsis. Blood. 114(19):4064-4076. (2009).
  • Chitteti BR, Cheng YH, Poteat B, Rodriguez-Rodriguez S, Goebel WS, Carlesso N, Kacena MA, Srour EF. Impact of interactions of cellular components of the bone marrow microenviroment on hematopoiesic stem and progenitor cell function. Blood. 115(16):3239-48. (2010).
  • Chitteti BR, Cheng YH, Streicher DA, Rodriguez-Rodriguez S, Carlesso N, Srour EF, Kacena MA. Osteoblast lineage cells expressing high levels of Runx2 enhance hematopoetic progenitor cell proliferation and function. Journal of Cellular Biochemistry. 111(2):284-94. (2010).
  • Cheng YH,* Chitteti BR,* Streicher DA, Morgan JA, Rodriguez-Rodriguez S, Carlesso N, Srour EF, Kacena MA. Impact of osteoblast maturational status on their ability to enhance the hematopoietic function of stem and progenitor cells. Journal of Bone Mineral Research. 26(5):111-1121. (2011).
  • Rodriguez S, Wang L, Mumaw C, Srour EF, Lo Celso C, Nakayama K, Carlesso N. The SKP2 E3 Ligase regulates basal homeostasis and stress induced regeneration of hematopoietic stem cells. Blood. 117(24):6505-6519. (2011).
  • Wang L, Zhang H, Rodriguez S, Cao L, Parish J, Mumaw C, Zollman A, Kamoka MM, Mu J, Chen DZ, Srour EF, Chitteti BR, Hoegenesh H, Tu X, Bellido TM, Boswell HS, Manshouri T, Verstovsek S, Yoder MC, Kapur R, Cardoso AA, Carlesso N. Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-kB-dependent manner. Cell Stem Cell. 15(1):51-65. (2014).
  • Zhang H, Rodriguez S, Wang L, Wang S, Serezani H, Kapur R, A Cardoso AA, Carlesso N. Activation of TRIF-dependent signaling causes hematopoietic stem cell exhaustion during sepsis. Stem Cell Reports. 6(6):940-956. (2016).
  • Kobayashi M, Nabinger SC, Bai Y, Yoshimoto M, Gao R, Chen S, Yao C, Dong Y, Zhang L, Rodriguez S, Yashiro-Ohtani Y, Pear WS, Carlesso N, Yoder MC, Kapur R, Kaplan MH, Lacorazza H, Zhang ZY, Liu Y. Protein Tyrosine Phosphatase PRL2 mediates Notch and Kit signals in early T-cell progenitors. Stem Cells. 35(4):1053-1064. (2017).
  • Batista A*, Rodriguez S*, Ding J, Shou W, Carlesso N, Cardoso A. Notch signaling is sustained by leukemia microenvironment and modulates IL-7 signals in T-ALL. * Equal contribution. Submitted
  • Rodriguez S, Wang L, Zhang H, Mehrota P, Zollman A, Kaplan MH, Sandusky G, Chiang GM, Mulloy JC, Wunderlich M, Palmer J, Yui MA, Cardoso AA, Carlesso N. Loss of the E3 ubiquitin ligase SKP2 limits the oncogenic potential of Notch in T-ALL. Submitted.
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