Sophia Apple

Sophia Apple, M.D., M.S

  • Chief and Clinical Professor, Division of Anatomic Pathology, Department of Pathology
  • Interim Chair, Department of Pathology

Sophia Apple, M.D., M.S

Clinical Specialties
  • Anatomic and Clinical Pathology
Research Focus
  • Breast Cancer
Other Languages Spoken
  • Korean
  • Japanese
I always dreamed about becoming a medical doctor since I was 5 years old.”
Born in Korea, Sophia Apple, M.D., M.S., survived a childhood bout with polio which left her with a slight limp and a determination to become a physician. In her second year of medical school, she became fascinated with pathology, which she calls “the brain of medicine.”
After more than 20 years at UCLA (15 as director of breast pathology), Dr. Apple came to City of Hope to expand her clinical and research work with breast cancer, in search of better treatments for her patients.
Dr. Apple studied biochemistry at New York University, received her medical degree from Wright State University in Dayton, Ohio, and completed her pathology residency and fellowship at UCLA. 
Dr. Apple literally “wrote the book” on combining breast imaging and pathology, co-authoring a definitive textbook on the subject and has published more than 70 peer-reviewed journal articles related to breast diseases. 
She’s grateful and loves America for the opportunities given to her to fulfill her dreams.
  • 2018 – Present, Chair and Clinical Professor, Department of Pathology, City of Hope, Duarte, CA
  • 2016 – 2018, Clinical Professor, Department of Pathology, City of Hope, Duarte, CA
  • 2002 – 2016, Director of Breast Pathology, Department of Pathology, University of California at Los Angeles Medical Center, CA
  • 1998 – 2002, Staff Pathologist and Partner, Southern California Kaiser Permanente, Woodland Hills Medical Center, CA
  • 2000 – 2002, Immunohistochemical Laboratory, Sherman Way, Kaiser Permanente, CA


City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA, 91010

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Phone :  626-256-4673


  • 1992, M.D., Wright State University School of Medicine, Dayton, Ohio
  • 1987, M.S. in Biochemistry, New York University, New York, New York
  • 1984, B.A. in Biochemistry, New York University, New York, New York


  • 1997, Surgical Pathology, University of California at Los Angeles, Los Angeles, CA
  • 1998, Cytopathology, University of California at Los Angeles, Los Angeles, CA


  • 1996, Anatomical and Clinical Pathology, University of California at Los Angeles, Los Angeles, CA
  • 1997, Chief Resident, Surgical Pathology, University of California at Los Angeles, Los Angeles, CA
  • 1998, American Board of Cytopathology
  • 1997, American Board of Anatomic Pathology & Clinical Pathology
  • 1994, State of California Medical Board License for Physicians and Surgeons (License #: G77815)
  • 1992, National Board of Medical Examiners, Part III
  • 1991, National Board of Medical Examiners, Part II
  • 1990, National Board of Medical Examiners, Part I
Apple S, Alzona MC, Jahromi SA and Grody W. Can different Thyroid Tumor Types Be Distinguished by Polymerase Chain Reaction-Based K-ras Mutation Detection? Molecular Diagnostic 1995; 3(3):143-148.
Apple S, Hecht JR, Novak J, Nieberg R, Rosenthal D and Grody W. Polymerase Chain Reaction-Based K-ras MutationDetection of Pancreatic Adenocarcinoma in Routine Cytology Smears.  Am J. Clin. Pathol. 1996; (105) 321-326.
Apple S. Alveolar Soft Part Sarcoma Check Sample I. American Society of Clinical Pathology 1997; SP 97–3, 35-46.
Apple S, Nieberg R and Hirschowitz S. Solitary Fibrous Tumor of the Pleura and Pitfalls. Acta Cytologica 1997;42:1528-1533.
Apple S, Nieberg R and Hirschowitz S. Infantile fibromatosis Colli, Fine Needle Aspiration. Acta Cytologica 1997;41:1373-76.
Barquist ES, Apple S, Jensen DM and Ashley SW. Jejunal lymphangioma. An unusual cause of chronic gastrointestinal bleeding. Dig Dis Sci 1997;42(6):1179-83.
Rao JY, Apple S, Hemstreet GP, Jin Y and Nieberg R. Single cell mutation biomarker analysis in archival breast fine-needle aspiration specimens: quantitative fluorescence image analysis of DNA content, p53, and G-actin as breast cancer biomarkers. Cancer Epidemiol Biomarkers Prev 1998;7(11):1027-33.
Salami N, Hirschowitz S, Nieberg R and Apple S. Evaluation of the Triple Test-Approach in Cases with Inadequate Breast Fine-Needle Aspiration Biopsies of Palpable Breast Lesions. Acta Cytologica 1999;43:339-343.
Apple S, Lewin D, Hecht JR, Jahomi S, Grody W and Nieberg R. Evidence of Multi-Steps Carcinogesis by Immunohistochemical Evaluation of K-ras, p53 and HER2/neu Expression in Preinvasive Pancreatic Lesions and Pancreatic Adenocarcinoma. Human Pathol. 1999;30:123-129.
Rao JY, Apple S, Jin Y, Lin S, Nieberg R and Hirschowitz S. Comparative Polymerase Chain Reaction Analysis of c-myc amplication on Archival Breast Fine-Needle Aspiration Materials. Cancer Epidemiology, Biomarkers and Prevention 2000;9: 175-179.
Singer A and Apple S. Inflammatory Pseudotumor of the Urinary Bladder. Infec Urol 2001;14 (3):68-74.
Sartippour MR,  Rao JY, Apple S, Wu D, Henning S. Wang H, Elashoff R,  Rubio R and MN Brooks. A pilot clinical study of short-term Isofalvone supplements in breast cancer patients. Nutrition and Cancer  2004;49(1), 59-65.
Zhang L, Maul RS, Rao JY, Apple S, Seligson D, Sartippour MR, Rubio R and Brooks M. Expression pattern of the novel gene EG-1 in cancer. Clinical Cancer Research 2004; (10), 3504-3508.
Apple S. Invasive ductal carcinoma with tissue neutrophila: a distinct entity? The Breast 2004; 13, 519-521.
Burge C, Chang H and Apple S. Do the results of breast cancer biomarker studies differ between core biopsy and surgical excision specimens? The Breast Journal 2005; 11(6): 433-439.
  • 2016, The annual College Outstanding Alumni Awards for 2016 from Wright State University
  • 2016, Wright State University Crystal Award from Heritage Society
  • 2015, Humanitarian Award from San Fernando Valley Food Bank
  • 2001, Outstanding Physician of the Year Award, Southern Kaiser Permanente at Woodland Hills Medical Center.
  • 1995, Honorary Recipient Award, Los Angeles Pathology Society Resident Award
  • 1990-1991, Wright State University School of Medicine Scholarship Recipient, Top 10 of Class Rank
  • 1990-1991, Honors in Psychiatry, Family Practice and Diagnostic Radiology
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