An NCI-designated Comprehensive Cancer Center
Vishal Khairnar

Vishal Khairnar, Ph.D.

Postdoctoral Fellow, Department of Systems Biology
Research Focus
  • Identification and analysis of different target genes in mantle cell lymphoma
  • Investigation of the role of PIK3 in acute lymphoblastic leukemia
  • Finding new targets for peripheral T cell lymphoma
Email: [email protected]

Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS. CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection. Nat Commun. 2018; 9:2561.

Sharma P, Khairnar V, Madunić IV, Singh Y, Pandyra A, Salker MS, Koepsell H, Sabolić I, Lang F, Lang PA, Lang KS. SGLT1 deficiency turns Listeria infection into a lethal disease in mice. Cell Physiol Biochem. 2017; 42:1358-1365. (Shared First Author)

Wagner JM, Jaurich H, Wallner C, Abraham S, Becerikli M, Dadras M, Harati K, Duhan V, Khairnar V, Lehnhardt M, Behr B. Diminished bone regeneration after debridement of posttraumatic osteomyelitis is accompanied by altered cytokine levels, elevated B cell activity and increased osteoclast activity. J Orthop Res. 2017; 35:2425-2434.

Shaabani N, Duhan V, Khairnar V, Gassa A, Ferrer-Tur R, Häussinger D, Recher M, Zelinskyy G, Liu J, Dittmer U, Trilling M, Scheu S, Hardt C, Lang PA, Honke N, Lang KS. CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection. Cell Death Dis. 2016; 7:e2446. (Shared First Author)

Bhavsar S, Singh Y, Sharma P, Khairnar V, Hosseinzadeh Z, Zhang S, Palmada M, Sabolic I, Koepsell H, Lang KS, Lang PA, Lang F. Expression of JAK3 sensitive Na+ coupled glucose carrier SGLT1 in activated cytotoxic T lymphocytes. Cell Physiol Biochem. 2016; 39:1209-1228.

Gassa A, Kalkavan H, Jian F, Duhan V, Khairnar V, Shaabani N, Honke N, Carpinteiro A, Botezatu L, Crivello P, Dolff S, Ferencik S, Häussinger D, Khandanpour C, Fleischhauer K, Witzke O, Wahlers T, Hardt C, Lang PA, Lang KS. High frequencies of anti-host reactive CD8+ T cells ignore non hematopoietic antigen after bone marrow transplantation in a murine model. Cell Physiol Biochem. 2016; 38:1343-53.

Shaabani N, Khairnar V, Duhan V, Zhou F, Tur RF, Häussinger D, Recher M, Tumanov AV, Hardt C, Pinschewer D, Christen U, Lang PA, Honke N, Lang KS. Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation. J Autoimmun. 2016; 67:82-89. (Shared First Author)

Duhan V, Khairnar V, Friedrich SK, Zhou F, Gassa A, Honke N, Shaabani N, Gailus N, Botezatu L, Khandanpour C, Dittmer U, Häussinger D, Recher M, Hardt C, Lang PA, Lang KS. Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8+ T-cell priming and viral control. Sci Rep. 2016; 6:19191. (Shared first author)

Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS. Virus-induced type I Interferon deteriorates control of systemic Pseudomonas aeruginosa infection. Cell Physiol Biochem. 2015; 36: 2379-2392.

Shaabani N, Honke N, Dolff S, Görg B, Khairnar V, Merches K, Duhan V, Metzger S, Recher M, Barthuber C, Hardt C, Proksch P, Häussinger D, Witzke O, Lang PA, Lang KS. IFN-γ licenses CD11b+ cells to induce progression of systemic lupus erythematosus. J Autoimmun. 2015; 62:11-21.

Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nat Commun. 2015; 6:6217.

Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M, Lang KS, Lang PA. Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection. J Virol. 2015; 89:4748-4759.

Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, Homey B, Ohashi PS, Häussinger D, Knolle PA, Honke N, Mak TW, Lang KS. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ. 2015; 22:164-173.

Lang KS, Lang PA, Meryk A, Pandyra AA, Boucher LM, Pozdeev VI, Tusche MW, Göthert JR, Haight J, Wakeham A, You-Ten AJ, McIlwain DR, Merches K, Khairnar V, Recher M, Nolan GP, Hitoshi Y, Funkner P, Navarini AA, Verschoor A, Shaabani N, Honke N, Penn LZ, Ohashi PS, Häussinger D, Lee KH, Mak TW. Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci USA. 2013; 110:2593-2598.

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