Zhirong Yin, Ph.D.
Research Pathologist, Department Of Pathology
Zhirong Yin plays a key role in the growth and success of City of Hope's many clinical trials. As a trained pathologist, she provides critical technical and scientific expertise, assisting in the development and validation of research methods.
Educated in China, Dr. Yin received her medical degree at Henan Medical University, followed by an advanced degree in pathology at Zhengzhou University.
Her passion to deepen her knowledge and expertise has taken her around the world, from China to a research position at the University of Bristol in the UK, to appointments at Ohio State University and Vanderbilt University in Nashville, TN.
Before joining City of Hope Dr. Yin spent several years in the research labs at St. Jude Children's Hospital in Memphis, TN. She was heavily involved in analyzing diagnostic and prognostic biomarkers for pediatric solid tumors.
Ph.D., Pathology, Zhengzhou University, Zhengzhou, China
M.Sc., Pathology, Henan Medical University, Zhengzhou, China
M.D., Clinical Medicine, Henan Medical University, China
2018-Present, Research Pathologist, City of Hope, Duarte, CA
2016-2018, Scientist, SNBL USA, Ltd., Everett, WA
2013-2015, Senior Research Technologist, St. Jude Children’s Hospital, Memphis, TN
2012-2013, Research Lab Specialist, St. Jude Children’s Hospital, Memphis, TN
2009-2012, Research Assistant Professor, Vanderbilt University, Nashville, TN
2004-2009, Postdoctoral Researcher, Ohio State University, Columbus, OH
2002-2004, Research Associate, University of Bristol, Bristol, UK
Olsen RR, Mary-Sinclair MN, Yin Z, Freeman KW. Antagonizing Bcl-2 family members sensitizes neuroblastoma and Ewing's sarcoma to an inhibitor of glutamine metabolism. PLoS One. 2015 Jan 23;10(1).
Charles Lu, Jinghui Zhang, Panduka Nagahawatte, John Easton, Seugiae Lee, Zhifa Liu, Li Ding, Matthew A Wyczalkowski, Marcus Valentine, Fariba Navid, Heather Mulder, Ruth G Tatevossian, James Dalton, James Davenport, Zhirong Yin, …James R Downing, Alberto Pappo and Armita Bahrami for the St Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project. The Genomic Landscape of Childhood and Adolescent Melanoma. J Invest Dermatol. 2014 Sep 30.
Slebos RJ, Jehmlich N, Brown B, Yin Z, Chung CH, Yarbrough WG, Liebler DC. Proteomic analysis of oropharyngeal carcinomas reveals novel HPV-associated biological pathways. Int J Cancer. 2013 Feb 1;132(3):568-79.
Pringle DR, Yin Z, Lee AA, Manchanda PK, Yu L, Parlow AF, Jarjoura D, La Perle KM, Kirschner LS. Thyroid-specific ablation of the Carney Complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer. Endocr Relat Cancer. 2012 May 24; 19(3):435-446.
Yin Z, Pringle DR, Jones GN, Kelly KM, Kirschner LS. Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of Carney Complex Gene Prkar1a. Mol Endocrinol. 2011 Oct; 25(10): 1786-93.
Liu D, Wang WD, Melville DB, Cha Y, Yin Z, Issaeva N, Knapik EW, Yarbrough WG. Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly. Dev Dyn. 2011 Jun; 240(6):1613-25.
Jones GN, Pringle DR, Yin Z, Carlton MM, Powell KA, Weinstein MB, Toribio RE, La Perle KM, Kirschner LS. Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification. Mol Endocrinol. 2010 Aug; 24(8):1559-68.
Jones, G.N., Yin Z., Carlton M., Powell K., Weinstein M., Kirschner L.S. Neural Crest-Specific loss of Prkar1a Causes Perinatal lethality Resulting from Defects in Intramembranous Ossification. Mol Endocrinol. 2010 Feb; 28(8):1559-1568.
Yin Z, Kirschner LS. The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis. Trends Cardiovasc Med., 2009 Feb, 19(2), 44-9.
Kirschner L, Yin Z, Jones G, Mahoney E. Mouse models of altered protein kinase A signaling. Endocr Relat Cancer. 2009 May 26.
Yin Z, Jones GN, Towns WH 2nd, Zhang X, Abel ED, Binkley PE, Jarjoura D, Kirschner LS. Heart-specific ablation of prkar1a causes failure of heart development and myxomagenesis. Circulation. 2008; 117(11):1414-22.
Yin Z, Williams-Simons L, Parlow AF, Asa S, Kirschner LS. Pituitary-specific Knockout of the Carney Complex Gene Prkar1a leads to pituitary tumorigenesis. Mol Endocrinol. 2008 Feb; 22(2):380-7.
Yin Z, Williams-Simons L, Rawahneh L, Asa S, Kirschner LS. Development of a pituitary-specific cre line targeted to the Pit-1 lineage. Genesis. 2008 Jan; 46(1):37-42.
Papageorgiou I, Yin Z, Ladon D, Baird D, Lewis AC, Sood A, Newson R, Learmonth ID, Case CP. Genotoxic effects of particles of surgical cobalt chrome alloy on human cells of different age in vitro. Mutat Res. 2007 Jun 1; 619(1-2):45-58.
Glaviano A, Nayak V, Cabuy E, Baird DM, Yin Z, Newson R, Ladon D, Rubio MA, Slijepcevic P, Lyng F, Mothersill C and Case CP. Effects of hTERT on metal ion-induced genomic instability. Oncogene, 2006; 25(24):3424-35.
Yin Z, Zhang Y, Chen D, et al. Construction of subtractive cDNA library esophageal cancer by using suppression subtractive hybridization. Journal of Henan Medical University, 2001, 52(5):516-518.
Z. Yin, G. N. Jones, C. Eng, M.D. Ringel, L.S. Kirschner. 2008. Mouse Models for Papillary and Follicular Thyroid Carcinoma Reveal Common Signaling Pathways. American Thyroid Association 79th Annual Meeting. Chicago, IL.
Z. Yin, L. Williams-Simons, A.F. Parlow, S. Asa, L. S. Kirschner. 2006. Pituitary-specific Knockout of the Carney Complex Gene Prkar1a Leads to Pituitary Tumorigenesis. WorldMEN 2006. Marseilles, France.
Z. Yin, S. Asa, L.S. Kirschner. 2006. Pituitary-specific Knockout of the Carney Complex Gene Prkar1a Leads to Pituitary Tumorigenesis (ORAL SESSION: BASIC - Endocrine-Related Cancer II: Pituitary Tumors). 88th Annual Meeting of the Endocrine Society. Boston, MA.