A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE


Led by pathologists renowned for diagnostic excellence, the Department of Pathology at City of Hope combines state-of-the-art laboratories equipped with the latest diagnostic techniques and advanced instrumentation with superior investigative skills to accurately and rapidly identify even the rarest and most complex diseases. Our experts provide comprehensive services, from initial diagnosis to monitoring of prognostic indicators throughout the treatment process. Our team also maintains a blood bank and offers a full complement of services relating to blood and bone marrow donors.
Pathology Consultation Services
Our Pathology Consultation Services offers a comprehensive program to fulfill all pathology needs. Physicians at City of Hope and from around the world choose to submit their biopsy samples here because our laboratories are of the highest caliber and our team of pathologists are recognized experts in diagnosing and monitoring disease.
Our team takes a coordinated and cooperative approach, and final interpretations are only made at a daily consensus conference of senior staff, reinforcing the validity of the initial pathologist’s opinion and minimizing any possibility of error.
Rapid, Integrated Results at Competitive Prices
Our highly efficient support staff – from receptionists to transcriptionists to managers – helps deliver complete, accurate reports quickly to the requesting physician. The results of multiple tests are combined into one integrated report, for quick, clear access to priority tests. In most cases, results are obtained within 24 to 48 hours, with automatic faxing capabilities once the reports are signed out. As a nonprofit institution, we are able to offer highly competitive prices for our services. Our regular rates are low, and contracts can be negotiated for prospective high-volume clients. Professional revenues generated are used to support the department’s research activities.



Pathology Case Submission

Cases submitted to a specific pathologist will be read by the designated party. Otherwise we will assign the case to an appropriate investigator.

Always include the patient's clinical history along with referring physician's name, phone and fax numbers on the requisition form.

Send cases to:

City of Hope
Attn: Anatomic Pathology
1500 E. Duarte Road
Duarte, CA 91010



Pathology Customer Service

Customer and Financial Services
We are committed to providing superior pathology consultation services and supporting your needs in an increasingly competitive and cost-conscious medical marketplace.
To that end, we endeavor to complete your case as quickly as technically possible while maintaining our high quality standards.
For your convenience, we will bill third party payers. Simply complete the insurance information on the requisition form. In the absence of complete third party information, the referring pathologist or facility will be billed.
Unfortunately, due to Medicare regulations, we are not able to bill a third party payer if the patient is an inpatient at the referring facility. In this case, the referring institution will be billed. However, we do offer contract prices for these cases with highly competitive rates.
Specimen Collection
We offer free courier services for facilities located in the Southern California area. For facilities outside of Southern California, please call 626-256-HOPE (4673), ext. 63875, to coordinate pick up.



Pathology Laboratories

Our immunohistochemistry laboratory includes three high-volume automated immunostainers using highly advanced epitope retrieval techniques.  We offer complete immunohistochemistry characterization of surgical and cytologic specimens, including estrogen and progesterone receptors and over 100 other monoclonal and polyclonal antibodies. Each year, our hematopathology laboratory performs cytochemistry on more than 1,000 cases of acute leukemia and processes thousands of bone marrow specimens annually.
Flow Cytometry
Our flow cytometry laboratory uses high-capacity instruments to analyze thousands of samples annually to measure a variety of parameters, including cell surface antigens. The presence or absence of certain cell surface antigens has shown great prognostic value in various neoplasia, where treatment protocols can be optimized by customizing the type of treatment based on the types of cell surface antigens present. We provide comprehensive cytochemical and immunophenotypic characterization of leukemias and lymphomas; B and T cell subset analysis for immunodeficiencies; stem cell counts; solid tumor DNA content and cell cycle analysis.
Every year, the cytogenetics laboratory processes a heavy volume of neoplastic specimens, utilizing both conventional cytogenetics as well as fluorescence in situ hybridization (FISH). FISH has become the recognized gold standard in determining the likely course of disease and appropriate treatment in leukemias such as chronic lymphocytic.
Molecular Biology
Our molecular biology laboratory performs Southern blot hybridization, polymerase chain reaction, and in situ hybridization studies for B and T cell gene rearrangements, many different chromosomal translocations for lymphoma and leukemia, including t(14;18), t(9;22), t(15;17), and Epstein-Barr virus. Many of the molecular tests can be performed on paraffin-embedded tissue.
Laboratory accreditation, certification and licensing
The Consultation Services Laboratories at City of Hope are fully accredited by the College of American Pathologists (CAP #22900-01), certified under the Clinical Laboratory Improvements Amendments of 1988 (CLIA '88, ID No. 05D0665695) and licensed by the state of California (CLF 268).

The laboratories participate in the CAP's external proficiency survey program for flow cytometry, immunophenotyping, immunohistochemistry, cytogenetics and molecular oncology. Specific details on our survey performance are available upon request.

Antibody Library

AFP (alpha-fetprotein)
ALK protein
CD117 (c-kit)
EMA (epithelial membrane  antigen)
ER (estrogen receptor)
Factor XIII (vWF)
Granzyme B
Hemoglobin A
Keratin 5/6
Keratin 8/18
Keratin 7
Keratin 8
Keratin 14
Keratin 19 (AE-1)
Keratin 20
Keratin cocktail (pan keratin)
34 βE 12 (HMW Keratin)
MPX (myeloperoxidase)
NF (neurofilament)
PacP (prostate acid phosphatase)
PLAP (placential alkaline phosphatase)
PR (progesterone receptor)
PSA (prostate specifice antigen)
SMA (smooth muscle actin)
TGB (thyroglobin)
vWF (factor VIII)

Specimen Draw and Shipping Requirements

Results for STATs, pre-BMT's and newly diagnosed leukemias are available within seven days. All others are available in seven to 10 days but our goal is to report results as soon as they are available. Complex studies may require additional days. Specimens are accepted Monday through Friday, 8 a.m. to 5:30 p.m.
Drawing specifications
  • Leukemia and myelodysplastic syndromes: A bone marrow aspirate is the specimen of choice in most cases of leukemia, myelodysplastic and myeloproliferative disorders.
  • Leukemia cytogenetics: Obtain 1 to 2 ml of bone marrow (minimum 0.5 ml) in a heparinized syringe (approximately 500 USP sodium heparin per ml of specimen) and transfer the specimen into a green top sodium heparin tube. Keep at room temperature and ship as soon as possible.
  • Leukemic peripheral blood: Draw 5 to 20 ml of peripheral blood into a green top sodium heparin tube. Mix well by inverting. Keep at room temperature and ship as soon as possible.
  • Lymphoma and solid tumor cytogenetics: Bone marrow core biopsies should be placed in HBSS or RPMI medium.
Flow cytometry / molecular diagnositcs
The laboratory is open Mondary through Friday, 8 a.m. to 5 p.m.
Drawing specifications
  • Peripheral blood: For leukemia and lymphoma panels, draw six green top tubes (sodium herapin) and one purple top tube. Maintain at room temperature and ship as soon as possible. ACD tubes are acceptable. Sodium lithium should not be used.
  • Bone marrow: Draw at least one purple top tube, maintain at room temperature and ship as soon as possible. ACD and sodium heparin tubes are acceptable.

Pathology Team

Support This Program

It takes the help of a lot of caring people to make hope a reality for our patients.  City of Hope was founded by individuals’ philanthropic efforts 100 years ago. Their efforts – and those of our supporters today -- have built the foundation for the care we provide and the research we conduct. It enables City of Hope to strive for new breakthroughs and better therapies – helping more people enjoy longer, better lives.

For more information on supporting this specific program, please contact our  Donor Relations Department at 800-667-5310 or developmentrelations@coh.org. Or, to make a gift that supports all the research at City of Hope,  donate online now . We thank you for your support.
Our Programs and Treatments

City of Hope is a national leader in cancer treatment and prevention. Read more...

City of Hope is committed to making the process of becoming a patient here as easy as possible. Call 800-826-HOPE (4673) or complete the Schedule a Callback form.
Our treatment facilities are located throughout our 100+ acre grounds in Duarte, California as well as in  Antelope Valley, South Pasadena, Santa Clarita and Palm Springs.
Led by multidisciplinary teams of volunteers and professionals, the Sheri & Les Biller Patient and Family Resource Center offers an integrated array of cancer support services.
City of Hope combines compassionate care with the best and most innovative science. Our 100+ acre campus is designed to meet the full range of needs of our patients and families. This guide is designed to help you take advantage of all that is offered at City of Hope - Duarte.
Clinical Trials
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials.
  • Cancer cells may be known for their uncontrollable growth and spread, but they also differ from normal tissue in another manner: how they produce energy. In healthy cells, energy is derived primarily from aerobic respiration, an oxygen-requiring process that extracts the maximum possible energy from glucose, or...
  • Clinical trials are expensive and complex, but they’re essential for bringing new therapies to patients. Edward Newman, Ph.D., associate professor of molecular pharmacology, just boosted City of Hope’s ability to conduct those studies with a five-year, $4.2 million grant from the National Cancer Institute...
  • Meet City of Hope’s new chair of the Department of Surgery – esteemed pancreatic and hepatobiliary surgeon, researcher and author Yuman Fong, M.D. As one of today’s most respected and recognizable physicians in the treatment of cancers of the liver, bile duct, gallbladder and pancreas, Fong has pioneered and en...
  • For most of her life, Southern California teenager Kayla Saikaly described herself as healthy, even very healthy. She played basketball. She never missed school with as much as a fever. Her worst childhood illness was nothing more than a cold. Then, when she was 13, her nose started bleeding after a basketball ...
  • Neuroblastoma is one of the deadliest childhood cancers, accounting for 15 percent of pediatric cancer deaths. For patients with high-risk neuroblastomas, the five-year survival rate is 40 to 50 percent even with the most rigorous treatments available today. But those odds may improve soon, thanks to a new comp...
  • For breast cancer survivors, a common worry is a recurrence of their cancer. Currently, these patients are screened with regular mammograms, but there’s no way to tell who is more likely to have a recurrence and who is fully cleared of her cancer. A new blood test – reported in Cancer Research, a journal of the...
  • Metastasis — the spreading of cancer cells from a primary tumor site to other parts of the body — generally leads to poorer outcomes for patients, so oncologists and researchers are constantly seeking new ways to detect and thwart this malicious process. Now City of Hope researchers may have identified a substa...
  • Deodorant, plastic bottles, grilled foods, artificial sweeteners, soy products … Do any of these products really cause cancer? With so many cancer myths and urban legends out there, why not ask the experts? They can debunk cancer myths while sharing cancer facts that matter, such as risk factors, preventi...
  • Cancer risk varies by ethnicity, as does the risk of cancer-related death. But the size of those differences can be surprising, highlighting the health disparities that exist among various ethnic groups in the United States. Both cancer incidence and death rates for men are highest among African-Americans, acco...
  • George Winston, known worldwide for his impressionistic, genre-defying music, considers music to be his first language, and admits he often stumbles over words – especially when he attempts languages other than English. There’s one German phrase he’s determined to perfect, however: danke schön. Winston thinks h...
  • Few decisions are more important than those involving health care, and few decisions can have such lasting impact, not only on oneself but on relatives and loved ones. Those choices, especially, should be made in advance – carefully, deliberately, free of pain and stress, and with much weighing of values and pr...
  • Using a card game to make decisions about health care, especially as those decisions relate to the end of life, would seem to be a poor idea. It isn’t. The GoWish Game makes those overwhelming, but all-important decisions not just easy, but natural. On each card of the 36-card deck is listed what seriously ill,...
  • Young adults and adolescents with cancer face unique challenges both during their treatment and afterward. Not only are therapies for children and older adults not always appropriate for them, they also must come to terms with the disease and treatment’s impact on their relationships, finances, school or ...
  • Breast cancer is the most common cancer, other than skin cancer, among women in the United States. It’s also the second-leading cause of cancer death, behind lung cancer. In the past several years, various task force recommendations and studies have questioned the benefits of broad screening guidelines fo...
  • Paternal age and the health effects it has on potential offspring have been the focus of many studies, but few have examined the effect parental age has on the risk of adult-onset hormone-related cancers (breast cancer, ovarian cancer and endometrial cancer). A team of City of Hope researchers, lead by Yani Lu,...