A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE

Pathology

Pathology
Led by pathologists renowned for diagnostic excellence, the Department of Pathology at City of Hope combines state-of-the-art laboratories equipped with the latest diagnostic techniques and advanced instrumentation with superior investigative skills to accurately and rapidly identify even the rarest and most complex diseases. Our experts provide comprehensive services, from initial diagnosis to monitoring of prognostic indicators throughout the treatment process. Our team also maintains a blood bank and offers a full complement of services relating to blood and bone marrow donors.
 
Pathology Consultation Services
Our Pathology Consultation Services offers a comprehensive program to fulfill all pathology needs. Physicians at City of Hope and from around the world choose to submit their biopsy samples here because our laboratories are of the highest caliber and our team of pathologists are recognized experts in diagnosing and monitoring disease.
 
Our team takes a coordinated and cooperative approach, and final interpretations are only made at a daily consensus conference of senior staff, reinforcing the validity of the initial pathologist’s opinion and minimizing any possibility of error.
 
Rapid, Integrated Results at Competitive Prices
Our highly efficient support staff – from receptionists to transcriptionists to managers – helps deliver complete, accurate reports quickly to the requesting physician. The results of multiple tests are combined into one integrated report, for quick, clear access to priority tests. In most cases, results are obtained within 24 to 48 hours, with automatic faxing capabilities once the reports are signed out. As a nonprofit institution, we are able to offer highly competitive prices for our services. Our regular rates are low, and contracts can be negotiated for prospective high-volume clients. Professional revenues generated are used to support the department’s research activities.

 

 

Pathology Case Submission

Cases submitted to a specific pathologist will be read by the designated party. Otherwise we will assign the case to an appropriate investigator.

Always include the patient's clinical history along with referring physician's name, phone and fax numbers on the requisition form.

Send cases to:

City of Hope
Attn: Anatomic Pathology
1500 E. Duarte Road
Duarte, CA 91010

 

 

Pathology Customer Service

Customer and Financial Services
We are committed to providing superior pathology consultation services and supporting your needs in an increasingly competitive and cost-conscious medical marketplace.
 
To that end, we endeavor to complete your case as quickly as technically possible while maintaining our high quality standards.
 
For your convenience, we will bill third party payers. Simply complete the insurance information on the requisition form. In the absence of complete third party information, the referring pathologist or facility will be billed.
 
Unfortunately, due to Medicare regulations, we are not able to bill a third party payer if the patient is an inpatient at the referring facility. In this case, the referring institution will be billed. However, we do offer contract prices for these cases with highly competitive rates.
 
Specimen Collection
We offer free courier services for facilities located in the Southern California area. For facilities outside of Southern California, please call 626-256-HOPE (4673), ext. 63875, to coordinate pick up.

 

 

Pathology Laboratories

Immunochistochemistry
Our immunohistochemistry laboratory includes three high-volume automated immunostainers using highly advanced epitope retrieval techniques.  We offer complete immunohistochemistry characterization of surgical and cytologic specimens, including estrogen and progesterone receptors and over 100 other monoclonal and polyclonal antibodies. Each year, our hematopathology laboratory performs cytochemistry on more than 1,000 cases of acute leukemia and processes thousands of bone marrow specimens annually.
 
Flow Cytometry
Our flow cytometry laboratory uses high-capacity instruments to analyze thousands of samples annually to measure a variety of parameters, including cell surface antigens. The presence or absence of certain cell surface antigens has shown great prognostic value in various neoplasia, where treatment protocols can be optimized by customizing the type of treatment based on the types of cell surface antigens present. We provide comprehensive cytochemical and immunophenotypic characterization of leukemias and lymphomas; B and T cell subset analysis for immunodeficiencies; stem cell counts; solid tumor DNA content and cell cycle analysis.
 
Cytogenetics
Every year, the cytogenetics laboratory processes a heavy volume of neoplastic specimens, utilizing both conventional cytogenetics as well as fluorescence in situ hybridization (FISH). FISH has become the recognized gold standard in determining the likely course of disease and appropriate treatment in leukemias such as chronic lymphocytic.
 
Molecular Biology
Our molecular biology laboratory performs Southern blot hybridization, polymerase chain reaction, and in situ hybridization studies for B and T cell gene rearrangements, many different chromosomal translocations for lymphoma and leukemia, including t(14;18), t(9;22), t(15;17), and Epstein-Barr virus. Many of the molecular tests can be performed on paraffin-embedded tissue.
 
Laboratory accreditation, certification and licensing
The Consultation Services Laboratories at City of Hope are fully accredited by the College of American Pathologists (CAP #22900-01), certified under the Clinical Laboratory Improvements Amendments of 1988 (CLIA '88, ID No. 05D0665695) and licensed by the state of California (CLF 268).

The laboratories participate in the CAP's external proficiency survey program for flow cytometry, immunophenotyping, immunohistochemistry, cytogenetics and molecular oncology. Specific details on our survey performance are available upon request.
 

Antibody Library

Actin
AFP (alpha-fetprotein)
ALK protein
bcl-1
bcl-2
bcl-6
BerEp4
BG8
Calcitonin
Calretinin
CD1
CD2
CD3
CD4
CD5
CD7
CD8
CD10
CD15
CD16
CD20
CD21
CD23
CD30
CD31
CD34
CD35
CD343
CD45RA
CD45/45RB
CD45RO
CD56
CD57
CD68
CD79A
CD99
CD117 (c-kit)
CD138
CEA-Gold1
CEA-Gold5
c-erb-2
Chromogranin
Collagen-IV
DBA.44
Desmin
EBV-LMP
EMA (epithelial membrane  antigen)
ER (estrogen receptor)
Factor XIII (vWF)
FASCIN
GCDFP-15
GFAP
Granzyme B
HBME-1
HCG
Helico
Hemoglobin A
HLA-DR
HMB45
Inhibin
Kappa
Keratin 5/6
Keratin 8/18
Keratin 7
Keratin 8
Keratin 14
Keratin 19 (AE-1)
Keratin 20
Keratin cocktail (pan keratin)
34 βE 12 (HMW Keratin)
Ki-67
Lambda
Lysozyme
Melan-A
mes-13
MOC
MPX (myeloperoxidase)
NF (neurofilament)
p53
PacP (prostate acid phosphatase)
Perforin
PLAP (placential alkaline phosphatase)
PR (progesterone receptor)
Prolactin
PSA (prostate specifice antigen)
S100
SMA (smooth muscle actin)
Surfactant
Synaptophysin
Tdt
TGB (thyroglobin)
Thrombomodulin
TIA-1
TRAP
Tryptase
TTF-1
Villin
Vimentin
vWF (factor VIII)

Specimen Draw and Shipping Requirements

Cytogenetics
Results for STATs, pre-BMT's and newly diagnosed leukemias are available within seven days. All others are available in seven to 10 days but our goal is to report results as soon as they are available. Complex studies may require additional days. Specimens are accepted Monday through Friday, 8 a.m. to 5:30 p.m.
 
Drawing specifications
  • Leukemia and myelodysplastic syndromes: A bone marrow aspirate is the specimen of choice in most cases of leukemia, myelodysplastic and myeloproliferative disorders.
  • Leukemia cytogenetics: Obtain 1 to 2 ml of bone marrow (minimum 0.5 ml) in a heparinized syringe (approximately 500 USP sodium heparin per ml of specimen) and transfer the specimen into a green top sodium heparin tube. Keep at room temperature and ship as soon as possible.
  • Leukemic peripheral blood: Draw 5 to 20 ml of peripheral blood into a green top sodium heparin tube. Mix well by inverting. Keep at room temperature and ship as soon as possible.
  • Lymphoma and solid tumor cytogenetics: Bone marrow core biopsies should be placed in HBSS or RPMI medium.
 
Flow cytometry / molecular diagnostics
The laboratory is open Monday through Friday, 8 a.m. to 5 p.m.
 
Drawing specifications
  • Peripheral blood: For leukemia and lymphoma panels, draw six green top tubes (sodium herapin) and one purple top tube. Maintain at room temperature and ship as soon as possible. ACD tubes are acceptable. Sodium lithium should not be used.
  • Bone marrow: Draw at least one purple top tube, maintain at room temperature and ship as soon as possible. ACD and sodium heparin tubes are acceptable.
 
 

Pathology Team

Support This Program

It takes the help of a lot of caring people to make hope a reality for our patients.  City of Hope was founded by individuals’ philanthropic efforts 100 years ago. Their efforts — and those of our supporters today — have built the foundation for the care we provide and the research we conduct. It enables City of Hope to strive for new breakthroughs and better therapies, ultimately helping more people enjoy longer, better lives.

For more information on supporting this specific program, please contact our Donor Relations Department at 800-667-5310 or developmentrelations@coh.org. Or, to make a gift that supports all the research at City of Hope, donate online now.
 
We thank you for your support.
 
 
 
Our Programs and Treatments

City of Hope is a national leader in cancer treatment and prevention. Read more...

Our treatment facilities are located throughout our 100+ acre grounds in Duarte, California as well as in  Antelope Valley, South Pasadena, Santa Clarita and Palm Springs.
City of Hope combines compassionate care with the best and most innovative science. Our 100+ acre campus is designed to meet the full range of needs of our patients and families. This guide is designed to help you take advantage of all that is offered at City of Hope - Duarte.
Clinical Trials
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials.
 
NEWS & UPDATES
  • Donating blood and platelets saves lives. We all know this. Yet every summer, potential blood donors become distracted by vacations and schedule changes. As a result, blood donations fall dramatically across the nation, leaving hospitals frantically trying to bring in much-needed blood for their patients. Earli...
  • To be a great cancer hospital, you need a great oncology program. Just ask City of Hope – and Becker’s Hospital Review. The health care publishing industry stalwart, described as the “leading hospital magazine for hospital business news and analysis for hospital and health system executives,” recently selected ...
  • Diagnostic errors are far from uncommon. In fact, a recent study found that they affect about 12 million people, or 1 in 20 patients,  in the U.S. each year. With cancer, those errors in diagnosis can have a profound impact. A missed or delayed diagnosis can make the disease that much harder to treat, as the Ag...
  • Eleven years ago, lymphoma patient Christine Pechera began the long road toward a cancer-free life. She had been diagnosed with non-Hodgkin lymphoma and told by doctors elsewhere that her lifespan likely would be measured in months, not years. Refusing to give up, she came to City of Hope for a second opinion. ...
  • Brain surgery is not for the faint of heart. It takes courage, as well as curiosity and compassion. The truly great surgeons also have a desire to find new, and better ways, of healing the brain. Enter Behnam Badie, M.D., chief of neurosurgery at City of Hope. Now a pioneer in brain tumor treatment, Badie enter...
  • Elizabeth Budde, M.D., Ph.D., wants to encourage infighting. She aims to turn the immune system on itself — to the benefit of patients with acute myeloid leukemia, or AML. AML arises when abnormal white blood cells grow out of control, amassing in the bone marrow and interfering with normal blood cell developme...
  • Six, to date; more soon. Outpatient bone marrow transplants, that is. Finding new ways to deliver quality care with the greatest benefit is a priority for a patient-centered institution like City of Hope. For example, not every bone marrow transplant patient needs to check into the hospital for treatment. In fa...
  • The best measure of success in the fight against cancer is in lives saved and families intact, in extra days made special simply because they exist. Yuman Fong, M.D., chair of the Department of Surgery at City of Hope, understands what precedes that special awareness. When cancer strikes, one minute a person ma...
  • In cancer, expertise matters. So do survival rates, patient safety, patient services and many other factors. City of Hope understands this, as does U.S.News & World Report. The magazine’s 2014-2015 list of best hospitals for cancer once again includes City of Hope, ranking the institution 12 out of 900 elig...
  • At 29, Kommah McDowell was a successful young professional engaged to be married to her best friend. She worked in the financial services sector and kick-boxed to keep in shape and to relax. Then came the diagnosis of triple-negative inflammatory breast cancer, a rare and very aggressive form of breast cancer. ...
  • The well-known drug tamoxifen might not always be the best choice for premenopausal women who have undergone treatment for breast cancer and face a heightened risk of recurrence. A new study suggests that the aromatase inhibitor exemestane, or Aromasin, works slightly better than tamoxifen in preventing cancer ...
  • At age 44, Bridget Hanchette, a mother of three from La Crosse, Wisconsin, was diagnosed with grade IV glioblastoma, the most aggressive type of malignant brain tumor. The cancer grows and spreads quickly, making it difficult to treat. Most patients with this diagnosis are not given much hope, but Hanchette’s i...
  • Survival rates for childhood cancer have improved tremendously over the past few decades, but postcancer care hasn’t always kept up. More children than ever are now coping with long-term complications and side effects caused by their disease and treatment — one of those being learning difficulties. A new ...
  • When Sheldon Querido, a retired manufacturer’s representative, was diagnosed with bladder cancer, his doctor told him that he’d need to have his bladder removed – and that he’d have to wear an external urine-collection bag for the rest of his life. “My first response was ‘I donR...
  • To stop smoking, two approaches might be better than one. A new study has found that using the medication varenicline, or Chantix – along with nicotine patches – was more effective than the medicine alone in helping people quit. The study, conducted by Stellanbosch University in Cape Town, South Africa, and pub...