Contact Information
Edouard Cantin, Ph.D.
  • Professor, Virology
  • Chair, Institutional Biosafety Committee

Departments/Division/Program
  • Virology

Biography

Dr. Cantin is director of the Laboratory of Neurovirology and Neuroimmunology. He investigates the role of cytokines/chemokines in herpes simplex virus (HSV) infections in vivo, with particular emphasis on latent infections. The laboratory has particular interest in the genetic and molecular biological characterization of determinants of natural resistance to HSV, with emphasis on the genetic explanation for sex-based differences in infection and the role of innate immunity in disease pathogenesis.

Professional Experience

  • 2002 - present, Professor, Laboratory of Neurovirology and Neuroimmunology, Department of Virology, Beckman Research Institute of City of Hope, Duarte, CA
  • 2002 - present, Associate Chair, Department of Virology, Beckman Research Institute
  • 1995 - present, Associate Professor (Adjunct), Department of Microbiology and Molecular Biology, Loma Linda University, School of Medicine, Loma Linda, CA
  • 1992 - 2001, Associate Professor, departments of Neurology and Virology, Beckman Research Institute of City of Hope, Duarte, CA
  • 1984 - 1991, Assistant Research Scientist, Division of Neurology, City of Hope, Duarte, CA
  • 1980 - 1983, Expert, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland (Molecular biological studies of herpes simplex virus latency in the mouse model system)
  • 1977 - 1980, Visiting Fellow, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland (Molecular biological studies of herpes simplex virus latency in the mouse model system)
  • 1974 - 1976, Tutor in Biochemistry, Newnham and Keyes Colleges, University of Cambridge, England
  • 1968 - 1970, Senior Laboratory Technician, London Oil, Medina, LTD, England
  • 1967, Laboratory Technician, Pathology Department, Mile End Hospital, London, England
  • 1966, Laboratory Technician, Unilever (S.A.Ltd.), Durban, South Africa

Education

Education/Training
  • 1999, University of California, Berkley, Advanced Immunology
  • 1981 - 1982, Foundation for Advanced Education in the Sciences, NIH, Bethesda, Maryland. Advanced courses in Molecular and Cellular Aspects of Immunology, Molecular Genetics of Viruses, and Fortran Computer Programming
  • 1976, University of Cambridge, England, Ph.D., Biochemistry
  • 1974, University of Cambridge, England, M.A., Biochemistry
  • 1973, University of Manchester Institute of Science and Technology, England, B.Sc. (Honors), Biochemistry
  • 1970, Norwood Technical College, London, England, advanced-A-levels in Pure Mathematics, Zoology and Chemistry
  • 1964 - 1965, University of Natal School of Medicine, Durban, Republic of South Africa, M.B.

Honors/Awards

Awards
  • 1973, Welcome Trust, UK. Scholarship for doctoral studies
  • 1972, Faculty prize, Dept. of Biochemistry, University of Manchester Institute of Science and Technology

Honors
  • 2008, Associate Editor, BMC Microbiology
  • 2005, Guest Editor, Viral Immunology. Special Focus Issue, Immunology of Herpesvirus Infection
  • 2004, Member of the Scientific Advisory Committee, 29th International Herpesvirus Workshop Meeting, Reno, NV.
  • 2004, Chairman, alphaherpesvirus I session, 29th International Herpesvirus Workshop
  • 2003, Invited Editor, Viral Immunology, Special Focus Issue, Herpesvirus Immunity
  • 2002, Chairman, Immunology I session, Association for Research in Vision and Ophthalmology
  • 1997 - 2002, Ad Hoc member, Special Review Committee, SBIR Grants
  • 1997 - 1999, Invited Lecturer, University of California Riverside, Department of Microbiology, School of Medicine, course of Virology lectures
  • 1992 - 2000, Ad Hoc member, Special Review Committee, NIAID, NCI, NIH
  • 1992 - 1996, Member, Biological and Clinical Aging Review Committee A, NIA, NIH
  • 1991 - present, Invited Lecturer, Loma Linda University Medical School, Department of Microbiology, and Molecular Biology, Molecular Virology Course
  • 1990 - 1991, Ad Hoc member, Special Review Committee, NCI, NIH, Program Project Grant
  • 1990, NIH, Site Visitor, Ponce School of Medicine, Puerto Rico
  • 1990, Ad Hoc member, Research Centers in Minority Institution Programs
  • 1986 - 1987, Ad Hoc member, Biomedical Sciences Study Section, Subcommittee 1, NIH
  • 1979 - 1981, Ad Hoc Member, RACC, NIH
 

Memberships

  • Associate Member, The Biochemical Society, England
  • Associate Member, Cambridge Philosophical Society, England
  • Member, American Association in the Advancement of Science
  • Member, Association for Research in Vision and Ophthalmology
  • Member, American Society for Microbiology

Publications

  • Chandran R, Openshaw H, and Cantin E. (2013) The case for immunomodulatory approaches in treating HSV encephalitis. Future Virol Mar 1; 8(3):259-272, 2013. PMID:23956785 PMCID: PMC3742040
  • Lundberg, P,Yang H-J, Jung S-J, Behlke A, Rose S, and Cantin E.  Protection against TNFα-Dependent Liver Toxicity by Intraperitoneal Liposome Delivered DsiRNA Targeting TNFα In Vivo. J Control Release, doi: 10.1016/j.jconrel. Jun 10; 160(2):194-9, 2012. PMID: 22094102 PMCID: PMC3321390
  • Welander P, Cantin E, Lundberg P. Using Taguchi-Based Statistics To Produce Robust PCR Results. BioProcess Journal 10(1):22-26. 2011
  • Chandran R, Newo-Soufo A, Shen Y-W, and Cantin E. Passively Administered Pooled Human Immunoglobulins Exert IL-10 Dependent Anti-inflammatory Effects that Protect Against Fatal HSV Encephalitis. PLOS Pathogens, 7 (6): e1002071. 2011 PMID:21655109 PMCID:PMC3107211
  • Lundberg, P., Chandran R., Brown, J., Tyszka, M.J., Hamamura, M., Hinton, D.R., Kovats, S., Nalcioglu, O., Weinberg, K., Openshaw, H., and Cantin, E.M. The Immune Response to Herpes Simplex Virus Type 1 Infection in Susceptible Mice is a Major Cause of CNS Pathology Resulting in Fatal Encephalitis. J Virol 82(14): 7078-88. 2008 PMID:18480436 PMCID:PMC2446972
  • Lundberg, P., Openshaw H,, Wang M., Yang H.J., and Cantin E.M.. Effects of CXCR3 Signaling on Development of Fatal Encephalitis, Corneal and Periocular Skin Disease in HSV-1 Infected Mice is Mouse Strain Dependent. Investigational Journal of Ophthalmology and Vision Research 48(9): 4162-70, 2007 PMID: 12815542
  • Cantin E.M., Rossi JJ.  News and Views- Entry granted. Nature Molecular Medicine 448: 33-34, 2007 PMID: 17724202
  • Lundberg, P., Welander PV, Edwards, CK 3rd, Van Rooijen, Cantin E.M.  Tumor necrosis factor (TNF) protects resistant C57BL/6 mice against herpes simplex virus-induced encephalitis independently of signaling via TNF receptor 1 or 2. J Virol 81(3): 1451-60. 2007 PMID: 17108044 PMCID: PMC1797509
  • Amarzguioui, M., Lundberg, P., Cantin E.M., Hagstrom, J., Behlke, M., and Rossi, J.J.  Rational design and in vitro/in vivo delivery of Dicer substrate siRNAs. Nature Protocols 1(2): 508-51. 2006 PMID: 17406276
  • Guest Editor:  Cantin, E.M. Immunology of Herpesvirus Infection. Viral Immunol 18 (3): 408-10
  • Special focus issue, 2005
  • Openshaw H., Cantin E.M.  Editorial commentary, Corticosteroids in herpes simplex encephalitis. J Neurol Neurosur Ps 76(11): 1469-7, 2005. PMID: 16227530
  • Kim, D.H., Longo, M., Han, Y., Lundberg, P., Cantin, E.M., and Rossi, J.J.  Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase.  Nature Biotechnol 22 (3): 321-5, 2004. PMID: 14990954
  • Lundberg, P., Han, X., Welander, P., and Cantin, E.M. Herpes Simplex Virus type 1 (HSV-1) DNA is Immunostimulatory In vitro and in vivo; A Potential role in Pathogenesis?   J Virol 77 (20): 11158-69, 2003. PMID: 14512563
  • Lundberg, P., and Cantin, E.M.  A Potential role for CXCR3 Chemokines in the response to ocular HSV infection. Curr Eye Res 26 (3-4): 137-150, 2003. PMID: 12815542
  • Lundberg, P., Welander, P., Openshaw, H., Edwards, C.K., Nalbandian, C., Moldowar, L., and Cantin, E.M. A Locus on Mouse Chromosome 6 that Determines Resistance to Herpes Simplex Virus also Influences Reactivation, While an Unlinked Locus Augments Resistance of Female Mice.  J Virol 77 (21): 11661-73, 2003. PMID: 14557652 PMCID: PMC229335
  • Han, X., Lundberg, P., Tanamachi, B., Openshaw, H., Longmate, J., Cantin, E.M.  Gender influences HSV-1 infection in normal and interferon-gamma mutant mice. [Erratum appears in J Virol 2001 Aug; 75(16): 7789]. J Virol 75(6): 3048-3052, 2001. PMID: 11222734 PMCID: PMC115935
  • Cantin, E.M., Tanamachi, B., Mann, J., Openshaw, H., and Clarke, K.  Interferon gamma receptor mutant mice are more susceptible to herpes simplex virus type 1 infection than interferon gamma ligand null-mutant mice.  J Virol  73 (6): 5196-200, 1999. PMID: 10233988 PMCID: PMC112570
  • Cantin, E.M., Mann, J. Genetic Variation Among 129 Substrains Practical Consequences Correspondence. J Immunol 162(10):6294, 1999. PMID: 10375305
  • Cantin, E.M., Tanamachi, B., Openshaw, H.  Role for gamma interferon in control of herpes simplex virus type-1 reactivation.  J Virol 73 (4): 3418-3423, 1999. PMID: 10074196 PMC104106
  • Eberle, R., Cantin, E.M., Openshaw, H., Tanamachi, B.  Genetic and functional complementation of the HSV1 UL27 gene and gB glycoprotein by simian alpha-herpesvirus homologs.  Arch Virol 142:721 736, 1997. PMID: 9170500
  • Lin, X.H., Ali, M.R., Openshaw, H., Cantin, E.M.  Deletion of the carboxy terminus of herpes simplex virus type I (HSV 1) glycoprotein B does not affect oligomerization, heparin binding activity, or its ability to protect against HSV challenge.  Arch Virol 141(6): 1153 1156, 1996. PMID: 8712932
  • Ali, M.R., Forghani, B., Cantin, E.M.  Characterization of an essential HSV 1 protein encoded by the UL25 gene reported to be involved in virus penetration and capsid assembly.  Virology 216 (1): 278 283, 1996. PMID: 8615003
  • Cantin, E.M., Hinton, D.R., Chen, J., Openshaw, H.  Gamma Interferon Expression during acute and latent nervous system infection by herpes simplex virus type 1.  J Virol 69(8): 4898 4905, 1995. PMID: 7609058 PMCID: PMC189304
  • Openshaw, H., McNeill, J.I., Lin, X.H., Niland, J. and Cantin, E.M.  Herpes Simplex Virus DNA in normal corneas:  Persistence without viral shedding from ganglia.  J Med Virol 46:75 80, 1995. PMID: 7623011
  • Cantin, E.M., Chen, J., Gaidulis, L., Valo, Z., McLaughlin Taylor, E.  Detection of Herpes Simplex Virus DNA Sequences in Human Blood and Bone Marrow Cells.  J Med Virol 42:279 286, 1994. PMID:8006641
  • Cantin, E.M., and Woolf, T.  Antisense Oligonucleotides:  Prospects and Problems.  Trends Microbiol 1:249 283. 1993  (Invited Review). PMID: 8162408
  • Lange, W., Cantin, E.M., Finke, J., Dolken, G.  In Vitro and In Vitro Effects of Synthetic Ribozymes Targeted against  BCR/ABL mRNA.  Leukemia 7:1786 1794. 1993 PMID: 8231247
  • Cantin, E.M., Podsakoff, G., Willey, D.E., Openshaw, H.  Antiviral effects of herpes simplex virus specific anti sense nucleic acids.  Adv Exp Med Bio 312:139 49, 1992. PMID: 1325101
  • Cantin, E.M., Chen, J., Willey, D., Taylor, J.L., O'Brien, W.J.  Persistence of Herpes Simplex Virus DNA in Rabbit Corneal Cells.  Invest Ophthal Vis Sci 33:2470 2475, 1992. PMID: 1321797
  • Cantin, E.M., Chen, J., McNeill, J., Willey, D.E., Openshaw, H.  Detection of herpes simplex virus DNA sequences in corneal transplant recipients by polymerase chain reaction assays.  Curr Eye Res 10:15 21, 1991. PMID: 1650662
  • Cantin, E.M., Lange, W. and Openshaw, H.  Application of Polymerase Chain Reaction Assays to Studies of Herpes Simplex Virus Latency.  Intervirology 32:93 100, 1991. PMID: 1851147
  • Cantin, E.M., Podsakoff, G., Willey D.E., Openshaw, H.  Antiviral effects of herpes simplex virus specific anti sense nucleic acids.  In:  Innovations in Antiviral Development and the Detection of Virus Infections.  Edited by L.R. Walsh.  Plenum Press, New York. Pages 139-149, 1991. PMID: 1325101
  • Zaia, J.A., Cantin, E.M., Chang, P.S., Sarver, N., and Rossi, J.J.  Antiviral Evaluation of HIV 1 Specific Ribozyme Expressed in CD4 + HeLa Cells.  In Advances in Molecular Biology and Targeted Treatments for AIDS.  Plenum Publishing Corp, New York.  Pages 335 343, 1991.
  • Chang, P.S., Cantin, E.M., Zaia, J.A., Ladne, P.A., Stephens, D.A., Sarver, N. and Rossi, J.J.  Ribozyme mediated site-specific cleavage of the HIV 1 genome.  Clinical Biotechnology 2:1 8, 1990.
  • Rossi, J.J., Cantin, E.M., Zaia, J.A., Ladne, P.L., Chen, J., Stephens, D.A., Sarver, N. and Chang, P.S.  Ribozymes as therapies for AIDS.  Ann NY Acad Sci, 1990. PMID: 2078019
  • Sarver, N., Cantin, E.M., Chang, P.S., Ladne, P., Stephens, D., Zaia, J.A. and Rossi, J.J.  Ribozymes as potential HIV 1 therapeutic agents.  Science, 247:1222 1225, 1990. PMID: 2107573
  • Openshaw, H., Cantin, E.M. and Hinton, D.  Potential interactions of HIV and the neurotropic herpesviruses in AIDS encephalopathy.  In: Herpesvirus, the Immune System, and AIDS.  Developments in Medical Virology.  Y. Becker, and L. Aurelian, Editors.  Kluwer Academic Publishers, Norwell, MA.   Chapter 10, Pp. 227 248, 1990.
  • Sarver, N., Hampel, A., Cantin, E.M., Chang, P., Tritz, R., Zaia, J.A. and Rossi J.J.  Exploring catalytic RNAs as potential HIV 1 therapeutic agents, In: Gene regulation, oncogenesis and AIDS. Takis S. Papas, Editor, Portofolio Publishing Co., Texas, 1990.
  • Sarver, N., Cantin, E.M., Chang, P.S., Ladne, P.A., Stephens, D.A., Zaia, J.A. and Rossi, J.J.  Ribozymes as potential HIV 1 therapeutic agents.  Science 247:1222 1225, 1990. PMID: 2107573
  • Rossi, J.J., Cantin, E.M., Sarver, N., Chang, P.F.  The potential use of catalytic RNAs in therapy of HIV infection and other diseases.  Pharmacol Therapeut 50 (2): 245 54, 1990. PMID: 1763136
  • Martin, S., Cantin, E.M. and Rouse, B.T.   Evaluation of antiviral immunity using vaccinia virus recombinants expressing cloned genes for herpes simplex virus type 1 glycoproteins. J Gen Virol 70:1359 1370, 1989. PMID: 2543783
  • Eskinazi, D.P. and Cantin, E.M.   Some monoclonal antibodies to HSV infection related antigens cross react with some tumor cell lines and tumor tissue sections, Oral Surg Oral Med O 65:308 315, 1988. PMID: 2832802
  • Martin, S., Cantin, E.M. and Rouse, B.T.   Cytotoxic T lymphocytes: their relevance in herpesvirus infections.  Ann NY  Acad Sci 532:257 272, 1988. PMID: 2845846
  • Cantin E.M., Eberle, R., Baldick, J.L., Moss, B., Willy, D.E., Notkins, A.L., and Openshaw, H. Expression of herpes simplex virus 1 glycoprotiens B by a recombinant vaccinia virus and protection of mice against lethal herpes simplex virus 1 infection. Proc Natl Acad Sci USA 84:5908-5912, 1987 PMID: 3303033 PMCID: PMC298972
  • Puga, A., Gomez Marquez, J., Brayton, P.R., Cantin, E.M., Long, L.K., Baracid, M, and Notkins, A.L. The immediate early enhancement of herpes simplex virus type 1 can replace a regulatory region of C Ha vas 1 oncogene required for transformation.  J Virol 54:879 881, 1985. PMID: 2987541
  • Sekizawa, T., Openshaw, H., Cantin, E.M., Puga, A., Notkins, A.L. Herpes simplex virus. Clin Virol (Japan) 12:419 424, 1985.
  • Puga, A., Cantin, E.M., Wohlenberg, C., Openshaw, H. and Notkins, A.L.  Different sizes of restriction endonuclease fragments from the terminal repetitions of the herpes simplex virus type 1 genome latent in trigeminal ganglia of mice.  J Gen Virol 65:437 444, 1984. PMID: 6319582
  • Cantin, E.M. and Puga, A. and Notkins, A.L.:  Molecular biology of herpes simplex virus latency.  In: Concepts in Viral Pathogenesis.  Editors: Notkins, A.L. and Oldstone, M.B.A., Pp. 172 177, Springer Verlag, New York, 1984.
  • Puga, A. Cantin, E.M., and Notkins, A.L.  Homology between murine and human cellular DNA sequences and the terminal repetition of the S component of the herpes simplex virus type 1 genome.  Cell 31:81 87, 1982. PMID: 6297755
  • Openshaw, H., Sekizawa, T., Cantin, E.M., Puga, A. and Notkins, A.L.   Latency and reactivation of herpes simplex virus:  Animal models.  In: Viral Infections in Oral Medicine.  J. Hooks and G. Jordan, Editors.  Elsevier/North Holland.  Pages 79 88, 1981.
 

Locations

  • City of Hope - Main Campus (Duarte)
    1500 East Duarte Road
    Duarte, CA 91010