Contact Information
Alexandra Levine, M.D., M.A.C.P.
  • Chief Medical Officer
  • Dr. Norman and Melinda Payson Professor of Medicine
  • Deputy Director of Clinical Affairs
  • Professor

Departments/Division/Program
  • Comprehensive Cancer Center

Biography

 
Alexandra Levine, M.D., M.A.C.P., serves as chief medical officer of City of Hope, is the Dr. Norman and Melinda Payson Professor of Medicine and Deputy Director of Clinical Affairs for the City of Hope Comprehensive Cancer Center. An internationally renowned expert in lymphoma, Hodgkin's disease and AIDS-related malignancies, Levine oversees all clinical and hospital care programs, including quality of service, patient safety, clinical research, clinical information management and professional education. She is also Professor of Hematology and Hematopoietic Cell Transplantation at City of Hope.

Levine was previously a distinguished professor and chair of the Division of Hematology at the Keck School of Medicine of the University of Southern California (USC), and medical director of USC/Kenneth Norris Jr. Cancer Hospital.

Her research interests include lymphoma, Hodgkin's disease and HIV/AIDS. For eight years, she worked with Jonas Salk, M.D., on the development and testing of an AIDS vaccine. Levine has also served as principal investigator or co-investigator on multiple major research grants, most funded by the National Institutes of Health.

Levine’s scientific and clinical contributions have received national and international recognition. In 1995, President Clinton appointed her to the Presidential Advisory Council on HIV/AIDS. She also chaired the council’s research committee.

She has served as a member of the board of councilors of the National Cancer Institute and is a member of the Oncologic Drug Advisory Board of the U.S. Food and Drug Administration. She also served as an HIV/AIDS consultant to the health departments of Chile, Russia, India and China.

Levine is a member of the American Society of Hematology, the American Society of Clinical Oncology and the International AIDS Society. In 2009, she was elected as a Master of the American College of Physicians. She is the recipient of the Lymphoma Research Foundation of America’s Evelyn Hoffman Memorial Award in recognition for her achievements in lymphoma research and patient care. An advocate for humanism in medicine, Levine was the inspiration for the Jerome Hellman film “Promises in the Dark,” a compassionate drama about a teenage girl fighting for her life, assisted by her female doctor played by Marsha Mason. Levine also served as a technical advisor on the film.

Levine has published more than 300 articles and chapters, which have appeared in the New England Journal of Medicine, Blood and the Journal of AIDS, among others.

Levine received her medical degree from USC in 1971 and completed fellowships at Emory University in Atlanta and Los Angeles County+USC Medical Center.

Professional Experience

  • 2007 - present, Chief Medical Officer, City of Hope, Duarte, CA
  • 2007 – present, Professor of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
  • 2000 - 2006, Distinguished Professor of Medicine, University of Southern California, Los Angeles, CA
  • 1991 - 2006, Chief, Division of Hematology,USC School of Medicine, Los Angeles, CA
  • 1985 - 1990, Executive Associate Dean, USC School of Medicine, Los Angeles, CA
  • 1983 - 2006, Medical Director, USC/Norris Cancer Hospital, Los Angeles, CA
  • 1983 - 1997, Deputy Clinical Director, USC/Norris Cancer Hospital and Research Institute, Los Angeles, CA

Education

Education/Training
  • Fellowship: July, 1974 - June, 1975, Hematology-Oncology Fellow, Emory University School of Medicine, Atlanta, GA
  • Residency: 1972 - 1974, LAC-USC Medical Center, Los Angeles, CA
  • Internship: 1971 - 1972, LAC-USC Medical Center, Los Angeles, CA
  • Medical School: 1971, University of Southern California, Los Angeles, California, M.D.
  • University: 1966, University of California, Berkeley, Berkeley, California. B.A.

Honors/Awards

Awards
  • 2005, Outstanding Clinical Professor Award, presented by graduating class of 2005
  • 2000, Outstanding Clinical Professor Award, presented by graduating class of 2000
  • 1996, Outstanding Clinical Professor Award, presented by graduating class of 1996
  • 1980, Outstanding Clinical Professor Award, presented by graduating class of 1980

Honors
  • 2012 - 2015, Board of Scientific Councilors, National Cancer Institute, NIH
  • 2008, Elected a Master of the American College of Physicians (ACP)
  • 2005, Commencement speaker, USC School of Medicine, chosen by graduating class of 2005
  • 1995 - 2001, Appointment by President Clinton to the Presidential Advisory Council on HIV/AIDS
  • 1997, Commencement speaker, USC School of Medicine, chosen by graduating class of 1997
  • 1994, Commencement speaker, USC School of Medicine, chosen by graduating class of 1994
  • 1994, Presidential Medallion, University of Southern California
  • 1985, Outstanding Clinical Professor Award, presented by graduating class of 1985
  • 1982, Commencement speaker, USC School of Medicine, chosen by graduating class of 1982

Memberships

  • American College of Physicians
  • American Society of Hematology
  • American Federation for Clinical Research
  • Society for Hematopathology (Charter Member)
  • American Society of Clinical Oncology
  • Golden Key National Honor Society

Publications

  • Levine AM, Noy A, Lee J, Tam W, Ramos JC, Henry D, Parekh S, Reid E, Mitsuyasu R, Colley T, Dezube B, Ratner L, Cesarman E, Tulpule A: Liposomal doxorubicin, rituximab, cylosphosphamide, vincristein and prednisone (DR-COP) in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047. J Clin Oncol 2012. In press
  • Villacres MC, Kono N, Mack WJ, Nowicki MJ, Anastos K, Augenbraun M, Liu C, Landay A, Greenblatt RM, Gange S, Levine AM: Interleukin 10 Responses Are Associated With Sustained CD4 T-Cell Counts in Treated HIV Infection. Jour Infect Dis. 2012; 206: 780-789.
  • Keller MJ, Burk RD, Xie X, Anastos K, Massad LS, Minkoff H, Xue, X, D’Souza G, Watts DH, Levine AM; Castle PE, Colie C, Palefsky JM, Strickler HD: Risk of cervical precancer and cancer among HIV infected women with normal cervical cytology and no evidence of oncogenic HPV infection. JAMA 2012: 308; 362-369.
  • D’Souza G, Burk R, Zhong Y, Minkhoff H, Massad S, Xue X, Watts H, Anastos K, Palefsky J, Levine AM, Castle P, Strickler H: Cervicovaginal HPV infection before and after hysterectomy: evidence of different tissue tropism for oncogenic and non-oncogenic HPV types in a cohort of HIV positive and HIV negative women. Int J Cancer 2012; 131(6): 1472-8.
  • Massad LS, Weber KM, Wilson TE, Goderre JL, Hessol NA, Henry D, Colie C, Strickler HD, Levine AM, Watts DH, Evans CT: Correlating knowledge of cervical cancer prevention and human papillomavirus with compliance after colposcopy referral. J Lower Genital Tract Dis. 2012; 16:98-105.
  • Liu CL, Wang C, Robison E, Levine AM, Gandhi M, Schwartz R, Weber KM, Merenstein D: Short term garlic supplement use and HAART adherence, CD4+ cell counts and HIV viral load. Altern Ther Health Med 2012; 18(1):18-22.
  • Massad LS, Xie X, Darragh T, Minkoff H, Levine AM, Watts DH, Wright RL, D’Souza G, Colie C, Strickler HD: Genital warts and vulvar intraepithelial neoplasia: Natural history and effects of treatment and HIV infection. Obstet Gynecol 2011; 118(4):831-9.
  • Merenstein DJ, Hu HH, Robison E, Levine AM, Greenblatt R, Schwartz R, Weber K, Young M, Sharp G, Liu CL. Relationship between complementary/alternative treatment use and illicit drug use among a cohort of women with, or at risk for, HIV infection. J Altern Complement Med 2010; 9(16): 989-993.
  • Hessol NA, Napolitano LA, Smith D, Lie Y, Levine AM, Young M, Cohen M, Minkoff H, Anastos K, D’Souza G, Greenblatt RM, and Goedert JJ. HIV Tropism and Decreased Risk of Breast Cancer. PLoS ONE 2010; 5(12):e14349. PMC3002931
  • Yin MT, Shi Q, Hoover DR, Anastos K, Sharma A, Young M, Levine AM, Cohen MH, Shane E, Golub ET, and Tien PC. Fracture incidence in HIV-infected women: results from the Women’s Interagency HIV Study. AIDS 2010; 24(17):2679-2686.
  • Massad LS, Evand C, Weber K, Goderre J, Hessol N, Henry D, Colie C, Strickler H, Levine AM, Watts DH, Wilson T: Changes in knowledge of cervical cancer prevention and human papillomavirus among women with HIV, 2006-2008. Obstet Gynecol 2010;116(4):941-947.
  • D’Souza G, Palefsky JM, Zhong Y, Minkoff H, Massad LS, Anastos K, Levine AM, Moxley M, Xue XN, Burk RD, Strickler HD: Marijuana use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV seropositive or HIV seronegative women. Cancer Epidemiol Biomarkers Prev 2010: 10 (3): 869-872. PMC2874245
  • Massad LS, Agniel D, Minkoff H, Watts DH, D’Souza G, Levine AM, Darragh TM, Young M, Cajigas A, Weber K. Effect of Stress and Depression on the Frequency of Squamous Intraepithelial Lesions. Journal of Lower Genital Tract Disease 2010; 15:42-47.
  • Xue X, Gange S, Zhong Y, Burk R, Minkoff H, Massad LS, Watts DH, Kuniholm M, Anastos K, Levine AM, D’Souza G, Moxley M, Palefsky J, Strickler H: Marginal and mixed effects models in the analysis of HPV natural history data. Ca Epidem, Biomarkers & Prevention 2010: 19 (1) 159-169. PMC 2839537
  • Frederick T, Burian P, Mack W, Terrault N, Cohen M, Augenbraun M, Young M, Kovacs A, Levine AM: Factors associated with prevalent hepatitis C infection among HIV infected women with no reported history of injection drug use: The Women’s Interagency HIV Study (WIHS). AIDS Patient Care and STDs. In press, 7/09.
  • Sparano JA, Lee J, Kaplan LD, Levine AM, Ramos JC, Ambinder R, Wachsman W, Aboulafia D, Noy A, Henry D, Von Roenn J, Dezube B, Remick S, Shah MH, Leichman L, Ratner L, Cesarman E, Chadburn AM, Mitsuyasu R: Rituximab plus concurrent infusional EOPOCH chemotherapy is highly effective without excessive toxicity in HIV associated, B cell non-Hodgkin’s lymphoma. Blood 2010; 15:3008-3016.
  • Sparano JA, Lee J, Kaplan LD, Levine AM, Ramos JC, Ambinder R, Wachsman W, Aboulafia D, Noy A, Henry D, Von Roenn J, Dezube B, Remick S, Shah MH, Leichman L, Ratner L, Cesarman E, Chadburn AM, Mitsuyasu R: Rituximab plus concurrent infusional EOPOCH chemotherapy is highly effective without excessive toxicity in HIV associated, B cell non-Hodgkin’s lymphoma. Blood 2010; 15:3008-3016.
  • Levine AM, Seaberg EC, Hessol NA, Preston-Martin S, Silver S, Cohen MH, Anastos K, Minkoff H, Orenstein J, Dominguez G, Watt DH: HIV as a risk factor for lung cancer in women: Data from the Women’s Interagency HIV Study (WIHS). J Clin Oncol 2010; 28:1514-19.
  • Minkoff H, Zhong Y, Burk RD, Palefsky JM, Xue X, Watts DH, Levine AM, Wright RL, Colie C, D’Souza G, Massad LS, Strickler HD: Influence of adherent and effective antiretroviral therapy use of human papillomavirus infection and squamous intraepithelial lesions in Human Immunodeficiency Virus-Positive Women. J Infect Dis 2010; 201:681-690. PMC 2818607
  • Lin L, Lee JY, Kaplan LD, Dezube BJ, Noy A, Krown SE, Levine AM, Yu Y, Hayward GS, Ambinder RF: Effects of chemotherapy in AIDS-associated non-Hodgkin’s lymphoma on KSHV DNA in blood. J Clin Oncol 2009; 27:2496-502.

Locations

  • City of Hope - Main Campus (Duarte)
    1500 East Duarte Road
    Duarte, CA 91010

Media Expertise

Media Expertise
  • HIV/AIDS
  • Patient Care
  • Lymphoma