Contact Information
Yuman Fong, M.D.
  • Chair, Department of Surgery
  • Associate Director for International Relations
  • Professor of Surgery

Primary Specialties
  • Surgical Oncology

Clinical Area / Sub-specialties
  • Hepatobiliary and Pancreatic Surgery


Languages Spoken
  • Cantonese (Chinese)



Surgery chair Yuman Fong, M.D.
on the progress of cancer research.
Yuman Fong, M.D., an internationally recognized expert in hepatobiliary cancer and in the use of genetically modified viruses to combat malignant disease, is the chair of the Department of Surgery at City of Hope. Dr. Fong is also Associate Director for International Relations at the comprehensive cancer center.
Dr. Fong joined City of Hope from Memorial Sloan Kettering Cancer Center in New York, where he held the Murray F. Brennan Chair in Surgery while also serving as a professor of surgery at Cornell Medical College. He has been a pioneer both in the operating room and in the laboratory, crafting new surgical techniques and instruments and creating entirely new treatment methods. Especially notable is his track record of launching human clinical trials of genetically modified viruses with the potential to fight cancer.

Dr. Fong has authored more than 600 peer-reviewed articles, including more than 200 basic scientific articles, and over 350 clinically oriented peer-reviewed publications, which have appeared in Nature, New England Journal of Medicine and Journal of Clinical Investigation, among others. He has served as author and editor of 11 textbooks as well as 65 book chapters.
Dr. Fong has received grant support as a principal investigator continuously over the past 17 years, most from the National Institutes of Health (NIH), and has been awarded five patents related to his work. He has served on the editorial boards of 14 journals and has received numerous honors and awards including the Franklin Martin Faculty Fellowship from the American College of Surgery and the Shipley Award from the Southern Surgical Association. Dr. Fong recently completed a two-year term as chair of the recombinant DNA advisory committee of the NIH.

Professional Experience

  • Assistant Member, Memorial Sloan-Kettering Cancer Center 1993-1997
  • Assistant Attending Surgeon, Memorial Hospital for Cancer and Allied Diseases 1993-1997
  • Associate Member, Memorial Sloan-Kettering Cancer Center 1997-2000
  • Associate Attending Surgeon, Memorial Hospital for Cancer and Allied Diseases, 1997-2000
  • Assistant Professor of Surgery, Cornell University Medical College 1993-2000
  • Assistant Professor of Cell Biology and Anatomy, Cornell University Medical College 1994-2000
  • Chief, Gastric and Mixed Tumor Service 2004-2008
  • Member (Tenured), Memorial Sloan-Kettering Cancer Center 2000-2014
  • Professor of Surgery, Weill Cornell Medical College 2000-2014
  • Murray F. Brennan Chair in Surgery, Memorial Sloan-Kettering Cancer Center 2001-2014
  • Vice Chair for Technology Development, Memorial Sloan-Kettering Cancer Center 2006-2012
  • Adjunct Professor of Surgery, Downstate Medical Center 2007-2014
  • Professor and Chair, Department of Surgery, City of Hope 2014-present

Education and Training


Baccalaureate Degree: Brown University B.A. Medieval Literature, 1981
Advanced Degree: Cornell University Medical College M.D., 1984
Internship: New York Hospital-Cornell Medical Center, 1984-1985
Residency: General Surgery, New York Hospital-Cornell Medical Center, 1985-1986, 1989-1990.
Chief Residency: New York Hospital-Cornell Medical Center, 1990-1991. (Mentor: G.T. Shires)
Nutrition Support Service, New York Hospital-Cornell Medical Center, 1986-1989
Research Fellow, Department of Surgery, Cornell University Medical College, 1986-1989 (Mentor: S.F. Lowry)
Surgical Oncology Fellow, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1991-1993 (Mentor: M.F. Brennan)
Chief Administrative Fellow, 1992-1993


  • Clarence C. Coryell Prize in Surgery- Cornell University Medical College, 1984
  • Clarence C. Coryell Prize in Medicine- Cornell University Medical College, 1984
  • George Ladas Prize in Gynecology- Cornell University Medical College, 1984
  • George S. Meister Prize in Pediatrics- Cornell University Medical College, 1984
  • House Staff Teaching Award- New York Hospital-Cornell Medical Center, 1986
  • Clinical Fellowship- American Cancer Society, 1987
  • Resident's Research Award- Association for Academic Surgery, 1988
  • Stanley Dudrick Research Scholar- American Society for Parenteral and Enteral Nutrition, 1994
  • Franklin Martin Faculty Fellowship- American College of Surgery, 1994
  • Boyer Research Award- Memorial Sloan-Kettering Cancer Center, 1996
  • James IV Surgical Traveler- James IV Association of Surgeons, 1999
  • Shipley Award- Southern Surgical Association, 2002
  • Honorary Membership Chinese American Medical Association, 2006
  • Honorary Membership Brazilian Surgical Association, 2010


Basic Science Peer Reviewed Publications, since 2012
  • He S, Li P, Chen CH, Bakst RL, Chernichenko N, Yu YA, Chen N, Szalay AA, Yu Z, Fong Y, Wong RJ. Effective oncolytic vaccinia therapy for human sarcomas. J Surg Res. 2012 Jun 53 15;175(2):e53-60. Epub 2011 Dec 14. PubMed PMID: 22341347; PubMed Central PMCID: PMC3350611.
  • Schoellnast H, Monette S, Ezell PC, Single G, Maybody M, Weiser MR, Fong Y, Solomon SB. Irreversible Electroporation Adjacent to the Rectum: Evaluation of Pathological Effects in a Pig Model. Cardiovasc Intervent Radiol. 2012 May 5. [Epub ahead of print] PubMed PMID: 22562481.
  • Au JT, Gonzalez L, Chen CH, Serganova I, Fong Y. Bioluminescence Imaging Serves as a Dynamic Marker for Guiding and Assessing Thermal Treatment of Cancer in a Preclinical Model. Ann Surg Oncol. 2012 Mar 31. [Epub ahead of print] PubMed PMID: 22466665.
  • Haddad D, Chen N, Zhang Q, Chen CH, Yu YA, Gonzalez L, Aguilar J, Li P, Wong J,Szalay AA, Fong Y. A Novel Genetically Modified Oncolytic Vaccinia Virus in Experimental Models is Effective Against a Wide Range of Human Cancers. Ann Surg Oncol. 2012 Jan 19. [Epub ahead of print] PubMed PMID: 22258815.
  • Winter JM, Tang LH, Klimstra DS, Brennan MF, Brody JR, Rocha FG, Jia X, Qin LX,D'Angelica MI, DeMatteo RP, Fong Y, Jarnagin WR, O'Reilly EM, Allen PJ. A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as biomarkers. PLoS One. 2012;7(7):e40157.
  • Gholami S, Chen CH, Lou E, De Brot M, Fujisawa S, Chen NG, Szalay AA, Fong Y. Vaccinia virus GLV-1h153 is effective in treating and preventing metastatic triple-negative breast cancer. Ann Surg. 2012 Sep;256(3):437-45.
  • Au JT, Gonzalez L, Chen CH, Serganova I, Fong Y. Bioluminescence imaging serves as a dynamic marker for guiding and assessing thermal treatment of cancer in a preclinical model. Ann Surg Oncol. 2012 Sep;19(9):3116-22.
  • Haddad D, Chen N, Zhang Q, Chen CH, Yu YA, Gonzalez L, Aguilar J, Li P, Wong J, Szalay AA, Fong Y. A novel genetically modified oncolytic vaccinia virus in experimental models is effective against a wide range of human cancers. Ann Surg Oncol. 2012 Jul;19 Suppl 3:S665-74.
  • Song TJ, Haddad D, Adusumilli P, Kim T, Stiles B, Hezel M, Socci ND, Gönen M, Fong Y. Molecular network pathways and functional analysis of tumor signatures associated with development of resistance to viral gene therapy. Cancer Gene Ther. 2012 Jan;19(1):38-48.
  • Carpenter S, Fong Y. Real-time fluorescence imaging of abdominal, pleural, and lymphatic metastases. Methods Mol Biol. 2012;872:141-57.
  • Haddad D, Chen CH, Carlin S, Silberhumer G, Chen NG, Zhang Q, Longo V, Carpenter SG, Mittra A, Carson J, Au J, Gonen M, Zanzonico PB, Szalay AA, Fong Y. Imaging characteristics, tissue distribution, and spread of a novel oncolytic vaccinia virus carrying the human sodium iodide symporter. PLoS One. 2012;7(8):e41647.
  • Cavel O, Shomron O, Shabtay A, Vital J, Trejo-Leider L, Weizman N, Krelin Y, Fong Y, Wong RJ, Amit M, Gil Z. Endoneurial macrophages induce perineural invasion of pancreatic cancer cells by secretion of GDNF and activation of RET tyrosine kinase receptor. Cancer Res. 2012 Nov 15;72(22):5733-43.
  • Haddad D, Zanzonico PB, Carlin S, Chen CH, Chen NG, Zhang Q, Yu YA, Longo V, Mojica K, Aguilar RJ, Szalay AA, Fong Y. A vaccinia virus encoding the human sodium iodide symporter facilitates long-term image monitoring of virotherapy and targeted radiotherapy of pancreatic cancer. J Nucl Med. 2012 Dec;53(12):1933-42.
  • Chernichenko N, Linkov G, Li P, Bakst RL, Chen CH, He S, Yu YA, Chen NG, Szalay AA, Fong Y, Wong RJ. Oncolytic vaccinia virus therapy of salivary gland carcinoma. JAMA Otolaryngol Head Neck Surg. 2013 Feb;139(2):173-82.
  • Qi J, Fong Y, Saltz L, D'Angelica MI, Kemeny NE, Gonen M, Shia J, Shukla-Dave A, Jarnagin WM, Do RK, Schwartz LH, Koutcher JA, Zakian KL. Serial measurement of hepatic lipids during chemotherapy in patients with colorectal cancer: a 1 H MRS study. NMR Biomed. 2013 Feb;26(2):204-12.
  • Gholami S, Chen CH, Belin LJ, Lou E, Fujisawa S, Antonacci C, Carew A, Chen NG, De Brot M, Zanzonico PB, Szalay AA, Fong Y. Vaccinia virus GLV-1h153 is a novel agent for detection and effective local control of positive surgical margins for breast cancer. Breast Cancer Res. 2013 Mar 18;15(2):R26. [Epub ahead of print] 5.
  • Au JT, Kingham TP, Jun K, Haddad D, Gholami S, Mojica K, Monette S, Ezell P, Fong Y. Irreversible electroporation ablation of the liver can be detected with ultrasound B-mode and elastography. Surgery. 2013 Jun;153(6):787-93.
  • Au JT, Craig G, Longo V, Zanzonico P, Mason M, Fong Y, Allen PJ. Gold nanoparticles provide bright long-lasting vascular contrast for CT imaging. AJR Am J Roentgenol. 2013 Jun;200(6):1347-51.
Clinical Practice Peer Reviewed Publications, since 2013
  • Winter JM, Tang LH, Klimstra DS, Liu W, Linkov I, Brennan MF, Dangelica MI, Dematteo RP, Fong Y, Jarnagin WR, Oreilly EM, Allen PJ. Failure Patterns in Resected Pancreas Adenocarcinoma: Lack of Predicted Benefit to SMAD4 Expression. Ann Surg.2013 Aug;258(2):331-5.
  • Correa-Gallego C, Gonen M, Fischer M, Grant F, Kemeny NE, Arslan-Carlon V, Kingham TP, Dematteo RP, Fong Y, Allen PJ, D'Angelica MI, Jarnagin WR. Perioperative complications influence recurrence and survival after resection of hepatic colorectal metastases. Ann Surg Oncol. 2013 Aug;20(8):2477-84.
  • Araujo RL, Gaujoux S, Huguet F, Gonen M, D'Angelica MI, Dematteo RP, Fong Y, Kingham TP, Jarnagin WR, Goodman KA, Allen PJ. Does pre-operative chemoradiation for initially unresectable or borderline resectable pancreatic adenocarcinoma increase postoperative morbidity? A case-matched analysis. HPB (Oxford). 2013 Aug;15(8):574-80.
  • Konstantinidis IT, Allen PJ, D'Angelica MI, Dematteo RP, Fischer ME, Grant F, Fong Y, Kingham TP, Jarnagin WR. Pancreas and Liver Resection in Jehovah's Witness Patients: Feasible and Safe. J Am Coll Surg. 2013 Jul 20. [Epub ahead of print]
  • Cavell LK, Allen PJ, Vinoya C, Eaton AA, Gonen M, Gerdes H, Mendelsohn RB, D'Angelica MI, Kingham TP, Fong Y, Dematteo R, Jarnagin WR, Kurtz RC, Schattner MA. Biliary self-expandable metal stents do not adversely affect pancreaticoduodenectomy. Am J Gastroenterol. 2013 Jul;108(7):1168-73.
  • Karanicolas PJ, Jarnagin WR, Gonen M, Tuorto S, Allen PJ, Dematteo RP, D'Angelica MI, Fong Y. Long-term Outcomes Following Tumor Ablation for Treatment of Bilateral Colorectal Liver Metastases. JAMA Surg. 2013 Jul 1;148(7):597-601.
  • Tan MC, Butte JM, Gonen M, Kemeny N, Fong Y, Allen PJ, Kingham TP, Dematteo RP, Jarnagin WR, D'Angelica MI. Prognostic significance of early recurrence: a conditional survival analysis in patients with resected colorectal liver metastasis. HPB (Oxford). 2013 Jun 19.
  • Frankel TL, Lafemina J, Bamboat ZM, D' Angelica MI, Dematteo RP, Fong Y, Kingham TP, Jarnagin WR, Allen PJ. Dysplasia at the surgical margin is associated with recurrence after resection of non-invasive intraductal papillary mucinous neoplasms. HPB (Oxford). 2013 Jun 19. 12137. [Epub ahead of print].
  • Ammori JB, Kemeny NE, Fong Y, Cercek A, Dematteo RP, Allen PJ, Kingham TP, Gonen M, Paty PB, Jarnagin WR, D'Angelica MI. Conversion to Complete Resection and/or Ablation Using Hepatic Artery Infusional Chemotherapy in Patients with Unresectable Liver Metastases from Colorectal Cancer: A Decade of Experience at a Single Institution. Ann Surg Oncol. 2013 Jun 15. [Epub ahead of print]
  • Konstantinidis IT, Vinuela EF, Tang LH, Klimstra DS, D'Angelica MI, Dematteo RP, Kingham TP, Fong Y, Jarnagin WR, Allen PJ. Incidentally Discovered Pancreatic Intraepithelial Neoplasia: What Is Its Clinical Significance? Ann Surg Oncol. 2013 Jun 8. [Epub ahead of print].
  • Bickenbach KA, Dematteo RP, Fong Y, Peter Kingham T, Allen PJ, Jarnagin WR, D'Angelica MI. Risk of occult irresectable disease at liver resection for hepatic colorectal cancer metastases: a contemporary analysis. Ann Surg Oncol. 2013 Jun;20(6):2029-34.
  • D'Amico FE, Allen PJ, Eaton AA, DeMatteo RP, Fong Y, Kingham TP, Blumgart LH, Jarnagin WR, D'Angelica MI. Vascular inflow control during hemi-hepatectomy: a comparison between intrahepatic pedicle ligation and extrahepatic vascular ligation. HPB (Oxford). 2013 Jun;15(6):449-56.
  • LaFemina J, Chou JF, Gönen M, Rocha FG, Correa-Gallego C, Kingham TP, Fong Y, D'Angelica MI, Jarnagin WR, DeMatteo RP, Allen PJ. Hepatic arterial nodal metastases in pancreatic cancer: is this the node of importance? J Gastrointest Surg. 2013 Jun;17(6):1092-7.
  • Power NE, Silberstein JL, Tarin T, Au J, Thorner D, Ezell P, Monette S, Fong Y, Rusch V, Finley D, Coleman JA. Endoscopic spray cryotherapy for genitourinary malignancies: safety and efficacy in a porcine model. Ther Adv Urol. 2013 Jun;5(3):135-41.
  • Butte JM, Torres J, Veras EF, Matsuo K, Gönen M, D'Angelica MI, Waugh E, Meneses M, Inayama Y, Fong Y, Dematteo RP, De La Fuente H, Endo I, Klimstra DS, Jarnagin WR. Regional differences in gallbladder cancer pathogenesis: insights from a comparison of cell cycle-regulatory, PI3K, and pro-angiogenic protein expression. Ann Surg Oncol. 2013 May;20(5):1470-81.
  • Araujo RL, Karkar AM, Allen PJ, Gönen M, Chou JF, Brennan MF, Blumgart LH, D'Angelica MI, Dematteo RP, Coit DG, Fong Y, Jarnagin WR. Timing of elective surgery as a perioperative outcome variable: analysis of pancreaticoduodenectomy. HPB (Oxford). 2013 Apr 18.
  • Elnekave E, Erinjeri JP, Brown KT, Thornton RH, Petre EN, Maybody M, Maluccio MA, Hsu M, Sofocleous CT, Getrajdman GI, Brody LA, Solomon SB, Alago W, Fong Y, Jarnagin WR, Covey AM. Long-Term Outcomes Comparing Surgery to Embolization-Ablation for Treatment of Solitary HCC <7 cm. Ann Surg Oncol. 2013 Apr 7. [Epub ahead of print]
  • O'Reilly M, Kohn DB, Bartlett J, Benson J, Brooks PJ, Byrne BJ, Camozzi C, Cornetta K, Crystal RG, Fong Y, Gargiulo L, Gopal-Srivastava R, High KA, Jacobson SG, Jambou RC, Montgomery M, Rosenthal E, Samulski RJ, Skarlatos SI, Sorrentino B, Wilson JM, Xie Y, Corrigan-Curay J. Gene therapy for rare diseases: summary of a national institutes of health workshop, september 13, 2012. Hum Gene Ther. 2013 Apr;24(4):355-62.
  • Katz SC, Bamboat ZM, Maker AV, Shia J, Pillarisetty VG, Yopp AC, Hedvat CV, Gonen M, Jarnagin WR, Fong Y, D'Angelica MI, DeMatteo RP. Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases. Ann Surg Oncol. 2013 Mar;20(3):946-55.
  • Karkar AM, Tang LH, Kashikar ND, Gonen M, Solomon SB, Dematteo RP, D'Angelica MI, Correa-Gallego C, Jarnagin WR, Fong Y, Getrajdman GI, Allen P, Kingham TP. Management of hepatocellular adenoma: comparison of resection, embolization and observation. HPB (Oxford). 2013 Mar;15(3):235-43.
  • Lafemina J, Katabi N, Klimstra D, Correa-Gallego C, Gaujoux S, Kingham TP, Dematteo RP, Fong Y, D'Angelica MI, Jarnagin WR, Do RK, Brennan MF, Allen PJ. Malignant progression in IPMN: a cohort analysis of patients initially selected for resection or observation. Ann Surg Oncol. 2013 Feb;20(2):440-7.
  • Mezhir JJ, Fourman LT, Do RK, Denton B, Allen PJ, D'Angelica MI, DeMatteo RP, Fong Y, Jarnagin WR. Changes in the management of benign liver tumours: an analysis of 285 patients. HPB (Oxford). 2013 Feb;15(2):156-63.
  • Correa-Gallego C, Brennan MF, Dangelica M, Fong Y, Dematteo RP, Kingham TP, Jarnagin WR, Allen PJ. Operative Drainage Following Pancreatic Resection: Analysis of 1122 Patients Resected Over 5 Years at a Single Institution. Ann Surg. 2013 Jan 28.
  • Weiss MJ, Ito H, Araujo RL, Zabor EC, Gonen M, D'Angelica MI, Allen PJ, DeMatteo RP, Fong Y, Blumgart LH, Jarnagin WR. Hepatic pedicle clamping during hepatic resection for colorectal liver metastases: no impact on survival or hepatic recurrence. Ann Surg Oncol. 2013 Jan;20(1):285-94.
  • Cardona K, Mastrodomenico P, D'Amico F, Shia J, Gönen M, Weiser MR, Paty PB, Kingham TP, Allen PJ, De Matteo RP, Fong Y, Jarnagin WR, D'Angelica MI. Detailed pathologic characteristics of the primary colorectal tumor independently predict outcome after hepatectomy for metastases. Ann Surg Oncol. 2013 Jan;20(1):148-54.
  • Ang CS, Kelley RK, Choti MA, Cosgrove DP, Chou JF, Klimstra D, Torbenson MS, Ferrell L, Pawlik TM, Fong Y, O'Reilly EM, Ma J, McGuire J, Vallarapu GP, Griffin A, Stipa F, Capanu M, Dematteo RP, Venook AP, Abou-Alfa GK. Clinicopathologic characteristics and survival outcomes of patients with fibrolamellar carcinoma: data from the fibrolamellar carcinoma consortium. Gastrointest Cancer Res. 2013 Jan;6(1):3-9.
  • Wolf PS, Park JO, Bao F, Allen PJ, DeMatteo RP, Fong Y, Jarnagin WR, Kingham TP, Gönen M, Kemeny N, Shia J, D'Angelica MI. Preoperative chemotherapy and the risk of  hepatotoxicity and morbidity after liver resection for metastatic colorectal cancer: a single institution experience. J Am Coll Surg. 2013 Jan;216(1):41-9.


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