Our 190,000-square-foot cancer center is located on 11 acres of the master-planned FivePoint Gateway community.
Patients receive fully integrated, multidisciplinary cancer care - from prevention through survivorship - in one convenient location, where every physician and staff member is solely focused on treating and curing cancer. City of Hope Orange County Lennar Foundation Cancer Center features the latest and most comprehensive suite of market-leading technology for screening, diagnosing, and treating cancer, delivered by highly specialized experts who raise the bar for scientific expertise and exceptional outcomes and is a provider-based facility of City of Hope National Medical Center, a general acute care hospital. Our physician-scientists will conduct Phase 1-3 clinical trials at our dedicated clinical research unit and infusion center to provide patients with pioneering treatments long before they become the standard of care.
City of Hope Orange County Lennar Foundation Cancer Center is seamlessly connected to Orange County’s only cancer specialty hospital exclusively focused on treating and curing cancer.
NOTE: City of Hope has two facilities in Irvine. When accessing driving directions via a navigation tool (e.g. Apple Maps, Google Maps, Waze, etc.) please make sure to choose the FivePoint Road location and not City of Hope Sand Canyon.
33.6515625, -117.7310014
Irvine, CA 92618
Monday - Friday: 6 a.m. to 6 p.m.
Primary visitors may visit during operational hours.
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- Acclaimed Cancer Expertise: Access to City of Hope’s 575 physicians and 1,000 researchers and scientists who only focus on cancer.
- Breakthrough Treatments: Targeted immunotherapies, including CAR T cell therapy, as well as bone marrow transplants, robotic minimally invasive surgeries and personalized treatments, such as stereotactic body radiation therapy. These innovations have demonstrated improved outcomes and a better quality of life for patients in treatment.
- Integrative Medicine: A trailblazing integrative medicine program combining the best of Western medicine and evidence-based complementary therapies, such as acupuncture, massage and meditation.
- Cancer Prevention: Programs that identify people and families with elevated cancer risk utilizing genetic risk assessments, biomarker panels and environmental surveys to help manage that risk.
- Early Detection: Novel blood testing and imaging techniques that find cancer early, when it is still easily curable. Patients will be among the first in the nation to access City of Hope’s new Center for Cancer Prevention and Early Detection.
- Precision Medicine: Best-in-class genomic testing to profile a patient’s tumor and determine the treatment that will be most effective for their cancer.
- Screening and Diagnostic Services: A suite of state-of-the-art imaging equipment for patients’ convenient access to mammography, colonoscopy, robotic bronchoscopy and other lifesaving services.
- A Clinical Research Unit: The epicenter for clinical investigational research that speeds the development of new drugs and interventions to the bedside, allowing patients to receive the latest treatments in cancer care
- Surgical Oncology: An outpatient surgery department that offers advanced perioperative care, an endoscopy suite and operating rooms with robotic-assisted surgical capabilities
For Patients And Visitors
Family and friends are always welcome and encouraged to visit patients during their stay at City of Hope.
Find out what you need to know about patient and family services available at our Lennar Foundation Cancer Center campus.
“Primary visitors” - typically the patient’s closest family or friends – will receive wristbands for visitation during operational hours: 6:00 am to 6:00 pm. Please note that for the patient's health, safety and well-being, staff may request visitors to leave the patient room and wait in the visitor lounges located near the elevators on each floor of the hospital. Please see our visitors policy.
For more information on all of our COVID-19 safety measures, please visit our Resource Hub.
Download the Irvine Academic Research campus map >
Upcoming Appointments
If you have an upcoming appointment at City of Hope Orange County Lennar Foundation Cancer Center, the MyCityofHope app makes the check-in process fast and simple. Our check-in page includes steps on how to check in successfully.
Is My Insurance Accepted?
View a list of insurance companies that City of Hope currently contracts with for its locations and physicians. Even if your plan is included, check with your insurance company to make sure you are covered. Your insurance company/medical group will tell you if you need any authorizations.
If you wish to receive treatment at City of Hope, but we're not currently contracted with your insurance plan, contact your insurance company and ask about obtaining authorization to receive treatment here.
View our pricing and billing
Provider based billing
No Surprise Billing
When you're treated by an out-of-network provider at an in-network facility, you are protected from balance billing. In these cases, you shouldn't be charged more than your plan's copayments, coinsurance and/or deductible. Learn about your rights and protections against surprise medical bills.
City of Hope is relentless in our drive to offer more positive outcomes to patients everywhere. Our research innovations become advances in clinical care without delay because people fighting cancer, diabetes and other life threatening illnesses need better options.
Learn More About Treatment and Care
Advanced technologies, treatment and expertise.
Explore Our Clinical Departments and Services
City of Hope is home to many of the nation's leading cancer doctors. Their clinical specialties extend across numerous medical fields, diverse languages and multiple locations throughout Southern California. Find a physician who fits your needs.
Find A Doctor Near You
City of Hope Orange County Lennar Foundation Cancer Center is home to many of the world’s best minds in preventing, treating and curing cancer. The 190,000-square-foot cancer center of the future is patient-focused, offering breakthrough research and pioneering treatments, ushering in a new era of hope for people with cancer.
The Sheri & Les Biller Patient and Family Resource Center at City of Hope Orange County Lennar Foundation Cancer Center provides a range of resources for patients and their loved ones as they navigate treatment and recovery. In this welcoming space, our staff can provide educational and basic needs resources, information about our many classes and support groups and advance care directive counseling.
City of Hope Orange County Cancer Specialty Hospital is a provider-based facility of City of Hope National Medical Center, a general acute care hospital. Together, they complete the region’s most advanced and fully integrated cancer care network, expanding access to specialized expertise, innovative acute and outpatient treatments, novel clinical trials, and groundbreaking technologies. Seamlessly connected to the Lennar Foundation Cancer Center, the hospital was intentionally designed with and for the community it serves.
