A National Cancer Institute-designated Comprehensive Cancer Center

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Comprehensive Cancer Center

City of Hope has a proud history of excellence in biomedical research, patient-centered medical care, and community outreach.
 
In recognition of our broad-based innovations in cancer research and treatment, our continuing commitment to compassionate patient care, and our initiatives in patient and community education, the National Cancer Institute (NCI) has designated City of Hope a Comprehensive Cancer Center — the highest level of recognition bestowed by the NCI. City of Hope is one of just a handful of elite institutions nationwide to receive this prestigious honor.
 
As a division of the National Institutes of Health, the NCI is the Federal Government's principal agency for cancer research and training. The NCI's Cancer Center program acknowledges institutions for their scientific excellence, as well as their ability to bring diverse research approaches to the problem of cancer. The "Comprehensive Cancer Center" designation indicates that City of Hope has undergone a rigorous review process and has met or exceeded NCI standards in these areas.
 
Cancer Center Research Programs
City of Hope Comprehensive Cancer Center researchers and resources are dedicated to developing innovative new disease-fighting strategies in the battle against cancer. Through these programs, and through the mission and vision of City of Hope physicians and scientists, City of Hope Comprehensive Cancer Center will continue to make a difference in the lives of current and potential cancer patients and their loved ones—around the world today and in the future.
 
 
All of these activities are made possible by a forward-thinking infrastructure supporting basic and translational research in biological and small molecule cancer therapeutics.

Cancer Center Leadership

Cancer Center Program Co-leaders

About Our Cancer Center Research Programs

City of Hope provides a multidisciplinary, interactive environment where basic, clinical and translational, and prevention and control scientists collaborate closely. This stimulating intellectual environment contributes to the productive translational research under way within the Comprehensive Cancer Center. Our research initiatives are divided into the following research programs:
 
Basic Science Research Program
The Comprehensive Cancer Center provides both the infrastructure and the environment for outstanding basic science research. ("Basic science" refers to research conducted in a laboratory setting.) In turn, this research contributes to our understanding of the underlying genetic, molecular and biological bases of cancer. The basic science research program at City of Hope is called Molecular Oncology (MONC).
 
Clinical and Translational Research Programs
The Comprehensive Cancer Center's clinical and translational research programs focus on the translation of novel laboratory observations into the treatment of patients (and their families) and, ultimately, throughout the world. The number of the Center's novel (Phases I and I/II) clinical trials increases yearly. The clinical and translational science research programs are:
 
 
Prevention and Control Program
Cancer prevention and control research at the Comprehensive Cancer Center is conducted within a program on Cancer Control and Population Sciences (CCPS). The members of this research program cover an extensive spectrum of disciplines, which is further broadened by additional collaborations with physician investigators. Such a confederation of expertise, working within a collaborative environment, maximizes productive interaction. The program focuses on four important areas of concentration:
 
  • Host and environmental determinants of cancer
  • Health-related outcomes and quality of life after cancer
  • Interventional studies to reduce cancer-related morbidity
  • Educational initiatives
 
Our five research programs, described above, represent a continuum, as shown in the figure below. Basic and translational studies can originate in either the basic science program,MO or the DCT Program. These studies can then link to phase I and II clinical protocols in all three clinical programs—DCT, CI and HM. They can also integrate into follow-up studies in survivorship and symptom management in the CCPS Program. On this continuum, CI spans both translational and clinical research, whereas HM is predominantly (but not exclusively) clinical. Frequent interaction between the principal investigators of each program ensures maximum benefit from shared insights. All these activities are made possible by City of Hope’s infrastructure, which supports basic and translational research in biological and in small molecule approaches to cancer.

The arrow in the figure below represents our realization that, even as activities move to the right toward clinical realization, there is a strong requirement to recycle back to developmental activities in response to the knowledge we gain in early clinical application. Our scientists are already doing this routinely, aided by our flexible and responsive infrastructure. The CCPS Program also contributes to the cycle by providing downstream information on effects of therapy and also potential prevention and therapeutic targets — findings arising out of survivorship and molecular epidemiological work of CCPS. These findings may then be explored by other programs in the continuum.
 

Community Outreach

As a Comprehensive Cancer Center, City of Hope plays an important role in the community. We continually use the knowledge gained from our ongoing research to influence the standards of prevention and care, and to educate physicians, caregivers, and patients alike.
 
 

Why Choose a Comprehensive Cancer Center?

Only a National Cancer Institute (NCI)-designated Comprehensive Cancer Center such as City of Hope offers a full complement of services designed to address all aspects of cancer, from understanding its origins, to developing new therapies and testing them in patient clinical trials, to delivering superior patient care and providing support and education to patients, their families and the public.
 
City of Hope is one of a select few cancer centers nationwide to have received this prestigious honor. NCI-funded cancer centers must go through a rigorous review process every five years, in which they are evaluated and ranked. Only those conducting the most promising cancer research are awarded Comprehensive Cancer Center status. It is an important credential to consider when choosing a cancer treatment facility.
 
As a patient, a diagnosis of cancer brings with it many questions and concerns. Choosing a Comprehensive Cancer Center such as City of Hope is an empowering step, equipping you with the best possible resources to fight the disease.
 
Attributes of a Comprehensive Cancer Center
To achieve the Comprehensive Cancer Center designation, organizations must support a broad range of research programs and approach the problem of cancer in many different ways. Comprehensive Cancer Centers like City of Hope must have strong programs in all of the following areas:
 
Comprehensive Cancer Centers also play important roles in their communities and regions, and influence the standards of prevention and care.
 
National Comprehensive Cancer Network Founding Member
Of the relatively few NCI-designated Comprehensive Cancer Centers, only an elite 21 comprise the National Comprehensive Cancer Network ( NCCN ), an alliance of the nation's leading Comprehensive Cancer Centers that defines and sets standards for cancer care. City of Hope is proud to be a founding member of the NCCN. NCCN member institutions are recognized for their world-renowned experts and for dealing with particularly complex, rare and aggressive forms of cancer. As an NCCN member institution, City of Hope plays a critical role in advancing state-of-the-art cancer treatment through education, research, and patient care. Learn more about the NCCN at www.nccn.org.
 

Comprehensive Cancer Center

Comprehensive Cancer Center

City of Hope has a proud history of excellence in biomedical research, patient-centered medical care, and community outreach.
 
In recognition of our broad-based innovations in cancer research and treatment, our continuing commitment to compassionate patient care, and our initiatives in patient and community education, the National Cancer Institute (NCI) has designated City of Hope a Comprehensive Cancer Center — the highest level of recognition bestowed by the NCI. City of Hope is one of just a handful of elite institutions nationwide to receive this prestigious honor.
 
As a division of the National Institutes of Health, the NCI is the Federal Government's principal agency for cancer research and training. The NCI's Cancer Center program acknowledges institutions for their scientific excellence, as well as their ability to bring diverse research approaches to the problem of cancer. The "Comprehensive Cancer Center" designation indicates that City of Hope has undergone a rigorous review process and has met or exceeded NCI standards in these areas.
 
Cancer Center Research Programs
City of Hope Comprehensive Cancer Center researchers and resources are dedicated to developing innovative new disease-fighting strategies in the battle against cancer. Through these programs, and through the mission and vision of City of Hope physicians and scientists, City of Hope Comprehensive Cancer Center will continue to make a difference in the lives of current and potential cancer patients and their loved ones—around the world today and in the future.
 
 
All of these activities are made possible by a forward-thinking infrastructure supporting basic and translational research in biological and small molecule cancer therapeutics.

Cancer Center Leadership

Cancer Center Leadership

Cancer Center Program Co-leaders

Cancer Center Program Co-leaders

Cancer Center Research Programs

About Our Cancer Center Research Programs

City of Hope provides a multidisciplinary, interactive environment where basic, clinical and translational, and prevention and control scientists collaborate closely. This stimulating intellectual environment contributes to the productive translational research under way within the Comprehensive Cancer Center. Our research initiatives are divided into the following research programs:
 
Basic Science Research Program
The Comprehensive Cancer Center provides both the infrastructure and the environment for outstanding basic science research. ("Basic science" refers to research conducted in a laboratory setting.) In turn, this research contributes to our understanding of the underlying genetic, molecular and biological bases of cancer. The basic science research program at City of Hope is called Molecular Oncology (MONC).
 
Clinical and Translational Research Programs
The Comprehensive Cancer Center's clinical and translational research programs focus on the translation of novel laboratory observations into the treatment of patients (and their families) and, ultimately, throughout the world. The number of the Center's novel (Phases I and I/II) clinical trials increases yearly. The clinical and translational science research programs are:
 
 
Prevention and Control Program
Cancer prevention and control research at the Comprehensive Cancer Center is conducted within a program on Cancer Control and Population Sciences (CCPS). The members of this research program cover an extensive spectrum of disciplines, which is further broadened by additional collaborations with physician investigators. Such a confederation of expertise, working within a collaborative environment, maximizes productive interaction. The program focuses on four important areas of concentration:
 
  • Host and environmental determinants of cancer
  • Health-related outcomes and quality of life after cancer
  • Interventional studies to reduce cancer-related morbidity
  • Educational initiatives
 
Our five research programs, described above, represent a continuum, as shown in the figure below. Basic and translational studies can originate in either the basic science program,MO or the DCT Program. These studies can then link to phase I and II clinical protocols in all three clinical programs—DCT, CI and HM. They can also integrate into follow-up studies in survivorship and symptom management in the CCPS Program. On this continuum, CI spans both translational and clinical research, whereas HM is predominantly (but not exclusively) clinical. Frequent interaction between the principal investigators of each program ensures maximum benefit from shared insights. All these activities are made possible by City of Hope’s infrastructure, which supports basic and translational research in biological and in small molecule approaches to cancer.

The arrow in the figure below represents our realization that, even as activities move to the right toward clinical realization, there is a strong requirement to recycle back to developmental activities in response to the knowledge we gain in early clinical application. Our scientists are already doing this routinely, aided by our flexible and responsive infrastructure. The CCPS Program also contributes to the cycle by providing downstream information on effects of therapy and also potential prevention and therapeutic targets — findings arising out of survivorship and molecular epidemiological work of CCPS. These findings may then be explored by other programs in the continuum.
 

Community Outreach

Community Outreach

As a Comprehensive Cancer Center, City of Hope plays an important role in the community. We continually use the knowledge gained from our ongoing research to influence the standards of prevention and care, and to educate physicians, caregivers, and patients alike.
 
 

Why Choose A Comprehensive Cancer Center?

Why Choose a Comprehensive Cancer Center?

Only a National Cancer Institute (NCI)-designated Comprehensive Cancer Center such as City of Hope offers a full complement of services designed to address all aspects of cancer, from understanding its origins, to developing new therapies and testing them in patient clinical trials, to delivering superior patient care and providing support and education to patients, their families and the public.
 
City of Hope is one of a select few cancer centers nationwide to have received this prestigious honor. NCI-funded cancer centers must go through a rigorous review process every five years, in which they are evaluated and ranked. Only those conducting the most promising cancer research are awarded Comprehensive Cancer Center status. It is an important credential to consider when choosing a cancer treatment facility.
 
As a patient, a diagnosis of cancer brings with it many questions and concerns. Choosing a Comprehensive Cancer Center such as City of Hope is an empowering step, equipping you with the best possible resources to fight the disease.
 
Attributes of a Comprehensive Cancer Center
To achieve the Comprehensive Cancer Center designation, organizations must support a broad range of research programs and approach the problem of cancer in many different ways. Comprehensive Cancer Centers like City of Hope must have strong programs in all of the following areas:
 
Comprehensive Cancer Centers also play important roles in their communities and regions, and influence the standards of prevention and care.
 
National Comprehensive Cancer Network Founding Member
Of the relatively few NCI-designated Comprehensive Cancer Centers, only an elite 21 comprise the National Comprehensive Cancer Network ( NCCN ), an alliance of the nation's leading Comprehensive Cancer Centers that defines and sets standards for cancer care. City of Hope is proud to be a founding member of the NCCN. NCCN member institutions are recognized for their world-renowned experts and for dealing with particularly complex, rare and aggressive forms of cancer. As an NCCN member institution, City of Hope plays a critical role in advancing state-of-the-art cancer treatment through education, research, and patient care. Learn more about the NCCN at www.nccn.org.
 
Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Clinical Trials
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials.
 
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Discover the wide range of progressive cancer treatment options at City of Hope designed to meet the individual needs of each patient. Here, medical research and clinical care are integrated, speeding the application of scientific discoveries toward better, more effective patient cancer treatments.
City of Hope Breakthroughs
Get the latest in City of Hope's research, treatment and news you can use on our blog, Breakthroughs.
 
 
When you support City of Hope, you help us shorten the time it takes to get from bold, innovative ideas to powerful new medical treatments. Make a gift online now.


NEWS & UPDATES
  • Equipping the immune system to fight cancer – a disease that thrives on mutations and circumventing the body’s natural defenses – is within reach. In fact, City of Hope researchers are testing one approach in clinical trials now. Scientists take a number of steps to turn cancer patients’ T cells – white b...
  • As treatments for lung cancer become more targeted and effective, the need for better technology to detect lung cancer mutations becomes increasingly important. A new clinical study at City of Hope is examining the feasibility of using blood and urine tests to detect lung cancer mutations, potentially allowing ...
  • When it comes to breast cancer risk, insulin levels may matter more than weight, new research has found. The study from Imperial College London School of Public Health, published in the journal Cancer Research, indicates that metabolic health – not a person’s weight or body mass index – increases breast cancer ...
  • No one ever plans to have cancer – and there’s never a good time. For Homa Sadat, her cancer came at a particularly bad time: just one year after losing her father to the pancreatic cancer he had battled for two years. She was working a grueling schedule managing three commercial office buildings. She’d just [&...
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  • Surgery is vital in the treatment of cancer – it’s used to help diagnose, treat and even prevent the disease – so a new colorectal cancer study linking a decrease in surgeries for advanced cancer to increased survival rates may raise more questions than it answers for some patients. The surgery-and-surviv...
  • Age is the single greatest risk factor overall for cancer; our chances of developing the disease rise steeply after age 50. For geriatric oncology nurse Peggy Burhenn, the meaning is clear: Cancer is primarily a geriatric condition. That’s why she is forging inroads in the care of older adults with cancer. Burh...
  • One of American’s great sportscasters, Stuart Scott, passed away from recurrent cancer of the appendix at the young age of 49. His cancer was diagnosed when he was only 40 years old. It was found during an operation for appendicitis. His courageous fight against this disease began in 2007, resumed again with an...
  • When Homa Sadat found a lump in her breast at age 27, her gynecologist told her what many doctors say to young women: You’re too young to have breast cancer. With the lump dismissed as a harmless cyst, she didn’t think about it again until she was at a restaurant six months later and felt […]
  • What most people call a “bone marrow transplant” is not actually a transplant of bone marrow; it is instead the transplantation of what’s known as hematopoietic stem cells. Such cells are often taken from bone marrow, but not always. Hematopoietic stem cells are simply immature cells that can ...
  • Doctors have long known that women with a precancerous condition called atypical hyperplasia have an elevated risk of breast cancer. Now a new study has found that the risk is more serious than previously thought. Hyperplasia itself is an overgrowth of cells; atypical hyperplasia is an overgrowth in a distorted...
  • Don’t kid yourself. Just because it’s mid-January doesn’t mean it’s too late to make resolutions for a happier, and healthier, 2015. Just consider them resolutions that are more mature than those giddy, sometimes self-deluded, Jan. 1 resolutions. To that end, we share some advice from Cary A. Presant, M.D., an ...
  • Sales and marketing executive Jim Murphy first came to City of Hope in 2002 to donate blood for a friend who was being treated for esophageal cancer. The disease is serious. Although esophageal cancer accounts for only about 1 percent of cancer diagnoses in the U.S., only about 20 percent of patients survive at...
  • Aaron Bomar and his family were celebrating his daughter’s 33rd birthday in September 2014 when he received alarming news: According to an X-ray taken earlier that day at an urgent care facility, he had a node on his aorta and was in danger of an aneurysm. Bomar held hands with his wife and daughter and s...
  • Explaining a prostate cancer diagnosis to a young child can be difficult — especially when the cancer is incurable. But conveying the need for prostate cancer research, as it turns out, is easily done. And that leads to action. Earlier this year, Gerald Rustad, 71, who is living with a very aggressive form of m...