Contact Information
Shiuan Chen, Ph.D.
  • Chair and Professor, Cancer Biology

Departments/Division/Program

Languages Spoken
  • English
  • Mandarin (Chinese)

Professional Experience

  • 2012 - present, Chair, Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA
  • 2009 - 2012, Director and Professor, Division of Tumor Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA
  • 2009 - 2012, Associate Chair, Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA
  • 2002 - 2009, Professor and Director, Division of Tumor Cell Biology, Department of Surgery, City of Hope, Duarte, CA
  • 1994 - 2002, Professor, Department of Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • 1988 - 1994, Associate Research Scientist, Department of Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • 1985 - 1988, Assistant Research Scientist, Department of Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • 1982 - 1985, Research Assistant Professor, School of Pharmacy, University of Southern California, Los Angeles, CA
  • 1981 - 1982, Assistant Researcher, Department of Biochemistry and Biophysics, University of Hawaii
  • 1978 - 1981, Junior Researcher, Department of Biochemistry and Biophysics, University of Hawaii

Education

Education/Training
  • University of Hawaii, Honolulu, Hawaii, Ph.D.,Biochemistry
  • National Taiwan College of Marine Science and Technology, Keelung Taiwan, Republic of China, B.S., Chemistry

Honors/Awards

Honors
  • 2008, Chair of the Aromatase 2008 meeting
  • 2007, Recipient of the Gallery of Achievement Award for Science, City of Hope
  • 2007, Co-chair of Gordon Research Conference on Hormone Action in Development & Cancer
  • 2007, Featured Researcher of the California Breast Cancer Research Program
  • 2007, President of the Chinese-American Faculty Association, Southern California
  • 2007, NCI/OCCAM Monthly Lecture Series presentation: Breast Cancer Prevention with Anti-aromatase Phytochemicals in Grapes and Mushrooms
  • 2006, Guest Professor, Fujian Medical University, China
  • 1998, Honorary Professor, The Third Medical University of China, Chongqing, China

Memberships

  • 2006, Programmatic review for the DOD Breast Cancer Research Program
  • 2006, Reviewer for applications for the Tumor Microenvironment Network, NIH
  • 2006 - present, Section Editor, Journal of Molecular Signaling
  • 2006, Reviewer for the Mouse Metabolic Phenotyping Centers Consortium, NIH
  • 2005, Member of the Scientific Committee, Food and Health Research Institute, Ayecue Foundation, Spain
  • 2004, Reviewer for the botanical center grant applications, NIH
  • 2002 - present, Corresponding Editor, The Journal of Steroid Biochemistry and Molecular Biology
  • 2002, Reviewer for the SCOR applications, NIH
  • 2000 - present, Member of Special Emphasis Panels, NIH
  • 1999-2000, Member of the Sudy Section for Insight Award for Breast Cancer, NIH
  • 1998-1999, U.S. Environmental Protection Agency, Endocrine Disruptor Study Section
  • 2000-2001, Chairman of the Student Research Committee, American Heart Association, Western States Affiliate
  • 1998 - 2002, Member of the Research Committee, American Heart Association, Western States Affiliate
  • 1996 - 1998, 2001-2003, 2005, Member of the Study Sections of the U.S. Army Breast Cancer Research Program
  • 2003 - 2005, Member of the Tumor Cell Biology Study Section, NIH
  • 2002 - 2003, Member of the Metabolic Pathology Study Section, NIH
  • 1996 - 2000, Member of the Reproductive Endocrinology Study Section, NIH
  • 1985 - present, Member of the City of Hope Cancer Center

Publications

1. Chen Z, Wang O, Nie M, Elison K, Zhou D, Li M, Jiang Y, Xia W, Meng X, Chen S, Xing X. Aromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism. Mol Cell Endocrinol. 2014 PMID: 25301327
2. Li F, Wong TY, Lin SM, Chow S, Cheung WH, Chan FL, Chen S, Leung LK. Coadministrating luteolin minimizes the side effects of the aromatase inhibitor letrozole. J Pharmacol Exp Ther, 351: 270-7, 2014 PMID: 25138022
3. Wong TY, Li F, Lin SM, Chan FL, Chen S, Leung LK. Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice. BMC Cancer, 14: 426, 2014 PMCID: PMC4070644
4. Wang Y, Zhou D, Chen S. SGK3 is an androgen-inducible kinase promoting prostate cancer cells proliferation trough activation of p70 S6 kinase and up-regulation of cyclin D1. Mol Endocrinol, 28: 935-948, 2014. PMCID: PMC4042072.
5. Wang Y, Wong TY, Chan FL, Chen S, Leung LK. Assessing the effect of food mycotoxins on aromatase by using a cell-based system. Toxicol In Vitro, 28: 640-6, 2014 PMID: 24512813
6. Chen S, Zhou D, Hsin LY, Kanaya N, Wong C, Yip R, Sakamuru S, Xia M, Yuan YC, Witt K, Teng C. AroER tri-screen™ is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor. Toxicological Sciences, 139: 198-209, 2014. PMID: 24496634
7. Wang YZ, Xu W, Zhou D, Neckers L, Chen S. Coordinated regulation of Serum- and GlucocorticoidInducible Kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex. J Biol Chem, 289: 4815-26, 2014. PMID: 24379398
8. Kanaya N, Adams L, Takasaki A, Chen S. Whole blueberry powder inhibits metastasis of triple negative breast cancer in a xenograft mous model through modulation of inflammatory cytokines. Nutr Cancer, 66: 242-8, 2013. PMID: 24364759
9. Amaral C, Varela C, Azevedo M, da Silva ET, Roleira FM, Chen S, Correia-da-Silva G, Teixeira N Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: aromatase inhibition and autophagy. J Steroid Biochem Mol Biol, 135: 51-9, 2013 PMID: 23318878
10. Warden CD, Kanaya N, Chen S, Yuan YC. BD-Func: a streamlined algorithm for predicting activation and inhibition of pathways.  PeerJ, 1: e159, 2013. PMCID: PMC3775632
11. Kanaya N, Vonderfecht S, Chen S, Androgren (dihydrotestosterone)-mediated regulation of food intake and obesity in female mice. J Steroid Biochem Mol Biol, 138: 100-6, 2013. PMID: 23665441
12. Kubo M, Kanaya N, Petrossian K, Ye J, Warden C, Liu Z, Nishimura R, Osako T, Okido M, Shimada K, Takahashi M, Chu P, Yuan YC, Chen S. Inhibition of the proliferation of acquired aromatase inhibitor-resistant breast cancer cells by histone deacetylase inhibitor LBH589 (panobinostat). Breast Cancer Res Treat, 137: 93-107, 2013.  PMCID: PMC3637924
13. Li F, Chow S, Cheung WH, Chan FL, Chen S, Leung LK. The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer. J Nutr Biochem, 2012 Dec 10. doi:pii: S0955-2863. PMID: 23238426
14. Wong C, Wang X, Smith D, Reddy K, Chen S. AKT-aro and HER2-aro, models for de novo resistance to aromatase inhibitors; molecular characterization and inhibitor response studies.  Breast Cancer Res Treat, 134: 671-81, 2012.  PMID: 22706627; 
15. Wong C, Chen S.  The development, application and limitations of breast cancer cell lines to study tamoxifen and aromatase inhibitor resistance. J Steroid Biochem Mol Biol, 131: 83-92, 2012.  PMID: 22265958
16. Kanaya N, Kubo M, Liu Z, Chu P, Wang C, Yuan YC, Chen S. Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women. PLoS One. 2011;6(10):e26654. PMID: 22046322; PMCID: PMC3201963.
17. Adams LS, Kanaya N, Phung S, Liu Z, Chen S. Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. J Nutr. 2011 Oct;141(10):1805-12. PMID: 21880954; PMCID: PMC3174855.
18. Hong Y, Rashid R, Chen S. Binding features of steroidal and nonsteroidal inhibitors. Steroids. 2011 Jul;76(8):802-6. PMID: 21420422; PMCID: PMC3253312.
19. Geisler J, Sasano H, Chen S, Purohit A. Steroid sulfatase inhibitors: promising new tools for breast cancer therapy? J Steroid Biochem Mol Biol. 2011 May;125(1-2):39-45. PMID: 21356310.
20. Wang Y, Zhou D, Phung S, Masri S, Smith D, Chen S. SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells. Mol Endocrinol. 2011 Jan;25(1):72-82. PMID: 21084382; PMCID: PMC3089033.
21. Kanaya N, Chen S. Conjugated linoleic acid reduces body weight gain in ovariectomized female C57BL/6J mice. Nutr Res. 2010 Oct;30(10):714-21. PMID: 21056287; PMCID: PMC3000560.
22. Wang Y, Chen B, Li Y, Zhou D, Chen S. PNRC accumulates in the nucleolus by interaction with B23/nucleophosmin via its nucleolar localization sequence. Biochim Biophys Acta. 2011 Jan;1813(1):109-19. PMID: 20888865; PMCID: PMC3085350.
23. Hong Y, Chen S. Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: structure-function studies and inhibitor development. Mol Cell Endocrinol. 2011 Jul 4;340(2):120-6. PMID: 20888390; PMCID: PMC3035767.
24. Chen S, Ye J, Kijima I, Evans D. The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11032-7. PMID: 20534486; PMCID: PMC2890707.
25. Adams LS, Phung S, Yee N, Seeram NP, Li L, Chen S. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res. 2010 May 1;70(9):3594-605. PMID: 20388778; PMCID: PMC2862148.

Research

For more information on Dr. Chen's research, please click here.