Contact Information
Shiuan Chen, Ph.D.
  • Chair and Professor, Cancer Biology

Departments/Division/Program

Languages Spoken
  • English
  • Mandarin (Chinese)

Professional Experience

  • 2012 - present, Chair, Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA
  • 2009 - 2012, Director and Professor, Division of Tumor Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA
  • 2009 - 2012, Associate Chair, Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA
  • 2002 - 2009, Professor and Director, Division of Tumor Cell Biology, Department of Surgery, City of Hope, Duarte, CA
  • 1994 - 2002, Professor, Department of Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • 1988 - 1994, Associate Research Scientist, Department of Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • 1985 - 1988, Assistant Research Scientist, Department of Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • 1982 - 1985, Research Assistant Professor, School of Pharmacy, University of Southern California, Los Angeles, CA
  • 1981 - 1982, Assistant Researcher, Department of Biochemistry and Biophysics, University of Hawaii
  • 1978 - 1981, Junior Researcher, Department of Biochemistry and Biophysics, University of Hawaii

Education

Education/Training
  • University of Hawaii, Honolulu, Hawaii, Ph.D.,Biochemistry
  • National Taiwan College of Marine Science and Technology, Keelung Taiwan, Republic of China, B.S., Chemistry

Honors/Awards

Honors
  • 2008, Chair of the Aromatase 2008 meeting
  • 2007, Recipient of the Gallery of Achievement Award for Science, City of Hope
  • 2007, Co-chair of Gordon Research Conference on Hormone Action in Development & Cancer
  • 2007, Featured Researcher of the California Breast Cancer Research Program
  • 2007, President of the Chinese-American Faculty Association, Southern California
  • 2007, NCI/OCCAM Monthly Lecture Series presentation: Breast Cancer Prevention with Anti-aromatase Phytochemicals in Grapes and Mushrooms
  • 2006, Guest Professor, Fujian Medical University, China
  • 1998, Honorary Professor, The Third Medical University of China, Chongqing, China

Memberships

  • 2006, Programmatic review for the DOD Breast Cancer Research Program
  • 2006, Reviewer for applications for the Tumor Microenvironment Network, NIH
  • 2006 - present, Section Editor, Journal of Molecular Signaling
  • 2006, Reviewer for the Mouse Metabolic Phenotyping Centers Consortium, NIH
  • 2005, Member of the Scientific Committee, Food and Health Research Institute, Ayecue Foundation, Spain
  • 2004, Reviewer for the botanical center grant applications, NIH
  • 2002 - present, Corresponding Editor, The Journal of Steroid Biochemistry and Molecular Biology
  • 2002, Reviewer for the SCOR applications, NIH
  • 2000 - present, Member of Special Emphasis Panels, NIH
  • 1999-2000, Member of the Sudy Section for Insight Award for Breast Cancer, NIH
  • 1998-1999, U.S. Environmental Protection Agency, Endocrine Disruptor Study Section
  • 2000-2001, Chairman of the Student Research Committee, American Heart Association, Western States Affiliate
  • 1998 - 2002, Member of the Research Committee, American Heart Association, Western States Affiliate
  • 1996 - 1998, 2001-2003, 2005, Member of the Study Sections of the U.S. Army Breast Cancer Research Program
  • 2003 - 2005, Member of the Tumor Cell Biology Study Section, NIH
  • 2002 - 2003, Member of the Metabolic Pathology Study Section, NIH
  • 1996 - 2000, Member of the Reproductive Endocrinology Study Section, NIH
  • 1985 - present, Member of the City of Hope Cancer Center

Publications

  • Wong C, Chen S. The development, application and limitations of breast cancer cell lines to study tamoxifen and aromatase inhibitor resistance. J Steroid Biochem Mol Biol. 2012 Jan 8. PMID: 22265958.
  • Kanaya N, Kubo M, Liu Z, Chu P, Wang C, Yuan YC, Chen S. Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women. PLoS One. 2011;6(10):e26654. PMID: 22046322; PMCID: PMC3201963.
  • Adams LS, Kanaya N, Phung S, Liu Z, Chen S. Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. J Nutr. 2011 Oct;141(10):1805-12. PMID: 21880954; PMCID: PMC3174855.
  • Hong Y, Rashid R, Chen S. Binding features of steroidal and nonsteroidal inhibitors. Steroids. 2011 Jul;76(8):802-6. PMID: 21420422; PMCID: PMC3253312.
  • Geisler J, Sasano H, Chen S, Purohit A. Steroid sulfatase inhibitors: promising new tools for breast cancer therapy? J Steroid Biochem Mol Biol. 2011 May;125(1-2):39-45. PMID: 21356310.
  • Chen S. An
  • Wang Y, Zhou D, Phung S, Masri S, Smith D, Chen S. SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells. Mol Endocrinol. 2011 Jan;25(1):72-82. PMID: 21084382; PMCID: PMC3089033.
  • Kanaya N, Chen S. Conjugated linoleic acid reduces body weight gain in ovariectomized female C57BL/6J mice. Nutr Res. 2010 Oct;30(10):714-21. PMID: 21056287; PMCID: PMC3000560.
  • Wang Y, Chen B, Li Y, Zhou D, Chen S. PNRC accumulates in the nucleolus by interaction with B23/nucleophosmin via its nucleolar localization sequence. Biochim Biophys Acta. 2011 Jan;1813(1):109-19. PMID: 20888865; PMCID: PMC3085350.
  • Hong Y, Chen S. Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: structure-function studies and inhibitor development. Mol Cell Endocrinol. 2011 Jul 4;340(2):120-6. PMID: 20888390; PMCID: PMC3035767.
  • Chen S, Ye J, Kijima I, Evans D. The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11032-7. PMID: 20534486; PMCID: PMC2890707.
  • Adams LS, Phung S, Yee N, Seeram NP, Li L, Chen S. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res. 2010 May 1;70(9):3594-605. PMID: 20388778; PMCID: PMC2862148.
  • Masri S, Liu Z, Phung S, Wang E, Yuan YC, Chen S. The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells. Breast Cancer Res Treat. 2010 Nov;124(1):89-99. PMID:20054641.
  • Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res (Phila). 2010 Jan;3(1):108-13. (AACR press release on this paper) PMID: 20051378; PMCID: PMC2805471
  • Hong Y, Li H, Ye J, Miki Y, Yuan YC, Sasano H, Evans DB, Chen S. Epitope characterization of an aromatase monoclonal antibody suitable for the assessment of intratumoral aromatase activity. PLoS One. 2009 Nov 30;4(11):e8050. PMID: 19956630; PMCID: PMC2778552.
  • Wong C, Chen S. Heat shock protein 90 inhibitors: new mode of therapy to overcome endocrine resistance. Cancer Res. 2009 Nov 15;69(22):8670-7. PMID: 19861537; PMCID: PMC2784253.
  • Su B, Chen S. Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6733-5. PMID: 19854050; PMCID: PMC2783870.
  • Adams LS, Chen S. Phytochemicals for breast cancer prevention by targeting aromatase. Front Biosci. 2009 Jan 1;14:3846-63. PMID: 19273315.
  • Masri S, Lui K, Phung S, Ye J, Zhou D, Wang X, Chen S. Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Res Treat. 2009 Aug;116(3):461-70. PMID: 18677558.
  • Adams LS, Phung S, Wu X, Ki L, Chen S. White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibitsprostate tumor growth in athymic mice. Nutr Cancer. 2008;60(6):744-56. PMID: 19005974.
  • Foster PA, Chander SK, Newman SP, Woo LW, Sutcliffe OB, Bubert C, Zhou D, Chen S, Potter BV, Reed MJ, Purohit A. A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor. Clin Cancer Res. 2008 Oct 15;14(20):6469-77. PMID: 18927286.
  • Chen B, Wang Y, Kane SE, Chen S. Improvement of sensitivity to tamoxifen in estrogen receptor-positive and Herceptin-resistant breast cancer cells. J Mol Endocrinol. 2008 Nov;41(5):367-77. PMID: 18768663.
  • Lisztwan J, Pornon A, Chen B, Chen S, Evans DB. The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer. Breast Cancer Res. 2008;10(4):R56. PMID: 18611244; PMCID: PMC2575527.
  • Masri S, Phung S, Wang X, Wu X, Yuan YC, Wagman L, Chen S. Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor. Cancer Res. 2008 Jun 15;68(12):4910-8 PMID: 18559539.
  • Lui K, Tamura T, Mori T, Zhou D, Chen S. MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands. Biochem Pharmacol. 2008 Jul 15;76(2):208-15. (evaluated by Martin Van den Berg: http://www.f1000biology.com/article/id/1118894/evaluation). PMID:18550029; PMCID: PMC2587126.

Research

For more information on Dr. Chen's research, please click here.