Contact Information
Fouad Kandeel, M.D., Ph.D.
  • Professor, Department of Diabetes and Metabolic Diseases Research
  • Director, Division of Development & Translational Diabetes and Endocrine Research
  • Chair and Professor, Department of Clinical Diabetes, Endocrinology and Metabolism

Biography

Dr. Fouad Kandeel is the Principal Investigator on the islet transplantation trial to determine the safety and efficacy of islet cell transplantation as a treatment for patients with type 1 diabetes. In addition, Dr. Kandeel has recently concluded a clinical project to identify genes related to the development of type 2 diabetes and cardiovascular disease in the Hispanic population. He also continues to oversee the Diabetes and Cardiovascular Risk Reduction Program, which he established several years ago at City of Hope. Due to his strong background in endocrine tumors and thyroid cancer, Dr. Kandeel participates in the development of the national guidelines for the management of neuroendocrine tumors and thyroid cancer.

Professional Experience

  • 2011-present, Director, Division of Development & Translational Diabetes and Endocrine Research, Beckman Research Institute of City of Hope, Duarte, CA
  • 2009–present, Professor, Department of Diabetes and Metabolic Disease Research, Beckman Research Institute of City of Hope, Duarte, CA
  • 2008–present, Chair and Professor, Department of Clinical Diabetes, Endocrinology & Metabolism, City of Hope, Duarte, CA
  • 1996–present, Associate Clinical Professor, Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA
  • 1999–2010, Assistant Program Director, General Clinical Research Center, City of Hope, Duarte, CA
  • 1999–2000, Acting Director, Department of Diabetes, Endocrinology & Metabolism, City of Hope, Duarte, CA
  • 1996 –1998, Consultant Endocrinologist, King Faisal Hospital & Research Center, Riyadh, Saudi Arabia
  • 1991–1999, Assistant Staff Physician, Department of Diabetes, Endocrinology & Metabolism, City of Hope, Duarte, CA
  • 1982–1984, Assistant Program Director, General Clinical Research Center, Harbor-UCLA Medical Center, Torrance, CA
  • 1973-1975, Assistant Lecturer, Department of Biochemistry, Tanta University, Egypt

Education

Education/Training
  • 1985-1986, Research Fellow in Nutrition and Metabolism, Harbor-UCLA Medical Center, Torrance, CA
  • 1984-1985, Clinical Fellow in Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA
  • 1982-1984, Research Fellow in Endocrinology, Harbor-UCLA Medical Center, Torrance, CA
  • 1980, School of Medicine and Central Birmingham Health District Hospital Birmingham University, United Kingdom, Ph.D., Endocrinology
  • 1979-1981, Research Fellow in Endocrinology and Medicine, Central Birmingham Health District Hospitals, Birmingham, United Kingdom
  • 1973, Faculty of Medicine, Tanta University, Egypt, M.Sc., Biochemistry
  • 1969, Faculty of Medicine and Kaser El Aini Hospital, Cairo University, Egypt, M.B., B.CH. (M.D.),

Honors/Awards

Awards
  • 2007, American Egyptian Organization Achievement Award
  • 1987-1990, Clinical Physician Associate Award, Clinical Research Center, Harbor-UCLA Medical Center

Memberships

  • Cell Transplant Society
  • International Society for Sexual and Impotence Research
  • International Society for the Study of Women’s Sexual Health (ISSWSH)
  • American Society of Andrology
  • American Diabetes Association
  • American Society for Reproductive Medicine
  • The Endocrine Society

Publications

"PARTIAL LIST OF PUBLICATIONS"
  • Kulke MH, Benson III, AB, Bergsland E, Berlin JD, Blaszkowsky LS, Choti MA, Clark OH, Doherty GM, Eason J, Emerson L, Engstrom PF, Goldner WS, Heslin MJ, Kandeel F, Kunz PL, Kuvshinoff II, BW, Moley JF, Pillarisetty VG, Saltz L, Schteingart DE, Shah MH, Shibata S, Strosberg JR, Vauthey J-N, White R, Yao JC. Neuroendocrine tumors: Clinical practice guidelines in oncology. JNCCN (2012);10(6):724-764.
  • Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, Naziruddin B, Oberholzer J, Odorico JS, Garfinkel MR, Levy M, Pattou F, Berney T, Secchi A, Messinger S, Senior PA, Maffi P, Posselt A, Stock PG, Kaufman DB, Luo X, Kandeel F, Cagliero E, Turgeon NA, Witkowski P, Naji A, O'Connell PJ, Greenbaum C, Kudva YC, Brayman KL, Aull MJ, Larsen C, Kay TW, Fernandez LA, Vantyghem MC, Bellin M, Shapiro AM. Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care. (2012) Jul;35(7):1436-1445. PMID: 22723582.
  • Wang M, Racine JJ, Song X, Li X, Nair I, Liu H, Avakian-Mansoorian A, Johnston HF, Liu C, Shen C, Atkinson M, Todorov I, Kandeel F, Forman S, Wilson B, Zeng D. Mixed chimerism and growth factors augment β-cell regeneration and reverse late-stage type 1 diabetes. Science Translational Medicine (2012) May; 4(133): art. no. 133ra59. PMID: 22572882.
  • Iglesias I, Valiente L, Shiang K-D, Ichii H, Kandeel F, Al-Abdullah IH. The effects of digestion enzymes on islet viability and cellular composition. Cell Transplantation (2012); 21(4):649-655. PMID: 22236690.
  • Wu Z, Todorov I, Li L, Bading JR, Li Z, Nair I, Ishiyama K, Colcher D, Conti PE, Fraser SE, Shively JE, Kandeel F. In vivo imaging of transplanted islets with 64Cu-D03A-VS-Cys40-Exendin-4 by targeting GLP-1 receptor. Bioconjug Chemistry (2011); 22(8):1587-1594. PMID: 21692471.
  • Asari S, Itakura S, Rawson J, Ito T, Todorov I, Nair I, Shintaku J, Liu C-P, Kandeel F, Mullen Y. Mesenchymal stem cells facilitate mixed hematopoietic chimerism induction and prevent onset of diabetes in nonobese diabetic mice. Pancreas (2011) Aug 40(6):846-854. PMID: 21562444.
  • Bentsi-Barnes K, Doyle ME, Abad D, Kandeel F, Al-Abdullah I. Detailed protocol for evaluation of dynamic perifusion of human islets to assess beta-cell function. Islets (2011) Sep 1; 3(5):284-290.
  • Omori K, Mitsuhashi M, Ishiyama K, Nair I, Rawson J, Todorov I, Kandeel F, Mullen Y. mRNA of the pro-apoptotic gene BBC serves as a molecular marker for TNF-alpha-induced islet damage in humans. Diabetologia (2011); 54(8):2056-2066. PMID: 21811103.
  • Omori K, Kandeel F et al. PUMA/BBC3, a pro-apoptotic gene, as a molecular marker for TNF-alpha-induced human islet damage. Diabetologia. (2011) Sep;54(9):2474. PMID: 21567299.
  • Steil GM, Palerm CC, Kurtz N, Voskanyan G, Roy A, Paz S, Kandeel F. The effect of insulin feedback on closed loop glucose control. J Clin Endo Metab (2011); 96(5):1402-1408. PMID: 21367930.
  • Shiang K-D, Kandeel F. A computational model of the human glucose-insulin regulatory system. J Biomed Res (2010); 24(5):347-364.
  • Tuttle RM, Ball DW, Byrd D, Dilawari RA, Doherty GM, Duh QY, Ehya H, Farrar WB, Haddad RI, Kandeel F, Kloos RT, Kopp P, Lamonica DM, Loree TR, Lydiatt WM, McCaffrey JC, Olson JA Jr, Parks L, Ridge JA, Shah JP, Sherman SI, Sturgeon C, Waguespack SG, Wang TN, Wirth LJ; National Comprehensive Cancer Network. Thyroid carcinoma. J Natl Compr Canc Netw (2010) Nov 8(11):1228-1274. PMID: 21081783.
  • Todorov I, Nair I, Avakian-Mansoorian A, Rawson J, Omori K, Mullen Y, Ito T, Valiente L, Iglesias-Meza I, Orr C, Shiang K, Ferreri K, Al-Abdullah I, Mullen Y, Kandeel F. Quantitative assessment of beta-cell apoptosis and cell composition of isolated, undisrupted human islets by laser scanning cytometry. Transplantation (2010) Oct 27;90(8):836-842. PMID: 20697327.
  • Wu Z, Kandeel F. 18F-labeled proteins. Curr Pharm Biotechnol (2010) Sep 1;11(6):572-80. PMID: 20497120.
  • Wu Z, Kandeel F. Radionuclide probes for molecular imaging of pancreatic beta-cells. Adv Drug Deliv Rev (2010) Aug 30;62(11):1125-1138. Epub 2010 Sep 18. Review. PMID: 20854861.
  • Ito T, Itakura S, Todorov I, Rawson J, Asari S, Shintaku J, Nair I, Ferreri K, Kandeel F, Mullen Y. Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function. Transplantation (2010) Jun 27;89(12):1438-1445. PMID: 20568673.
  • Nduaguibe C, Bentsi-Barnes K, Mullen Y, Kandeel F, Al-Abdullah I. Serine protease inhibitors suppress pancreatic endogenous proteases and modulate bacterial neutral proteases. Islets (2010) (May/June);2(3):200-206. PMID: 21099314.
  • Salehian B, Forman SJ, Kandeel FR, Bruner DE, He J, Atkinson RL. Adenovirus 36 DNA in adipose tissue of patients with unusual visceral obesity. Emerg Infect Dis. (2010) May:16(5):850-2. PMID: 20409382.
  • Omori K, Shintaku J, Rawson J, Ferreri K, Todorov I, Nair I, Al-Abdullah I. H., Higgins L, Medicherla S, Kandeel F, Mullen Y. p38 alpha-selective mitogen-activated protein kinase inhibitor for improvement of cultured human islet recovery. Pancreas (2010) May;39(4):436-43. PMID: 20084046.
  • Tuttle RM, Ball DW, Byrd D, Daniels GH, Dilawari RA, Doherty GM, Duh QY, Ehya H, Farrar WB, Haddad RI, Kandeel F, Kloos RT, Kopp P, Lamonica DM, Loree TR, Lydiatt WM, McCaffrey J, Olson JA Jr, Parks L, Ridge JA, Shah JP, Sherman SI, Sturgeon C, Waguespack SG, Wang TN, Wirth LJ; National Comprehensive Cancer Network. Medullary carcinoma. J Natl Compr Canc Netw (2010) May; 8(5):512-530. PMID: 20495082.
  • Omori K, Mitsuhashi M, Todorov I, Rawson J, Shiang K, Kandeel F, Mullen Y. Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation. Transplantation (2010) 89: 146–154. PMID: 20098276.
  • Kissler HJ, Niland JC, Olack B, Ricordi C, Hering B, Naji A, Kandeel FR, Oberholzer J, Fernandez L, Contreras J, Stiller T, Sowinski J, Kaufman DB. Validation of methodologies for quantifying isolated human islets: an islet cell resources study. Epub 2009 Aug 30 Clinical Transplant (2010) Mar-Apr;24(2):236-42 PMID: 19719726.
  • Salehian B, Liu Z, Kandeel FR. Genetic alterations in differentiated thyroid cancers. Endocr Metab Immune Disord Drug Targets (2009) 9(3):257-268. PMID: 19594419.
  • Tangsheng Y, Ying C, Lin W, Gong D, Huang D, Zhao DC, Johnstone H, Young J, Todorov I, Umetsu DT, Chen L, Iwakura Y, Kandeel FR, Forman S, Zeng D. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft versus host disease. Blood (2009);114(14):3101-3112. PMID: 19602708.
  • Kuroda A, Rauch TA, Todorov I, Ku HT, Al-Abdullah IH, Kandeel FR, Mullen Y, Pfeifer GP, Ferreri K. Insulin gene expression is regulated by DNA methylation. PLoS One. (2009) Sep 9;4(9):e6953. PMID:19742322.
  • Yi T, Chen Y, Wang L, Du G, Huang D, Zhao D, Johnston H, Young J, Todorov I, Umetsu DT, Chen L, Iwakura Y, Kandeel FR, Forman S, Zeng D. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood. (2009) Oct 1;114(14):3101-12. Epub 2009 Jul 14. PMID: 19602708.

Clinical Trials

Locations

  • City of Hope - Main Campus (Duarte)
    1500 East Duarte Road
    Duarte, CA 91010

Media

Book
  • Male Sexual Dysfunction: Pathophysiology and Treatment. FR Kandeel, T Lue, J Pryor, R Swerdloff (eds). Informa Healthcare Inc., 2007.
  • Male Reproductive Dysfunction: Pathophysiology and Treatment. FR Kandeel, R Swerdloff, J Pryor (eds). Informa Healthcare Inc., 2007.