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Clinical Trials
Clinical trials – research studies that involve volunteer patients – are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
 
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials. Last year, City of Hope conducted more than 300 studies enrolling almost 5,000 patients.

By participating in a clinical trial, you could receive the latest treatments available – treatments that hold promise, but are unproven. As with all decisions regarding your medical care, the choice is yours to make.
 
Types of clinical trials

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
  • Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
  • Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
  • Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
  • Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
  • Quality of life: explore ways to define and measure the patient’s experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.
 

Can you provide me with information about treatment or clinical trials at City of Hope?

You can access Clinical Trials On-Line to find out about clinical trials that are being conducted at City of Hope right away; but before you can participate in a specific trial, you must be seen by a doctor to discuss whether you are eligible. Once a patient has been seen by a City of Hope physician, he or she will be provided with information about treatment and can inquire about clinical trials.

Who should participate in a clinical trial?

A patient participating in a clinical trial typically receives a promising new treatment that needs to be investigated in order to receive government approval. For many patients facing life-threatening diseases who have exhausted the available treatment options, clinical trials offer new hope for survival.
 
The range of trials available today is extremely broad. Although many trials focus on patients with more advanced disease, a significant number of studies fall into areas such as screening techniques, early disease treatment and alleviation of symptoms. All clinical trials have specific guidelines for participant eligibility. These guidelines are based on such factors as type of disease, age, medical history and current medical condition. Before entering into a clinical trial, you must meet the criteria for the study.
 
The benefits and risks
Participating in a clinical trial can be a way of helping yourself and others. Patients who participate in a clinical trial often feel they are taking a more active role in their care. In a clinical trial, participants have access to new drugs and treatments before they are widely available. Because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. In addition, the data gathered from the trial can go on to benefit others.
 
There are risks to participating in clinical trials that must be weighed against the potential benefits. There may be some unpleasant or serious side effects from treatment. The trial may take a lot of time with repeat hospital visits, additional treatments and involved dosages. And the treatment may not end up being effective for the person participating.

What are the different types of clinical trials?

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
 
Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
 
Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
 
Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
 
Quality of life: explore ways to define and measure the patient's experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.

What is a protocol?

All clinical trials are based upon a study plan called a protocol. Designed with great care, the plan helps to ensure the safety of the participants and answer specific research questions. A protocol details the specifics of the study: who can participate, different procedures, test schedules, medications and dosages, and the length of the study.

What are the different phases of a clinical trial?

Clinical trials are conducted in four different phases with each phase serving a specific purpose to researchers.
 
Phase I: Assess the safety of a new drug. The phase is usually done with a small group of people (20 to 80) and evaluates how the body handles the drug, safe dosage ranges and side effects.
 
Phase II: The drug or treatment is given to a larger group (100 to 300) to determine effectiveness and to continue to evaluate safety.
 
Phase III: Hundreds or even thousands of people may receive a new drug or treatment and be followed for several years. This phase helps confirm the effectiveness of the drug, gauge side effects and gather information so the drug or treatment can be used safely.
 
Phase IV: The drug or treatment has received Food and Drug Administration approval and is widely marketed. This allows researchers to gather additional safety information on an even larger group of people and gather data on a drug or treatment's long-term effectiveness and how it affects quality of life. The drug or treatment may also be evaluated for cost and against other similar drugs already on the market.

How do I find out more about clinical trials at City of Hope?

A listing of our active clinical trials are available online. To speak with one of our care professionals about treatment at City of Hope, contact our New Patient Services online or call us at 800-826-HOPE (4673).

What exactly are 'clinical trials'?

A clinical trial is a scientifically designed study conducted to:
 
  • Answer specific questions about vaccines, new therapies or novel ways of using known treatments.
  • Determine whether new drugs or treatments are effective.
  • Develop new procedures and treatments to improve patient outcomes and advance medical science.
 
Each trial is a partnership involving a patient, a physician, a medical organization and frequently a government agency or private company that sponsors the research. City of Hope currently conducts many promising and innovative clinical trials through our involvement in the National Comprehensive Cancer Network (NCCN). These clinical trials help to redefine treatment outcomes and care standards for patients nationwide.

What are the benefits of clinical trials?

Clinical trials offer an opportunity for patients to take an active role in their health care. By participating, patients have the chance to make a difference in their own lives and those of future generations.
 
A clinical trial may also be the best way to get the most advanced, leading-edge treatment. Participants may have access to new drugs and treatments before they are widely available, and because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. If you are interested in taking part in a clinical trial or would like more information about City of Hope's clinical trials, contact Clinical Trials On-Line, or call 800-826-HOPE (4673).

Find a Clinical Trial

Clinical Trials
Clinical trials – research studies that involve volunteer patients – are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
 
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials. Last year, City of Hope conducted more than 300 studies enrolling almost 5,000 patients.

By participating in a clinical trial, you could receive the latest treatments available – treatments that hold promise, but are unproven. As with all decisions regarding your medical care, the choice is yours to make.
 
Types of clinical trials

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
  • Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
  • Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
  • Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
  • Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
  • Quality of life: explore ways to define and measure the patient’s experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.
 

Can you provide me with information about treatment or clinical trials at City of Hope?

You can access Clinical Trials On-Line to find out about clinical trials that are being conducted at City of Hope right away; but before you can participate in a specific trial, you must be seen by a doctor to discuss whether you are eligible. Once a patient has been seen by a City of Hope physician, he or she will be provided with information about treatment and can inquire about clinical trials.

Who should participate in a clinical trial?

A patient participating in a clinical trial typically receives a promising new treatment that needs to be investigated in order to receive government approval. For many patients facing life-threatening diseases who have exhausted the available treatment options, clinical trials offer new hope for survival.
 
The range of trials available today is extremely broad. Although many trials focus on patients with more advanced disease, a significant number of studies fall into areas such as screening techniques, early disease treatment and alleviation of symptoms. All clinical trials have specific guidelines for participant eligibility. These guidelines are based on such factors as type of disease, age, medical history and current medical condition. Before entering into a clinical trial, you must meet the criteria for the study.
 
The benefits and risks
Participating in a clinical trial can be a way of helping yourself and others. Patients who participate in a clinical trial often feel they are taking a more active role in their care. In a clinical trial, participants have access to new drugs and treatments before they are widely available. Because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. In addition, the data gathered from the trial can go on to benefit others.
 
There are risks to participating in clinical trials that must be weighed against the potential benefits. There may be some unpleasant or serious side effects from treatment. The trial may take a lot of time with repeat hospital visits, additional treatments and involved dosages. And the treatment may not end up being effective for the person participating.

What are the different types of clinical trials?

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
 
Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
 
Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
 
Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
 
Quality of life: explore ways to define and measure the patient's experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.

What is a protocol?

All clinical trials are based upon a study plan called a protocol. Designed with great care, the plan helps to ensure the safety of the participants and answer specific research questions. A protocol details the specifics of the study: who can participate, different procedures, test schedules, medications and dosages, and the length of the study.

What are the different phases of a clinical trial?

Clinical trials are conducted in four different phases with each phase serving a specific purpose to researchers.
 
Phase I: Assess the safety of a new drug. The phase is usually done with a small group of people (20 to 80) and evaluates how the body handles the drug, safe dosage ranges and side effects.
 
Phase II: The drug or treatment is given to a larger group (100 to 300) to determine effectiveness and to continue to evaluate safety.
 
Phase III: Hundreds or even thousands of people may receive a new drug or treatment and be followed for several years. This phase helps confirm the effectiveness of the drug, gauge side effects and gather information so the drug or treatment can be used safely.
 
Phase IV: The drug or treatment has received Food and Drug Administration approval and is widely marketed. This allows researchers to gather additional safety information on an even larger group of people and gather data on a drug or treatment's long-term effectiveness and how it affects quality of life. The drug or treatment may also be evaluated for cost and against other similar drugs already on the market.

How do I find out more about clinical trials at City of Hope?

A listing of our active clinical trials are available online. To speak with one of our care professionals about treatment at City of Hope, contact our New Patient Services online or call us at 800-826-HOPE (4673).

What exactly are 'clinical trials'?

A clinical trial is a scientifically designed study conducted to:
 
  • Answer specific questions about vaccines, new therapies or novel ways of using known treatments.
  • Determine whether new drugs or treatments are effective.
  • Develop new procedures and treatments to improve patient outcomes and advance medical science.
 
Each trial is a partnership involving a patient, a physician, a medical organization and frequently a government agency or private company that sponsors the research. City of Hope currently conducts many promising and innovative clinical trials through our involvement in the National Comprehensive Cancer Network (NCCN). These clinical trials help to redefine treatment outcomes and care standards for patients nationwide.

What are the benefits of clinical trials?

Clinical trials offer an opportunity for patients to take an active role in their health care. By participating, patients have the chance to make a difference in their own lives and those of future generations.
 
A clinical trial may also be the best way to get the most advanced, leading-edge treatment. Participants may have access to new drugs and treatments before they are widely available, and because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. If you are interested in taking part in a clinical trial or would like more information about City of Hope's clinical trials, contact Clinical Trials On-Line, or call 800-826-HOPE (4673).
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NEWS & UPDATES
  • It was 2009 when a City of Hope patient in her 40s learned that the cancer she had been fighting for several years had metastasized to her lungs. Her medical team ran genetic tests on the tumor, but none of the drug therapies available at the time targeted the known mutations in the tumor cells. […]
  • Acute myeloid leukemia (AML) is characterized by a rapidly-developing cancer in the myeloid line of blood cells, which is responsible for producing red blood cells, platelets and several types of white blood cells called granulocytes. Because AML grows rapidly, it can quickly crowd out normal blood cells, leadi...
  • Rachel Divine is a yoga therapist and patient leader for the Sheri & Les Biller Patient and Family Resource Center. She’s also a former City of Hope patient. When someone you know has cancer, even the word “cancer” can make you feel nervous, sleepless, depressed or more. But, as a yoga teacher for 15 ...
  •   Diagnosed with type 1 diabetes when she was 9 years old, Gina Marchini accepted the fact that she would need insulin the rest of her life. Every day, she injected herself with the lifesaving hormone. She also carefully controlled her diet and monitored the rise and fall of her blood glucose with military...
  • The defeat of cancer will require a team effort. Nowhere is this more necessary (or apparent) than in efforts to combat two of the most deadly forms of the disease  – pancreatic cancer and triple-negative breast cancer. It’s the approach City of Hope is taking with its newly launched multidisciplinary teams, br...
  • It’s a reasonable question: Why is the National Cancer Institute funding a study on preventing heart failure? The answer is reasonable as well: Rates of heart failure are drastically high among childhood cancer survivors — 15 times higher than among people the same age who were never treated for cancer. T...
  • Many teenagers take a break from academics during the summer, but not the eight high school students enrolled in the California Institute for Regenerative Medicine (CIRM) Creativity Awards program at City of Hope. They took the opportunity to obtain as much hands-on research experience as possible, learning fro...
  • About one in eight women will develop breast cancer at some point in her life. In fact, breast cancer is the most common cancer in American women, behind skin cancer. Although women can’t change some risk factors, such as genetics and the natural aging process, there are certain things they can do to lower thei...
  • As genetic testing becomes more sophisticated, doctors and their patients are finding that such tests can lead to the discovery of previously unknown cancer risks. In his practice at City of Hope, Thomas Slavin, M.D., an assistant clinical professor in the Division of Clinical Cancer Genetics, sees the full spe...
  • And the winners are … everyone in the San Gabriel Valley. The recipients of City of Hope’s first-ever Healthy Living grants have been announced, and the future is looking healthier already. In selecting San Gabriel Valley organizations to receive the grants, City of Hope’s Community Benefits Advisory Council ch...
  • Barry Leshowitz is a former City of Hope patient and a family advisor for the Sheri & Les Biller Patient and Family Resource Center. It’s been almost seven years since I checked into a local hospital in Phoenix for a hip replacement, only to be informed by the surgeon that he had canceled the surgery....
  • When it comes to science, the best graduate schools don’t just train scientists, they prepare their students for a lifetime of learning, accomplishment and positive impact on society. At City of Hope, the Irell & Manella Graduate School of Biological Sciences goes one step further – by preparing students to...
  • Cancer affects not just the cancer patient, but everyone around him or her, even after treatment is complete. The challenges can include the fear of cancer recurrence, coping with cancer’s economic impact and the struggle to achieve work-life balance post-treatment. Family members and loved ones of cancer patie...
  •   Bladder cancer facts: Bladder cancer is a disease in which malignant (cancer) cells form in the tissues of the bladder. 2015 estimates: 74,000 new cases of bladder cancer diagnosed 16,000 deaths from bladder cancer (about 11,510 in men and 4,490 in women) Risk factors for bladder cancer: Smoking: Smokers...
  • Women with ovarian cancer have questions about the most promising treatment options, revolutionary research avenues, survivorship and, of course, the potential impact on their personal lives. Now, together in one place, are experts who can provide answers. On Saturday, Sept. 12, the 2015 Ovarian Cancer Survivor...