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Clinical Trials
Clinical trials – research studies that involve volunteer patients – are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
 
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials. Last year, City of Hope conducted more than 300 studies enrolling almost 5,000 patients.

By participating in a clinical trial, you could receive the latest treatments available – treatments that hold promise, but are unproven. As with all decisions regarding your medical care, the choice is yours to make.
 
Types of clinical trials

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
  • Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
  • Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
  • Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
  • Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
  • Quality of life: explore ways to define and measure the patient’s experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.
 

Can you provide me with information about treatment or clinical trials at City of Hope?

You can access Clinical Trials On-Line to find out about clinical trials that are being conducted at City of Hope right away; but before you can participate in a specific trial, you must be seen by a doctor to discuss whether you are eligible. Once a patient has been seen by a City of Hope physician, he or she will be provided with information about treatment and can inquire about clinical trials.

Who should participate in a clinical trial?

A patient participating in a clinical trial typically receives a promising new treatment that needs to be investigated in order to receive government approval. For many patients facing life-threatening diseases who have exhausted the available treatment options, clinical trials offer new hope for survival.
 
The range of trials available today is extremely broad. Although many trials focus on patients with more advanced disease, a significant number of studies fall into areas such as screening techniques, early disease treatment and alleviation of symptoms. All clinical trials have specific guidelines for participant eligibility. These guidelines are based on such factors as type of disease, age, medical history and current medical condition. Before entering into a clinical trial, you must meet the criteria for the study.
 
The benefits and risks
Participating in a clinical trial can be a way of helping yourself and others. Patients who participate in a clinical trial often feel they are taking a more active role in their care. In a clinical trial, participants have access to new drugs and treatments before they are widely available. Because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. In addition, the data gathered from the trial can go on to benefit others.
 
There are risks to participating in clinical trials that must be weighed against the potential benefits. There may be some unpleasant or serious side effects from treatment. The trial may take a lot of time with repeat hospital visits, additional treatments and involved dosages. And the treatment may not end up being effective for the person participating.

What are the different types of clinical trials?

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
 
Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
 
Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
 
Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
 
Quality of life: explore ways to define and measure the patient's experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.

What is a protocol?

All clinical trials are based upon a study plan called a protocol. Designed with great care, the plan helps to ensure the safety of the participants and answer specific research questions. A protocol details the specifics of the study: who can participate, different procedures, test schedules, medications and dosages, and the length of the study.

What are the different phases of a clinical trial?

Clinical trials are conducted in four different phases with each phase serving a specific purpose to researchers.
 
Phase I: Assess the safety of a new drug. The phase is usually done with a small group of people (20 to 80) and evaluates how the body handles the drug, safe dosage ranges and side effects.
 
Phase II: The drug or treatment is given to a larger group (100 to 300) to determine effectiveness and to continue to evaluate safety.
 
Phase III: Hundreds or even thousands of people may receive a new drug or treatment and be followed for several years. This phase helps confirm the effectiveness of the drug, gauge side effects and gather information so the drug or treatment can be used safely.
 
Phase IV: The drug or treatment has received Food and Drug Administration approval and is widely marketed. This allows researchers to gather additional safety information on an even larger group of people and gather data on a drug or treatment's long-term effectiveness and how it affects quality of life. The drug or treatment may also be evaluated for cost and against other similar drugs already on the market.

How do I find out more about clinical trials at City of Hope?

A listing of our active clinical trials are available online. To speak with one of our care professionals about treatment at City of Hope, contact our New Patient Services online or call us at 800-826-HOPE (4673).

What exactly are 'clinical trials'?

A clinical trial is a scientifically designed study conducted to:
 
  • Answer specific questions about vaccines, new therapies or novel ways of using known treatments.
  • Determine whether new drugs or treatments are effective.
  • Develop new procedures and treatments to improve patient outcomes and advance medical science.
 
Each trial is a partnership involving a patient, a physician, a medical organization and frequently a government agency or private company that sponsors the research. City of Hope currently conducts many promising and innovative clinical trials through our involvement in the National Comprehensive Cancer Network (NCCN). These clinical trials help to redefine treatment outcomes and care standards for patients nationwide.

What are the benefits of clinical trials?

Clinical trials offer an opportunity for patients to take an active role in their health care. By participating, patients have the chance to make a difference in their own lives and those of future generations.
 
A clinical trial may also be the best way to get the most advanced, leading-edge treatment. Participants may have access to new drugs and treatments before they are widely available, and because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. If you are interested in taking part in a clinical trial or would like more information about City of Hope's clinical trials, contact Clinical Trials On-Line, or call 800-826-HOPE (4673).

Find a Clinical Trial

Clinical Trials
Clinical trials – research studies that involve volunteer patients – are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
 
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials. Last year, City of Hope conducted more than 300 studies enrolling almost 5,000 patients.

By participating in a clinical trial, you could receive the latest treatments available – treatments that hold promise, but are unproven. As with all decisions regarding your medical care, the choice is yours to make.
 
Types of clinical trials

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
  • Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
  • Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
  • Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
  • Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
  • Quality of life: explore ways to define and measure the patient’s experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.
 

Can you provide me with information about treatment or clinical trials at City of Hope?

You can access Clinical Trials On-Line to find out about clinical trials that are being conducted at City of Hope right away; but before you can participate in a specific trial, you must be seen by a doctor to discuss whether you are eligible. Once a patient has been seen by a City of Hope physician, he or she will be provided with information about treatment and can inquire about clinical trials.

Who should participate in a clinical trial?

A patient participating in a clinical trial typically receives a promising new treatment that needs to be investigated in order to receive government approval. For many patients facing life-threatening diseases who have exhausted the available treatment options, clinical trials offer new hope for survival.
 
The range of trials available today is extremely broad. Although many trials focus on patients with more advanced disease, a significant number of studies fall into areas such as screening techniques, early disease treatment and alleviation of symptoms. All clinical trials have specific guidelines for participant eligibility. These guidelines are based on such factors as type of disease, age, medical history and current medical condition. Before entering into a clinical trial, you must meet the criteria for the study.
 
The benefits and risks
Participating in a clinical trial can be a way of helping yourself and others. Patients who participate in a clinical trial often feel they are taking a more active role in their care. In a clinical trial, participants have access to new drugs and treatments before they are widely available. Because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. In addition, the data gathered from the trial can go on to benefit others.
 
There are risks to participating in clinical trials that must be weighed against the potential benefits. There may be some unpleasant or serious side effects from treatment. The trial may take a lot of time with repeat hospital visits, additional treatments and involved dosages. And the treatment may not end up being effective for the person participating.

What are the different types of clinical trials?

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
 
Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
 
Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
 
Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
 
Quality of life: explore ways to define and measure the patient's experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.

What is a protocol?

All clinical trials are based upon a study plan called a protocol. Designed with great care, the plan helps to ensure the safety of the participants and answer specific research questions. A protocol details the specifics of the study: who can participate, different procedures, test schedules, medications and dosages, and the length of the study.

What are the different phases of a clinical trial?

Clinical trials are conducted in four different phases with each phase serving a specific purpose to researchers.
 
Phase I: Assess the safety of a new drug. The phase is usually done with a small group of people (20 to 80) and evaluates how the body handles the drug, safe dosage ranges and side effects.
 
Phase II: The drug or treatment is given to a larger group (100 to 300) to determine effectiveness and to continue to evaluate safety.
 
Phase III: Hundreds or even thousands of people may receive a new drug or treatment and be followed for several years. This phase helps confirm the effectiveness of the drug, gauge side effects and gather information so the drug or treatment can be used safely.
 
Phase IV: The drug or treatment has received Food and Drug Administration approval and is widely marketed. This allows researchers to gather additional safety information on an even larger group of people and gather data on a drug or treatment's long-term effectiveness and how it affects quality of life. The drug or treatment may also be evaluated for cost and against other similar drugs already on the market.

How do I find out more about clinical trials at City of Hope?

A listing of our active clinical trials are available online. To speak with one of our care professionals about treatment at City of Hope, contact our New Patient Services online or call us at 800-826-HOPE (4673).

What exactly are 'clinical trials'?

A clinical trial is a scientifically designed study conducted to:
 
  • Answer specific questions about vaccines, new therapies or novel ways of using known treatments.
  • Determine whether new drugs or treatments are effective.
  • Develop new procedures and treatments to improve patient outcomes and advance medical science.
 
Each trial is a partnership involving a patient, a physician, a medical organization and frequently a government agency or private company that sponsors the research. City of Hope currently conducts many promising and innovative clinical trials through our involvement in the National Comprehensive Cancer Network (NCCN). These clinical trials help to redefine treatment outcomes and care standards for patients nationwide.

What are the benefits of clinical trials?

Clinical trials offer an opportunity for patients to take an active role in their health care. By participating, patients have the chance to make a difference in their own lives and those of future generations.
 
A clinical trial may also be the best way to get the most advanced, leading-edge treatment. Participants may have access to new drugs and treatments before they are widely available, and because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. If you are interested in taking part in a clinical trial or would like more information about City of Hope's clinical trials, contact Clinical Trials On-Line, or call 800-826-HOPE (4673).
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As a Comprehensive Cancer Center – the highest designation given by the National Cancer Institute – we are widely regarded as a leader in cancer prevention and treatment.
 

For the 11th year, U.S.News & World Report has named City of Hope one of the top cancer hospitals in the country.


NEWS & UPDATES
  • Cancer cells are voracious eaters. Like a swarm of locusts, they devour every edible tidbit they can find. But unlike locusts, when the food is gone, cancer cells can’t just move on to the next horn o’ plenty. They have to survive until more food shows up — and they do. Mei Kong, Ph.D., assistant […]
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Repr...
  • When 25-year-old Angelina Mattos was diagnosed with Stage 4 oral cancer earlier this year, she learned that her only hope of survival was through the removal of her tongue, a surgery that leaves people without the ability to talk or eat normally, sometimes permanently ending their ability to speak. After hearin...
  • Two years ago, Joselyn Miller and her family sat together as stem cells from her brother’s bone marrow were infused into her – a precious gift of life that the family is excited to have the chance to pass to another patient in need. Today, the stem cell recipient is healthy. Her 23-year-old son Rex, who […...
  • Even as the overall rate of oral cancers in the United States steadily declines, the rate of tongue cancer is increasing — especially among white females ages 18 to 44. An oral cancer diagnosis, although rare, is serious. Only half of the people diagnosed with oral cancer are still alive after five years, accor...
  • Sometimes cancer found in the lungs is not lung cancer at all. It can be another type of cancer that originated elsewhere in the body and spread, or metastasized, to the lungs through the bloodstream or lymphatic system. These tumors are called lung metastases, or metastatic cancer to the lungs, and are not the...
  • When it comes to research into the treatment of hematologic cancers, City of Hope scientists stand out. One study that  they presented this week at the annual meeting of the American Society of Hematology suggests a new standard of care for HIV-associated lymphoma, another offers promise for the treatment of re...
  • Patients with HIV-associated lymphoma may soon have increased access to the current standard of care for some non-HIV infected patients – autologous stem cell transplants. Impressive new data, presented Monday at the annual meeting of the American Society of Hematology (ASH) in San Francisco, indicate that HIV-...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the Rose Parade is “Inspiring Stories.”...
  • The holidays can create an overwhelming urge to give to people in need — especially to sick children and families spending the holidays in a hospital room. That’s a good thing. Holiday donations of toys and gifts can bolster the spirits, and improve the lives, of people affected by illness, and hospitals ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Here...
  • Cancer has a way of “talking” to the immune system and corrupting it to work on its own behalf instead of defending the body. Blocking this communication would allow the immune system to see cancer cells for what they are – something to be fought off – and stop them from growing. A breakthrough Scientists [R...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” By V...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” The ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” In 2...