A National Cancer Institute-designated Comprehensive Cancer Center

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Pancreatic Cancer

Pancreatic cancer is one of the most challenging diseases to treat since it rarely shows symptoms in its early stages. However, aggressive therapies and specialized care can significantly improve outcomes and increase likelihood of a cure.
 
City of Hope has one of the most experienced pancreatic cancer programs in the United States, with a multidisciplinary team that takes an integrated approach to fighting cancers of the pancreas. This includes using advanced technologies and specialized techniques such as:
 
  • advanced tumor imaging using 3D computed tomography (CT) scans that can improve treatment planning by accurately locating pancreatic cancer
  • minimally-invasive, robotically-assisted techniques for complex surgeries — such as the Whipple procedure — that can remove tumors with less discomfort, reduced risk of complications and shorter recovery times
  • highly precise radiation therapy that can target hard-to-resect tumors with minimal exposure to surrounding normal tissue
  • combination regimens integrating surgery, radiation, chemotherapy and immunotherapy for maximum cancer-fighting effectiveness
 
Additionally, City of Hope patients have access to our extensive team of supportive care experts — including dieticians, supportive medicine physicians and rehabilitation specialists. Working closely with the patient’s primary care team, they can detect and address quality of life issues related to pancreatic cancer and its treatments. This includes managing symptoms (such as pain, nausea and fatigue), adjusting to a new diet and lifestyle post-treatment and being aware of possible long-term effects.
 
 
As one of a handful of institutes to attain the elite designation of Comprehensive Cancer Center by the National Cancer Institute, City of Hope is acknowledged as a leader in pancreatic cancer research and treatment. With our decades of experience, specialized therapy protocols and extensive program of clinical trials, newly diagnosed or relapsed patients can find a treatment regimen that is tailored to their needs and gives them the best chance for survival. U.S. News & World Report also named City of Hope as one of the top cancer hospitals in the country.
 
 
In collaboration with other departments and cancer centers, City of Hope’s pancreatic cancer program has an active portfolio of clinical trials studying novel treatments, including trials of new surgery, radiation and drug therapy regimens that are more effective against the disease and/or less harmful to the patient. Many of these promising therapies are only available to patients being treated at the City of Hope.
 
 
If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.
 
 

Pancreatic Cancer Team

About Pancreatic Cancer

Pancreatic cancer is a disease in which malignant cells form in the pancreas, an organ in the upper abdomen that aids in digestion and secretes various hormones to regulate body functions (such as insulin to control blood-sugar levels.)
 
Pancreatic cancers are classified based on the type of cells affected: exocrine (which produce the digestive juices that go into the small intestine) or endocrine (which produce several hormones that go directly into the bloodstream). Approximately 95% of pancreatic cancers originate in the exocrine cells.
 
Signs and Symptoms of Pancreatic Cancer
 
Screening for pancreatic cancer is not currently recommended for the general population, but high risk groups — like those hereditary conditions that elevate cancer risk — should discuss early detection options with their doctors.
 
Pancreatic cancer rarely displays symptoms in its early stages, but they can include:
 
  • Jaundice (yellowing in the skin and whites of the eyes)
  • Discomfort or pain in the upper abdomen
  • Light-colored or greasy stools
  • Dark-colored urine
  • Unexplained weight loss
  • Loss of appetite or feeling very full after a small meal
  • Fatigue
 
While many of these symptoms may be caused by other conditions, early pancreatic cancer detection is critical to successful treatment. If you or a loved one experiences any of the above symptoms, please contact a doctor for further evaluation.
 
Risk Factors of Pancreatic Cancer
 
Risk factors associated with pancreatic cancer include:
 
  • Age: Approximately two-thirds of pancreatic cancer diagnoses are among people 65 or older
  • Diseases and Conditions:
    • Chronic pancreatitis: A disease characterized by long-term inflammation of the pancreas, this condition is linked to a higher risk of developing pancreatic cancer.
    • Cirrhosis: A chronic and progressive disease in which liver cells are replaced with scar tissue, people with cirrhosis have a higher risk of getting pancreatic cancer
    • Diabetes: Diabetics are more likely to get pancreatic cancer, particularly if they have another risk factor such as chronic pancreatitis or cirrhosis; conversely, pancreatic cancer can lead to diabetes if it affects the insulin-producing cells of that organ
    • Genetic Conditions: Inherited gene mutations that are passed from parents to children may account for as many as 10 percent of pancreatic cancer cases. These include BRCA2 gene mutations, familial melanoma, familial pancreatitis, hereditary non-polyposis colorectal cancer (HNPCC/Lynch syndrome), Peutz-Jeghers syndrome and Von Hippel-Lindau syndrome
    • Helicobacter pylori infection: H. pylori is a bacteria that is associated with stomach ulcers, but infection with this pathogen can also elevate pancreatic cancer risk as well
  • Ethnicity: In the United States, African Americans have an elevated risk of developing pancreatic cancer
  • Family History: In addition to genetic conditions that can elevate pancreatic cancer risk, a family history of pancreatic cancer can also raise an individual’s likelihood of developing this disease
  • Gender: Men are 30% more likely to develop pancreatic cancer than women
  • Obesity: Obese people are 20% more likely to develop pancreatic cancer
  • Tobacco Use: Compared to non-smokers, smokers are twice as likely to be diagnosed with pancreatic cancer. Use of smokeless tobacco products (such as chewing tobacco) increases pancreatic risk as well.
 
If you suspect that you or a loved one may have an elevated risk of pancreatic cancer, please consult with a doctor on preventive and early detection measures that are available.
 
 
If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.
 
Sources: American Cancer Society, National Cancer Institute

How We Diagnose and Stage Pancreatic Cancer

Diagnosing Pancreatic Cancer
 
A timely and accurate detection of pancreatic cancer is essential to planning the best course of treatment. In addition to a routine physical examination and blood tests, City of Hope doctors may also use the following tests to diagnose pancreatic cancer:
 
  • 3D computed tomography (CT) scan: Using advanced imaging technology and specialized techniques, radiologists at City of Hope can obtain highly clear and precise images of the pancreas. This allows the care team to better detect and locate tumors with minimal impact on surrounding normal tissues.
  • Endoscopic retrograde cholangiopancratography (ERCP): A technique that uses a thin, flexible tube with a camera attached (endoscope). The tube is inserted orally, through the stomach and into the bile duct, allowing a physician to look for abnormalities and inject dyes so that the pancreas is better visualized with X-rays.
  • Endoscopy / Laparoscopy: A thin, lit tube is inserted either orally or through a small incision in the abdomen to check for signs for pancreatic cancer. In addition to identifying tumors, the procedure can also extract suspicious tissue for further evaluation.
  • Biopsy: Abnormal-looking cells are extracted from the pancreas and checked by a pathologist for cancerous signs.
  • Genetic testing: A genetic test of the cells extracted during biopsy can show whether the cancer is sensitive or resistant to specific treatments, so your care team can plan the most effective regimen against the disease.
 
Other tests that may be used for diagnosis or further evaluation include X-rays, magnetic resonance imaging (MRI), positron emission tomography (PET) and ultrasound scans.
 
Staging Pancreatic Cancer
 
To properly plan for treatment, pancreatic cancer patients are staged in accordance to how advanced the disease is. This is primarily done by taking a number of factors into consideration, including:
 
  • Size of the tumor
  • If the tumor has grown into a blood vessel or adjacent organs, such as the stomach or liver
  • Whether the cancer has spread to nearby lymph nodes and how many lymph nodes are affected
  • Whether the cancer has metastasized to distant organs
  • If the cancer can be completely removed by surgery
 
Based on these factors, patients are staged according to their risk level, with higher risk patients typically requiring more intensive treatments.
 
More information on pancreatic cancer staging criteria is available on the National Cancer Institute’s website.
 
 
If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.

Our Treatment Approach to Pancreatic Cancer

Since it is usually diagnosed at a later and more advanced stage, pancreatic cancer can be a difficult disease to treat. Thus, therapy needs to be rapid and aggressive — requiring the expertise of experienced specialists — to ensure optimal results and best chance at a cure.

City of Hope has one of the most renowned pancreatic cancer programs in the United States, with a multidisciplinary team of medical experts across different fields including surgery, radiation oncology, medical oncology and supportive care medicine. Together, they work collaboratively to plan and implement a treatment regimen that is individually tailored to the patient to enhance outcomes and quality of life.

Surgery

Surgery can be curative for early stage pancreatic cancer patients and can also improve survival outcomes and reduce discomfort for advanced pancreatic cancer patients.
 
To treat pancreatic cancer, the surgeon may perform:
 
  • Whipple procedure: removing the head of the pancreas along with nearby structures such as the bile duct, gallbladder and part of the stomach and small intestine.
  • Total pancreatectomy: removing the entire pancreas along with bile duct, gallbladder, nearby lymph nodes and parts of the stomach and small intestine.
  • Distal pancreatectomy: removing the tail portion of the pancreas, sometimes with the spleen.
  • Ablative treatments: instead of removing the tumor, this therapy uses extreme heat or cold to destroy the tumor while it’s still in the body.
  • Embolization: this type of therapy aims to kill the tumor by cutting of the blood supply that feeds it.
 
Surgery may also be performed to alleviate symptoms associated with pancreatic cancer, such as a gastric or biliary bypass if the tumor is blocking the flow of food or bile, respectively.
 
The expertise of City of Hope’s surgeons also means that they can treat pancreatic cancers that are considered inoperable elsewhere. This is done through advanced procedures that can navigate around sensitive areas (such as major blood vessels) and working with radiation and medical oncologists, who may be able to shrink the tumor to down to an operable size and shape with radiation and drug therapies.
 
City of Hope’s surgeons specialize in  minimally invasive and robotically-assisted surgical procedures for pancreatic cancer. By using smaller incisions compared to an open procedure, patients experience less pain, recover faster, have shorter hospital stays and are less likely to have post-surgical complications.
 

Radiation Therapy

Radiation can be used alone or in conjunction with other therapies to treat pancreatic cancer by killing cancer cells or preventing the tumor growing larger. It can be applied externally using one or more radioactive beams focused on the tumor or internally by placing small radioactive pellets into or next to the tumor (brachytherapy).
 
Radiation therapy can also improve quality of life by relieving pain and stopping bleeds.
 
In addition to standard radiation regimens, City of Hope also offers Helical TomoTherapy , an advance technology combining radiation delivery with advanced imaging that results in more focused beams of radiation focused on the tumor while minimizing exposure to adjacent tissues and organs, including the heart, lungs and spine.
 

Drug Therapy

City of Hope uses a wide range of chemotherapy and targeted therapy drugs to treat localized and metastatic pancreatic cancer. In addition to standard drug regimens, patients have access to newly developed drugs (or drug combinations) through our clinical trials program.
 
Cancer fighting drugs can also enhance the effectiveness of surgery or radiation therapy, by shrinking the tumor before the procedure and making it easier to remove (neoadjuvant therapy), or given after the procedure to minimize the chance of recurrence (adjuvant therapy.)
 
Chemotherapy may also be given alongside radiation therapy to enhance the cancer-fighting effectiveness of both (chemoradiation.)
 
As part of the treatment team, a medical oncologist will evaluate the patient’s cancer, health and other factors, so that the chemotherapy, if appropriate, can be tailored to the patient throughout the continuum of care.
 

Become a Patient

If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.

Pancreatic Cancer Research and Clinical Trials

There is extensive collaboration between City of Hope clinicians and researchers to develop and evaluate new pancreatic cancer therapies designed to improve survival and quality of life outcomes. City of Hope patients have access to a wide variety of clinical trials ranging from new chemotherapy and targeted therapies, novel surgical techniques and new radiation approaches — all focused on enhancing  treatment, detection and prevention of pancreatic cancer.
 
Some of our current research projects:
 
  • City of Hope is part of a trial to test an investigational drug called PEGPH20, which can dismantle pancreatic cancer cells’ defense against chemotherapy. The drug does so by reducing levels of hyaluronan, a substance that can create a barrier around tumors and reduce effectiveness of anti-cancer drugs. In this study, patients with metastatic pancreatic cancer will receive standard chemotherapy with or without PEGPH20 to see if adding this drug will improve outcomes.
  • Despite advances in treatments, pancreatic cancer has a high likelihood of recurrence. Joseph Kim, M.D., is currently conducting a trial comparing the blood samples of healthy adults and pancreatic cancer patients to see if there are any DNA abnormalities that can be detected, with the hope of designing a highly sensitive DNA test that can catch cancer recurrence and spread at its earliest stages. Ultimately, this will improve treatment planning and evaluation, and it can enable the care team to intervene faster.
  • Pancreatic cancer and its treatments can be a source of burden for the patient that significantly affects his or her well-being. City of Hope is currently designing a palliative/supportive care program to see if timely interventions (i.e. inquiring patients about physical/emotional/social issues throughout their treatment and then connecting them with appropriate resources) can reduce worry and improve their quality of life, improving the overall care experience.
 
 
If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.

Living with Pancreatic Cancer

While our primary goal is to cure or control the disease, another top priority is relieving suffering and discomfort for pancreatic cancer patients undergoing cancer treatments.
 
In addition to curative treatments, City of Hope pancreatic cancer patients and their caregivers have access to the broad range of services offered by our Department of Supportive Care Medicine. The department’s staff of professionals, including registered dieticians, rehabilitation specialists, supportive medicine physicians and clinical social workers, can help patients and loved ones with a variety of care and wellness issues including:
 

 
The  Sheri & Les Biller Patient and Family Resource Center is the heart of the Department of Supportive Care Medicine, integrating City of Hope's support services under one umbrella. The Biller Resource Center provides a warm and welcoming space where patients, families and caregivers can access the resources, education and support they need to strengthen and empower themselves, before, during and after treatment. For more information or to contact the Biller Resource Center staff, please call 626-256-4673, ext. 32273 (3CARE).
 
 
This site includes tips, tools and online resources to help cancer patients and their families with issues that arise during cancer treatment.
 
Additional Resources
 
 
 
If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.

Support this program

It takes the help of a lot of caring people to make hope a reality for our patients. City of Hope was founded by individuals' philanthropic efforts more than 100 years ago. Their efforts − and those of our supporters today − have built the foundation for the care we provide and the research we conduct. It enables us to strive for new breakthroughs and better therapies − helping more people enjoy longer, better lives.

For more information on supporting this specific program, please contact us below.

Joe Komsky
Senior Development Officer
Phone: 626-218-6291
Email: jkomsky@coh.org

 
 

Pancreatic Cancer

Pancreatic Cancer

Pancreatic cancer is one of the most challenging diseases to treat since it rarely shows symptoms in its early stages. However, aggressive therapies and specialized care can significantly improve outcomes and increase likelihood of a cure.
 
City of Hope has one of the most experienced pancreatic cancer programs in the United States, with a multidisciplinary team that takes an integrated approach to fighting cancers of the pancreas. This includes using advanced technologies and specialized techniques such as:
 
  • advanced tumor imaging using 3D computed tomography (CT) scans that can improve treatment planning by accurately locating pancreatic cancer
  • minimally-invasive, robotically-assisted techniques for complex surgeries — such as the Whipple procedure — that can remove tumors with less discomfort, reduced risk of complications and shorter recovery times
  • highly precise radiation therapy that can target hard-to-resect tumors with minimal exposure to surrounding normal tissue
  • combination regimens integrating surgery, radiation, chemotherapy and immunotherapy for maximum cancer-fighting effectiveness
 
Additionally, City of Hope patients have access to our extensive team of supportive care experts — including dieticians, supportive medicine physicians and rehabilitation specialists. Working closely with the patient’s primary care team, they can detect and address quality of life issues related to pancreatic cancer and its treatments. This includes managing symptoms (such as pain, nausea and fatigue), adjusting to a new diet and lifestyle post-treatment and being aware of possible long-term effects.
 
 
As one of a handful of institutes to attain the elite designation of Comprehensive Cancer Center by the National Cancer Institute, City of Hope is acknowledged as a leader in pancreatic cancer research and treatment. With our decades of experience, specialized therapy protocols and extensive program of clinical trials, newly diagnosed or relapsed patients can find a treatment regimen that is tailored to their needs and gives them the best chance for survival. U.S. News & World Report also named City of Hope as one of the top cancer hospitals in the country.
 
 
In collaboration with other departments and cancer centers, City of Hope’s pancreatic cancer program has an active portfolio of clinical trials studying novel treatments, including trials of new surgery, radiation and drug therapy regimens that are more effective against the disease and/or less harmful to the patient. Many of these promising therapies are only available to patients being treated at the City of Hope.
 
 
If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.
 
 

Pancreatic Cancer Team

Pancreatic Cancer Team

About Pancreatic Cancer

About Pancreatic Cancer

Pancreatic cancer is a disease in which malignant cells form in the pancreas, an organ in the upper abdomen that aids in digestion and secretes various hormones to regulate body functions (such as insulin to control blood-sugar levels.)
 
Pancreatic cancers are classified based on the type of cells affected: exocrine (which produce the digestive juices that go into the small intestine) or endocrine (which produce several hormones that go directly into the bloodstream). Approximately 95% of pancreatic cancers originate in the exocrine cells.
 
Signs and Symptoms of Pancreatic Cancer
 
Screening for pancreatic cancer is not currently recommended for the general population, but high risk groups — like those hereditary conditions that elevate cancer risk — should discuss early detection options with their doctors.
 
Pancreatic cancer rarely displays symptoms in its early stages, but they can include:
 
  • Jaundice (yellowing in the skin and whites of the eyes)
  • Discomfort or pain in the upper abdomen
  • Light-colored or greasy stools
  • Dark-colored urine
  • Unexplained weight loss
  • Loss of appetite or feeling very full after a small meal
  • Fatigue
 
While many of these symptoms may be caused by other conditions, early pancreatic cancer detection is critical to successful treatment. If you or a loved one experiences any of the above symptoms, please contact a doctor for further evaluation.
 
Risk Factors of Pancreatic Cancer
 
Risk factors associated with pancreatic cancer include:
 
  • Age: Approximately two-thirds of pancreatic cancer diagnoses are among people 65 or older
  • Diseases and Conditions:
    • Chronic pancreatitis: A disease characterized by long-term inflammation of the pancreas, this condition is linked to a higher risk of developing pancreatic cancer.
    • Cirrhosis: A chronic and progressive disease in which liver cells are replaced with scar tissue, people with cirrhosis have a higher risk of getting pancreatic cancer
    • Diabetes: Diabetics are more likely to get pancreatic cancer, particularly if they have another risk factor such as chronic pancreatitis or cirrhosis; conversely, pancreatic cancer can lead to diabetes if it affects the insulin-producing cells of that organ
    • Genetic Conditions: Inherited gene mutations that are passed from parents to children may account for as many as 10 percent of pancreatic cancer cases. These include BRCA2 gene mutations, familial melanoma, familial pancreatitis, hereditary non-polyposis colorectal cancer (HNPCC/Lynch syndrome), Peutz-Jeghers syndrome and Von Hippel-Lindau syndrome
    • Helicobacter pylori infection: H. pylori is a bacteria that is associated with stomach ulcers, but infection with this pathogen can also elevate pancreatic cancer risk as well
  • Ethnicity: In the United States, African Americans have an elevated risk of developing pancreatic cancer
  • Family History: In addition to genetic conditions that can elevate pancreatic cancer risk, a family history of pancreatic cancer can also raise an individual’s likelihood of developing this disease
  • Gender: Men are 30% more likely to develop pancreatic cancer than women
  • Obesity: Obese people are 20% more likely to develop pancreatic cancer
  • Tobacco Use: Compared to non-smokers, smokers are twice as likely to be diagnosed with pancreatic cancer. Use of smokeless tobacco products (such as chewing tobacco) increases pancreatic risk as well.
 
If you suspect that you or a loved one may have an elevated risk of pancreatic cancer, please consult with a doctor on preventive and early detection measures that are available.
 
 
If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.
 
Sources: American Cancer Society, National Cancer Institute

Diagnosing Pancreatic Cancer

How We Diagnose and Stage Pancreatic Cancer

Diagnosing Pancreatic Cancer
 
A timely and accurate detection of pancreatic cancer is essential to planning the best course of treatment. In addition to a routine physical examination and blood tests, City of Hope doctors may also use the following tests to diagnose pancreatic cancer:
 
  • 3D computed tomography (CT) scan: Using advanced imaging technology and specialized techniques, radiologists at City of Hope can obtain highly clear and precise images of the pancreas. This allows the care team to better detect and locate tumors with minimal impact on surrounding normal tissues.
  • Endoscopic retrograde cholangiopancratography (ERCP): A technique that uses a thin, flexible tube with a camera attached (endoscope). The tube is inserted orally, through the stomach and into the bile duct, allowing a physician to look for abnormalities and inject dyes so that the pancreas is better visualized with X-rays.
  • Endoscopy / Laparoscopy: A thin, lit tube is inserted either orally or through a small incision in the abdomen to check for signs for pancreatic cancer. In addition to identifying tumors, the procedure can also extract suspicious tissue for further evaluation.
  • Biopsy: Abnormal-looking cells are extracted from the pancreas and checked by a pathologist for cancerous signs.
  • Genetic testing: A genetic test of the cells extracted during biopsy can show whether the cancer is sensitive or resistant to specific treatments, so your care team can plan the most effective regimen against the disease.
 
Other tests that may be used for diagnosis or further evaluation include X-rays, magnetic resonance imaging (MRI), positron emission tomography (PET) and ultrasound scans.
 
Staging Pancreatic Cancer
 
To properly plan for treatment, pancreatic cancer patients are staged in accordance to how advanced the disease is. This is primarily done by taking a number of factors into consideration, including:
 
  • Size of the tumor
  • If the tumor has grown into a blood vessel or adjacent organs, such as the stomach or liver
  • Whether the cancer has spread to nearby lymph nodes and how many lymph nodes are affected
  • Whether the cancer has metastasized to distant organs
  • If the cancer can be completely removed by surgery
 
Based on these factors, patients are staged according to their risk level, with higher risk patients typically requiring more intensive treatments.
 
More information on pancreatic cancer staging criteria is available on the National Cancer Institute’s website.
 
 
If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.

Pancreatic Cancer Treatment Options

Our Treatment Approach to Pancreatic Cancer

Since it is usually diagnosed at a later and more advanced stage, pancreatic cancer can be a difficult disease to treat. Thus, therapy needs to be rapid and aggressive — requiring the expertise of experienced specialists — to ensure optimal results and best chance at a cure.

City of Hope has one of the most renowned pancreatic cancer programs in the United States, with a multidisciplinary team of medical experts across different fields including surgery, radiation oncology, medical oncology and supportive care medicine. Together, they work collaboratively to plan and implement a treatment regimen that is individually tailored to the patient to enhance outcomes and quality of life.

Surgery

Surgery can be curative for early stage pancreatic cancer patients and can also improve survival outcomes and reduce discomfort for advanced pancreatic cancer patients.
 
To treat pancreatic cancer, the surgeon may perform:
 
  • Whipple procedure: removing the head of the pancreas along with nearby structures such as the bile duct, gallbladder and part of the stomach and small intestine.
  • Total pancreatectomy: removing the entire pancreas along with bile duct, gallbladder, nearby lymph nodes and parts of the stomach and small intestine.
  • Distal pancreatectomy: removing the tail portion of the pancreas, sometimes with the spleen.
  • Ablative treatments: instead of removing the tumor, this therapy uses extreme heat or cold to destroy the tumor while it’s still in the body.
  • Embolization: this type of therapy aims to kill the tumor by cutting of the blood supply that feeds it.
 
Surgery may also be performed to alleviate symptoms associated with pancreatic cancer, such as a gastric or biliary bypass if the tumor is blocking the flow of food or bile, respectively.
 
The expertise of City of Hope’s surgeons also means that they can treat pancreatic cancers that are considered inoperable elsewhere. This is done through advanced procedures that can navigate around sensitive areas (such as major blood vessels) and working with radiation and medical oncologists, who may be able to shrink the tumor to down to an operable size and shape with radiation and drug therapies.
 
City of Hope’s surgeons specialize in  minimally invasive and robotically-assisted surgical procedures for pancreatic cancer. By using smaller incisions compared to an open procedure, patients experience less pain, recover faster, have shorter hospital stays and are less likely to have post-surgical complications.
 

Radiation Therapy

Radiation can be used alone or in conjunction with other therapies to treat pancreatic cancer by killing cancer cells or preventing the tumor growing larger. It can be applied externally using one or more radioactive beams focused on the tumor or internally by placing small radioactive pellets into or next to the tumor (brachytherapy).
 
Radiation therapy can also improve quality of life by relieving pain and stopping bleeds.
 
In addition to standard radiation regimens, City of Hope also offers Helical TomoTherapy , an advance technology combining radiation delivery with advanced imaging that results in more focused beams of radiation focused on the tumor while minimizing exposure to adjacent tissues and organs, including the heart, lungs and spine.
 

Drug Therapy

City of Hope uses a wide range of chemotherapy and targeted therapy drugs to treat localized and metastatic pancreatic cancer. In addition to standard drug regimens, patients have access to newly developed drugs (or drug combinations) through our clinical trials program.
 
Cancer fighting drugs can also enhance the effectiveness of surgery or radiation therapy, by shrinking the tumor before the procedure and making it easier to remove (neoadjuvant therapy), or given after the procedure to minimize the chance of recurrence (adjuvant therapy.)
 
Chemotherapy may also be given alongside radiation therapy to enhance the cancer-fighting effectiveness of both (chemoradiation.)
 
As part of the treatment team, a medical oncologist will evaluate the patient’s cancer, health and other factors, so that the chemotherapy, if appropriate, can be tailored to the patient throughout the continuum of care.
 

Become a Patient

If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.

Pancreatic Cancer Research and Clinical Trials

Pancreatic Cancer Research and Clinical Trials

There is extensive collaboration between City of Hope clinicians and researchers to develop and evaluate new pancreatic cancer therapies designed to improve survival and quality of life outcomes. City of Hope patients have access to a wide variety of clinical trials ranging from new chemotherapy and targeted therapies, novel surgical techniques and new radiation approaches — all focused on enhancing  treatment, detection and prevention of pancreatic cancer.
 
Some of our current research projects:
 
  • City of Hope is part of a trial to test an investigational drug called PEGPH20, which can dismantle pancreatic cancer cells’ defense against chemotherapy. The drug does so by reducing levels of hyaluronan, a substance that can create a barrier around tumors and reduce effectiveness of anti-cancer drugs. In this study, patients with metastatic pancreatic cancer will receive standard chemotherapy with or without PEGPH20 to see if adding this drug will improve outcomes.
  • Despite advances in treatments, pancreatic cancer has a high likelihood of recurrence. Joseph Kim, M.D., is currently conducting a trial comparing the blood samples of healthy adults and pancreatic cancer patients to see if there are any DNA abnormalities that can be detected, with the hope of designing a highly sensitive DNA test that can catch cancer recurrence and spread at its earliest stages. Ultimately, this will improve treatment planning and evaluation, and it can enable the care team to intervene faster.
  • Pancreatic cancer and its treatments can be a source of burden for the patient that significantly affects his or her well-being. City of Hope is currently designing a palliative/supportive care program to see if timely interventions (i.e. inquiring patients about physical/emotional/social issues throughout their treatment and then connecting them with appropriate resources) can reduce worry and improve their quality of life, improving the overall care experience.
 
 
If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.

Living with Pancreatic Cancer

Living with Pancreatic Cancer

While our primary goal is to cure or control the disease, another top priority is relieving suffering and discomfort for pancreatic cancer patients undergoing cancer treatments.
 
In addition to curative treatments, City of Hope pancreatic cancer patients and their caregivers have access to the broad range of services offered by our Department of Supportive Care Medicine. The department’s staff of professionals, including registered dieticians, rehabilitation specialists, supportive medicine physicians and clinical social workers, can help patients and loved ones with a variety of care and wellness issues including:
 

 
The  Sheri & Les Biller Patient and Family Resource Center is the heart of the Department of Supportive Care Medicine, integrating City of Hope's support services under one umbrella. The Biller Resource Center provides a warm and welcoming space where patients, families and caregivers can access the resources, education and support they need to strengthen and empower themselves, before, during and after treatment. For more information or to contact the Biller Resource Center staff, please call 626-256-4673, ext. 32273 (3CARE).
 
 
This site includes tips, tools and online resources to help cancer patients and their families with issues that arise during cancer treatment.
 
Additional Resources
 
 
 
If you have been diagnosed with pancreatic cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling 800-826-HOPE or filling out the Request a New Patient Appointment Online form.

Support This Program

Support this program

It takes the help of a lot of caring people to make hope a reality for our patients. City of Hope was founded by individuals' philanthropic efforts more than 100 years ago. Their efforts − and those of our supporters today − have built the foundation for the care we provide and the research we conduct. It enables us to strive for new breakthroughs and better therapies − helping more people enjoy longer, better lives.

For more information on supporting this specific program, please contact us below.

Joe Komsky
Senior Development Officer
Phone: 626-218-6291
Email: jkomsky@coh.org

 
 
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Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials.
 
For the 11th year, U.S.News & World Report has named City of Hope one of the top cancer hospitals in the country.


NEWS & UPDATES
  • The outlook and length of survival has not changed much in the past 25 years for patients suffering from an aggressive form of pancreatic cancer known as pancreatic ductal adenocarcinoma (PDAC). These patients still have few options for therapy; currently available therapies are generally toxic and do not incre...
  • “With bladder cancer, the majority of patients that I see can be cured,” said urologist Kevin Chan, M.D., head of reconstructive urology at City of Hope. “The challenge is to get patients the same quality of life that they had before surgery.” To meet this challenge, Chan and the urologic team at City of Hope [...
  • Already pioneers in the use of immunotherapy, City of Hope researchers are now testing the bold approach to cancer treatment against one of medicine’s biggest challenges: brain cancer. This month, they will launch a clinical trial using patients’ own modified T cells to fight advanced brain tumors. One of but a...
  • Brain cancer may be one of the most-frightening diagnoses people can receive, striking at the very center of who we are as individuals. Further, it often develops over time, causing no symptoms until it’s already advanced. Listen to City of Hope Radio as Behnam Badie, M.D., director of the Brain Tumor Pro...
  • The whole is greater than the sum of its parts. It takes a village. No man is an island. Choose your aphorism: It’s a simple truth that collaboration usually is better than isolation. That’s especially true when you’re trying to introduce healthful habits and deliver health care to people at risk of disease and...
  • When Maryland Governor Larry Hogan announced earlier this week that he has the most common form of non-Hodgkin lymphoma, he was giving voice to the experience of more than 71,000 Americans each year. The announcement came with Hogan’s promise to stay in office while undergoing aggressive treatment for the...
  • The spine can be affected by many different kinds of tumors. Malignant, or cancerous, tumors can arise within the spine itself. Secondary spinal tumors, which are actually much more common, begin as cancers in another part of the body, such as the breast and prostate, and then spread, or metastasize, to the spi...
  • Although most cancer occurs in older adults, the bulk of cancer research doesn’t focus on this vulnerable and fast-growing population. City of Hope and its Cancer and Aging Research Team aim to change that, and they’re getting a significant boost from Professional Practice Leader Peggy Burhenn, R.N....
  • Liz Graef-Larcher’s first brain tumor was discovered by accident six years ago. The then-48-year-old with a long history of sinus problems and headaches had been sent for an MRI, and the scan found a lesion in her brain called a meningioma – a tumor that arises in the meninges, the layers of tissue that cover a...
  • The colon and rectum are parts of the body’s gastrointestinal system, also called the digestive tract. After food is digested in the stomach and nutrients are absorbed in the small intestine, the remaining material moves down into the lower large intestine (colon) where water and nutrients are absorbed. The low...
  • If there is one truism about hospital stays it is that patients want to get out. For many, however, the joy of being discharged is tempered by the unexpected challenges that recovery in a new setting may pose. Even with professional help, the quality of care and treatment that patients receive at City of Hope [...
  • Jana Portnow, M.D., associate director of the Brain Tumor Program at City of Hope, didn’t expect to specialize in treating brain tumors. But, early in her career, she undertook a year of research on pain management and palliative care and, in that program, got to know many patients with brain tumors. After that...
  • Ask any patient: Nurses are as pivotal in their care as doctors. They answer the call of a patient in the middle of the night, they hold the patient’s hand as he or she takes on yet another round of treatment and, in the best-case scenario, they wave goodbye as the patient leaves the hospital, […]
  • Many oncologists, not to mention their patients, might think that there’s no place for mathematical analysis in the treatment of cancer. They might think that all treatment decisions are based on unique factors affecting individual patients, with no connection to other patients and their treatment regimen...
  • Within three days in 2007, Stephanie Hosford, then 37, learned that she was pregnant with her long-awaited second child – and that she had triple-negative breast cancer. Soon afterward, Hosford discovered that she and her husband, Grant, had been approved to adopt a little girl from China.  After encountering m...