Chao Liu, Ph.D.
Staff Scientist, Cancer Genetics And Epigenetics
Clinical Expertise
Cancer Genetics And Epigenetics
Research Teams
Dr. Liu has a broad background in molecular biology and cancer biology, with specific training and expertise in DNA damage response and autophagy. His research focused on post-translational modifications during DNA damage response and function study of key factors in DNA damage repair process and autophagy. As a postdoctoral researcher and staff scientist, he analyzed the role of key factors functioning in DNA damage repair process, including MDC1, 53BP1, PARP1, CHFR, RAP80, RAD6 and H2AX.
2015, Postdoctoral, Molecular Biology, University of Michigan
2011, Ph.D., Genetics, Fudan University, Shanghai, China
2005, B.S., Biotechnolgy, East China Normal University, Shanghai, China
2016-present, Staff Scientist, City of Hope, Duarte, CA
2015-2016, Postdoctoral research fellow, City of Hope, Duarte, CA
2011-2015, Postdoctoral research fellow, University of Michigan, Ann Arbor, MI
2013, Grand Prize of Researchpalooza, University of Michigan Medical School
2011, Champion of Roche LightCycler HRM Analysis Contest, Roche
2010-2011, Graduate Research Fellowship, Fudan University
2004-2005, First National Scholarship for outstanding students, East China Normal University
2003-2004, First National Scholarship for outstanding students, East China Normal University
Bian C, Zhang C, Luo T, Vyas A, Chen S-H, Liu C, Kassab MA, Yang Y, Kong M, Yu X. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression. Nature Communicationsvolume 10(2019).
Buettner R, Nguyen LXT, Kumar B, Morales C, Liu C, Chen LS, Pemovska T, Synold TW, Palmer J, Thompson R, Li L, Hoang DH, Zhang B, Ghoda L, Kowolik C, Kontro M, Leitch C, Wennerberg K, Yu X, Chen C-C, Horne D, Gandhi V, Pullarkat V, Marcucci G, T. Rosen ST. 8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia. Journal of cellular physiology(2019).
Yang G, Liu C, Chen S-H, Kassab MA, Hoff JD, Walter NG, Yu X. Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors. Nucleic acids research 46, 3446-3457(2018).
Liu C, Vyas A, Kassab MA, Singh AK, Yu X. The role of poly ADP-ribosylation in the first wave of DNA damage response. Nucleic Acids Research(2017).
Yang H, Palmbos PL, Wang L, Kim EH, Ney GM, Liu C, Prasad J, Misek, DE, Yu X, Ljungman M. ATDC (Ataxia Telangiectasia Group D Complementing) promotes radioresistance through an interaction with the RNF8 ubiquitin ligase. Journal of Biological Chemistry 290, 27146-27157(2015).
Liu C, Yu X. ADP-ribosyltransferases and poly ADP-ribosylation. Current Protein and Peptide Science 16, 491-501(2015).
Jiang W, Crowe JL, Liu X, Nakajima S, Wang Y, Li C, Lee BJ, Dubois RL, Liu C, Yu X. Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining. Molecular Cell 58, 172–185(2015).
Zuo J, Cai H, Wu Y, Ma H, Jiang W, Liu C, Han D, Ji G, Yu L. TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma. Biochemical and biophysical research communications 446, 61-67(2014).
Ma H, Cai H, Zhang Y, Wu J, Liu X, Zuo J, Jiang W, Ji G, Zhang Y, Liu C. Membrane palmitoylated protein 3 promotes hepatocellular carcinoma cell migration and invasion via up-regulating matrix metalloproteinase 1. Cancer letters 344, 74-81(2014).
Ma H, Cai H, Zhang Y, Wu J, Liu X, Zuo J, Jiang W, Ji G, Zhang Y, Liu C. Membrane palmitoylated protein 3 promotes hepatocellular carcinoma cell migration and invasion via up-regulating matrix metalloproteinase 1. Cancer letters 344, 74-81(2014).
Liu C, Xia Y, Jiang W, Liu Y, Yu Long. Low expression of GABARAPL1 is associated with a poor outcome for patients with hepatocellular carcinoma. Oncology reports 31, 2043-2048(2014).
Xiao Q, Qu K, Wang C, Kong Y, Liu C, Jiang D, Saiyin H, Jia F, Ni C, Chen T. HDGF-related protein-3 is required for anchorage-independent survival and chemoresistance in hepatocellular carcinomas. Gut 62, 440-451(2013).
Liu C, Wang D, Wu J, Keller J, Ma T, Yu X. RNF168 forms a functional complex with RAD6 during the DNA damage response. J Cell Sci 126, 2042-2051(2013).
Liu C, Ma H, Wu J, Huang Q, Liu JO, Yu L. Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins. BMC cell biology 14, 27(2013).
Wu J, Liu C, Chen J, Yu X. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. Journal of Biological Chemistry 287, 22919-22926(2012).
Liu G, Jiang S, Wang C, Jiang W, Liu Z, Liu C, Saiyin H, Yang X, Shen S, Jiang D. Zinc finger transcription factor 191, directly binding to β‐catenin promoter, promotes cell proliferation of hepatocellular carcinoma. Hepatology 55, 1830-1839(2012).
Liu C, Wu J, Paudyal SC, You Z, Yu X. CHFR is important for the first wave of biquitination at DNA damage sites. Nucleic acidsresearch 41, 1698-1710(2012).
Wu J, Dang Y, Su W, Liu C, Ma H, Shan Y, Pei Y, Wan B, Guo J, Yu L. Molecular cloning and characterization of rat LC3A and LC3B—two novel markers of autophagosome. Biochemical and biophysical research communications 339, 437-442(2006).
Su W, Ma H, Liu C, Wu J, Yang J. Identification and characterization of two rice autophagy associated genes, OsAtg8 and OsAtg4. Molecular biology reports 33, 273-278(2006).