Personalized, Expert Treatment, When and Where You Need It

City of Hope® — a nationally recognized leader in cancer research and treatment with one of the largest and most successful bone marrow transplantation programs in the country — is bringing new hope to cancer patients in and around the Midwest, including Chicago, northern Illinois and southeastern Wisconsin.

Experience the City of Hope difference closer to home — from sophisticated surgical care and Magnet®-designated nurses to world-class blood cancer care and 5-star overall and patient experience ratings, the highest ratings from the Centers for Medicare and Medicaid Services.

Whether you choose our North Shore, Lake County or downtown Chicago location, you’ll be cared for by a team of physicians with expertise in treating all types of cancer. Because we know that time is of the essence, we also offer appointments in as little as 24 hours, personalized treatment plans within an average of seven days and rapid turnaround times on diagnostic test results.

Exterior image of City of Hope

City of Hope Cancer Center Chicago

All located under one roof at our Zion, Illinois, cancer center, City of Hope Chicago’s multidisciplinary team delivers comprehensive cancer treatment for the whole patient — mind, body and soul.

Directions: 2520 Elisha Avenue, Zion, Illinois 60099

Existing Patients Call: (847) 510-2822

New Patients Call: (866) 985-1468


Explore your cancer hospital
Other Area Locations:
Karin N., Breast Cancer Stage 3A | City of Hope
Discovering that I had options for cancer treatment was very empowering for me. Realizing that I can get a second opinion, as many opinions as I want, really, was vital to my recovery. I found a place that gave me the knowledge that I needed. Later, when it came to addressing the lymphedema, City of Hope was right there at the leading edge, offering the right treatment.”
Karin N.
Breast Cancer — Stage 3A

Cancer Second Opinions

One of the most important decisions you’ll make on your cancer journey is who to trust with your care. Many patients make that final decision after seeking a second opinion on their diagnosis and treatment plan. At City of Hope — a national network of cancer experts who collaborate coast to coast — we understand that you need accurate answers, quickly.  

That’s why, when you seek a second opinion at one of our locations close to home, our cancer experts work to perform the comprehensive evaluation you need, with the urgency you deserve. When you make a second opinion appointment with us, you’ll get results you can trust, delivered by a team of specialists who will collaborate on treatment recommendations personalized to your individual diagnosis, needs and preferences.

Our goal: to provide an individualized treatment plan that gives you confidence in the road ahead and allows you to get back to your life as quickly as possible.

Why Choose City of Hope Chicago?

Accredited by the Commission on Cancer for nearly 40 years, City of Hope Chicago is dedicated to providing compassionate care backed by innovative treatment options, offering patients access to: 

  • A bone marrow transplantation and blood cancer program that is accredited by the Foundation for the Accreditation of Cellular Therapy and nationally recognized as “high-performing” by U.S. News & World Report’s 2023-24 rankings 
  • Our breast cancer program, which is one of only 70 U.S. Certified Quality Breast Centers of Excellence™ recognized by the National Quality Measures for Breast Centers program
  • Supportive care options designed to help manage both the physical and emotional side effects of cancer, including pain, neuropathy, malnutrition and anxiety
  • A well-coordinated experience that helps handle the stressful responsibilities of  gathering medical records, verifying insurance information and managing appointment scheduling
  • Leading-edge cancer care for patients insured through a wide range of providers, including Medicare and most Illinois Medicaid programs

Refer a Cancer Patient 

Our National Cancer Institute-designated comprehensive cancer center in Duarte, California, is a recognized leader in innovative discoveries and novel treatments that continue to revolutionize the fields of cancer research, prevention, detection and care. Now, with a national network that extends to Chicago and surrounding communities, City of Hope is able to transport this expertise to more patients in need. This means your patient will have access to leading-edge diagnostics and treatments — some of which may not be available elsewhere.

When you refer a patient to City of Hope, we build customized plans around your patient, including proactive recommendations, and ensure that, as a referring physician, you stay well informed for seamless continuity of care. Patients with complex cases have access to the nation’s top subspecialists, with case reviews and tumor boards collaboratively reviewed by national experts to provide optimal information sharing and care across all locations. As part of a unified City of Hope system, many of our physicians' academic appointments in their clinical specialties expand their ability to initiate knowledge sharing, promote collaboration and, above all else, ensure quality patient care.


Portrait of Chris P., Pancreatic Cancer Survivor
For more than two years, I returned to City of Hope every month for five to six days at a time. I received chemotherapy intravenously and took advantage of all the supportive care services City of Hope offered.”
Chris P.
Pancreatic Cancer — Stage 4

Cancer Clinical Trials

Clinical studies evaluate the safety and effectiveness of new approaches to treating cancer, either with new drug development, new technologies or by using existing treatments in new ways. New treatments often take years of study before they win regulatory approval from the Food and Drug Administration (FDA). While the trials take their course, they often offer participating patients new options that may otherwise be unavailable to them, especially after exhausting conventional cancer treatments.

We offer a robust precision medicine program that provides patients with the education and assistance they need to help with any financial barriers they may have. Since 2016, our locations in Chicago, Atlanta and Phoenix have conducted more than 15,000 next-generation sequencing tests, and over the last eight years, we have enrolled over 700 patients into precision medicine-based clinical trials. Our research team is dedicated to ensuring patient safety and a positive patient experience, continuously measuring our safety event rates, performing better than available national benchmarks.

What to Expect at City of Hope

At City of Hope we understand how critical the decision-making process is when facing a cancer diagnosis — and the anxiety that often comes with it. That’s why we strive to make becoming a patient as easy and stress-free as possible — from your first call and first evaluation to your diagnosis, comprehensive treatment regimen and post-treatment survivorship plan. And beyond. We’re here for you, every step of the way.

Loving family joining together in hospital lobby
Pankaj Vashi, Vice Chief of Staff, City of Hope Chicago
We always put patients in charge of their care. That's the model at City of Hope.”
Pankaj Vashi, M.D., A.G.A.F., F.A.S.P.E.N.
Vice Chief of Staff, City of Hope Chicago
Hope Matters, Chicago

Need Help?

We’re here for you. Contact us, and we’ll answer any questions.