Jia-Ling Teo, Ph.D.
Assistant Research Professor, Department Of Molecular Medicine
Jia-Ling Teo, Ph.D., is an assistant research professor in the department of molecular medicine performing research involving investigations in the Wnt signaling pathway in both normal development and diseases including cancer and neurodegeneration at the Beckman Research Institute of City of Hope.
2003, Ph.D., Pathobiology, University of Washington, Washington
2019-present, Assistant Research Professor, Department of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California
2017-2019, Staff Scientist, Department of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California
2010-2017, Technical Manuscript/Grant Writer, Center for Molecular Pathways & Drug Discovery, University of Southern California, Los Angeles, California
Henderson WR, Chi EY, Teo J-L, Kahn M. A small molecule inhibitor of redox-regulated NF--B and AP-1 transcription blocks allergic airway inflammation in a mouse asthma model. J Immunol. 169, 5249-5299 (2002).
Nguyen C, Teo JL, Matsuda A, Eguchi M, Chi EY, Henderson WR Jr, Kahn M. Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma. Proc Natl Acad Sci USA. 100(3), 1169-1173 (2003).
Emami KH, Nguyen C, Ma H, Kim DH, Jeong KW, Eguchi M, Moon RT, Teo J-L, Kim HY, Moon SH, Ha JR, Kahn M. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci USA. 101(34), 12682-12687. [Erratum in: Proc Natl Acad Sci USA. 101(47), 16707] (2004).
Teo J-L, Ma H, Nguyen C, Lam C, Kahn M. Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Proc Natl Acad Sci USA. 102(34), 12171-12176 (2005).
Miyabayashi T, Teo J-L, Yamamoto M, McMillan M, Nguyen C, Kahn M. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci USA. 104(13), 5668-5673 (2007).
Hasegawa K, Yasuda SY, Teo J-L, Nguyen C, McMillan M, Hsieh CL, Suemori H, Nakatsuji N, Yamamoto M, Miyabayashi T, Lutzko C, Pera MF, Kahn M. Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med. 1(1), 18-28 (2012).
Pohl A, El-Khoueiry A, Yang D, Zhang W, Lurje G, Ning Y, Winder T, Hu-Lieskoven S, Iqbal S, Danenberg KD, Kahn M, Teo J-L, Shriki J, Stebbing J, Lenz HJ. Pharmacogenetic profiling of CD133 is associated with response rate (RR) and progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC), treated with bevacizumab-based chemotherapy. Pharmacogenomics J. 13(2), 173-180 (2013).
Zhao Y, Masiello D, McMillian M, Nguyen C, Wu Y, Kida A, Melendez E, Smbatyan G, He Y, Teo J-L, Kahn M. Specific Inhibition of CBP/Catenin Signaling Safely Eliminates Drug Resistant Leukemia Initiating Cells. Oncogene 35(28), 3705–3717 (2016).
Manegold P, Lai KKY, Wu Y, Teo J-L, Lenz HJ, Genyk YS, Pandol SJ, Wu K, Lin DP, Chen Y, Nguyen C, Zhao Y, Kahn M. Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer. Cancers (Basel). 10(4), 95 (2018).
Lai KKY, Nguyen C, Lee KS, Lee A, Lin DP, Teo J-L, Kahn M. Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage. Curr. Mol. Pharmacol. 12(3), 167–183 (2019).
Lukaszewicz AI, Nguyen C, Melendez E, Lin DP, Teo J-L, Lai KKY, Huttner WB, Shi SH, Kahn M. The Mode of Stem Cell Division Is Dependent on the Differential Interaction of β-Catenin with the Kat3 Coactivators CBP or p300. Cancers (Basel). 11(7), 962 (2019).
Che M, Kweon SM, Teo J-L, Yuan YC, Melstrom LG, Waldron RT, Lugea A, Urrutia RA, Pandol SJ, Lai KKY. Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells. Cancers (Basel). 2020 Jun 5;12(6):1476.