Christine Brown Bio Portrait

Christine Brown, Ph.D.

  • Heritage Provider Network Professor in Immunotherapy
  • Associate Director, T cell Therapeutics Research Laboratory
  • Associate Research Professor, Departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology

Christine Brown, Ph.D.

Research Focus :
  • Chimeric Antigen Receptor T cell therapy for cancer, with particular focus on its application to brain tumors
  • Brain tumor immunology
  • Glioma cancer stem cells

Dr. Christine Brown is a faculty member in the Departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology.

As associate director of the T Cell Therapeutics Research Laboratory, Dr. Brown provides scientific oversight for the preclinical research program, as well as the ongoing clinical trial program focused on the development of chimeric antigen receptor (CAR)-engineered T cells for the treatment of hematological malignancies and solid tumors. Dr. Brown’s personal research efforts are focused on developing and refining redirected CAR T cells for the treatment of malignant brain tumors.  
 
Dr. Brown received her doctoral degree from the University of California Berkeley, and was a Leukemia & Lymphoma Scholar during her postdoctoral fellowship at Pennsylvania State University. Her scientific contributions to the development and optimization of tumor-specific CAR T cells for the treatment of glioblastoma are supported by the California Institute for Regenerative Medicine and are the basis of an ongoing phase I clinical trial which is supported by Gateway for Cancer Research and R01 FD005129.

  • 2016 - present, Heritage Provider Network Professor in Immunotherapy, City of Hope, Duarte, CA
  • 2013 - present, Associate Director, T Cell Therapeutics Research Laboratory, City of Hope, Duarte, CA
  • 2010 - present, Associate Research Professor, Departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology, City of Hope, Duarte, CA
  • 2005 - 2013, Group Leader, T cell Therapy Preclinical Research, Department of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • 2002 - 2010, Assistant Research Professor, Department of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • Hematology & Hematopoietic Cell Transplantation
  • Immuno-Oncology
  • Neuro-Oncology Disease Team
  • Cancer Center Program Member, Cancer Immunotherapeutics Program
  • T Cell Therapeutics Research Laboratory

Degrees

  • 1992 - 1998, Ph.D., Department of Cell and Molecular Biology, University of California Berkeley, Berkeley, CA
  • 1985 - 1990, Bachelor of Science, Combined Science - emphasis Biochemistry, minor Chemistry, Santa Clara University, Santa Clara, CA

Fellowship

  • 1998 - 2001, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA

My research is focused on the development of chimeric antigen receptor (CAR) T cell therapy for the treatment of cancer. I conceptualize, perform and oversee studies to evaluate CAR design, T cell manufacturing, cell-based immunological assays and in vivo animal models. My primary independent research efforts are focused on the development of CAR T cell therapy for the treatment of primary and metastatic brain tumors.

As associate director of the T Cell Therapeutics Research Laboratory, I also lead multifunctional teams to translate these therapies to the clinical, participating in all stages of the regulatory process.

Information listed here is obtained from Pubmed, a public database; City of Hope is not responsible for its accuracy. View all publications.

  • American Association for Cancer Research
  • American Society of Gene and Cell Therapy
  • Society of Immunotherapy of Cancer
  • Society of Neuro-Oncology
  • Caltech/UCLA/CHLA/COH Engineered Immunity Consortium
  • 1998, Postdoctoral Fellowship, Howard Hughes Medical Institute
  • 2000, Scholar, Leukemia and Lymphoma Society
  • 2012, Values in Action Award for Intellectual Curiosity, City of Hope
  • 2013, Developmental Research Award Recipient, Lymphoma SPORE
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