An NCI-designated Comprehensive Cancer Center
WenYong Chen, Ph.D.

WenYong Chen, Ph.D.

Associate Professor, Department of Cancer Biology
Research Focus
  • Cancer Biology
Other Languages Spoken
  • Mandarin

Research Teams

Locations

City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

  • Wang Z., Chen, C.C., and Chen, W.Y. (2015) CD150- side population defines leukemia stem cells in a mouse model of chronic myelogenous leukemia in BABL/c mice and is depleted by genetic loss of SIRT1. Stem Cells. (In press)
  • Chen, WY. (2014) SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)). Atlas Genet Cytogenet Oncol Haematol (Hyperlink)
  • Li L, Osdal T, Ho Y, Chun S, McDonald T, Agarwal P, Lin A, Chu S, Qi J, Li L, Hsieh YT, Dos Santos C, Yuan H, Ha TQ, Popa M, Hovland R, Bruserud O, Gjertsen BT, Kuo YH, Chen WY, Lain S, McCormack E, Bhatia R.  (2014)  SIRT1 activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells. Cell Stem Cell.  15: 431-46.  PMID: 25280219
  • Wang, Z., Liu, Z., Wu X., Chu, S.,  Wang, J.H., Yuan, H., Roth, M., Yuan, Y.C., Bhatia, R. and Chen, W.Y.  (2014)  ATRA-induced cellular differentiation and CD38 expression inhibits acquisition of BCR-ABL mutations for CML acquired resistance. PloS Genet  10: e1004414. PMID: 24967705
  • Roth, M. and Chen W.Y.  (2014)  Sorting out functions of sirtuins in cancer.  Oncogene.  33(13):1609-20. PMID: 23604120
  • Roth,M., Wang, Z. and Chen W.Y. (2013) Sirtuins in hematological aging and malignancy. Critical Reviews in Oncogenesis.  18(6):485-501.
  • Yuan, H. Su, L. and Chen, W.Y. (2013) The emerging and diverse roles of sirtuins in cancer: A clinical perspective.  Oncotarget & Therapy  6:1399-1416.
  • Wang, Z. and Chen, W.Y. (2013) Emerging roles of SIRT1 in cancer drug resistance. Genes & Cancer.  4: 82-90.
  • Chen, W.Y. and Bhatia, R.  (2013) Roles of SIRT1 in leukemogenesis. Curr Opin Hematol  20: 308-313.
  • Wang, Z., Yuan, H., Roth M., Stark, J., Bhatia, R. and Chen, W.Y. (2013) SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells. Oncogene  32: 589-598. PMID: 22410779; PMCID: PMC3376246.
  • Chen, W.Y. (2012) Accelerating cancer evolution: a dark side of SIRT1 in genome maintenance. Oncotarget 3: 363-364.
  • Chakraborty, S., Stark, J.M., Sun,C.L., Modi, H., Chen, W.Y., O’Connor T., Forman, S.J., Bhatia, S., and Bhatia R. (2012) Chronic Myelogenous Leukemia Stem and Progenitor Cells Demonstrate Chromosomal Instability Related to Repeated Breakage-Fusion-Bridge Cycles Mediated by Non-Homologous End Joining. Blood 119: 6187-6197. PMCID: PMC3383199
  • Nam S., Scuto A., Yang F., Chen W.Y., Park S., Yoo H.S., Konig H., Bhatia R., Cheng X., Merz K.H., Eisenbrand G., and Jove R. (2012) Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of STAT5 signaling.  Molecular Oncology  6: 276-283.
  • Yuan, H., Wang, Z ., Zhang, H., Bhatia, R. and Chen, W.Y. (2012) Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model.  Carcinogenesis 33: 285-293.  PMID: 22116466; PMCID: PMC3271265
  • Li, L., Wang, L., Li, L., McDonald, T., Ho, Y., Holyoake T., Chen, W.Y.# and Bhatia, R. # (2012)  Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with Imatinib. Cancer Cell  21: 266-281.  PMCID: PMC3285436#Co-corresponding authors.
  • Yuan, H., Wang, Z., Li, L., Zhang, H., Modi, H., Horne, D., Stark, J., Bhatia, R. # and Chen, W.Y. #  (2012)  Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis.  Blood 119: 1904-1914.  PMID: 22207735; PMCID: PMC3293644   #Co-corresponding authors.     
  • Wang, B., Hasan, K.M., Alvarado, E., Yuan, H., Wu, H. and Chen, W.Y.  (2011) NAMPT over-expression in prostate cancer and its contribution to tumor cell survival and stress response. Oncogene 30: 907-921. PMID: 20956937
  • Chen, W.Y., Yuan, H. and Wang, Z.  (2011) De novo acquisition of BCR-ABL mutations for CML acquired resistance. In Myeloid Leukemia: Basic Mechanisms of Leukemogenesis. Steffen Koschmieder and Utz Krug (eds). pp 69-84. (Hyperlink)
  • Yuan, H., Wang, Z., Gao, C., Chen, W., Huang, Q., Yee, J.K., Bhatia, R., and Chen, W.Y.  (2010)  BCR-ABL gene expression is required for its mutations in a novel KCL-22 cell culture model for acquired resistance of chronic myelogenous leukemia.  J Biol Chem 285:5085-5096. PMCID: PMC2836111
  • Chen W.Y., Wang, D.H., Chiu, R.W., Lou, J.Y., Gu, W, and Baylin, S.B. (2005) Tumor suppressor HIC1 directly regulates SIRT1 deacetylase to modulate p53-dependent apoptotic DNA damage responses.  Cell, 123:437-448. PMID: 16269335
  • Chen, W.Y., Cooper, T.K., Zahnow, C.A., Overholtzer, M, Zhao, Z,  Ladanyi, M.,   Karp, .E., Gokgoz, N., Wunder, J.S., Andrulis, I.L., Levine, A.J., Mankowski, J.L., & Baylin, S.B. (2004) Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell, 6:387-398. PMID: 15488761.
  • Chen W.Y., Zeng X., Carter M.G., Morrell C.N., Chiu Yen R.W., Esteller M., Watkins D.N., Herman J.G., Mankowski J.L. & Baylin S.B. (2003) Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet, 33, 197-202.  PMID: 12539045.
  • Chen W.Y., Wu X., Levasseur D.N., Liu H., Lai L., Kappes J.C. & Townes T.M. (2000) Lentiviral vector transduction of hematopoietic stem cells that mediate long-term reconstitution of lethally irradiated mice. Stem Cells, 18, 352-359.
  • Chen W.Y. & Townes T.M. (2000) Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. Proc Natl Acad Sci U S A, 97, 377-382. PMID: 10618426; PMCID: PMC26671.
  • Chen W.Y., Bailey E.C., McCune S.L., Dong J.Y. & Townes T.M. (1997) Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. Proc Natl Acad Sci U S A, 94, 5798-5803. PMID: 9159154; PMCID: PMC20860
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