Angel Gu, D.V.M., Ph.D., is a knowledgeable, self-driven and results-oriented veterinary scientist and immunologist with extensive experience in experimental design, analysis of results and interpretation of data from pre-clinical animal models of disease. She has experience in manufactory sterilization process, knowledge about the standard of AAMI guidance and Extensive experience on embryonic stem cells, human and mouse T cells and hematopoietic stem cells handling, expansion, and banking.
Dr. Gu recently developed a robust humanized mouse model for use in screening anti-viral gene therapy strategies for HIV that is the basis of the proposed experiments in the enclosed R01 application to study HIV latency.
Gu, Angel, Monica Torres-Coronado, Chy-Anh Tran, Hieu Vu, Elizabeth W. Epps, Janet Chung, Nancy Gonzalez, Suzette Blanchard, and David L. DiGiusto. (2014) Engraftment and lineage potential of Adult Hematipoietic Stem and Porgentior cells is compromised following short-term culture in presence of an Aryl Hydrocarbon Receptor Antagonist. Human Dene Therapy Methods Aug. 2014
Janet Chung1, Lisa Scherer, Angel Gu, Agnes Gardner, Monica Torres-Coronado, Elizabeth Epps, David L. DiGiusto, John J. Rossi1,4 (2014) Optimized Lentiviral Vectors for HIV Gene Therapy: Multiplexed Expression of Small RNAs and Inclusion of MGMTP140K Drug Resistance Gene. Mol Ther. 2014 Feb 28.
Li, Lijing, Mónica Torres-Coronado, Angel Gu, Anitha Rao, Agnes M. Gardner, Elizabeth W. Epps, Nancy Gonzalez, Chy-Anh Tran, David L. DiGiusto, 3Enhanced genetic modification of adult growth factor mobilized peripheral blood hematopoietic stem and progenitor cells with rapamycin. (2014 under revision, Stem Cells)
Tran, CA., Torres-Coronado, M., Gardner, A., Gu, A. Vu, H., Rao, A., Cao, L-F., Ahmed, A. and DiGiusto, D. (2012). Optimized Processing of Growth Factor Mobilized Peripheral Blood CD34+ Products by Counterflow Centrifugal Elutriation. Stem Cells Trans. Med. 2012 1:422-429.
Gu, Angel and Shively, JE.: Angiopoietins-1 and -2 play opposing roles in endothelial sprouting of embryoid bodies in 3D culture and their receptor Tie-2 associates with the cell-cell adhesion molecule PECAM1. Exp Cell Res 2011 Sep 10;317(15):2171-82
Gu, Angel, Zhang Z, Zhang N, Tsark W, Shively JE.: Generation of human CEACAM1 transgenic mice and binding of Neisseria Opa protein to their neutrophils. PLoS One. 2010 Apr 9;5(4):e10067.
Gu, Angel, Tsark,Walter, Holmes, KV, Shively JE.: Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 2009 Jun 10; 315(10):1668-82.
Gu, Angel Sheng-rui and Hou, Jia-Fa. “How the foot and mouth disease infects goats?” Journal of Animal Disease, 1997.Vol. 10, September