Felix Wussow, Ph.D.

Felix Wussow, Ph.D.

  • Assistant Research Professor, Department of Experimental Therapeutics

Felix Wussow, Ph.D.

Research Focus :
  • Developing vaccine strategies to prevent congenital cytomegalovirus infection
  • Optimizing Modified Vaccinia virus Ankara as vaccine vector using CRIPR/Cas9 and BAC technology
  • Identifying protective humeral and cellular immune responses for a Zika virus vaccine
  • Developing vectored virus-like particles as vaccine platform
  • 2016 - present, Assistant Research Professor, Department of Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA
  • 2014 – 2015, Staff Scientist, Department of Experimental Therapeutics/Translational Vaccine Research Laboratory, Beckman Research Institute of City of Hope, Duarte, CA
  • 2010 – 2014, Postdoctoral Fellow, Translational Vaccine Research Laboratory, Beckman Research Institute of City of Hope, Duarte, CA
  • 2009 - University of Kiel, Germany, Ph.D. (Dr. rer. nat.), Cell biology
  • 2005 - University of Heidelberg, Germany, M.S. (German Diploma), Biology
  • Chiuppesi F, Wussow F, Kaltcheva T, Zhuo M, Diamond DJ. A cryptic epitope on human cytomegalovirus UL128 induces neutralizing antibodies in mice (In Preparation)
  • Chiuppesi F , Wussow F, Scharf L, Gao H, Zhuo M, Bjorkman PJ, Diamond DJ. Comparison of homologous and heterologous prime boost immunization strategies against cytomegalovirus (In Preparation)
  • Wussow F, Chiuppesi F, Martinez J, Meng Z, Nguyen J, Diamond DJ. A Bacterial Artificial Chromosome Clone of MVA Allows Induction of Potent Neutralizing Antibodies Against Human Cytomegalovirus by a Self-cleaving Pentamer Complex (In Preparation)
  • Bialas KM, Tanaka T, Tran D, Varner V, Cisneros De La Rosa E, Chiuppesi F, Wussow F, Kattenhorn L, Macri S, Kunz EL, Estroff JA, Kirchherr J, Yue Y, Fan Q, Lauck M, O'Connor DH, Hall AH, Xavier A, Diamond DJ, Barry PA, Kaur A, Permar SR. Maternal CD4+ T Cells Protect Against Severe Congenital Cytomegalovirus Disease in a Novel Nonhuman Primate Model of Placental Cytomegalovirus Transmission. Proc Natl Acad Sci U S A. 2015
  • Chiuppesi F, Wussow F, Johnson E, Bian C, Zhuo M, Rajakumar A, Barry PA, Britt WJ, Chakraborty R, Diamond DJ. Vaccine-Derived Neutralizing Antibodies to the Human Cytomegalovirus gH/gL Pentamer Potently Block Primary Cytotrophoblast Infection. J Virol. 2015
  • Swanson EC, Gillis P, Hernandez-Alvarado N, Fernández-Alarcón C, Schmit M, Zabeli JC, Wussow F, Diamond DJ, Schleiss MR. Comparison of Monovalent Glycoprotein B with Bivalent gB/pp65 (GP83) Vaccine for Congenital Cytomegalovirus Infection in a Guinea Pig Model: Inclusion of GP83 Reduces gB Antibody Response but Both Vaccine Approaches Provide Equivalent Protection Against Pup Mortality. Vaccine. 2015
  • Wussow F, Chiuppesi F, Martinez J, Campo J, Johnson E, Flechsig C, Newell M, Tran E, Ortiz J, La Rosa C, Herrmann A, Longmate J, Chakraborty R, Barry PA, Diamond DJ. Human Cytomegalovirus Vaccine Based on the Envelope gH/gL Pentamer Complex. PLoS Pathog. 2014  
  • Gillis PA, Hernandez-Alvarado N, Gnanandarajah JS, Wussow F, Diamond DJ, Schleiss MR. Development of a Novel, Guinea Pig-specific IFN-γ ELISPOT Assay and Characterization of Guinea Pig Cytomegalovirus GP83-specific Cellular Immune Responses Following Immunization with a Modified Vaccinia Virus Ankara (MVA)-vectored GP83 Vaccine. Vaccine. 2014
  • Wussow F, Yue Y, Martinez J, Deere JD, Longmate J, Herrmann A, Barry PA, Diamond DJ. A Vaccine Based on the Rhesus Cytomegalovirus UL128 Complex Induces Broadly Neutralizing Antibodies in Rhesus Macaques. J Virol. 2013
  • Wussow F, Spieckermann T, Brunnemann A, Huske L, Toptan T, Fickenscher F. Bacterial Genetics of Large Mammalian DNA Viruses: Bacterial Artificial Chromosome as a Prerequisite for Efficiently Studying viral DNA Replication and Functions. In: DNA Replication-Current Advances. 669-694. 2011
  • Wussow F, Fickenscher H, Tischer BK. Red-mediated Transposition and Final Release of the Mini-F vector of a Cloned Infectious Herpesvirus Genome. PLoS One. 2009
  • Tischer BK, Kaufer BB, Sommer M, Wussow F, Arvin AM, Osterrieder N. A Self-excisable Infectious Bacterial Artificial Chromosome Clone of Varicella-Zoster Virus Allows Analysis of the Essential Tegument Protein Encoded by ORF9. J Virol. 2007

View all publications

  • 2012, Award for Innovation in CMV Vaccine Research. Awarded by the Brendan B. McGinnis Congenital CMV Foundation at the 4th International Congenital CMV Conference/14th International CMV/Beta Herpesvirus Workshop. San Francisco, CA.
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