Steven T. Rosen, M.D.

Steven T. Rosen, M.D., is a professor, Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation, and executive vice president and director emeritus, Comprehensive Cancer Center and Beckman Research Institute of City of Hope.

Prior to joining City of Hope, Dr. Rosen was the Genevieve Teuton Professor of Medicine at the Feinberg School of Medicine at Northwestern University in Chicago. He served for 24 years as director of Northwestern's Robert H. Lurie Comprehensive Cancer Center. Under his leadership, the center received continuous National Cancer Institute (NCI) funding beginning in 1993 and built nationally recognized programs in laboratory sciences, clinical investigations, translational research and cancer prevention and control. The center attained comprehensive status in 1997.

Dr. Rosen has published more than 400 original reports, editorials, books and book chapters. His research has been funded by the NCI, American Cancer Society, The Leukemia & Lymphoma Society and Multiple Myeloma Research Foundation. Dr. Rosen also has served as an adviser for several of these organizations and on the external advisory boards of more than a dozen NCI-designated comprehensive cancer centers. He is the current editor-in-chief of the textbook series "Cancer Treatment & Research."

Recognized as one of the "Best Doctors in America," Dr. Rosen is a recipient of the Martin Luther King Humanitarian Award from Northwestern Memorial Hospital and the Man of Distinction Award from the Israel Cancer Research Fund. He is also a member of the American Institute for Medical and Biological Engineering’s College of Fellows. Dr. Rosen earned his bachelor's degree and medical degree with distinction from Northwestern University, and is a member of the Alpha Omega Alpha Honor Society.

• Robert Chen, Alex Herrera, Jessie Hou, Lu Chen, Jun Wu, Yuming Guo, Timothy Synold, Vu Ngo, Sandrine Puverel, Matthew Mei, Leslie Popplewell, Stephen Forman, Larry Kwak, Steven Rosen, and Edward Newman.  Inhibition of MDRI overcomes resistnace to brentuximab vendotin in Hodgkin Lymphoma. Clinical Cancer Research, August 2019 (submitted).
• Domenico Viola, Ada Dona, Marianna Martella, Emine Gulsen Gunes, Estelle Troadec, Enrico Caserta, Francesca Besi, Xiwei Wu, Sergio Branciamore, Tinisha McDonald , Lucy Ghoda, James F Sanchez, Chatchada Karanes, Myo Htut, Xiuli Wang, Ling Li, Nadia Carlesso, Michael Rosenzweig, Douglas Sborov, Aaron Miller, Steven J Forman, Paul Yazaki, Jonathan J Keats, John Shively, Steven T Rosen, Guido Marcucci, Amrita Krishnan and Flavia Pichiorri. Daratumumab mechanisms of action in myeloma patients highlight the role of CD38 as immune activator.  (submitted)
• Xochiquetzal Martinez, Cosimo Di Raimondo, Farah Abdulla, Jasmine Zain, Steven Rosen, Christiane Querfeld.  Leukaemic Variants of Cutaneious T-Cell Lymphome : Erythrodermic Mycosis Fungoides and SÉZARY Syndrome.  Journal: Best Practice & Research Clinical Haematology (accepted)
• Ralf Buettner, Corey Morales, Xiwei Wu, James F. Sanchez, Hongzhi Li, Laleh G. Meldstrom and Steven T. Rosen.  Leflunomide Synergizes with Gemcitabine in Grown Inhibition of PC Cells and Impairs c-Myc Signaling through PIM Kinase Targeting.  Molecular Therapy: Oncolytics Vol. 14, September 2019.  doi.org/10.1016/j.omto.2019.04.006.
• Nguyen LXT, Troadec E, Kalvala A, Kumar B, Hoang DH, Viola D, Zhang B, Nguyen DQ, Aldoss I, Ghoda L, Budde E, Pichiorri F, Rosen S, Foramn SJ, Marcucci G, Pullarkat V.  The Bcl-2 Inhibitor Venetoclax inhibits Nrf2 Antioxidant Pathway Activation induced by hypomethylating agents in AML.  Journal of Cellular Physiology 2019 Aug; 234(8):14040-14049. doi: 10.1002/jcp.28091.
• Lansigan F, Horwitz SM, Pinter-Brown LC, Rosen ST, Pro B, His ED, Federico M, Gisselbrecht C, Schwartz M, Bellm LA, Acosta M, Shustov AR, Advani RH, Feldman T, Lechowicz MJ, Smith SM, Tulpule A, Craig MD, Greer JP, Kahl BS, Leach JW, Morganstein N, Casulo C, Park SI, Foss FM. Outcomes for Relapsed and Refractory Peripheral T-Cell Lymphoma Patients After Front Line Therapy from the COMPLETE Registry. Acta Haematologica 2019 Jul 17:1-11. doi: 10.1159/000500666.
• Lu Yang, Anthony K.N. Chun, Kazuya Myashita, Chris Delaney, Xi Wang, Hongzhi Li, Wen-Han Chang, Sheela Pangeni Pokharel, Sandra Li, Kevin Yining Chen, Yanchun Guo, Mingli Li, Xiaobao Xu, Jinhui Wang, David Horne, Nagarajan Vaidehi, Yuan Chen, Jianjun Chen, Markus Müschen, Steven T. Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Scott A. Armstrong, Chun-Wei Chen. Saturating CRISPR gene body scan identifies sub-domain functional elements in proteins" (reference number: NBT-RA47887). (submitted to Nature Biotechnology) May 2019.
• Dean Ho, Steven T. Rosen, Quake, Edward R.B. McCabe, Megan L. Frisk, wee Joo Chng, Edward Chow, Xianting Ding, Bruce D. Gelb, Geoffrey S. Ginsburg, Chih-Ming Ho, William Mobley, Garry  Nolan,  Patrick Tan, Yen Yun, Ali Zarrinpar.  Engineering Enabling Technologies for Personalized and Precision Medicine. (accepted)  
• Buettner R, Nguyen LXT, Kumbar B, Morales C, Liu C, Chen LS, Pemovska T, Synold TW, Palmer J, Thompson R, Li L, Hoang DH, Zhang B, Ghoda L, Kowolik C, Kontro M, Leitch C, Wennerberg K, Yu X, Chen CC, Horne D, Gandhi V, Pullarkat V, Marcucci G, Rosen ST.  8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia.  Journal of Cellular Physiology 2019 February 15. doi: 10.1002/jcp.28294.
• Ralf Buettner, Corey Morales, Enrico Caserta, Estelle Troadec, Emine G. Gunes, Domenico Viola, Jihane Khalife, Hongzhi Li, Jonathan J. Keats, Austin Christofferson, Xiwei Wu, Timothy W. Synold, Joycelynne Palmer, James F. Sanchez, Aleander Pozhitkov, Nagarajan Vaidehi, Guido Marcucci, Amrita Krishnan, Michael a. Rosenzweig, Flavia Pichiorri and Steven T. Rosen.  Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting.  Blood Advances 2019 3:1027-1032; doi:  https//doi.org/10.11.1182.2018027227
• Chang L, Shen L, Zhou H, Gao J, Pan H, Zheng L, Armstrong B, Peng Y, Peng G, Zhou BP, Rosen ST, Shen B. ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response. Nucleic Acids Res. 2019 Jan 25;47(2):824-842. doi: 10.1093/nar/gky1199.
• Atish, Mohanty, Natalie Sandoval, An Phan, Thang V. Nguyen, Robert W. Chen, Elizabeth Budde, Matthew Mei, Leslie Popplewell, Lan V. Pham, Larry W. Kwak, Dennis D. Weisenburger, Steven T. Rosen, Wing C. Chan, Markus Müschen and Vu N. Ngo.  Regulation of SOX11 expression through CCND1 and STAT3 in mantle cell lymphoma.  Blood. 24 January 2019; Volume 133, Number 4.
• Ndiya Ogba, PhD, Nicole M. Arwood, PharmD, Nancy L. Bartlett, MD, Mara Bloom, JD, Patrick Brown, MD, Christine Brown, PhD, Elizabeth Lihua Budde, MD, PhD, Robert Carlson, MD, Stephanie Farnia, MPH, Terry J. Fry, MD, Morgan Garber, MSW, Rebecca A. Gardner, MD, Lauren Gurschick, NP, Patricia Kropf, MD, Jeff J. Reitan, MA, Craig Sauter, MD, Bijal Shah, MD, Elizabeth J. Shpall, MD and Steven T Rosen, MD.  Chimeric Antigen Receptor T-Cell Therapy.  Journal of the National Comprehensive Cancer Network (JNCCN); Volume 16-Number 9-September 2018.
• Li YJ, Du L, Aldana-Masangkay G, Wang X, Urak R, Forman SJ, Rosen ST, Chen Y.  Regulation of miR-34b/c-targeted gene expression program by SUMOylation.  Nucleic Acids Res. 2018 Aug 21;46(14):7108-7123. doi: 10.1093/nar/gky484.  PMID: 29893976. PMCID: PMC6101486.
  221.    Ghose J, Viola D, Terrazas C, Caserta E, Troadec E, Khalife J, Gunes EG, Sanchez J, McDonald T, Marcucci G, Kaur B, Rosenzweig M, Keats J, Rosen S, Krishnan A, Satoskar AR, Hofmeister CC, Pichiorri F. Daratumumab induces CD38 internalization and impairs myeloma cell adhesion. Oncoimmunology. 2018 July 23;7(10):e1486948.
• Chen RW, Palmer JM, Tomassetti S, Popplewell LL, Alluin J, Chomchan P, Nademanee AP, Siddiqi T, Tsai NC, Chen L, Zuo F, Abary R, Cai JL, Herrera AF, Rossi JJ, Rosen ST, Forman SJ, Kwak LW, Holmberg LA.  Multi-center phase II trial of bortezomib and rituximab maintenance combination therapy in patients with mantle cell lymphoma after consolidative autologous stem cell transplantation. J Hematol Oncol. 2018 Jun 28;11(1):87. doi: 10.1186/s13045-018-0631-3.  PMID: 29954415. PMCID: PMC6022297.
• Herrera AF, Rodig SJ, Song JY, Kim Y, Griffin GK, Yang D, Nikolaenko L, Mei M, Bedell V, Dal Cin P, Pak C, Alyea EP, Budde LE, Chen R, Chen YB, Chan WC, Cutler CS, Ho VT, Koreth J, Krishnan A, Murata-Collins JL, Nikiforow S, Palmer J, Pihan GA, Pillai R, Popplewell L, Rosen ST, Siddiqi T, Sohani AR, Zain J, Kwak LW, Weisenburger DD, Weinstock DM, Soiffer RJ, Antin JH, Forman SJ, Nademanee AP, Armand P.  Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma.  Biol Blood Marrow Transplant 2018 Mar;24(3): 514-520. doi: 10.1016/j.bbmt.2017.11.023.
• Xu Hannah Zhang, Sangkil Nam, Jun Wu, Xuxiang Liu, Hongzhi Li, Timothy Mckeithan, Qiang Gong, Wing Chan, Hongwei Yin, Yate-Ching Yuan, Raju Pillai, David Horne, Yuan Chen, Steven Rosen.  Multi-kinase Inhibitor with Anti-p38y Activity in Cutaneous T cell Lymphoma. Journal of Investigative Dermatology. 2018, doi:10.1016/j.jid.2018.04.030
• Christiane Querfeld, Samantha Leung, Patricia L. Myskowski, Shane A. Curran, Debra A. Goldman, Glen Heller, Xiwei Wu, Sung Hee Kil, Sneh Sharma, Kathleen J. Finn Steven Horowitz, Alison Moskowitz, Babak Mehrara, Steven T. Rosen, Allan C. Halpern, James W. Young.  Primary Cells from Cutaneous T-cell Lymphoma Skin Explants Display an Exhausted Immune Checkpoint Profile.  Cancer Immunology Research; 6(8) August 2018.
• Martinez-Escala, M.E., Posligua, A.L., Wickless, H., Rutherford, A., Sable, K.A., Rubio-Gonzalez, B., Zhou, X.A., Kaplan, J.B., Pro, B., Choi, J., Querfeld, C., Rosen, S.T., & Guitart, J.  Progression of undiagnosed cutaneous lymphoma after anti-tumor necrosis factor-alpha therapy. Journal of the American Academy of Dermatology. 2018, Jun: 78(6); 1068-1076.
• Kumar B, Kalvala A, Chu S, Rosen S, Forman SJ, Marcucci G, Chen CC, Pullarkat V.  Antileukemic Activity and Cellular Effects of the Antimalarial Agent Artesunate in Acute Myeloid Leukemia. Leuk Res. 2017 Aug;59:124-135. doi: 10.1016/j.Leukres.2017.05.007. Epub 2017 May 10.
• Seymour JF, Ma S, Brander D, Choi M, Barrientos J, Davids MS, Anderson MA, Beaven A,  Rosen ST, Tam C,  Prine B,  Agarwal S,  Munasinghe W,  Zhu M,  Cerri E,  Verdugo M,  Kim SY, Humerickhouse R, Gordon G, Kipps T,  Roberts AW.  Venetoclax plus rituximab in relapsed or refractory chronic leukaemia: a phase 1b study.  Lancet Oncology.  2017 Feb;18(2):230-240.  doi: 10.1016/S1470-2045(17)30012-8. Epub 2017 Jan 13.
• Mohanty A, Sandoval N, Das M, Pillai R, Chen L, Chen RW, Amin H, Wang M, Marcucci G, Weisenburger DD, Rosen ST, Pham LV, Ngo VN.  CCND1 mutations increase protein stability and promote stability and promote ibrutinib resistance in mantle cell lymphoma.  Oncotarget.  2016 Nov 8;7(45):73558-73572.  doi: 10.18632/oncotarget.12434.
• Carson KR, Horwitz SM, Pinter-Brown LC, Rosen ST, Pro B, Hsi ED, Gisselbrecht C, Schwartz M, Bellm LA, Acosta MA, Shustov AR, Advani RH, Feldman TA, Lechowicz MJ, Smith SM, Lansigan F, Tulpule A, Craig MD, Greer JP, Kahl BS, Leach JW, Morganstein N, Casulo C, Park SI, Foss FM.  A prospective cohort study of patients with peripheral T-cell lymphoma in the United States. Cancer. 2017 Apr 1;123(7):1174-1183. doi: 10.1002/cncr.30416. Epub 2016 Dec 2.
• Hsi E, Foss F, Horwitz S, Carson K, Pinter-Brown L, Rosen ST, Pro B, Federico M, Gisselbrecht C, Schwartz M, Bellm L, Acosta M, Collie A, Gruver A, Grzywacz B, Turakhia S, Shustov A, Advani R, Feldman T, Lechowicz M, Smith S, Lansigan F, Tulpule A, Craig M, Greer J, Kahl B, Leach J, Morganstein N, Casulo C, Park S.  Analysis of Peripheral T-Cell Lymphoma Diagnostic Work-Up in the United States. Clin Lymhoma Myeloma Leuk.  2017 Apr;17(4): 193-200. doi: 10.1016/j.clml.2016.10.001. Epub 2017 Jan 10.
• Alex F. Herrera, Matthew Mei, Lawrence Low, Haesook T. Kim, Gabriel K. Griffin, Joo Y Song, Reid W. Merryman, Victorial Bedell, Christine Pak, Heather Sun, Tanya Paris, Tracey Stiller, Jennifer R. Brown, Lihua E. Budde, Wing C. Chan, Robert Chen, Matthew S. Davids, Arnold S. Freedman, David C. Fisher, Eric D. Jacobsen, Caron A. Jacobson, Ann S. LaCasce, Joyce Murate-Collins, Auayporn P. Nademanee, Joycelynne M. Palmer, German A. Phihan, Raju Pillai, Leslie Popplewell, Tanya Siddiqi, Aliyah R. Sohani, Jasmine Zain, Steven T. Rosen, Larry W. Kwak, David M. Weistock, Stephen J. Forman, Dennis D. Weisenburger, Young Kim, Scott J. Rodig, Amrita Krishnan, and Philippe Armand. Relapsed or Refractory Double-Expressor and double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplant. Journal of Clinical Oncology. Volume 35, Number 1, January 1, 2017.
• Rubio-Gonzalez B, Zain J, Rosen ST, Querfeld C. Clinical manifestations and pathogenesis of cutaneous lymphomas; current status and future directions, British Journal of Haematology, Volume 176, Issue 1, 26 October 2016.
• Rubio-Gonzalez B, Zain J, Garcia L, Rosen ST, Querfeld C.  Cutaneous gamma-delta T-cell lymphoma – successfully treated with brentuximab vedotin. JAMA Dermatol (online Sept 21, 2016) 152:12, 2016.
• Virmani P, Jawed S, Myskowski P, Horwitz S, Lucas A, Moskowitz A, Pulitzer M, Zain J, Rosen ST, Querfeld C.  Long-term followup and management of small/medium-sized CD4+ T cell lymphoma and CD8+ lymphoid proliferation of acral sites: a multi-center experience.  Int J Dermatology. 2016 Jul 1. doi: 10.1111/ijd. 13340. [Epub ahead of print]
• Nardi E, Wolfson J, Rosen ST, Diasio R, Gerson S, Parker B, Alvarnas J, Levine H, Fong Y, Weisenburger D, Fitzgerald C, Egang M, Stranford S, Carlson R, Benz Jr E. Value, Access, and Cost of Cancer Care Delivery at Academic Cancer Centers.  J Natl Compr Canc Netw. 2016 Jul;14(7):837-47.
• Martinez-Escala, M.E., Kuzel, T.M., Kaplan, J.B., Petrich, A., Nardone, B., Rosen, S.T., & Guitart, J. Durable Responses With Maintenance Dose-Sparing Regimens of Romideepsin in Cutaneious T-Cell Lymphoma.  JAMA Oncology. 2016, June: 2(6); 790-793.