Xiaohua Xu, Ph.D.

800-826-4673
Xiaohua Xu
Staff Scientist, Cancer Genetics and Epigenetics
Location
Education & Experience
Degrees

  • 2004, Ph.D., Tottori University, Japan

  • 1997, Bachelors of Science, Fuzhou University,China

Professional Experience

  • 2011 - Present, Staff Scientist, Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope

  • 2011 - 2011, Associate Research Scientist, Department of Therapeutic Radiology, Yale University

  • 2008 - 2010, Postdoctoral research associate, Department of Therapeutic Radiology, Yale University

  • 2005 - 2007, Postdoctoral research fellow, Department of Structural Biology, Stanford University

  • 1997 - 2001, Research assistant, Institute of Biotechnology Fuzhou University, China

Awards & Memberships
Awards

  • 2001 - 2004, Japanese government (Monbusho) scholarship

Publications
Li M*., Xu X*., Chang ZW*., Zheng l. et al.  RECQ5 facilitates chromatin remodeling via SUMO2-PCNA to prevent transcription-replication conflict. Nat. Commun. 9(1):2706. doi: 10.1038/ s41467-018-05236-y      *co-1st author
 
Xu X., Wang JT., Li M., Liu Y. (2016) TIMELESS suppresses the accumulation of aberrant CDC45-MCM2-7-GINS replicative helicase complexes on human chromatin. J. Biol. Chem. 291, 22544-22558
 
Li M., *Pokharel S., *Wang JT., *Xu X., Liu Y. (2015) RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability. Nat. Commun. 6:6720. doi: 10.1038/ncomms7720 *co-2nd author
 
Wang J., Xu X., Alontaga A., Chen y., Liu Y. (2014) Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction. Cell Rep. pii: S2211-1247
 
Hansen JE., Chan G., Liu Y., Hegan DC., Dalal S., Dray E., Kwon Y., Xu Y., Xu X. et al (2012). Targeting cancer with a lupus autoantibody. Sci Transl Med. 4,157ra142
 
Machwe A., Karale R., Xu X., Liu Y., Orren D.K. (2011) The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holiday junctions to functional replication forks. Biochemistry. 50, 6774-6788
 
Li M., Xu X., Liu Y. (2011) The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability. Mol Cell Biol. 31, 2090-2099
 
Xu X*., Rochette PJ*. et al. (2009) MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication. EMBO J. 28, 3005-3014 *co-1st author
 
Aygün O., Xu X., Liu Y., Takahashi H. et al. (2009) Direct inhibition of RNA polymerase II transcription by RECQL5. J. Biol. Chem. 284, 23197-23203
 
Xu X., Liu Y. (2009) Dual DNA unwinding activities of the human Rothmund-T homson Syndrome protein, RECQ4. EMBO J. 28, 568-577
 
Xu X., Wang S. et al. (2007) The periplasmic bacterial molecular chaperone SurA adapts its structure to bind peptides in alternate conformations to assert a sequence preference for aromatic residues. J. Mol. Biol. 373, 367-381
 
Xu X., Azakami H. et al. (2004) P-domain and lectin site are involved in the chaperone function of Saccharomyces cerevisiae calnexin homologue (Cne1p). FEBS Lett. 570, 155-160
 
Xu X., Kanbara K. et al. (2004) Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue. J. Biochem (Tokyo). 135, 615-618
 
 Xu X., Kashima O. et al. (2004) Structural and functional properties of chicken lysozyme fused serine-rich hetapeptides at C-terminus. Biosci. Biotechnol. Biochem. 68, 1273-1278
 
Begum S., Saito A., Xu X. et al. (2003) Improved functional properties of the ovoinhibitor by conjugating with galactomannan. Biosci. Biotechnol. Biochem. 67, 1897-1902
 
Xu X., Li R. et al. (2002) Quantification of cholesterol in foods using non-aqueous capillary electrophoresis. J Chromatogr. B Biomed. Sci. Appl. 768, 369-373
 
Chen G.R., Xu X. et al. (2001) Fractionation of Corynebacterium pekinense AS 1.299 phage subtypes by anion-exchange chromatography. J. Virol. Methods 95, 11-17
 
Zhang R., Xu X. et al. (2000) An assay for angiotensin-converting enzyme using capillary zone electrophoresis. Anal. Biochem. 280, 286-290