Elizabeth Lihua Budde, M.D., Ph.D.
Elizabeth Budde, M.D., Ph.D. is a well-recognized clinical expert and researchers in the area of blood cancers. Her academic and clinical interests center on novel treatment for patients with lymphoma and leukemia. As a physician scientist, she leads a group of researchers in her laboratory designing and investigating the use of immunotherapy to treat blood cancers and other diseases.
She leads the Immunotherapy Modality Team and chairs the Clinical Cellular Immunotherapy Committee at the institution. She also serves as a member on several national committees including National Comprehensive Cancer Network (NCCN) guidelines for B Cell Lymphoma, NCCN guidelines for Management of Immunotherapy-related Toxicities, and Alliance of American Cancer Institute CAR T Working Group.
Dr. Budde has received many honors and awards for her work. She was chosen as a Special Fellow in Clinical Research awardee by The Leukemia & Lymphoma Society, and an awardee of the Stop Cancer Foundation seed grant in 2016. She is also a recipient of the prestigious Damon Runyon Cancer Research Foundation Clinical Investigator Award (2014-2019). She has published many peer-reviewed articles that have been featured in prominent journals including the Journal of Clinical Oncology, Blood, Clinical Cancer Research, Journal of Immunology. She has also given many invited presentations at national and international meetings on her work.
Dr. Budde holds patents for new drugs currently under development in lymphoma and leukemia. She is the principal investigator of innovative translational research protocols and maintains a dynamic portfolio of clinical trials. Dr. Budde is devoted to making promising new treatments available to all her patients.
Medical Oncology
Internal Medicine
2001, M.D., Ph.D., Duke University of Medicine, Durham, NC
1995, Bachelor of Medicine, Tongji Medical University Wuhan, Hubei, China
2006-2009, University of Washington/ Fred Hutchinson Cancer Research Center, Seattle, WA
2004-2006, Washington University School of Medicine, St. Louis, MO
2003-2004, Intern, Internal Medicine, Washington University School of Medicine, St. Louis, MO
2020-present, Staff Physician and Associate Professor, Division of Lymphoma, Department of Hematologic Oncology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
2013-2020, Staff Physician and Assistant Professor, Department of Hematologic Oncology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
2009-2013, Acting Instructor, Department of Medicine, University of Washington, Seattle, Washington
2009-2013, Attending Physician, Hematopoietic Cell Transplant Service, Seattle Cancer Care Alliance, Seattle, Washington
2009-2013, Attending Physician, Lymphoma Clinic, Seattle Cancer Care Alliance, Seattle, Washington
2017-2019, Clinical investigator (continuation award), Damon Runyon Cancer Research Foundation
2014-2017, Clinical investigator, Damon Runyon Cancer Research Foundation
2016, Greg Wiviott and Sharon & Robert Wiviott Seed grant, Stop Cancer Foundation
2014-2017, Clinical investigator, Damon Runyon Cancer Research Foundation
2014-2016, Tim Nesvig Lymphoma Research Foundation Fellow
2013-2016, Awardee, Developmental Research Program, City of Hope Lymphoma SPORE (P50 CA 107399)
2013-2016, Awardee, Career Enhancement Program, City of Hope Lymphoma SPORE
2013-2015, Margaret E. Early Medical Trust Fund
2013, Tower Cancer Foundation Research Grant
2010-2012, Edson Immunotherapy Pilot Award
2009-2012, Special Fellow in Clinical Research, Leukemia & Lymphoma Society
2009, Participant, AACR/ASCO Workshop in Clinical Cancer Research
2008, Participant, The 13th Annual NCCN Fellow Recognition Program
2007, Participant, AACR Workshop on Molecular Biology in Clinical Oncology Workshop
2005, Best Poster Presentation in Research Category for Medical Residents, American College of Physicians, Missouri Chapter Annual Meeting
1999, Graduate Student Travel Award, B Cell Biology, Keystone International Meeting
1997-2000, Research Assistantship, Duke University
1995-1997, Graduate School Fellowship, Duke University
1995, Graduation with Highest Honors, Tongji Medical University
NCCN Guidelines for B Cell Lymphoma Panel
NCCN Guidelines for Management of Immunotherapy Related Toxicities Panel
AACI CAR T Working Group
Mantle Cell Lymphoma Consortium, Lymphoma Research Foundation
American Society of Hematology, Member
American Society of Clinical Oncology
Chinese American Faculty Association in Southern California (President, 2016)
- Kumar A, Casulo C, Advani RH, Budde E, Barr PM, Batlevi CL, Caron P, Constine LS, Dandapani SV, Drill E, Drullinsky P, Friedberg JW, Grieve C, Hamilton A, Hamlin PA, Hoppe RT, Horwitz SM, Joseph A, Khan N, Laraque L, Matasar MJ, Moskowitz AJ, Noy A, Palomba ML, Schöder H, Straus DJ, Vemuri S, Yang J, Younes A, Zelenetz AD, Yahalom J, Moskowitz CH. Brentuximab Vedotin Combined With Chemotherapy in Patients With Newly Diagnosed Early-Stage, Unfavorable-Risk Hodgkin Lymphoma. J Clin Oncol. 2021 Jul 10;39(20):2257-2265. doi: 10.1200/JCO.21.00108. Epub 2021 Apr 28. PMID: 33909449.
- Thompson JA, Schneider BJ, Brahmer J, Andrews S, Armand P, Bhatia S, Budde LE, Costa L, Davies M, Dunnington D, Ernstoff MS, Frigault M, Kaffenberger BH, Lunning M, McGettigan S, McPherson J, Mohindra NA, Naidoo J, Olszanski AJ, Oluwole O, Patel SP, Pennell N, Reddy S, Ryder M, Santomasso B, Shofer S, Sosman JA, Wang Y, Weight RM, Johnson-Chilla A, Zuccarino-Catania G, Engh A. NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities, Version 1.2020. J Natl Compr Canc Netw. 2020 Mar;18(3):230-241. doi: 10.6004/jnccn.2020.0012. PMID: 32135517.
- Park SI, Shea TC, Olajide O, Reddy NM, Budde LE, Ghosh N, Deal AM, Noe JF, Ansell SM. ABVD followed by BV consolidation in risk-stratified patients with limited-stage Hodgkin lymphoma. Blood Adv. 2020 Jun 9;4(11):2548-2555. doi: 10.1182/bloodadvances.2020001871. PMID: 32516414; PMCID: PMC7284091.
- Wang X, Huynh C, Urak R, Weng L, Walter M, Lim L, Vyas V, Chang WC, Aguilar B, Brito A, Sarkissian A, Bandara NA, Yang L, Wang J, Wu X, Zhang J, Priceman SJ, Qin H, Kwak LW, Budde LE, Thomas SH, Clark MC, Popplewell L, Siddiqi T, Brown CE, Forman SJ. The cerebroventricular environment modifies CAR T cells for potent activity against both central nervous system and systemic lymphoma. Cancer Immunol Res. 2020 Oct 22: canimm.0236.2020. doi: 10.1158/2326-6066.CIR-20-0236. Epub ahead of print. PMID: 33093217.
- Jacobson CA, Hunter BD, Redd R, Rodig SJ, Chen PH, Wright K, Lipschitz M, Ritz J, Kamihara Y, Armand P, Nikiforow S, Rogalski M, Maakaron J, Jaglowski S, Maus MV, Chen YB, Abramson JS, Kline J, Budde E, Herrera A, Mei M, Cohen JB, Smith SD, Maloney DG, Gopal AK, Frigault MJ, Acharya UH. Axicabtagene Ciloleucel in the Non-Trial Setting: Outcomes and Correlates of Response, Resistance, and Toxicity. J Clin Oncol. 2020 Sep 20;38(27):3095-3106. doi: 10.1200/JCO.19.02103. Epub 2020 Jul 15. PMID: 32667831; PMCID: PMC7499617.
- Stevens BM, Zhang W, Pollyea DA, Winters A, Gutman J, Smith C, Budde E, Forman SJ, Jordan CT, Purev E. HYPERLINK "https://www.ncbi.nlm.nih.gov/pubmed/31136781" CD123 CAR T cells for the treatment of myelodysplastic syndrome. Exp Hematol. 2019
- Budde LE, Wu D, Martin DB, Philip M, Shustov AR, Smith SD, Gooley TA, Chen TL, Libby EN, Chen EY, Kojouri K, Publications Langerak A, Roden JE, Press OW, Gopal AK. Bendamustine with rituximab, etoposide and carboplatin (T(R)EC) in relapsed or refractory aggressive lymphoma: a prospective multicentre phase 1/2 clinical trial. Br J Haematol. 2018 Nov;183(4):601-607. doi: 10.1111/bjh.15585. Epub 2018 Sep 14. PMID: 30596402; PMCID: PMC6314205.
- Xue T, *Budde LE. Immunotherapies Targeting CD123 for Blastic Plasmacytoid Dendritic Cell Neoplasm. Hematol Oncol Clin North Am. 2020 Jun;34(3):575-587. doi: 10.1016/j.hoc.2020.01.006. Epub 2020 Mar 27. PMID: 32336421. *corresponding author
- Langerak A, Roden JE, Press OW, Gopal AK. Bendamustine with rituximab, etoposide and carboplatin (T(R)EC) in relapsed or refractory aggressive lymphoma: a prospective multicentre phase 1/2 clinical trial. Br J Haematol. 2018 Nov;183(4):601-607. doi: 10.1111/bjh.15585. Epub 2018 Sep 14. PMID: 30596402; PMCID: PMC6314205.
- Dulan SO, Viers KL, Wagner JR, Clark M, Chang B, Gorospe GL, Londrc A, Brown AS, Rosenthal J, Smith EP, Forman SJ, Snyder DA, *Budde LE. Developing and Monitoring a Standard-of-Care Chimeric Antigen Receptor (CAR) T Cell Clinical Quality and Regulatory Program Biol Blood Marrow Transplant 2020;26(8):1386-1393. *corresponding author
- Xue T, *Budde LE. Immunotherapies Targeting CD123 for Blastic Plasmacytoid Dendritic Cell Neoplasm. Hematol Oncol Clin North Am. 2020 Jun;34(3):575-587. doi: 10.1016/j.hoc.2020.01.006. Epub 2020 Mar 27. PMID: 32336421. *corresponding author
- Kumar A, Casulo C, Advani RH, Budde E, Barr PM, Batlevi CL, Caron P, Constine LS, Dandapani SV, Drill E, Drullinsky P, Friedberg JW, Grieve C, Hamilton A, Hamlin PA, Hoppe RT, Horwitz SM, Joseph A, Khan N, Laraque L, Matasar MJ, Moskowitz AJ, Noy A, Palomba ML, Schöder H, Straus DJ, Vemuri S, Yang J, Younes A, Zelenetz AD, Yahalom J, Moskowitz CH. Brentuximab Vedotin Combined With Chemotherapy in Patients With Newly Diagnosed Early-Stage, Unfavorable-Risk Hodgkin Lymphoma. J Clin Oncol. 2021 Jul 10;39(20):2257-2265. doi: 10.1200/JCO.21.00108. Epub 2021 Apr 28. PMID: 33909449.
- Wang X, Huynh C, Urak R, Weng L, Walter M, Lim L, Vyas V, Chang WC, Aguilar B, Brito A, Sarkissian A, Bandara NA, Yang L, Wang J, Wu X, Zhang J, Priceman SJ, Qin H, Kwak LW, Budde LE, Thomas SH, Clark MC, Popplewell L, Siddiqi T, Brown CE, Forman SJ. The cerebroventricular environment modifies CAR T cells for potent activity against both central nervous system and systemic lymphoma. Cancer Immunol Res. 2020 Oct 22: canimm.0236.2020. doi: 10.1158/2326-6066.CIR-20-0236. Epub ahead of print. PMID: 33093217.
- Jacobson CA, Hunter BD, Redd R, Rodig SJ, Chen PH, Wright K, Lipschitz M, Ritz J, Kamihara Y, Armand P, Nikiforow S, Rogalski M, Maakaron J, Jaglowski S, Maus MV, Chen YB, Abramson JS, Kline J, Budde E, Herrera A, Mei M, Cohen JB, Smith SD, Maloney DG, Gopal AK, Frigault MJ, Acharya UH. Axicabtagene Ciloleucel in the Non-Trial Setting: Outcomes and Correlates of Response, Resistance, and Toxicity. J Clin Oncol. 2020 Sep 20;38(27):3095-3106. doi: 10.1200/JCO.19.02103. Epub 2020 Jul 15. PMID: 32667831; PMCID: PMC7499617.
- Park SI, Shea TC, Olajide O, Reddy NM, Budde LE, Ghosh N, Deal AM, Noe JF, Ansell SM. ABVD followed by BV consolidation in risk-stratified patients with limited-stage Hodgkin lymphoma. Blood Adv. 2020 Jun 9;4(11):2548-2555. doi: 10.1182/bloodadvances.2020001871. PMID: 32516414; PMCID: PMC7284091.
- Thompson JA, Schneider BJ, Brahmer J, Andrews S, Armand P, Bhatia S, Budde LE, Costa L, Davies M, Dunnington D, Ernstoff MS, Frigault M, Kaffenberger BH, Lunning M, McGettigan S, McPherson J, Mohindra NA, Naidoo J, Olszanski AJ, Oluwole O, Patel SP, Pennell N, Reddy S, Ryder M, Santomasso B, Shofer S, Sosman JA, Wang Y, Weight RM, Johnson-Chilla A, Zuccarino-Catania G, Engh A. NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities, Version 1.2020. J Natl Compr Canc Netw. 2020 Mar;18(3):230-241. doi: 10.6004/jnccn.2020.0012. PMID: 32135517.
- Stevens BM, Zhang W, Pollyea DA, Winters A, Gutman J, Smith C, Budde E, Forman SJ, Jordan CT, Purev E. HYPERLINK CD123 CAR T cells for the treatment of myelodysplastic syndrome. Exp Hematol. 2019 Jun;74:52-63.