Dr. Huang earned his Ph.D. in the Department of Molecular Genetics with Dr. Benoit de Crombrugghe at the University of Texas M.D. Anderson Cancer Center, followed by a postdoctoral fellowship with Dr. David Moore at Baylor College of Medicine. Dr. Huang joined City of Hope in 2005 and is now a senior faculty member in the Department of Diabetes Complications and Metabolism of the Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope. He is also adjunct professor in the Center of Liver Diseases at the Keck School of Medicine at University of Southern California.
Dr. Huang is the associate editor and academic editor for a number of journals. He has served on both national and international grant review panels. He has received several research awards, including the Research Scholar Award from the American Cancer Society, the Concern Foundation Award, the Kimmel Scholar Award from the Sidney Kimmel Foundation for Cancer Research, and the March of Dimes Basil O’Connor Starter Scholar Research Award.
2000, Ph.D., Molecular Genetics, University of Texas Houston Health Science Center and M.D. Anderson Cancer Center
2000-2005, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX
2016-present, Professor, Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes & Metabolism Research Institute and Beckman Research Institute of City of Hope, Duarte, CA
2010-2016, Associate Professor, Division of Molecular Diabetes Research, Beckman Research Institute of City of Hope, Duarte, CA
2008-present, Adjunct Faculty, Department of Biochemistry & Molecular Biology, USC Norris Comprehensive Cancer Center, Los Angeles, CA
2005-2010, Assistant Professor, Division of Gene Regulation and Drug Discovery, Beckman Research Institute of City of Hope, Duarte, CA
Metabolic regulation in Diabetes and cancer
We are interested in the molecular mechanisms underlying metabolism and cancer. One focus of the lab is to understand the function of nuclear receptors. Nuclear receptors are activated by their cognate ligands to alter transcription. Certain nuclear receptors were found to play pivotal roles in regulating a number of metabolic pathways. These nuclear receptors work as sensors of metabolic signals and regulate the expression of essential genes. Studies in this area have suggested that these factors may significantly impact human diseases such as diabetes, obesity and cancer. A second focus of the lab is to identify and characterize novel signaling pathways in metabolism and cancer through genetic and epigenetic approaches. We have identified novel miRNA-mediated pathways in metabolic diseases as well as in cancer growth and metastasis. Transgenic mouse models of these miRNAs have been generated to further study their roles in obesity, diabetes and cancer development. Moreover, we screen and identify novel small chemical compounds to target diabetes and cancer. The long-term goal is to identify novel signaling pathways in metabolism and cancer in order to provide new targets for drug discovery. Current research projects include:
Identification of novel signaling molecules and pathways in regulating metabolism, diabetes and cancer.
Small molecules and RNA-targeted therapy for diabetes and cancer.
Mechanisms underlying the effects of bariatric surgery on metabolic syndrome and diabetes.
Awards & Memberships
2011, Research Scholar Award, American Cancer Society
2008, Ibrahim El-hefni Technical Training Foundation Award (TTF)
2008, Concern Foundation Award
2007, Kimmel Scholar Award, Sidney Kimmel Foundation for Cancer Research
2007, March of Dimes Basil O’Connor Starter Scholar Research Award
American Association of Cancer Research
International Society for the Study of Xenobiotics
SELECTED PUBLICATIONS (from over 110 total publications)
Fu XH, Dong BN, Tian Y, Lefebvre P, Meng Z, Wang X, Pattou F, Han W, Wang X, Lou F, Jove R, Staels B, Moore DD, Huang W. (2015) MiR-26a regulates insulin sensitivity and metabolism of glucose and lipids. J. Clin. Invest. 125(6):2497-509. PMC – in process
Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold M, Moore DD. (2015) Activating CAR and β-Catenin Induces Uncontrolled Liver Growth and Tumorigenesis. Nat Comm. 6:5944.
Pan RL, Xiang LX, Wang P, Liu XY, Nie L, Huang W* and Shao JZ*. (2015) FGF2lmw attenuates hepatic fibrosis via epigenetic downregulation of Delta-like1. Hepatology 61(5):1708-20. (*co-correspondent author)
Fu XH, Jin L, Wang XC, Hu JK, Zheng XW, Tsark WM, Riggs AD, Ku HT, Huang W. (2013) MiR-26a targets TET enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci. 110(44):17892-7.
Chen T, Meng Z, Gan Y, Wang X, Gu Y, Xu X, Tang J, Zhou H, Zhang X, Gan X, Van Ness C, Xu F, Xu G, Huang L, Zhang X, Fang Y, Zheng S, Jin J, Huang W*, Xu R*. (2013) The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells. Leukemia 27(7):1469-78. (*co-correspondent author)
Chen WD, Fu X, Dong B, Wang YD, Shiah S, Moore DD, Huang W. (2012). Epigenetic misprogramming mediated by the xenobiotic receptor CAR results in permanent changes of drug metabolism in mouse liver. Hepatology. 56(4):1499-509. PMID: 22488010
Lee CG, Kim YW, Kim EH, Meng Z, Huang W, Hwang SJ, Kim SG. (2012). FXR Protects Hepatocytes from Injury by Repressing miR-199a-3p, which Increases Levels of LKB1. Gastroenterology. PMID: 22265968
Wang YD, Chen WD, Yu D, Forman BM, Huang W. (2011). The G-protein coupled bile acid receptor Gpbar1 (TGR5) negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappaB. Hepatology. 54(4):1421-32. PMID: 21735468.
Meng, Z., Liu, N., Fu, X., Wang, X., Zhang, L., Chen, W., Wang, Y., Forman, B.M., Huang, W. (2011). Insufficient bile acid signaling impairs liver repair in CYP27 knockout mice. J. Hepatol. 55(4):885-95. PMID: 21334403
Meng Z., Fu X., Chen X, Zeng S., Tian Y., Jove R., Xu R., Huang W. (2010). miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells. Hepatology. 52:2148-57. PMID: 20979124
Chen W., Wang Y., Zhang L., Shiah S., Wang M., Yang F., Yu D., Forman B.M. and Huang W. (2009). Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology. 51:953-62. PMID: 19998409
Wang Y., Chen W., Huang M., Yu D., Forman B.M., and Huang, W. (2008) Farnesoid X receptor antagonizes NF-kB in hepatic inflammatory response. Hepatology 48:1632-43. PMID: 18972444
Wang Y., Chen W., Moore D.D., and Huang, W. (2008) FXR - metabolic regulator and cell protector. Cell Res. 18:1087-95. PMID: 18825165
Murphy M.J., Blanco-Bose W.E., Ehninger A, Offner S., Dubey C., Huang W., Moore D.D., and Trumpp A. (2008) c-Myc and its target FoxM1b are critical downstream effectors of TCPOBOP-CAR induced direct liver hyperplasia. Hepatology 48:1302-11. PMID: 18798339
Yang F., Huang X., Yi T., Yen Y., Moore D.D., and Huang W. (2007) Spontaneous development of liver tumors in the absence of the bile acid receptor Farnesoid X Receptor. Cancer Res. 67: 863-867.
Baskin-Bey E., Huang W., Ishimura N., Bronk S.F., Werneburg N., Moore D.D., and Gores G. J. (2006) Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 44:252-262.
Huang W., Ma K., Zhang J., Qatanani M., Cuvillier J., Liu J., Dong B., Huang X., and Moore D.D. (2006) Nuclear receptor dependent bile acid signaling is required for normal liver regeneration. Science(Article) 312:233-236.
Columbano A., Ledda-Columbano G.M., Pibiri M., Cossu C., Menegazzi M., Moore D.D., Huang W., Tian J., and Locker J. (2005) GADD45b is induced through a CAR-dependent TNF-independent pathway in liver hyperplasia. Hepatology 42, 1118-1126.
Huang W., Zhang J., and Moore D.D. (2004) A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J. Clin. Invest. 113, 137-143. Comment in: Dev.cell 2004 Mar;46(3):539-40.
Huang W.*, Zhang J.*, Chua S.S., Qatanani M., Hang Y., Granata R., and Moore D.D. (2003) Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc.Natl.Acad.Sci. USA 100, 4156-4161. (*co-first author)
Zhang J.*, Huang W.*, Chua S.S., Wei P., and Moore D.D. (2002) Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 298, 422-424. (*co-first author)
Bi W., Huang W., Whitworth D.J., Deng J., Zhang Z., Behringer R.R., and de Crombrugghe B. (2001). Haploinsufficiency of Sox9 results in defective precartilaginous mesenchymal condensations and premature skeletal mineralization. Proc.Natl.Acad.Sci. USA 98, 6698-6703.
Huang W., Chung U., Kronenberg H.M., and de Crombrugghe B. (2001). The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc.Natl.Acad.Sci. USA 98, 160-165.