Zhen Bouman Chen, Ph.D.
Built upon her interdisciplinary training in medicine, vascular biology, bioengineering and data science, Dr. Chen leads an active research program focused on noncoding RNAs and endothelial stress response. Her team integrates innovative high-throughput sequencing technologies, bioinformatics approaches, and multi-scale models to elucidate RNA-mediated endothelial biology in the context of diabetes. Dr. Chen is passionate about mentorship and peer support and has served as a member on the Women Leadership Committee of the Arteriosclerosis, Thrombosis, and Vascular Biology Council of the AHA and is currently the Vice-Chair of the committee.
Location
Duarte Cancer Center
Duarte, CA 91010
Education & Experience
2021, Certificate, University of California San Diego Extension, Data Science and Visualization
2010, Ph.D., Biomedical Sciences, University of California Riverside, Riverside, CA
2005, B.S., Basic Medical Sciences, Peking University Health Science Center, China
2021-present, Associate Professor, Department of Diabetes Complications & Metabolism, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA
2016-2021, Assistant Professor, Department of Diabetes Complications & Metabolism, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA
2012-2016, Postdoctoral scholar, Division of Cardiology, University of California San Diego, La Jolla, CA
2010-2012 Postdoctoral scholar, Division of Biomedical Sciences, University of California Riverside, Riverside, CA
2010, Visiting Scholar, Genomics Research Center, Academia, Sinica, Taiwan
2006-2010, Ph.D. Candidate, Division of Biomedical Sciences, University of California Riverside, Riverside, CA
2004-2005, Undergraduate Research Assistant, Department of Physiology and Diabetes Center, Peking University Health Science Center, China
Awards & Memberships
Awards
2024, National Heart, Lung, and Blood Institute R35 Emerging Investigator Award
2023, Chinese American Diabetes Association, Young Investigator Award
2020, North American Vascular Biology Organization, Springer Junior Investigator Award
2018, New Investigator Award, American Physiological Society-Cardiovascular Section
2014, Best of American Heart Association Specialty Conference: Arteriosclerosis, Thrombosis, and Vascular Biology
2014, Junior Investigator Award for Women finalist, American Heart Association Arteriosclerosis, Thrombosis, and Vascular Biology Council
2014, K99 Career Development Award (K99HL122368), National Institutes of Health
2011, Postdoctoral Fellowship (11POST7590128), American Heart Association Western States Affiliate Research Programs
2010, Outstanding Achievement Award in Biomedical Sciences, University of California Riverside
2007, Joy K. Tilton Cancer Research Award, University of California Riverside
2005, Best Thesis, Institute of Basic Medical Sciences, Peking University, Health Science Center
Memberships
Member and Vice-Chair, Women's Leadership Committee of the Council on Arteriosclerosis, Thrombosis and Vascular Biology, American Heart Association
Member, Editorial Advisory Board, Life Sciences
Member, Editorial Advisory Board, American Journal of Physiology-Cell Physiology
Member, American Heart Association
Member, American Diabetes Association
Member, American Physiological Society
Member, American Society of Biochemistry and Molecular Biology
Publications
- Huang H-C, Wang T-Y, Rousseau J, Orlando M, Mungaray M, Michaud C, Plaisier C, Bouman Chen Z, Wang K-C. Biomimetic nanodrug targets inflammation and Suppresses YAP/TAZ to Ameliorate Atherosclerosis. Biomaterials. 2024.
- Chen L-J, Yi J-YS, Nguyen P, He M, Bouman Chen Z, Subramaniam S, Shyy J-YJ, Chien S. Single-cell RNA sequencing unveils unique transcriptomic signatures of endothelial cells and role of ENO1 in response to disturbed Flow. Proceedings of the National Academy of Sciences. 2024.
- Sriram K, Qi Z, Yuan D, Malhi NK, Liu X, Calandrelli R, Luo Y, Tapia A, Jin S, Shi J, Salas M, Dang R, Armstrong B, Priceman SJ, Wang PH, Liao J, Natarajan R., Zhong S, Bouman Chen Z. Regulation of nuclear transcription by mitochondrial RNA in endothelial Cells. eLife. 2024.
- Malhi NK, Southerland KW, Lai L, Bouman Chen Z. Epigenetic regulation of angiogenesis in peripheral artery disease. Methodist DeBakey Cardiovascular Journal. 2023.
- Heon S, Leung A, Costello KR, Senapati P, Kato H, Moore RE, Lee M, Lin D, Tang X, Pirrotte P, Bouman Chen Z, Schones DE. Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome. eLife. 2023.
- Tang X, Lai CH, Malhi NK, Chadha R, Luo Y, Liu X, Yuan D, Tapia A, Abdollahi M, Zhang G, Calandrelli R, Shiu YT, Wang ZV, Rhee JW, Zhong S, Natarajan R, Bouman Chen Z. Genetic Deletion of the LINC00520 Homolog in mouse aggravates angiotensin II-Induced hypertension. Non-coding RNA. 2023.
- Furuta K, Tang X, Islam S, Tapia A, Bouman Chen Z, Ibrahim SH. Endotheliopathy in the metabolic syndrome: mechanisms and clinical implications. Pharmacology & therapeutics. 2023.
- Bouman Chen Z, He M, Yi J-S, Shyy J-YJ, Chien S. Epitranscriptional Regulation: From the perspectives of cardiovascular bioengineering. Annual review of biomedical engineering. 2023.
- Deng J, Jiang Y, Bouman Chen Z, Rhee J-W, Deng Y, Wang ZV. Mitochondrial dysfunction in cardiac arrhythmias. cells. 2023.
- Tang X, Luo Y, Yuan D, Calandrelli R, Malhi MK, Sriram K, Miao Y, Lou CH, Tsark W, Tapia A, Chen AT, Zhang G, Roeth D, Kalkum M, Wang ZV, Chien S, Natarajan R, Cooke JP, Zhong S, Bouman Chen Z. Long Non-Coding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models. J Clin invest. 2023.