The focus of our lab is to determine the molecular mechanisms that promote inflammation, and vascular and renal complications in diabetes. In this regard, we focus on the role of epigenetics and noncoding RNAs. We have an interest in learning how prior hyperglycemia-associated epigenetic changes can impart metabolic memory and lead to gene malfunction and organ disease despite restoration of glucose balance. Our group uses state-of-the-art genomic approaches in cell culture, animal and clinical models to examine these mechanisms, and develop innovative therapeutic interventions for diabetic complications.
Built upon her interdisciplinary training in medicine, vascular biology, bioengineering and data science, Zhen Chen, M.D., Ph.D, leads an active research program focused on noncoding RNAs and endothelial stress response.
Duarte, CA 91010