Lab members

Center for Bioinnovation and Manufacturing

The Center for Bioinnovation and Manufacturing is dedicated to facilitating Phase 1 or 2 clinical trial development of innovative biologics through collaboration or contract with academic and corporate groups across the United States.

The Center for Bioinnovation and Manufacturing (CBM) at City of Hope® collaborates with academic and industry partners in both the clinical and biopharmaceutical fields to translate leading-edge research into real-world solutions.

CBM is a not-for-profit center that focuses on translating innovative therapies to Phase 1 and 2 clinical trials. The CBM includes process and analytical development, Good Manufacturing Practice (GMP), quality control and quality assurance teams, as well as the Office of IND Development and Regulatory Affairs. Its laboratories include three development labs, two GMP facilities and support spaces, which together span over 30,000 square feet.

History of Our Center

Founded in 2000, the GMP capabilities at City of Hope started with lentivirus productions, which later were expanded to include other viral technologies. Over the past decade, the CBM has expanded GMP capabilities to include stem cell products, projects largely funded by the California Institute for Regenerative Medicine. As one of the most extensive and advanced cancer research and treatment organizations in the United States, we annually manufacture a large number of CAR T therapies to treat patients.

CBM Capabilities

The CBM offers support for the entire bioinnovation lifecycle, from process development to scale-up, manufacturing, quality control, quality assurance and regulatory affairs. Through partnerships with leading biotech companies and academic institutions nationwide, the CBM has helped accelerate the translation of state-of-the-art biotechnologies to clinical trials. In 2024, we continued our high level of productivity, resulting in the following outcomes:

30 ongoing projects
ONGOING PROJECTS
23 active CGT inds
Active Cell and Gene Therapy INDS
90 MFG productions
Manufacturing Productions
16 external sponsors
EXTERNAL SPONSORS
8 FDA master files
FDA MASTER FILES
CAR T cell therapy productions
CAR T CELL THERAPY PRODUCTIONS

Explore the Center

Innovation Lab

The Innovation Lab at City of Hope’s Center for Bioinnovation and Manufacturing works to develop new cellular GMP therapies for cancer patients.

Development Projects

The Center for Bioinnovation and Manufacturing at City of Hope consistently engages in development projects to further scientific breakthroughs. 

GMP

City of Hope’s Center for Bioinnovation and Manufacturing collaborates with key partners to develop innovative biologics for clinical trials.

Contact the Center for Bioinnovation and Manufacturing

For clinical researchers or private industry partners interested in collaborating with the center
Email [email protected]