Department of Diabetes & Cancer Metabolism

Founded in 2020, the Department of Diabetes & Cancer Metabolism at City of Hope is the first of its kind anywhere in the world. Pursuing cutting-edge science to improve the human condition, we focus on diabesity and cancer as constellations of disease that dysregulate the allocation of resources and that can be better diagnosed and treated through analysis of metabolism.

City of Hope is the ideal home for our department, with its international reputation as a leader in research and care for cancer and diabetes. Accordingly, our work connects investigations in the Comprehensive Cancer Center and the Arthur Riggs Diabetes & Metabolism Research Institute. Driven to turn laboratory discoveries into solutions that will benefit patients, we collaborate with colleagues in the City of Hope National Medical Center on clinical research.
Our department is located on the newly remodeled second floor of the Fox North building on City of Hope’s Duarte campus, close to state-of-the-art shared resources. We mentor the next generation of innovative biomedical investigators by participating in the Irell & Manella Graduate School of Biological Sciences and the Postdoctoral Training Office.


Charles Brenner, Ph.D.
Charles Brenner, Ph.D.
Alfred E. Mann Family Foundation Chair in Diabetes and Cancer Metabolism; Professor, Department of Diabetes & Cancer Metabolism

The Brennar Lab dissects the disturbances of the four nicotinamide adenine dinucleotide (NAD) coenzymes — the central catalysts of metabolism — to develop tools that improve health. 

Yingfeng Deng CV
Yingfeng Deng, Ph.D.
Assistant Professor, Department of Diabetes, & Cancer Metabolism

The Deng laboratory studies the homeostasis of uridine and its role in metabolism, which provides a new angle for understanding the pathophysiology of obesity, diabetes and cancer. 

Sarah Shuck, Ph.D.
Sarah Shuck, Ph.D.
Assistant Professor, Department of Diabetes & Cancer Metabolism, Arthur Riggs Diabetes & Metabolism Institute

The Sarah Shuck lab is investigating the biochemistry involved when excess sugar damages important molecules such as proteins and DNA.

Zhao Wang
Zhao Wang, Ph.D.
Associate Professor, Diabetes & Cancer Metabolism

The Zhao Wang lab focuses on pathological cardiac remodeling due to cardiac hypertrophy, heart failure, cancer treatment, myocardial infarction, senescence and diabetes.