Levine-Riggs Diabetes Research Symposium Program

Tuesday, November 29, 2022

6:00 pm

Registration

Epigenetics Round Table

Moderator: Jack Shively, Ph.D., City of Hope, Duarte, CA

6:30 pm to 7:30 pm

Sarah Elgin, Ph.D., Washington University in St. Louis, St. Louis, MO

Gerd Pfeifer, Ph.D., Van Andel Institute, Grand Rapids, MI

Peter Jones, Ph.D., Van Andel Institute, Grand Rapids, MI

7:30 pm

Symposium Dinner

 

Wednesday, November 30, 2022

7:00 am

Registration and Breakfast

Session 1: Epigenetics Meets Genomics: The Big Picture

Moderators: Rama Natarajan, Ph.D., City of Hope, Duarte, CA and Zhen Bouman Chen, Ph.D., City of Hope, Duarte, CA

8:00 am to 10:00 am

Liver chromatin accessibility and cardiometabolic traits

Karen Mohlke, Ph.D., University of North Carolina, Chapel Hill, NC

Epigenomic integrative analysis of aberrant transcriptional programming in chronic kidney disease

Katalin Susztak, M.D., Ph.D., Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Molecular/cellular and computational analysis of non-coding genome in T2D

Stephen Parker, Ph.D., University of Michigan, Ann Arbor, MI

Cellular and molecular mechanisms of beta-cell failure in T2D

Anna Gloyn, DPhil, Stanford University, Palo Alto, CA

10:00 am

Refreshment Break

Session 2: GWAS/Epigenetics of T1D

Moderators: Stephen Rich, Ph.D., University of Virginia School of Medicine, Charlottesville, VA and 

John Kaddis, Ph.D., City of Hope, Duarte, CA

10:15 am to 12:15 pm

Multi-omic analysis applied to T1D

Suna Onengut-Gumuscu, Ph.D., University of Virginia School of Medicine, Charlottesville, VA 

Epigenetics mechanisms underlying metabolic memory of diabetic complications in T1D

Rama Natarajan, Ph.D., City of Hope, Duarte, CA

Genomic and epigenomic approaches for understanding islet (mis)adaptation in diabetes

Klaus Kaestner, Ph.D., University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Genetics and genomics of type 1 diabetes risk in the pancreas

Kyle Gaulton, Ph.D., University of California San Diego, San Diego, CA

12:15 pm

Lunch Break

Session 3: GWAS/Epigenetics of T2D

Moderators: Stephen Parker, Ph.D., University of Michigan, Ann Arbor, MI and Rama Natarajan, Ph.D., City of Hope, Duarte, CA

1:45 pm to 3:25 pm

Genetic origins of type 2 diabetes in Southwestern American Indian pedigrees

Leslie Baier, Ph.D., NIDDK, NIH, Phoenix, AZ

Epigenetics in beta cell development

Sangeeta Dhawan, Ph.D., City of Hope, Duarte, CA

Epigenetics of human beta cells and insulinomas

Esra Karakose, Ph.D., Icahn School of Medicine at Mount Sinai, New York, NY

Molecular mechanisms of T2D GWAS in pancreatic islet cell types

Michael Stitzel, Ph.D., The Jackson Laboratory for Genomic Medicine, Farmington, CT

Genomic and epigenomic analysis of primary pancreatic cells

H. Efsun Arda, Ph.D., NCI Center for Cancer Research, Bethesda, MD

4:10 pm

Refreshment Break 

Session 4: The Beta Cell in T1D

Moderators: Lori Sussel, Ph.D., Barbara Davis Center, Aurora, CO and Rupangi Vasavada, Ph.D., City of Hope, Duarte, CA

4:25 pm to 6:25 pm

In vivo imaging of islet autophagy

Amelia Linnemann, Ph.D., Indiana University School of Medicine, Indianapolis, IN 

Senescence

Peter Thompson, Ph.D., University of Manitoba, Canada

Retrograde mitochondrial control of beta cell identity and maturity

Scott Soleimanpour, M.D., University of Michigan, Ann Arbor, MI

New adventures for old proteins in metabolic regulation

Debbie Thurmond, Ph.D., City of Hope, Duarte, CA

Profiling of beta cells in T1D

Peter Linsley, Ph.D., Benaroya Research Institute at Virginia Mason, Seattle, WA

 

Thursday, December 1, 2022

7:30 am

Registration and Breakfast

Session 1: Developing Human Pancreas (pre and post natal)

Moderators: Sangeeta Dhawan, Ph.D., City of Hope, Duarte, CA and Ben Shih, Ph.D., City of Hope, Duarte, CA

8:00 am to 10:00 am

ES cell and iPS cell fate decisions for generating endoderm patterning for the pancreas

Paul Gadue, Ph.D., Children’s Hospital of Philadelphia, Philadelphia, PA 

Islet niche and imaging, stem cell differentiation to functional beta cells

Julie Sneddon, Ph.D., University of California San Francisco, San Francisco, CA

Biology of pancreatic islets, development, and regulation of islet function

Marcela Brissova, Ph.D., Vanderbilt University Medical Center, Nashville, TN

IPS to beta cell generation

Shuibing Chen, Ph.D., Weill Cornell Medicine, New York, NY

10:00 am

Refreshment Break

Rachmiel Levine Award Lecture

Moderator: Fouad Kandeel, M.D., Ph.D., City of Hope, Duarte, CA

10:15 am

Finding a way forward despite unplanned sharp turns

David Harlan, M.D., University of Massachusetts Medical School, Worcester, MA

10:55 am

Q&A

Session 2: RNA Biology in Diabetes

Moderators: Lori Sussel, Ph.D., Barbara Davis Center, Aurora, CO and Wendong Huang, Ph.D., City of Hope, Duarte, CA

11:00 am to 12:35 pm

RNA binding proteins and RNA processing: Updates on systems biology approaches

Gene Yeo, Ph.D., University of California San Diego, La Jolla, CA

Shedding light on the dark matter: Noncoding RNA-mediated endothelialopathy in diabetes

Zhen Bouman Chen, Ph.D., City of Hope, Duarte, CA

LncRNAs and alternative splicing in glucose homeostasis

Lori Sussel, Ph.D., Barbara Davis Center, Aurora, CO

12:35 pm

Lunch Break

Session 3: Functional Imaging of the Pancreas

Moderators: Mark Huising, Ph.D., University of California Davis, Davis, CA and Debbie Thurmond, Ph.D., City of Hope, Duarte, CA

2:00 pm to 4:00 pm

Beta cell functional heterogeneity

Richard Benninger, Ph.D., University of Colorado Denver, Anschutz Medical Campus, Aurora, CO

Integrated functional imaging of islet communication

Mark Huising, Ph.D., University of California Davis, Davis, CA

Focus on the dynamics of insulin secretory granule secretion

Melkam Kebede, Ph.D., The University of Sydney, Australia

Visualization of innervation of pancreatic islets

Sarah Stanley, MBBCh, Ph.D., Icahn School of Medicine at Mount Sinai, New York, NY

4:00 pm

Refreshment Break 

Session 4: Functional Assessments of Stem Cell-Derived Beta Cells in Comparison to Human Beta Cells

Moderators: Charles Brenner, Ph.D., City of Hope, Duarte, CA and Ping Wang, M.D., City of Hope, Duarte, CA

4:15 pm to 6:50 pm

Islet transplantation/Gastrin in T1D

Fouad Kandeel, M.D., Ph.D., City of Hope, Duarte, CA

Generating beta cells from stem cells: Gene regulatory maps help pave the way

Maike Sander, M.D., University of California San Diego, La Jolla, CA

More than one way to create a functional human beta cell in a dish?

Jeffrey Millman, Ph.D., Washington University School of Medicine, St. Louis, MO

FDA’s current considerations for islet cell studies

Patricia Beaston, M.D., Ph.D., Food and Drug Administration, Silver Spring, MD

 

Friday, December 2, 2022

6:30 am

Registration and Breakfast

Session 1: Autoimmunity of T1D

Moderators: Mark Anderson, M.D., Ph.D., University of California San Francisco, San Francisco, CA and 

Defu Zeng, M.D., City of Hope, Duarte, CA

7:00 am to 8:40 am

3D genome organization in primary immune cells related to T1D

Golnaz Vahedi, Ph.D., University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Autoimmunity in T1D

Mark Anderson, M.D., Ph.D., University of California San Francisco, San Francisco, CA

Myeloid cell function in islet autoimmunity: Gatekeepers, instigators, and peacekeepers

Rachel Friedman, Ph.D., University of Colorado, Barbara Davis Center, Aurora, CO

Rethinking old paradigms

Mia Smith, Ph.D., DVM, University of Colorado, Barbara Davis Center, Aurora, CO

9:00 am

Refreshment Break

Arthur Riggs Award Lecture

Moderator: Fouad Kandeel, M.D., Ph.D., City of Hope, Duarte, CA

9:15 am

Andrew Stewart, M.D., Icahn School of Medicine at Mount Sinai, New York, NY

9:55 am

Q&A

Debate: Current Challenges in T1D prevention

Moderator: David Harlan, M.D., University of Massachusetts Medical School, Worcester, MA

10:00 am to 11:15 am

Anette-Gabriele Ziegler, M.D., Ph.D., Helmholtz Zentrum München, Germany

Marian Rewers, M.D., Ph.D., University of Colorado, Barbara Davis Center, Aurora, CO

11:15 am

Refreshment Break 

Session 2: Precision Medicine in T1D: Tailoring Therapeutic Strategies to Patients

Moderators: David Harlan, M.D., University of Massachusetts Medical School, Worcester, MA and

Fouad Kandeel, M.D., Ph.D., City of Hope, Duarte, CA

11:30 am to 1:30 pm

Applying metabolic analyses to type 1 diabetes prevention efforts

Emily Sims, M.D., Indiana University School of Medicine, Indianapolis, IN

Immune cloaking stem cell derived beta cells for transplantation

Jon Odorico, M.D., University of Wisconsin School of Medicine, Madison, WI

CAR T-cell

James Riley, Ph.D., Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Engineering Tregs for T1D

Qizhi Tang, Ph.D., University of California San Francisco, San Francisco, CA