Levine-Riggs Diabetes Research Symposium Program
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Tuesday, November 29, 2022 |
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6:00 pm |
Registration |
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Epigenetics Round Table Moderator: Jack Shively, Ph.D., City of Hope, Duarte, CA |
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6:30 pm to 7:30 pm |
Sarah Elgin, Ph.D., Washington University in St. Louis, St. Louis, MO |
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Gerd Pfeifer, Ph.D., Van Andel Institute, Grand Rapids, MI |
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Peter Jones, Ph.D., |
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7:30 pm |
Symposium Dinner |
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Wednesday, November 30, 2022 |
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7:00 am |
Registration and Breakfast |
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Session 1: Epigenetics Meets Genomics: The Big Picture Moderators: Rama Natarajan, Ph.D., City of Hope, Duarte, CA and Zhen Bouman Chen, Ph.D., City of Hope, Duarte, CA |
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8:00 am to 10:00 am |
Liver chromatin accessibility and cardiometabolic traits |
Karen Mohlke, Ph.D., University of North Carolina, Chapel Hill, NC |
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Epigenomic integrative analysis of aberrant transcriptional programming in chronic kidney disease |
Katalin Susztak, M.D., Ph.D., Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA |
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Molecular/cellular and computational analysis of non-coding genome in T2D |
Stephen Parker, Ph.D., University of Michigan, Ann Arbor, MI |
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Cellular and molecular mechanisms of beta-cell failure in T2D |
Anna Gloyn, DPhil, Stanford University, Palo Alto, CA |
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10:00 am |
Refreshment Break |
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Session 2: GWAS/Epigenetics of T1D Moderators: Stephen Rich, Ph.D., University of Virginia School of Medicine, Charlottesville, VA and John Kaddis, Ph.D., City of Hope, Duarte, CA |
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10:15 am to 12:15 pm |
Multi-omic analysis applied to T1D |
Suna Onengut-Gumuscu, Ph.D., University of Virginia School of Medicine, Charlottesville, VA |
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Epigenetics mechanisms underlying metabolic memory of diabetic complications in T1D |
Rama Natarajan, Ph.D., City of Hope, Duarte, CA |
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Genomic and epigenomic approaches for understanding islet (mis)adaptation in diabetes |
Klaus Kaestner, Ph.D., University of Pennsylvania Perelman School of Medicine, Philadelphia, PA |
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Genetics and genomics of type 1 diabetes risk in the pancreas |
Kyle Gaulton, Ph.D., University of California San Diego, San Diego, CA |
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12:15 pm |
Lunch Break |
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Session 3: GWAS/Epigenetics of T2D Moderators: Stephen Parker, Ph.D., University of Michigan, Ann Arbor, MI and Rama Natarajan, Ph.D., City of Hope, Duarte, CA |
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1:45 pm to 3:25 pm |
Genetic origins of type 2 diabetes in Southwestern American Indian pedigrees |
Leslie Baier, Ph.D., NIDDK, NIH, Phoenix, AZ |
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Epigenetics in beta cell development |
Sangeeta Dhawan, Ph.D., City of Hope, Duarte, CA |
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Epigenetics of human beta cells and insulinomas |
Esra Karakose, Ph.D., Icahn School of Medicine at Mount Sinai, New York, NY |
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Molecular mechanisms of T2D GWAS in pancreatic islet cell types |
Michael Stitzel, Ph.D., The Jackson Laboratory for Genomic Medicine, Farmington, CT |
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Genomic and epigenomic analysis of primary pancreatic cells |
H. Efsun Arda, Ph.D., NCI Center for Cancer Research, Bethesda, MD |
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4:10 pm |
Refreshment Break |
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Session 4: The Beta Cell in T1D Moderators: Lori Sussel, Ph.D., Barbara Davis Center, Aurora, CO and Rupangi Vasavada, Ph.D., City of Hope, Duarte, CA |
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4:25 pm to 6:25 pm |
In vivo imaging of islet autophagy |
Amelia Linnemann, Ph.D., Indiana University School of Medicine, Indianapolis, IN |
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Senescence |
Peter Thompson, Ph.D., University of Manitoba, Canada |
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Retrograde mitochondrial control of beta cell identity and maturity |
Scott Soleimanpour, M.D., University of Michigan, Ann Arbor, MI |
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New adventures for old proteins in metabolic regulation |
Debbie Thurmond, Ph.D., City of Hope, Duarte, CA |
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Profiling of beta cells in T1D |
Peter Linsley, Ph.D., Benaroya Research Institute at Virginia Mason, Seattle, WA |
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Thursday, December 1, 2022 |
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7:30 am |
Registration and Breakfast |
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Session 1: Developing Human Pancreas (pre and post natal) Moderators: Sangeeta Dhawan, Ph.D., City of Hope, Duarte, CA and Ben Shih, Ph.D., City of Hope, Duarte, CA |
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8:00 am to 10:00 am |
ES cell and iPS cell fate decisions for generating endoderm patterning for the pancreas |
Paul Gadue, Ph.D., Children’s Hospital of Philadelphia, Philadelphia, PA |
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Islet niche and imaging, stem cell differentiation to functional beta cells |
Julie Sneddon, Ph.D., University of California San Francisco, San Francisco, CA |
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Biology of pancreatic islets, development, and regulation of islet function |
Marcela Brissova, Ph.D., Vanderbilt University Medical Center, Nashville, TN |
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IPS to beta cell generation |
Shuibing Chen, Ph.D., Weill Cornell Medicine, New York, NY |
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10:00 am |
Refreshment Break |
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Rachmiel Levine Award Lecture Moderator: Fouad Kandeel, M.D., Ph.D., City of Hope, Duarte, CA |
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10:15 am |
Finding a way forward despite unplanned sharp turns |
David Harlan, M.D., University of Massachusetts Medical School, Worcester, MA |
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10:55 am |
Q&A |
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Session 2: RNA Biology in Diabetes Moderators: Lori Sussel, Ph.D., Barbara Davis Center, Aurora, CO and Wendong Huang, Ph.D., City of Hope, Duarte, CA |
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11:00 am to 12:35 pm |
RNA binding proteins and RNA processing: Updates on systems biology approaches |
Gene Yeo, Ph.D., University of California San Diego, La Jolla, CA |
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Shedding light on the dark matter: Noncoding RNA-mediated endothelialopathy in diabetes |
Zhen Bouman Chen, Ph.D., City of Hope, Duarte, CA |
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LncRNAs and alternative splicing in glucose homeostasis |
Lori Sussel, Ph.D., Barbara Davis Center, Aurora, CO |
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12:35 pm |
Lunch Break |
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Session 3: Functional Imaging of the Pancreas Moderators: Mark Huising, Ph.D., University of California Davis, Davis, CA and Debbie Thurmond, Ph.D., City of Hope, Duarte, CA |
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2:00 pm to 4:00 pm |
Beta cell functional heterogeneity |
Richard Benninger, Ph.D., University of Colorado Denver, Anschutz Medical Campus, Aurora, CO |
Integrated functional imaging of islet communication |
Mark Huising, Ph.D., University of California Davis, Davis, CA |
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Focus on the dynamics of insulin secretory granule secretion |
Melkam Kebede, Ph.D., The University of Sydney, Australia |
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Visualization of innervation of pancreatic islets |
Sarah Stanley, MBBCh, Ph.D., Icahn School of Medicine at Mount Sinai, New York, NY |
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4:00 pm |
Refreshment Break |
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Session 4: Functional Assessments of Stem Cell-Derived Beta Cells in Comparison to Human Beta Cells Moderators: Charles Brenner, Ph.D., City of Hope, Duarte, CA and Ping Wang, M.D., City of Hope, Duarte, CA |
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4:15 pm to 6:50 pm |
Islet transplantation/Gastrin in T1D |
Fouad Kandeel, M.D., Ph.D., City of Hope, Duarte, CA |
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Generating beta cells from stem cells: Gene regulatory maps help pave the way |
Maike Sander, M.D., University of California San Diego, La Jolla, CA |
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More than one way to create a functional human beta cell in a dish? |
Jeffrey Millman, Ph.D., Washington University School of Medicine, St. Louis, MO |
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FDA’s current considerations for islet cell studies |
Patricia Beaston, M.D., Ph.D., Food and Drug Administration, Silver Spring, MD |
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Friday, December 2, 2022 |
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6:30 am |
Registration and Breakfast |
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Session 1: Autoimmunity of T1D Moderators: Mark Anderson, M.D., Ph.D., University of California San Francisco, San Francisco, CA and Defu Zeng, M.D., City of Hope, Duarte, CA |
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7:00 am to 8:40 am |
3D genome organization in primary immune cells related to T1D |
Golnaz Vahedi, Ph.D., University of Pennsylvania Perelman School of Medicine, Philadelphia, PA |
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Autoimmunity in T1D |
Mark Anderson, M.D., Ph.D., University of California San Francisco, San Francisco, CA |
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Myeloid cell function in islet autoimmunity: Gatekeepers, instigators, and peacekeepers |
Rachel Friedman, Ph.D., University of Colorado, Barbara Davis Center, Aurora, CO |
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Rethinking old paradigms |
Mia Smith, Ph.D., DVM, University of Colorado, Barbara Davis Center, Aurora, CO |
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9:00 am |
Refreshment Break |
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Arthur Riggs Award Lecture Moderator: Fouad Kandeel, M.D., Ph.D., City of Hope, Duarte, CA |
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9:15 am |
Andrew Stewart, M.D., Icahn School of Medicine at Mount Sinai, New York, NY |
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9:55 am |
Q&A |
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Debate: Current Challenges in T1D prevention Moderator: David Harlan, M.D., University of Massachusetts Medical School, Worcester, MA |
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10:00 am to 11:15 am |
Anette-Gabriele Ziegler, M.D., Ph.D., Helmholtz Zentrum München, Germany |
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Marian Rewers, M.D., Ph.D., University of Colorado, Barbara Davis Center, Aurora, CO |
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11:15 am |
Refreshment Break |
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Session 2: Precision Medicine in T1D: Tailoring Therapeutic Strategies to Patients Moderators: David Harlan, M.D., University of Massachusetts Medical School, Worcester, MA and Fouad Kandeel, M.D., Ph.D., City of Hope, Duarte, CA |
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11:30 am to 1:30 pm |
Applying metabolic analyses to type 1 diabetes prevention efforts |
Emily Sims, M.D., Indiana University School of Medicine, Indianapolis, IN |
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Immune cloaking stem cell derived beta cells for transplantation |
Jon Odorico, M.D., University of Wisconsin School of Medicine, Madison, WI |
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CAR T-cell |
James Riley, Ph.D., Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA |
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Engineering Tregs for T1D |
Qizhi Tang, Ph.D., University of California San Francisco, San Francisco, CA |
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