Comprehensive Metabolic Phenotyping
The Comprehensive Metabolic Phenotyping (CMP) Core provides sophisticated metabolic testing in mouse models on a fee-for-service basis. The CMP Core is comprised of expert staff and state-of-the-art equipment to perform a cadre of metabolic tests for both internal and external investigators in both academia and industry. Among the Core equipment are an EchoMRI for body composition analysis, a TSE Systems LabMaster/PhenoMaster system for assessing food and water consumption, locomotor activity, and energy expenditure, a rodent treadmill for forced exercise studies, running wheels in the TSE system for voluntary exercise studies, and two Seahorse systems for metabolic experiments in cells and tissues.
The Core provides a series of in vivo metabolic tests, including glucose, insulin, and pyruvate tolerance test, hyperinsulinemic-euglycemic clamps to assess insulin action, hyperglycemic clamps for measuring insulin secretion, and hypoglycemic clamps for assessing gluco-counterregulation. The CMP Core was established in 2016 with Dr. Patrick Fueger as its founding Director. New services can be offered by the Core at the request of investigators.