2008, Cancer Institute of Zhejiang University, Hangzhou, China, Ph.D. in Medical Oncology
2003, Zhejiang University, Hangzhou, China, B.S. in Biotechnology
2008-2013, Postdoctoral Research Fellow, Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope, Duarte, CA
2020-Present, Associate Professor, Department of Hematologic Malignancies Translational Science, Beckman Research Institute of City of Hope, Duarte, CA
2017-2020, Assistant Professor, Department of Hematologic Malignancies Translational Science, Beckman Research Institute of City of Hope, Duarte, CA
2015-2017, Assistant Professor, Division of Stem Cell and Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA
2013 - 2014, Staff scientist, Division of Stem Cell and Leukemia Research, City of Hope, Duarte, CA
Awards & Memberships
2014-2019, National Cancer Institute's K99/R00 Pathway to Independence Award
2013, ASH Abstract Achievement Award
2011, ASH Abstract Achievement Award
2007-2008, National Competition for National Best Doctoral Thesis, Zhejiang University
American Society of Hematology
American Association of Cancer Research
Peer-reviewed Publications (Selected List)
Li L, Bhatia R. Role of SIRT1 in the Growth and Regulation of Normal Hematopoietic and Leukemia Stem Cells. (2015). Current Opinion in Hematology. 22(4):324-329. [PMCID:PMC4482757]
Wang L, Li L, et al. MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors. Blood.2015;125(8):1302-13. PMID: 25515961
Li L, Osdal T, Ho Y, et al. SIRT1 activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells. (2014). Cell Stem Cell. 15(4), 431-446. [PMCID: PMC430539]
Cook AM, Li L, Ho Y, Lin A, Li L, et al. Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells. Blood. 2014;123:2826-37.
Tian W, Deng Y, Li L, et al. Honokiol synergizes chemotherapy drugs in multidrug resistant breast cancer cells via enhanced apoptosis and additional programmed necrotic death. Int J Oncol. 2013;42:721-32.
Li L, Wang L, Li L, et al. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell. 2012; 21(2), 266–281.(Featured Article)
Yuan H*, Wang Z*, Li L*, et al. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood. 2012; 119(8), 1904-1914 (*equal contribution, co-first author)
Han W, Xie J, Li L, Liu Z, Hu X. Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis. Apoptosis. 2009; 14(5), 674-686.
Chen W, Zhao Z, Li L, et al. Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway. Free Radical Biology & Medicine. 2008; 45(1), 60–72.
Li L, Pan Q, Han W, Liu Z, Li L, Hu X. Schisandrin B Prevents Doxorubicin-induced Cardiotoxicity via Enhancing Glutathione Redox Cycling. Clin Cancer Res. 2007; 13(22 Pt 1), 6753-6760.
Han W, Li L, Qiu S, Lu Q, Pan Q, Gu Y, Luo J, Hu X. Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther. 2007; 6(5), 1641-1649.
Li L, Han W, Gu Y, Qiu S, Lu Q, Jin J, Luo J, Hu X. Honokiol Induces a Necrotic Cell Death through the Mitochondrial Permeability Transition Pore. Cancer Research. 2007; 67(10), 4894-4903.
Li L, Lu Q, Shen Y, Hu X. Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells. Biochem Pharmacol. 2006; 71(5), 584-595.
Li L, Bhatia R.The controversial role of Sirtuins in tumorigenesis - SIRT7 joins the debate. Cell Research. 2013; 23(1), 10–12.
Li L, Bhatia R. Stem Cell Quiescence. Clinical Cancer Research. 2011; 17(15), 4936-4941.
Hu X, Han W, Li L. Targeting the Weak Point of Cancer by Induction of Necroptosis. Autophagy. 2007; 3(5), 490-492.
Selected Conference Presentations
Oral Presentation in 2009 ASH (American Society of Hematology) annual meeting. Title: Role of the SIRT1 Deacetylase in Survival and Imatinib Resistance of CML CD34+ Progenitors. Blood. vol. 114, pp. A189, 2009.
Oral Presentation in 2010 ESH international conference Chronic Myeloid Leukemia-Biological Basis of Therapy. Title: SIRT1 inhibition induces apoptosis in human CML progenitors.
Oral Presentation in 2010 ASH annual meeting. Title: SIRT1 inhibition induces apoptosis in human CML progenitors by enhancing p53 acetylation and activation. Blood. vol. 116, pp. A200, 2010.
Oral Presentation in 2011 ASH annual meeting. Title: Pharmacological inhibition of the stress-related deacetylase SIRT1 with the small molecule inhibitor Tenovin-6 enhances eradication of CML LSC in combination with TKI treatment. Blood. vol.118, pp. A448, 2011.
Poster Presentation in 2012 ASH annual meeting. Title: FLT3-ITD+ AML Stem/Progenitor Cells Demonstrate Increased SIRT1 Expression and Enhanced Sensitivity to SIRT1 Inhibition. Blood. vol.120, pp. A1368, 2012.
Poster Presentation in 2013 ASH annual meeting. Title: Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI Treatment. Blood. vol.122, pp. A2685, 2013.
Poster Presentation in 2010 ASH annual meeting. L Wang, L Li, et al.Title: MicroRNA-486-5p Targets Foxo1 and Regulates Human Hematopoietic Stem Cell Proliferation and Erythroid Differentiation. Blood. vol. 116, pp. A3871, 2010.
Poster Presentation in 2011 ASH annual meeting. L Wang, L Li, et al.Title: Role of MicroRNA-486-5p Overexpression In CML CD34+ Cells In Modulating BCR-ABL Mediated Hematopoietic Stem/Progenitor Cell Transformation and Imatinib Sensitivity. Blood. vol. 118, pp. A1667, 2011.
Poster Presentation in 2014 ASH annual meeting. Duchartre Y, L Li, et al. Increased p53 Acetylation By SIRT1 Inhibition Is Required for Optimal Activation of p53 Activity and Significantly Enhances the Ability of HDM2 Inhibitors to Target CML LSC. Blood. 2014; vol.124.pp. A4521.