Matthew Hedberg, M.D., Ph.D.

(877) 460-4673
Matthew Hedberg, M.D., Ph.D.
Pathologist
Clinical Expertise
  • Anatomic Pathology
  • Dermotopathology
Academic Appointments
  • Assistant Clinical Professor, Department of Pathology
Clinical Teams
Pathology

Matthew Hedberg, M.D., Ph.D., is an assistant clinical professor of pathology at City of Hope® Cancer Center Duarte. As a dermatopathologist, he specializes in providing thorough and accurate pathology reports for skin cancer patients, helping their care teams identify innovative and targeted treatment options personalized to each patient. As a researcher, Dr. Hedberg studies the molecular mechanisms of skin disease, with a focus on skin cancers. Dr Hedberg was inspired to pursue a career as a physician-scientist because it combined his love of science with his desire to help others.

Following his undergraduate studies in chemistry at the University of Utah, where he researched translocation-associated sarcomas in the laboratory of Nobel laureate Dr. Mario Capecchi. Dr. Hedberg earned a combined M.D./Ph.D. at the University of Pittsburgh-Carnegie Mellon University’s Medical Scientist Training Program. His graduate research investigated the genetic and molecular underpinnings of upper aerodigestive tract cancers and biomarker-driven personalized medicine approaches for head and neck cancers. After completing a residency in anatomic pathology at the Washington University School of Medicine in St. Louis, Dr. Hedberg pursued sub-specialty fellowship training in dermatopathology at the University of Pennsylvania’s Perelman School of Medicine. Following fellowship, Dr. Hedberg joined the faculty as an Instructor and attending dermatopathologist, and was also named the inaugural Waine C. Johnson Endowed Research Fellow of Dermatopathology.

His research has been published in journals including Cancer Discovery, Nature Communications and the Journal of Clinical Investigation.

Location

Education & Experience

Board Certification

  • 2021–Present, Dermatopathology, American Board of Pathology
  • 2020–Present, Anatomic Pathology, American Board of Pathology

Degrees

  • 2016, Doctor of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • 2015, Doctor of Philosphy, Molecular Pharmacology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • 2009, Bachelor of Arts, Chemistry, University of Utah, Salt Lake City, UT

Fellowship

  • 2020–2021, Fellowship, Dermatopathology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Residency

  • 2017–2020, Residency, Anatomic Pathology, Washington University School of Medicine in St. Louis, St. Louis, MO

Professional Experience

  • 2024–Present, Assistant Clinical Professor, Department of Pathology, City of Hope, Duarte, CA
  • 2023–2024, Physician–Dermatopathologist, Division of Dermatology, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
  • 2021–2024, Instructor and Waine C. Johnson Endowed Research Fellow of Dermatopathology, Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Awards & Memberships

Awards

  • 2023, Career Development Award, Dermatology Foundation
  • 2022, Future Leaders in Dermatology Travel Award, Society for Investigative Derm.
  • 2021–2024, Waine C. Johnson Endowed Research Fellowship in Dermatopathology
  • 2019, Siteman Cutaneous Malignancy Scholar Award
  • 2017, AACR Scholar in Training Award
  • 2021, Research Grant, Dermatology Foundation
  • 2014–2016, F30 Ruth L. Kirschstein Individual Predoctoral NRSA
  • 2014, Travel Award, NHGRI Advances in Genomics Research Program
  • 2013, Pilot Grant, American Head and Neck Society
  • 2013, Poster Award, Pitt Dept. of Pharm. and Chem. Biol. Retreat
  • 2013, Travel Award, ASCI/AAP
  • 2010, Travel Award, Physicians for a National Health Program
  • 2009, Departmental Honors Degree in Chemistry Award, University of Utah
  • 2009, Undergraduate Research Scholar Award, University of Utah

Memberships

  • Philadelphia Dermatological Society
  • Society for Investigative Dermatology
  • American Board of Pathology
  • American Society of Dermatopathology
  • American Association for Cancer Research
  • American Physician Scientists Association
  • American Society of Dermatopathology
  • Wagih Bari Society of St. Louis Pathologists
  • United States & Canadian Academy of Pathology
  • College of American Pathologists
  • American Society for Clinical Pathology
  • American Society for Clinical Oncology
  • American Medical Association

Publications

  • Patel B, Hedberg ML, Lipoff JB. Exanthematous Eruption in a Patient With Known Chronic Graft-vs-Host Disease and Recent Measles Vaccination. JAMA Dermatol. 2024 Jul 24. doi: 10.1001/jamadermatol.2024.2042. Epub ahead of print. PMID: 39046717.
  • Banbury S, Chu B, Hedberg ML, Ogunleye TA, Kim E, Rosenbach M. Four cases of cutaneous Rosai-Dorfman in Black patients: A review of a single institution's experience with this rare disease. JAAD Case Rep. 2023 Oct 11;42:117-121. doi: 10.1016/j.jdcr.2023.09.032. PMID: 38090658; PMCID: PMC10711361.
  • Roche FC, Hedberg ML, Fischer AS, Ray A, Dentchev T, Rice X, Taylor SC, Seykora JT. Activation of STAT3 in lymphocytes associated with central centrifugal cicatricial alopecia. J Am Acad Dermatol. 2023 Dec;89(6):1245-1246. doi: 10.1016/j.jaad.2023.01.045. Epub 2023 Feb 21. PMID: 36813135.
  • Sprow G, Afarideh M, Dan J, Hedberg ML, Werth VP. Bullous systemic lupus erythematosus in females. Int J Womens Dermatol. 2022 Jul 25;8(3):e034. doi: 10.1097/JW9.0000000000000034. PMID: 35923586; PMCID: PMC9324630.
  • Hedberg ML, Berry CT, Moshiri AS, Xiang Y, Yeh CJ, Attilasoy C, Capell BC, Seykora JT. Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma. Int J Mol Sci. 2022 Mar 23;23(7):3478. doi: 10.3390/ijms23073478. PMID: 35408839; PMCID: PMC8998533.
  • Modi MB, Pei S, Hedberg ML, Fischer AS, Guerrero J, Carreon CK, Cooper K, Seykora JT. Clinical, pathologic, and molecular analyses of superficial low-grade fibromyxoid sarcoma in two young patients: A rare and deceptive mimic of benignancy. J Cutan Pathol. 2022 Jul;49(7):638-644. doi: 10.1111/cup.14215. Epub 2022 Mar 6. PMID: 35191077; PMCID: PMC9232983.
  • Ko KI, Merlet JJ, DerGarabedian BP, Zhen H, Suzuki-Horiuchi Y, Hedberg ML, Hu E, Nguyen AT, Prouty S, Alawi F, Walsh MC, Choi Y, Millar SE, Cliff A, Romero J, Garvin MR, Seykora JT, Jacobson D, Graves DT. NF-κB perturbation reveals unique immunomodulatory functions in Prx1+ fibroblasts that promote development of atopic dermatitis. Sci Transl Med. 2022 Feb 2;14(630):eabj0324. doi: 10.1126/scitranslmed.abj0324. Epub 2022 Feb 2. PMID: 35108061; PMCID: PMC8979241.
  • Ran NA, Hedberg ML, Rosenbach M. Blue Pigmentation of the Skin, Sclera, and Teeth. JAMA. 2021 Nov 9;326(18):1851-1852. doi: 10.1001/jama.2021.16176. PMID: 34751725.
  • Beer J, Bittar J, Hedberg ML, Seykora JT. Violaceous truncal plaques consistent with amyloid light-chain amyloidosis. J Cutan Pathol. 2022 Oct;49(10):889-892. doi: 10.1111/cup.14086. Epub 2021 Jul 15. PMID: 34263931.
  • Hedberg M, Seykora JT. Clarifying Progress on the Genomic Landscape of Actinic Keratosis. J Invest Dermatol. 2021 Jul;141(7):1622-1624. doi: 10.1016/j.jid.2021.02.761. PMID: 34167719.
  • Yanes AF, Hedberg ML, Lipoff JB. Purpuric Edematous Nodules and Plaques in an Immunosuppressed Older Man. JAMA Dermatol. 2021 Jul 1;157(7):866-867. doi: 10.1001/jamadermatol.2021.1207. PMID: 34009272.
  • Hedberg ML, Chibnall RJ, Compton LA. Symptomatic vulvar demodicosis: A case report and review of the literature. J Cutan Pathol. 2020 Nov;47(11):1063-1066. doi: 10.1111/cup.13816. Epub 2020 Aug 26. PMID: 33448447.
  • Hedberg ML, Peyser ND, Bauman JE, Gooding WE, Li H, Bhola NE, Zhu TR, Zeng Y, Brand TM, Kim MO, Jordan RCK, VandenBerg S, Olivas V, Bivona TG, Chiosea SI, Wang L, Mills GB, Johnson JT, Duvvuri U, Ferris RL, Ha P, Johnson DE, Grandis JR. Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer. J Exp Med. 2019 Feb 4;216(2):419-427. doi: 10.1084/jem.20181936. Epub 2019 Jan 25. PMID: 30683736; PMCID: PMC6363423.
  • Li YY, Chung GT, Lui VW, To KF, Ma BB, Chow C, Woo JK, Yip KY, Seo J, Hui EP, Mak MK, Rusan M, Chau NG, Or YY, Law MH, Law PP, Liu ZW, Ngan HL, Hau PM, Verhoeft KR, Poon PH, Yoo SK, Shin JY, Lee SD, Lun SW, Jia L, Chan AW, Chan JY, Lai PB, Fung CY, Hung ST, Wang L, Chang AM, Chiosea SI, Hedberg ML, Tsao SW, van Hasselt AC, Chan AT, Grandis JR, Hammerman PS, Lo KW. Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations. Nat Commun. 2017 Jan 18;8:14121. doi: 10.1038/ncomms14121. PMID: 28098136; PMCID: PMC5253631.
  • Hedberg ML, Goh G, Chiosea SI, Bauman JE, Freilino ML, Zeng Y, Wang L, Diergaarde BB, Gooding WE, Lui VW, Herbst RS, Lifton RP, Grandis JR. Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. J Clin Invest. 2016 Apr 1;126(4):1606. doi: 10.1172/JCI86862. Epub 2016 Apr 1. Erratum for: J Clin Invest. 2016 Jan;126(1):169-80. doi: 10.1172/JCI82066. PMID: 27035818; PMCID: PMC4811141.

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