Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Cancer and Diabetes: More Connections Than You Think

January 18, 2017 | Abe Rosenberg

Many people struggle with both diabetes and cancer at the same time — none of this is random or coincidental. Rather, it's clear that, from biology to risk factors to treatment options, cancer and diabetes are intimately related in many ways.

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The Future of Diabetes: A Focus on Personalized Care

January 16, 2017 | Katie Neith

Diabetes affects over 422 million people worldwide according to the World Health Organization, but no two patients are alike. So in 2017 and beyond, treatments will increasingly make use of precision medicine to personalize treatment options. At City of Hope, researchers are combining the forces of a transformative gift with new resources to speed these treatments to patients.

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City of Hope Aims to Cure Type 1 Diabetes in Six Years

January 16, 2017 | City of Hope

City of Hope’s Diabetes & Metabolism Research Institute is committed to developing a cure for type 1 diabetes within six years, fueled by a $50 million funding program led by the Wanek family.

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A doctor’s quest to better treat children with brain tumors in underserved countries

January 12, 2017 | Denise Heady

City of Hope's Rahul Jandial, M.D., Ph.D., is making a lasting and global impact by performing and teaching children's brain surgery in developing countries.

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Low Vaccination Rates for HPV a Serious ‘Public Health Threat’

January 11, 2017 | City of Hope

Several types of high-risk HPV are responsible for the vast majority of cervical, anal, oropharyngeal (middle throat) and other genital cancers that affect men and women. Although many of these HPV-associated cancers are preventable with a safe and effective vaccine, HPV vaccination (HPVV) rates across the U.S. remain low.

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Trial Results Point to Promising Treatments for Hodgkin Lymphoma Patients

January 9, 2017 | Abe Rosenberg

Everything changed when Hodgkin lymphoma patient Lowell Winer joined a Phase II clinical trial examining the effectiveness of brentuximab vedotin (BV) after a failed transplant. The BV worked immediately, achieving a complete remission which, year after year, proved to be durable beyond anyone's expectations.

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New Treatments and Personalized Care Offer Hope for Stomach Cancer Patients

January 6, 2017 | Samantha Bonar

Although it is uncommon in the U.S., stomach cancer is a serious, often devastating disease. But less than 25 percent of patients who are diagnosed with stomach cancer in the U.S. survive for five years. City of Hope’s physicians and scientists are committed to changing this.

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Inside CAR-T Cell Brain Surgery

January 4, 2017 | Stephanie Smith

Sketches of a brain surgery performed on B., one of several patients in a breakthrough clinical trial for brain cancer at City of Hope. Early results of the trial — describing promising results using CAR-T cells for a 50-year-old patient with an aggressive brain cancer called glioblastoma multiforme — were published recently in the New England Journal of Medicine.

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CAR-T cells: ‘Soldiers of the Immune System’

December 30, 2016 | Stephanie Smith

When viewed under a microscope, T cells - sentinels of the immune system whose job inside the body is to seek out foreign invaders - quiver as they surround and consume cancer cells. They were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.

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City of Hope researchers find CAR-T cell therapy effective in treatment of glioblastoma

December 29, 2016 | Denise Heady

City of Hope researchers have found that using CAR-T therapy, a type of immunotherapy, can be effective in the treatment of glioblastoma — one of the most aggressive brain tumors known to medicine.

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