A Phase II Randomized Double-Blind Placebo-Controlled Study of Fisetin to Improve Physical Function in Frail Older Breast Cancer Survivors

What Is Fisetin?

Fisetin is a natural compound found in strawberries and other fruits and vegetable, Fisetin is widely available as a supplement.

How Does Fisetin Work?

Previous research suggests that fisetin has antioxident, anti-iflammatory and anti-aging properties. Early research shows that fisetin works by countering an aging process called cellular senescence. Cellular senescence is when a cell permanently stops dividing, but does not die. As we age, these 'senescence cells' can build up and release harmful substances that lead to inflammation and damage healthy cells.

Why Are We Interested In Studying Fisetin In Postmenopausal Breast Cancer Patients After Chemotherapy?

Chemotherapy can lead to loss of energy, muscle weakness and accelerated aging. Studies show that these changes are in part dues to increased senescent cells triggered by chemotherapy, and the effect is especially strong in postmenopausal women. Research suggests that fisetin can clear these senescent cells and improve health in postmenopausal breast cancer survivors who have low energy after completing chemotherapy.

If You Are Eligible, What Does the Study Involve?

Tablets and research tests will be provided by the study staff at no charge to the patient.

You May Qualify If You

• Are menopausal
• Have been diagnosed with Stage 1 to 3 breast cancer
• Have completed chemotherapy within the last 12 months
• Have been experiencing weakness, fatigue, weight loss or low activity levels since finishing chemotherapy

If you’re a patient interested in this trial, please contact study staff:

Keilani Luna
(626) 218-0644

Cynthia Basulto
(626) 218-7667

Jennifer Lopez
(626) 218-7461

This study is multi-site with UCLA as the lead/sponsor.