2004/2005: Infrastructure to Support Clinical Trials
$500,000- Clinical lmmunobiology Correlative Studies Laboratory (CICSL)
$150,000 - Laboratory Specialist
2006: Research Into a Key Protein for Cancer
$150,000 - STAT3 Protein Study (Fast Track)
2007: Clinical Research Advancement Fund
$500,000 - Fund Hiring Five Clinical Trial Physicians
The growth of the clinical trials program required an increase of doctors to treat and monitor patients in therapies being brought from the laboratory bench to the patient bedside. This grant was established to support the salary requirements for up to five doctors. These physician-researchers were specifically recruited to help design and then execute the phase 1 and 2 trials ready for in-human treatment. Initially three doctors were recruited in 2008 and the grant has allowed another five doctors to be recruited through 2012.
2009: Studies That Seek to Improve Care for Older Adults
$250,000 - Creating Geriatric-Specific Treatment Protocols
2011: Targeting the Mechanism Behind Cancer's Growth
$250,000 - Attacking the DNA That Replicates Cancer Cells
The Board of Governors provided Linda Malkas, Ph.D., a $250,000 grant to support her work in targeting the mechanism behind cancer’s growth.
2013: Merging of Eastern and Western Medicine
$100,000 - Using Natural Compounds Found in Traditional Asian Medicine
The Board of Governors grant to John Yim, M.D. was to assist with the opening of a phase 1 clinical trial to study the effect of a compound found in a Chinese root, baicalein, which has been studied to activate a protein that causes cancer cells to kill themselves and makes them more susceptible to the person’s immune system.
$100,000 - BioRad QX100 Droplet Digital PCR Instrument
2014 Activation of the Immune Response to Fight Cancer: The "PAC-MAN" Strategy.
$200,000: Develop and deliver therapeutic small molecule to cells capable of blocking cancer growth
Daniela Castanotto, Ph.D., a research professor in the, Department of Medical Oncology & Therapeutics Research, and her research team worked on creating a small RNA or DNA molecule that can identify abnormal cells or HIV-infected cells and deliver a “therapeutic cargo” directly and only to those cells.
2015 Next Generation Drug Discovery--new technology to radically accelerate drug discovery
$200,000: Revolutionize how drugs are discovered and how they are delivered.
Jacob Berlin, Ph.D., an assistant professor in the Department of Molecular Medicine at the, Beckman Research Institute of City of Hope, and his team completed the first prototype of a system that will revolutionize the discovery of new drugs to fight cancer. They are developing a method to place 1 billion different molecules on a microscope slide-sized chip using nanotechnology, the science of extremely small things. These chips will then be used to identify which molecules are good potential drugs for proteins that other researchers at City of Hope have identified as promising new areas for treating cancer. This will revolutionize and accelerate how drugs are discovered and how they are delivered.
$250,000: Understanding the Pathways Responsible for CAR T Cell Activity and Survival
$250,000: Help Support a Staff Scientist, Research Associate and Animal Technician in the Aboody lab