Jonathan Young, M.D.
Radiologist
Clinical Expertise
Neuroradiology
Brain Tumor Imaging
Appointments
Associate Clinical Professor, Department Of Diagnostic Radiology
I was drawn to City of Hope because of its reputation as a worldwide leader in cancer diagnosis and treatment.
A fascination with the anatomy of the human brain led Jonathan R. Young, M.D., to a career in radiology.
Dr. Young is an associate clinical professor in the Department of Diagnostic Radiology. He focuses his research on two main areas: 1) Identifying imaging biomarkers that can help predict the molecular expression of brain and kidney tumors, as well as their response to treatment; and 2) Finding the safest possible contrast agents for children undergoing MRIs (magnetic resonance imaging). He has published dozens of peer-reviewed papers on these subjects and has given numerous invited lectures and oral presentations at national radiology conferences.
A perennial honors student, Dr. Young graduated summa cum laude from Union College in Schenectady, New York, where he received his Bachelor of Science degree with honors in biology and economics. He was the valedictorian of his graduating class and was inducted into the Phi Beta Kappa Honor Society. Dr. Young received his medical degree from UCLA's David Geffen School of Medicine, where he was inducted into the Alpha Omega Alpha Honor Medical Society. He also received the Leo G. Rigler Outstanding Medical Student Award from the UCLA Department of Radiology. He continued his training at UCLA with a residency in radiology and a fellowship in neuroradiology. Dr. Young was the recipient of the 2016 Society of Abdominal Radiology Howard S. Stern Research Award for his project “Identifying Multiphasic MDCT Biomarkers to Predict the Expression of Carbonic Anhydrase-IX, Hypoxia-Inducible Factor 1α, and PTEN, Important Prognostic Molecular Targets in Clear Cell Renal Cell Carcinoma.”
Dr. Young sees City of Hope as a perfect fit for his research interests and his desire “to help people on a daily basis.”
2017, Board Certified, American Board of Radiology
2018, American Board of Radiology Subspecialty Certificate in Neuroradiology
2011, M.D., David Geffen School of Medicine, UCLA, Los Angeles, CA
2007, B.S. With Honors, Biology-Economics, Union College, Schenectady, NY
2016-2017, Neuroradiology, Ronald Reagan-UCLA Medical Center
2012-2016, Radiology, Ronald Reagan-UCLA Medical Center
2011-2012, Internal Medicine, Olive View-UCLA Medical Center
2022-present, Associate Clinical Professor, Department of Diagnostic Radiology, City of Hope, Duarte, California
2019-2022, Assistant Clinical Professor, Department of Diagnostic Radiology, City of Hope, Duarte, California
2017-2018, Assistant Professor of Clinical Radiology, University of California Davis School of Medicine, Sacramento, California
2017, Third Place, UCLA Department of Radiology Annual Research Day Poster Competition
2016, Society of Abdominal Radiology Howard S. Stern Research Award
2011, Leo G. Rigler Outstanding Medical Student Award, UCLA Department of Radiology
2010, Alpha Omega Alpha
2007, Phi Beta Kappa
2007, Sigma Xi, the Scientific Research Society
2007, Second Place, Inter-University Consortium for Political and Social Research Undergraduate Research Paper Competition
2006, Omicron Delta Epsilon, the International Honor Society in Economics
American Society of Neuroradiology
Radiological Society of North America
American Roentgen Ray Society
PEER-REVIEWED PUBLICATIONS:
- Young JR, Ressler JA, Shiroishi MS. Mortimer JE, Schmolze D, Fitzgibbons M, Chen BT. Association of Relative Cerebral Blood Volume from Dynamic Susceptibility Contrast-Enhanced Perfusion MR with HER2 Status in Breast Cancer Brain Metastases. Academic Radiology. Published online ahead of print on December 21, 2022.
- Young JR, Ressler JA, Mortimer JE, Schmolze D, Fitzgibbons M, Chen BT. Association of Lesion Contour and Lesion Composition on MR with HER2 Status in Breast Cancer Brain Metastases. Magnetic Resonance Imaging. 2023. 96:60-66.
- Young JR, Ressler JA, Mortimer JE, Schmolze D, Fitzgibbons M, Chen BT. Performance of Enhancement on Brain MRI for Identifying HER2 Overexpression in Breast Cancer Brain Metastases. European Journal of Radiology. 2021. 144:109948. doi: 10.1016/j.ejrad.2021.109948.
- Young JR, Pope WB. Letter to the Editor in Reply to “Gadolinium in Brain – More Indicator than Main Tissue at Risk?” European Radiology. Published Online on July 14, 2020.
- Young JR, Pope WB. Letter to the Editor in Reply to "Gadolinium in Brain - More Indicator than Main Tissue at Risk?" European Radiology. Published Online on July 14, 2020.
- Coy H, Young JR, Pantuck AJ, Douek ML, Sisk A, Magyar C, Brown MS, Sayre J, Raman SS. Association of Tumor Grade, Enhancement on Multiphasic CT and Microvessel Density in Patients with Clear Cell Renal Cell Carcinoma. Abdominal Radiology. 2020. 45:3184-3192
- Coy H, Hsieh K, Wu W, Nagarajan MB, Young JR, Douek ML, Brown MS, Scalzo F, Raman SS. Deep Learning and Radiomics: The Utility of Google TensorFlow™ Inception in Classifying Clear Cell Renal Cell Carcinoma and Oncocytoma on Multiphasic CT. Abdominal Radiology. 2019. 44:2009-2020.
- Coy H, Young JR, Douek ML, Pantuck AJ, Brown M, Sayre J, Raman SS. Association of Qualitative and Quantitative Imaging Features on Multiphasic Multidetector CT with Tumor Grade in Clear Cell Renal Cell Carcinoma. Abdominal Radiology. 2019. 44:180-189.
- Young JR, Pope WB, Bobinski M. Gadolinium Deposition within the Pediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus Following the Administration of a Minimum of Four Doses of the Macrocyclic Agent Gadoteridol. American Journal of Neuroradiology. 2018. 39:1604-1608.
- Young JR, Qiao J, Orosz I, Salamon N, Franke MA, Kim HJ, Pope WB. Gadolinium Deposition within the Paediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus Following the Administration of a Minimum of Four Doses of the Macrocyclic Agent Gadobutrol. European Radiology. 2018. 28:4882-4889.
- Young JR, Coy H, Kim HJ, Douek M, Sisk A, Pantuck AJ, Raman SS. Association of the Gross Appearance of Intratumoral Vascularity at MDCT With the Carbonic Anhydrase IX Score in Clear Cell Renal Cell Carcinoma. American Journal of Roentgenology. 2018. 211: 1254-1258.
- Young JR, Coy H, Kim HJ, Douek M, Sisk A, Pantuck AJ, Raman SS. Clear Cell Renal Cell Carcinoma: Identifying PTEN expression on Multiphasic MDCT. Abdominal Radiology. 2018. 43:3410-3417.
- Young JR, Coy H, Kim HJ, Douek M, Sisk A, Belldegrun A, Pantuck AJ, Raman SS. Utility of Multiphasic Multidetector Computed Tomography in Discriminating Between Clear Cell Renal Cell Carcinomas with High and Low Carbonic Anhydrase-IX Expression. Abdominal Radiology. 2018. 43:2734-2742.
- Young JR, Orosz I, Franke MA, Kim HJ, Woodworth D, Ellingson BM, Salamon N, Pope WB. Gadolinium Deposition in the Pediatric Brain: T1-Weighted Hyperintensity within the Dentate Nucleus Following Repeated Gadolinium-Based Contrast Agent Administration. Clinical Radiology. 2018. 73:290-295.
- Young JR, Young JA, Margolis DJ, Sauk S, Sayre J, Pantuck AJ, Raman SS. Sarcomatoid Renal Cell Carcinoma and Collecting Duct Carcinoma: Discrimination from Common Renal Cell Carcinoma Subtypes and Benign RCC Mimics on Multiphasic MDCT. Academic Radiology. 2017. 24:1226-1232.
- Young JR, Coy H, Douek M, Lo P, Sayre J, Pantuck AJ, Raman SS. Clear Cell Renal Cell Carcinoma: Identifying the Loss of the Y Chromosome on Multiphasic MDCT. American Journal of Roentgenology. 2017. 209:333-338.
- Young JR, Coy H, Douek M, Lo P, Sayre J, Pantuck AJ, Raman SS. Type 1 Papillary Renal Cell Carcinoma: Differentiation from Type 2 Papillary RCC on Multiphasic MDCT. Abdominal Radiology. 2017. 42:1911–1918.
- Coy H, Young JR, Douek ML, Brown MS, Sayre J, Raman SS. Quantitative Computer-Aided Diagnostic Algorithm for Automated Detection of Peak Lesion Attenuation in Differentiating Clear Cell from Papillary and Chromophobe Renal Cell Carcinoma, Oncocytoma and Fat-poor Angiomyolipoma on Multiphasic Multidetector Computed Tomography. Abdominal Radiology. 2017. 42:1919–1928.
- Young JR, Coy H, Kim HJ, Douek M, Lo P, Pantuck AJ, Raman SS. Performance of Relative Enhancement on Multiphasic MR Imaging for Differentiation of Clear Cell Renal Cell Carcinoma from Papillary and Chromophobe RCC Subtypes and Oncocytoma. American Journal of Roentgenology. 2017. 208:812–819.
- Young JR, Coy H, Douek M, Lo P, Sayre J, Pantuck AJ, Raman SS. Clear Cell Renal Cell Carcinoma: Identifying the Gain of Chromosome 12 on Multiphasic MDCT. Abdominal Radiology. 2017. 42:236-241.
- Young JR, Young JA, Margolis D, Sauk S, Pantuck AJ, Sayre J, Raman SS. Clear Cell Renal Cell Carcinoma: Identifying the Gain of Chromosome 20 on Multiphasic MDCT. Abdominal Radiology. 2016. 41:2175-2181.
- Young JR, Margolis D, Sauk S, Pantuck AJ, Sayre J, Young JA, Hsu M, Raman SS. Clear Cell Renal Cell Carcinoma: Multiphasic MDCT Enhancement Can Predict the Loss of Chromosome 8p. Abdominal Imaging. 2014. 39:543-549.
- Lee-Felker SA, Felker ER, Tan N, Margolis D, Young JR, Sayre J, Raman SS. Qualitative and Quantitative MDCT Features for Differentiating Clear Cell Renal Cell Carcinoma From Other Solid Renal Cortical Masses. American Journal of Roentgenology. 2014. 203:W516-W524.
- Young JR, Margolis D, Sauk S, Pantuck AJ, Sayre J, Raman SS. Clear Cell Renal Cell Carcinoma: Discrimination from Other Renal Cell Carcinoma Subtypes and Oncocytoma at Multiphasic Multidetector CT. Radiology. 2013. 267: 444-453.
- Pope WB, Young JR, Ellingson BM. Advances in MRI Assessment of Gliomas and Response to Anti-VEGF Therapy. Current Neurology and Neuroscience Reports. 2011. 11:336-344.
- Pope WB, Lai A, Mehta R, Kim HJ, Qiao J, Young JR, Xue X, Goldin J, Nghiemphu P, Tran A, Cloughesy TF. Apparent Diffusion Coefficient Histogram Analysis Stratifies Progression-Free Survival in Newly Diagnosed Bevacizumab-Treated Glioblastoma. American Journal of Neuroradiology. 2011. 32:882-889.
- Pope WB, Kim HJ, Huo J, Alger J, Brown MS, Gjertson D, Sai V, Young JR, Tekchandani L, Cloughesy T, Mischel P, Lai A, Nghiemphu P, Rahmanuddin S, Goldin J. Recurrent Glioblastoma Multiforme: ADC Histogram Analysis Predicts Response to Bevacizumab Treatment. Radiology. 2009. 252:182-189.
NON-PEER-REVIEWED PUBLICATIONS:
- Young JR, Gelabert H, Moriarty J. Managing Paget-Schroetter Syndrome. Endovascular Today. August 2014. 34-38.