We've been looking at glass slides for hundreds of years but in the last 30 to 40 years the whole field has changed completely. We are now a major contributor to driving therapy. I hope I can contribute in a meaningful way.
Stanley R. Hamilton, M.D., is one of the premier pathologists of his generation and a nationally known leader who built the pathology and laboratory medicine department at MD Anderson Cancer Center into a world class facility. He now brings more than four decades of expertise to City of Hope as chair of the Department of Pathology.
A native of Indiana, Dr. Hamilton received his medical degree at Indiana University, continued his training at Johns Hopkins University in Baltimore, then helped grow the Hopkins pathology department for the next 20 years before moving on to MD Anderson in 1998. Along the way he became nationally known as an expert in gastro-intestinal/colon cancer pathology.
Dr. Hamilton is excited to join the City of Hope family, which he describes as “great people, all dedicated to the mission. It's a wonderful environment.” He plans to leverage the digital transformation now taking place in his field, bringing state-of-the-art pathology services to every patient at every City of Hope community practice site, while improving and enhancing the biomarker data used in clinical trials, and further integrating digital pathology into the overall informatics of the institution.
Rawlings W, Jr, Moss J, Cooper HS, Hamilton SR. Hepatocellular carcinoma and partial deficiency of alpha-1 antitrypsin (MZ). Ann Intern Med 81:771-3, 12/1974. PMID: 4372920.
Hamilton SR, Yardley JH. Regenerative of cardiac type mucosa and acquisition of Barrett mucosa after esophagogastrostomy. Gastroenterology 72(4 Pt 1):669-75, 4/1977. PMID: 838221.
Yardley JH, Keren DF, Hamilton SR, Brown GD. Local (immunoglobulin A) immune response by the intestine to cholera toxin and its partial suppression with combined systemic and intra-intestinal immunization. Infect Immun 19(2):589-97, 2/1978. PMCID: PMC414124.
Hamilton SR, Wimsatt T, Torrieri R, Rock RC. Serum creatine kinase isoenzyme MB activity: evaluation of a kit employing agarose-gel electrophoresis with overlay paper fluorescence scanning. Clin Chim Acta 91(3):285-94, 2/1979. PMID: 761405.
Hamilton SR, Miller ME, Jessop M, Charache S. Comparison of microchromatography and electrophoresis with elution for hemoglobin A2 (Hb A2) quantitation. Am J Clin Pathol 71(4):388-96, 4/1979. PMID: 443196.
Hamilton SR, Yardley JH, Brown GD. Suppression of local intestinal immunoglobulin A immune response to cholera toxin by subcutaneous administration of cholera toxoids. Infect Immun 24(2):422-6, 5/1979. PMCID: PMC414318.
Cameron JL, McPhee SJ, Hamilton SR. Pancreatectomy and autotransplantation for chronic pancreatitis. Johns Hopkins Med J 144(6):215-9, 6/1979. PMID: 110972.
Hamilton SR, Bussey HJ, Mendelsohn G, Diamond MP, Pavlides G, Hutcheon D, Harbison M, Shermeta D, Morson BC, Yardley JH. Ileal adenomas after colectomy in nine patients with adenomatous polyposis coli/Gardner's syndrome. Gastroenterology 77(6):1252-7, 12/1979. PMID: 499712.
Goodman ZD, Hamilton SR. Transient increase in serum creatine kinase isoenzyme BB activity after prostatectomy in a patient with massive benign prostatic hyperplasia. Clin Chem 26(3):511-2, 3/1980. PMID: 6153944.
Zaatari GS, Hamilton SR, Jacobs J, Datiles TB. Comparison of nephelometry and immunofluorescence for immunoglobulin quantitation in pathologic sera. Clin Chim Acta 103(3):357-66, 5/1980. PMID: 6772348.
Hamilton SR, Keren DF, Boitnott JK, Robertson SM, Yardley JH. Enhancement by cholera toxin of IgA secretion from intestinal crypt epithelium. Gut 21(5):365-9, 5/1980. PMCID: PMC1419096.
Pennington L, Hamilton SR, Bayless TM, Cameron JL. Surgical management of Crohn's disease. Influence of disease at margin of resection. Ann Surg 192(3):311-8, 9/1980. PMCID: PMC1344907.
Bishop AE, Polak JM, Bryant MG, Bloom SR, Hamilton S. Abnormalities of vasoactive intestinal polypeptide-containing nerves in Crohn's disease. Gastroenterology 79(5 Pt 1):853-60, 11/1980. PMID: 7419008.
Amano, Bulkley GB, Gorey T, Hamilton SR, Horn SD, Zuidema GD. Role of microvascular patency in the recovery of small intestine from ischemic injury. Surgical Forum 31:157-159, 1980.
Hamilton SR, Keren DF, Yardley JH, Brown G. No impairment of local intestinal immune response to keyhole limpet haemocyanin in the absence of Peyer's patches. Immunology 42(3):431-5, 3/1981. PMCID: PMC1458454.
Bulkley GB, Zuidema GD, Hamilton SR, O'Mara CS, Klacsmann PG, Horn SD. Intraoperative determination of small intestinal viability following ischemic injury: a prospective, controlled trial of two adjuvant methods (Doppler and fluorescein) compared with standard clinical judgment. Ann Surg 193(5):628-37, 5/1981. PMCID: PMC1345136.
Hamilton SR, Gupta PK, Marshall ME, Donovan PA, Wingard JR, Zaatari GS. Cerebrospinal fluid cytology in histiocytic proliferative disorders. Acta Cytol 26(1):22-8, Jan-Feb, 1/1982. PMID: 6175126.
Parks DA, Bulkley GB, Granger DN, Hamilton SR, McCord JM. Ischemic injury in the cat small intestine: role of superoxide radicals. Gastroenterology 82(1):9-15, 1/1982. PMID: 6273253.
Hamilton SR, Bussey HJ, Morson BC. En face histopathologic technic for examining colonic mucosa of resection specimens. Am J Clin Pathol 78(4):514-17, 10/1982. PMID: 6753564.
Lake AM, Whitington PF, Hamilton SR. Dietary protein-induced colitis in breast-fed infants. J Pediatr 101(6):906-10, 12/1982. PMID: 7143166.
Hamilton SR, Keren DF, Yardley JH, Brown G. Effects of parenteral keyhole limpet hemocyanin or cholera toxin on intestinal immune response to keyhole limpet hemocyanin. Int Arch Allergy Appl Immunol 68(3):242-6, 1982. PMID: 7085119.
Walsh TJ, Hamilton SR. Disseminated aspergillosis complicating hepatic failure. Arch Intern Med 143(6):1189-91, 6/1983. PMID: 6860047.
White CL, Hamilton SR, Diamond MP, Cameron JL. Crohn's disease and ulcerative colitis in the same patient. Gut 24(9):857-62, 9/1983. PMCID: PMC1420082.
Hsu SH, Luk GD, Krush AJ, Hamilton SR, Hoover HH. Multiclonal origin of polyps in Gardner syndrome. Science 221(4614):951-3, 9/1983. PMID: 6879192.
Riddell RH, Goldman H, Ransohoff DF, Appelman HD, Fenoglio CM, Haggitt RC, Ahren C, Correa P, Hamilton SR, Morson BC, et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 14(11):931-68, 11/1983. PMID: 6629368.
Wheaton, Strandberg JD, Hamilton SR, Bulkley GB. A comparison of three techniques for intraoperative prediction of small intestinal injury. Journal of the American Animal Hospital Association 19:897-902, 1983.
Hamilton SR, Hutcheon DF, Ravich WJ, Cameron JL, Paulson M. Adenocarcinoma in Barrett's esophagus after elimination of gastroesophageal reflux. Gastroenterology 86(2):356-60, 2/1984. PMID: 6690363.
Smith RR, Hamilton SR, Boitnott JK, Rogers EL. The spectrum of carcinoma arising in Barrett's esophagus. A clinicopathologic study of 26 patients. Am J Surg Pathol 8(8):563-73, 8/1984. PMID: 6465417.
Qualman SJ, Haupt HM, Yang P, Hamilton SR. Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease. Gastroenterology 87(4):848-56, 10/1984. PMID: 6088351.
Jones B, Bayless TM, Hamilton SR, Yardley JH. "Bubbly" duodenal bulb in celiac disease: radiologic-pathologic correlation. AJR Am J Roentgenol 142(1):119-22, 1984. PMID: 6606944.
Amano H, Hamilton SR, Bulkley GB. [Studies on the prediction of intestinal recovery from ischemic injury by fluorescein fluorescence patterns]. Nippon Geka Gakkai Zasshi 85(1):56-64, 1984. PMID: 6738489.
Vogelstein B, Fearon ER, Hamilton SR, Feinberg AP. Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors. Science 227(4687):642-5, 2/1985. PMID: 2982210.
Pan Q, Hamilton SR, Hyland J, Boitnott JK. Effects of carcinogen dosage on experimental colonic carcinogenesis by azoxymethane: an ultrastructural study of grossly normal colonic mucosa. J Natl Cancer Inst 74(3):689-98, 3/1985. PMID: 3856071.
Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228(4696):187-90, 4/1985. PMID: 2579435.
Goelz SE, Hamilton SR, Vogelstein B. Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun 130(1):118-26, 7/1985. PMID: 2992457.
Ghory MJ, Pekcan M, Hebiguchi T, Hamilton SR, Dudgeon DL. A muscle ablation sphincter to prevent diarrhea after total colectomy in puppies: a preliminary report. J Pediatr Surg 20(4):302-6, 8/1985. PMID: 4045653.
Hamilton SR. Colorectal carcinoma in patients with Crohn's disease. Gastroenterology 89(2):398-407, 8/1985. PMID: 2989075.
Sanfey H, Hamilton SR, Smith RR, Cameron JL. Carcinoma arising in Barrett's esophagus. Surg Gynecol Obstet 161(6):570-4, 12/1985. PMID: 4071370.
Sarr MG, Hamilton SR, Marrone GC, Cameron JL. Barrett's esophagus: its prevalence and association with adenocarcinoma in patients with symptoms of gastroesophageal reflux. Am J Surg 149(1):187-93, 1985. PMID: 3966636.
Fearon ER, Feinberg AR, Hamilton SR, and Vogelstein B. Loss of genes on the short arm of chromosome 11 in bladder cancer. Nature 318:377-380, 1985.
Hamilton SR, Reese J, Pennington L, Boitnott JK, Bayless TM, Cameron JL. The role of resection margin frozen section in the surgical management of Crohn's disease. Surg Gynecol Obstet 160(1):57-62, 1985. PMID: 3964965.
Greyson-Fleg RT, Jones B, Fishman EK, Hamilton SR, Siegelman SS. Computed tomography findings in gastrointestinal involvement by opportunistic organisms in acquired immune deficiency syndrome. J Comput Tomogr 10(2):175-81, 4/1986. PMID: 3009090.
Bailey RW, Bulkley GB, Hamilton SR, Morris JB, Smith GW. Pathogenesis of nonocclusive ischemic colitis. Ann Surg 203(6):590-9, 6/1986. PMID: 3718027.
Walsh TJ, Belitsos NJ, Hamilton SR. Bacterial esophagitis in immunocompromised patients. Arch Intern Med 146(7):1345-8, 7/1986. PMID: 3718132.
Wong AJ, Ruppert JM, Eggleston J, Hamilton SR, Baylin SB, Vogelstein B. Gene amplification of c-myc and N-myc in small cell carcinoma of the lung. Science 233(4762):461-4, 7/1986. PMID: 3014659.
Luk GD, Hamilton SR, Yang P, Smith JA, O'Ceallaigh D, McAvinchey D, Hyland J. Kinetic changes in mucosal ornithine decarboxylase activity during azoxymethane-induced colonic carcinogenesis in the rat. Cancer Res 46(9):4449-52, 9/1986. PMID: 3731101.
Jessurun J, Paplanus SH, Nagle RB, Hamilton SR, Yardley JH, Tripp M. Pseudosarcomatous changes in inflammatory pseudopolyps of the colon. Arch Pathol Lab Med 110(9):833-6, 9/1986. PMID: 3755892.
Jones B, Fishman EK, Hamilton SR, Rubesin SE, Bayless TM, Cameron JC, Siegelman SS. Submucosal accumulation of fat in inflammatory bowel disease: CT/pathologic correlation. J Comput Assist Tomogr 10(5):759-63, 9/1986. PMID: 3745545.
Rogers EL, Goldkind SF, Iseri OA, Bustin M, Goldkind L, Hamilton SR, Smith RL. Adenocarcinoma of the lower esophagus. A disease primarily of white men with Barrett's esophagus. J Clin Gastroenterol 8(6):613-8, 12/1986. PMID: 3805655.
Hamilton SR, Zhang SZ, O'Ceallaigh D, McAvinchey D. Growth characteristics of autochthonous experimental colonic tumors as assessed by serial colonoscopic measurement in rats. Gastroenterology 91(6):1511-20, 12/1986. PMID: 3770375.