Gynecologic Cancers

Overview

A gynecological cancer diagnosis can be life-altering. At City of Hope, our dedicated team of experts take an integrated, patient-centered approach to diagnose and treat ovariancervicalendometrial/uterine, vaginal, vulvar and fallopian tube cancers.

By working collaboratively, our clinicians and researchers transform innovative scientific discoveries into promising new treatments that are more effective against the cancer with less side effects for the patient.

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If you have been diagnosed with breast cancer, are at a high risk for developing breast cancer or are looking for a second opinion consultation about your treatment, you may  request an appointment online or contact us at 800-826-4673 (HOPE). Please visit Making Your First Appointment for more information.

 

 

 

 

 

 

City of Hope is a nationally recognized leader in the research and treatment of gynecological cancers. We are one of the few facilities designated a Comprehensive Cancer Center by the National Cancer Institute.

Highlights of our gynecologic oncology program include:

  • Advanced imaging technologies that can accurately pinpoint a tumor’s size, shape and location, enhancing our doctors’ detection and treatment planning capabilities.
  • Minimally-invasive and robotically-assisted surgical techniques that can offer optimal outcomes with less pain, reduced scarring and faster healing time.
  • Cytoreductive (tumor debulking) procedures that can enhance radiation and chemotherapy responses and improve outcomes for both early- and advance-stage cancer patients.
  • Targeted radiation regimens that is sculpted to the size and shape of the tumor, focusing its impact on cancer cells while minimizing exposure to nearby normal tissues.
  • Our specialization in heated intraperitoneal chemotherapy (HIPEC), which applies cancer drugs directly in the abdominal cavity, instead of orally or through the bloodstream. This can increase the drugs’ effectiveness and improve outcomes.
  • A drug development pipeline that quickly identifies new cancer drugs and turns them into promising therapies for clinical trials.
  • Fertility-preserving options for younger patients who want to have children after cancer treatment.
  • All gynecologic cancer patients can participate in our survivorship program after their treatment completes. Our doctors and researchers are working to develop resources to help improve the quality of life for survivors, and all patients are able to participate in ongoing long-term research related to their life after cancer.

Additionally, City of Hope patients have access to our extensive team of supportive care experts, who will help you and your caregivers achieve and maintain a better quality of life during and after your cancer treatment.

NEWS & BREAKTHROUGHS

Here at City of Hope, our team of experts uses leading-edge methods to treat gynecologic cancers.

Highlights of our cervical cancer treatment program include:

  • Minimally invasive and robotic surgery, which uses smaller incisions than a traditional open procedure, resulting in less blood loss, reduced pain, shorter recovery time and quicker return to normal activities
  • Advanced radiation therapy delivery that is more focused on cancerous cells with less exposure on surrounding normal tissues
  • Fertility-preserving therapy options for young women who want to preserve their fertility after cancer treatment
  • Individually customized chemotherapy regimens, including novel drugs and drug combinations in our clinical trials program

Highlights of our ovarian cancer treatment program include:

Cytoreductive (debulking) surgery with heated intraperitoneal chemotherapy (HIPEC), which extensively removes cancerous tissue followed by applying cancer-fighting drugs directly into the abdominal and pelvic area, increasing its effectiveness in killing any remaining cancer cells
  • Pelvic floor reconstruction procedures that can restore continence and reduce discomfort
  • Image-guided radiation delivery systems that can accurately target radiation to tumor sites while minimizing exposure in normal, healthy tissues
  • Fertility-preserving options for patients who wish to have children after cancer treatment
  • Innovative ovarian cancer clinical trials with treatments that may be more effective and less toxic, including cancer-fighting viruses, immunity-boosting vaccine therapies and drugs that can overcome the cancer’s defense mechanisms

Highlights of our endometrial/uterine cancer treatment program include:

  • Minimally invasive and robotic surgery, which uses smaller incisions than a traditional open procedure, resulting in less blood loss, reduced pain, shorter recovery time and quicker return to normal activities
  • Cytoreductive (debulking) surgery, which can improve outcomes and increase likelihood of a cure
  • Advanced radiation therapy delivery that is more focused on cancerous cells with less exposure on surrounding normal tissues
  • Fertility-preserving therapy options for young women who want to preserve their fertility after cancer treatment
  • Intraperitoneal (IP) and heated intraperitoneal chemotherapy (HIPEC), which can improve outcomes for women with advanced cancers.

Learn more about additional treatment options for cervicalovarian and endometrial/uterine cancers.

City of Hope’s renowned physicians and researchers utilize the latest in technology and innovation to treat cancer, coupled with our enduring belief in providing unparalleled compassionate care.

Female Pelvic Medicine and Reconstructive Surgery

Christopher Chung, M.D.

Clinical Specialties

  • Female Pelvic Medicine and Reconstructive Surgery
  • Urogynecology

Gynecologic Oncology

Thanh H. Dellinger, M.D.

Clinical Specialties

  • Gynecologic Oncology
Amy Hakim, M.D., M.S.

Clinical Specialties

  • Gynecologic Oncology
Ernest S. Han, M.D., Ph.D., F.A.C.O.G.

Clinical Specialties

  • Gynecologic Oncology
Stephen J. Lee, M.D.

Clinical Specialties

  • Gynecologic Oncology
Paul Lin, M.D.

Clinical Specialties

  • Gynecologic Oncology
Wei-Chien Michael Lin, M.D.

Clinical Specialties

  • Gynecologic Oncology
Mark Wakabayashi, M.D., M.P.H.

Clinical Specialties

  • Gynecologic Oncology
Maria C.B. de Leon, M.D.

Clinical Specialties

  • Gynecologic Oncology

Medical Oncology

Mihaela C. Cristea, M.D.

Clinical Specialties

  • Medical Oncology
Lucille A Leong, M.D.

Clinical Specialties

  • Medical Oncology
  • Hematology
Robert J. Morgan, Jr., M.D., F.A.C.P.

Clinical Specialties

  • Medical Oncology

Radiation Oncology

Yi-Jen Chen, M.D., Ph.D.

Clinical Specialties

  • Radiation Oncology

Gynecologic cancer research and clinical trials

City of Hope is a recognized leader in gynecologic cancer research. We offer access to numerous clinical trials and new therapies that are not readily available elsewhere.

Some of our current cervical cancer research projects include:
  • Evaluating the best therapy for relieving malignant bowel obstruction due to cervical cancer or its treatments
  • Enhancing the quality of life for cervical cancer patients and survivors by engaging them in a peer-to-peer support program with other survivors
  • Improving cancer caregivers’ quality of life by connected them with a nurse to educate them on symptom evaluation and management, caregivers’ self-care needs and resources available to them
Some of our current ovarian research projects include:
  • Developing a cancer vaccine against a mutant variation of the p53 protein, which has lost the tumor suppressing ability of a normal p53 protein and instead may help ovarian and other cancers grow and spread
  • Enhancing the use of cytoreductive (debulking) surgery followed by hyperthermic intraperitoneal chemotherapy for ovarian cancer patients, including using magnetic resonance imaging to help detect and locate tumor sites before and during the surgery
  • Using adoptive T cell therapy to reprogram a patient’s immune system to recognize and attack ovarian cancer cells throughout the body.
  • Building oncolytic —– or cancer-killing — viruses that can destroy ovarian cancer cells at the tumor sites and throughout the body
  • City of Hope researchers have found that a group of proteins called TWIST is responsible for ovarian cancer’s resistance against chemotherapy, and are now looking to develop drugs (TWIST inhibitors) that can overcome this defense mechanism.
  • Enhancing the quality of life for ovarian cancer patients and survivors by engaging them in a peer-to-peer support program with other survivors
Some of our current endometrial/uterine research projects include:
  • Developing more precise surgical and radiation techniques for better tumor removal
  • Identifying better drugs that help prevent relapses
  • Finding chemotherapy agents that are more effective against the cancer or less toxic for the patient

Learn more about our clinical trials here.

Support the Gynecologic Cancers Program

We deliver exquisite care at the leading edge of cancer treatment. It takes the help of a lot of caring people to make hope a reality for our patients. City of Hope was founded by individuals' philanthropic efforts over 100 years ago. Their efforts - and those of our supporters today - have built the foundation for the care we provide and the research we conduct. It enables City of Hope to strive for new breakthroughs and better therapies - helping more people enjoy longer, better lives.

For more information on supporting this specific program, please contact:

Janet Morgan
Senior Development Officer
Phone: 626-218-6250
Email: [email protected]

Or, you can Donate Now to make a gift to support all the research at City of Hope.