Gynecologic Cancers Research

Gynecologic Cancer Research And Clinical Trials

City of Hope is a recognized leader in gynecologic cancer research. We offer access to numerous clinical trials and new therapies that are not readily available elsewhere.

Some of our current cervical cancer research projects include:
  • Evaluating the best therapy for relieving malignant bowel obstruction due to cervical cancer or its treatments
  • Enhancing the quality of life for cervical cancer patients and survivors by engaging them in a peer-to-peer support program with other survivors
  • Improving cancer caregivers’ quality of life by connected them with a nurse to educate them on symptom evaluation and management, caregivers’ self-care needs and resources available to them
Some of our current ovarian research projects include:
  • Developing a cancer vaccine against a mutant variation of the p53 protein, which has lost the tumor suppressing ability of a normal p53 protein and instead may help ovarian and other cancers grow and spread
  • Enhancing the use of cytoreductive (debulking) surgery followed by hyperthermic intraperitoneal chemotherapy for ovarian cancer patients, including using magnetic resonance imaging to help detect and locate tumor sites before and during the surgery
  • Using adoptive T cell therapy to reprogram a patient’s immune system to recognize and attack ovarian cancer cells throughout the body.
  • Building oncolytic —– or cancer-killing — viruses that can destroy ovarian cancer cells at the tumor sites and throughout the body
  • City of Hope researchers have found that a group of proteins called TWIST is responsible for ovarian cancer’s resistance against chemotherapy, and are now looking to develop drugs (TWIST inhibitors) that can overcome this defense mechanism.
  • Enhancing the quality of life for ovarian cancer patients and survivors by engaging them in a peer-to-peer support program with other survivors
Some of our current endometrial/uterine research projects include:
  • Developing more precise surgical and radiation techniques for better tumor removal
  • Identifying better drugs that help prevent relapses
  • Finding chemotherapy agents that are more effective against the cancer or less toxic for the patient

Learn more about our clinical trials here.