Sarcoma
Sarcomas are uncommon cancers that develop in your body’s connective tissues, including bone, cartilage, fat, muscle, nerves, blood vessels and lymph vessels. This group of cancers is quite rare, and each one is unique, requiring expert detection, treatment and rehabilitation for successful treatment.
“I have built relationships with patients, nurses, doctors and supportive care team members. Those relationships are what carried me through treatment and gave me the strength to continue to fight.”
- Hannah Komai, bone cancer survivor
Sarcomas are typically divided into two main types, bone cancer (osteosarcoma) and soft tissue sarcoma, which has over 50 classifications, depending on tissue type affected.
Precise sarcoma tests are crucial for treatment planning, and City of Hope is equipped with state-of-the-art technologies and specialized staff to ensure an accurate, comprehensive diagnosis of these cancers.
Due to their unique nature in types and locations affected, sarcomas require a personalized treatment plan for the best clinical and quality-of-life outcomes. Our team comprises surgeons, radiation oncologists, medical oncologists, pathologists, rehabilitation and supportive care medicine.
City of Hope is a nationally recognized leader in researching and treating sarcomas. Our clinicians and researchers collaborate extensively to develop and evaluate new therapies for better survival and quality-of-life outcomes.
Patient Stories

Our Expertise
With an independent, National Cancer Institute-designated comprehensive cancer center that is ranked top 5 in the nation for cancer care by U.S. News & World Report at its core, City of Hope’s uniquely integrated model spans cancer care, research, and academics and training. City of Hope’s national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and cancer treatment centers and outpatient facilities in the Atlanta, Chicago and Phoenix regions.
The multidisciplinary staff pursues an integrated approach to treating sarcomas by combining the latest research findings with outstanding patient care. This includes using advanced technologies and specialized techniques such as:
- Minimally invasive surgical approaches that reduce discomfort, blood loss and recovery time
- Innovative limb-sparing surgeries — such as bone transport for the reconstruction of bone after tumor resection — that can preserve patients' range of motion and quality of life
- Expandable limb implants that can "grow" with the patient, eliminating the need for additional surgeries
- Bone transport to correct bone defects or limb-length discrepancies
- Highly precise radiation delivery that uses advanced imaging technology to guide radiation dose and focus, increasing its cancer-fighting effectiveness while minimizing exposure in normal tissues
- Individually customized chemotherapy and targeted therapy regimens, including isolated-limb delivery that may be more effective against cancer and less toxic to the patient
- Comprehensive rehabilitation program to help restore motion and function after treatment
- An adolescent and young adults program to address the concerns of sarcoma patients, who are typically diagnosed at a younger age
Additionally, City of Hope patients have access to our extensive team of supportive care experts, who will help you and your caregivers achieve and maintain a better quality of life during and after your cancer treatment.

City of Hope is one of the few facilities designated a comprehensive cancer center by the National Cancer Institute.

Our developments in the areas of breakthrough cancer drugs, bone marrow transplants and CAR T cell therapy are recognized internationally.

Our leadership in research and innovation continually enhances our ability to provide novel and differentiated approaches to cancer care.