Breast Cancer Care in Orange County
Many breakthrough treatments offer new hope for today’s breast cancer patients. You can access this level of world-class care in Orange County. Our top-ranked breast cancer physicians and other specialists help those with breast cancer navigate and manage their care, from diagnosis to treatment and transition to recovery.
Why Choose City of Hope Orange County for Breast Cancer Care?
With leading-edge technology and surgical expertise, City of Hope breast cancer specialists deliver outstanding outcomes that are difficult to achieve elsewhere.
- A track record of exceptional breast cancer survival outcomes for patients at all stages.
- Advanced techniques such as nipple-sparing mastectomies, high-precision radiation and immunotherapies.
- A comprehensive, supportive care program to address a wide range of cancer and treatment-related concerns from diagnosis to remission and beyond.
A collaborative and caring multidisciplinary team of breast cancer experts that understands your needs and background to provide a whole-person approach to treatment.
- Access to promising new therapies through more than 100 innovative, ongoing research and clinical trials for breast cancer.
- Long-term survivorship and follow-up programs focused on minimizing recurrence risk and improving quality of life.
- An expanding clinical network throughout Orange County is bringing world-renowned physicians closer to homes in the region.
Clinical trial participation is a critical aspect of care for many patients living with cancer. Our patients can access more than 1,000 innovative Phase 1–3 clinical trials at City of Hope each year — more cancer-focused clinical trials than anywhere in the area — to provide promising new treatments long before they become the standard of care.

We Specialize in State-of-the-Art Treatments for Breast Cancer
Our advanced cancer treatments and screenings include:
- Targeted therapy for breast cancer that selectively attacks cancer cells based on specific characteristics
- Novel therapies, many of which have been discovered or developed at City of Hope®, and the identification and monitoring of tumor markers to inform changes in treatment over time
- Endocrine (hormone) therapy to decrease the production of cancer-fueling hormones to prevent, slow or stop cancer
- Breast-conserving surgery that removes early-stage tumors while delivering excellent cosmetic outcomes
- Skin and nipple-sparing mastectomies with breast reconstruction in one procedure (and a multicenter national clinical trial evaluating robotic surgery for mastectomies)
- Direct-to-implant postmastectomy breast reconstruction surgery that is performed without the use of tissue expanders.
- Complex, autologous tissue-based (flap) reconstructions
- 3D Mammogram to better detect and locate breast cancer
- Magnetic resonance imaging and ultrasound for people with dense breasts or high breast cancer risk
- High-Risk Breast Clinic at City of Hope Orange County Lennar Foundation Cancer Center, where adults with a familial history of breast cancer can meet with a compassionate team of experts to determine their best options for surveillance and risk reduction
- A clinical trial through City of Hope Precision Medicine that offers free germline panel testing to assess a women’s genetic risk for breast and other cancers
- Oncoplastic surgery
City of Hope Orange County Breast Cancer Doctors
City of Hope Orange County has a team of cancer specialists who are known for their expertise in breast cancer prevention, detection, and treatment.
Breast Cancer Leadership
Jennifer Tseng, M.D., is the Medical Director of Breast Surgery, City of Hope Orange County.
Irene Kang, M.D., is medical director of women’s health medical oncology and assistant professor in medical oncology and therapeutics research.
Radiation Oncology
Amanda Schwer, M.D., is an Assistant Clinical Professor, Department of Radiation Oncology at City of Hope Orange County. As a third-generation Orange County native, Dr. Schwer is proud to play a part in bringing extraordinary cancer care to the community that is so close to her heart.
Surgical Oncology
Dr. Natalie Johnson is a prominent specialist in surgery for breast cancer, thyroid cancer, parathyroid disease, and melanoma.

Specializing in bioengineering and tumor micro-environment in cancer development and progression, Andrew Nguyen, M.D., is an assistant clinical professor in the Division of Surgical Oncology in the Department of Surgery at City of Hope.
Plastics & Reconstructive Surgery
Plastic surgeon Mouchammed Agko, M.D., understands that many cancer survivors want to continue their lives after treatment without physical reminders of the disease. His goal is to help them achieve that — in addition to providing additional aesthetic improvements, if it meets a patient’s needs.
Medical Oncology
Wade Smith, M.D., is a medical oncologist specializing in breast cancer at City of Hope's Orange County, Newport Beach and Duarte locations.
Luke Chen, M.D., is a medical oncologist and hematologist at City of Hope Orange County Lennar Foundation Cancer Center and Seacliff locations. Dr. Chen’s research has explored ways to improve treatment for prostate cancer and other malignancies.
Sudarsan Vishnu Kollimuttathuillam, M.D., is a medical oncologist and hematologist at City of Hope Orange County's Lennar Foundation Cancer Center and Seacliff locations. Dr. Kollimuttathuillan places a priority on offering his patients access to innovative treatments and clinical trial options.
Danny Nguyen, M.D., is a medical oncologist and hematologist at City of Hope Orange County's Lennar Foundation Cancer Center and Seacliff locations. Dr. Nguyen is also an assistant clinical professor in the Department of Medical Oncology & Therapeutics Research.

Karla Olmedo, M.D., is a rising star in hematology/oncology. Dr. Olmedo is driven by the pursuit of advances in immunology and the promise of cell therapy in effectively fighting cancer.

Krushangi Patel, M.D., is a highly engaged practitioner who prioritizes not only her patients' physical well-being but also their emotional and spiritual needs.

George Bernard Semeniuk, III, M.D., is a hematologist/oncologist specializing in leukemia, lymphoma and hematopoietic cell transplantation.

Tingting Tan, M.D., Ph.D., is a medical oncologist and assistant clinical professor in the Department of Medical Oncology & Therapeutics Research at City of Hope.
Lihong Wu, M.D., is a medical oncologist and hematologist at City of Hope's Long Beach Elm and Worsham locations. Dr. Wu has made it her mission to help others triumph over cancer. She prides herself on being there for her patients and finding the best possible treatments for them.
Supportive Care
Richard T. Lee, M.D., is the medical director of the Integrative Medicine Program in the Department of Supportive Care Medicine at City of Hope.

Jessica Cheng, M.D., is among the nation’s few, and Orange County’s only, fellowship-trained experts in cancer rehabilitation medicine. This is a subspecialty of physical medicine and rehabilitation (PM&R) also known as physiatry.
Where you get a mammorgram matters.
City of Hope Orange County offers the most advanced mammography technology available.
Regular screening is one of the best ways to find breast cancer early. Early detection can make treatment easier and more effective.

A trailblazing integrative medicine program combining the best of Western medicine and evidence-based complementary therapies, such as acupuncture, massage and meditation.
City of Hope is a national leader in evidence-based supportive care. The Sheri & Les Biller Patient and Family Resource Center at the Lennar Foundation Cancer Center will facilitate easy access to a wide range of programs, including care navigation, survivorship programs, psychological and spiritual counseling, pain management and more.
Marybelle's is a full-service salon extending a specialty shopping experience with oncology-trained cosmetologists.
The on-site pharmacy fills and dispenses prescriptions and offers over-the-counter medications, alleviating the burden of going elsewhere.