Atish Ranjan Mohanty, Ph.D.

626-256-4673
Atish Mohanty, Ph.D.
Assistant Research Professor, Department of Medical Oncology & Therapeutics Research

Education & Experience

Degrees

  • 2012, Ph.D., Molecular Biology and Biochemistry, University of Tokyo

  • 2004, Masters, Biotechnology, Ravenshaw College, Utkal University

Fellowship

  • 2007-2008, Molecular Biology and Biochemistry, University of Tokyo

  • 2005-2007, Central Silk Board, Seri Biotech Research Laboratory

Professional Experience

  • 2020 – Present, Assistant Research Professor, City of Hope, Duarte, California

  • 2018-2020, Staff Scientist, Medical Oncology, City of Hope, Duarte, California

Publications

  • Nam, A.; Mohanty, A*.; Bhattacharya, S.; Kotnala, S.; Achuthan, S.; Hari, K.; Srivastava, S.; Guo, L.; Nathan, A.; Chatterjee, R.; Jain, M.; Nasser, M.W.; Batra, S.K.; Rangarajan, G.; Massarelli, E.; Levine, H.; Jolly, M.K.; Kulkarni, P.; Salgia, R. Dynamic Phenotypic Switching and Group Behavior Help Non-Small Cell Lung Cancer Cells Evade Chemotherapy. Biomolecules 2022, 12, 8.
  • A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer. Atish Mohanty, Arin Nam, Alex Pozhitkov, Lu Yang, Saumya Srivastava, Anusha Nathan, Xiwei Wu, Isa Mambetsariev, Michael Nelson, A.R. Subbalakshmi, Linlin Guo, Leonidas D. Arvanitis, Mohd W. Nasser, Surinder K. Batra, John Orban, Mohit Kumar Jolly, Erminia Massarelli, Prakash Kulkarni, Ravi Salgia, iScience, Volume 23, Issue 9, 2020, 101496.
  • FAK-targeted and combination therapies for the treatment of cancer: an overview of phase I and II clinical trials. A Mohanty, RR Pharaon, A Nam, S Salgia, P Kulkarni, E Massarelli. Expert Opinion on Investigational Drugs 29 (4), 399-409, 2020.
  • Inhibition of BRAF induces PD-L1 expression in BRAF-mutated papillary thyroid carcinoma Atish Mohanty, Michelle Afkhami, Rebecca Pharaon, Holly Yin, Jonathan Sun, Arin Nam, Sue Chang, Thomas Gernon, Robert Kang, Arya Amini, Sagus Sampath, Nayana L Vora, Behrouz Salehian, Raju Pillai, Ravi Salgia, Ellie Maghami, Erminia Massarelli. International Journal of Radiation Oncology• Biology• Physics 106 (5), 1192-1193, 2020.
  • Suppressing chemoresistance in lung cancer via dynamic phenotypic switching and intermittent therapy. Arin Nam, Atish Mohanty*, Supriyo Bhattacharya, Sourabh Kotnala, Srisairam Achuthan, Kishore Hari, Anusha Nathan, Govindan Rangarajan, Erminia Massarelli, Herbert Levine, Mohit Kumar Jolly, Prakash Kulkarni, Ravi Salgia, bioRxiv, 2020.
  • Phenotypic switching and adaptive strategies of cancer cells in response to stress: insights from live cell imaging and mathematical modeling. Arin Nam, Atish Mohanty*, Supriyo Bhattacharya, Sourabh Kotnala, Srisairam Achuthan, Kishore Hari, Anusha Nathan, Govindan Rangarajan, Erminia Massarelli, Herbert Levine, Mohit Kumar Jolly, Prakash Kulkarni, Ravi Salgia, bioRxiv, 2020.
  • Regulation of SOX11 expression through CCND1 and STAT3 in mantle cell lymphoma. Atish Mohanty, Natalie Sandoval, An Phan, Thang V Nguyen, Robert W Chen, Elizabeth Budde, Matthew Mei, Leslie Popplewell, Lan V Pham, Larry W Kwak, Dennis D Weisenburger, Steven T Rosen, Wing C Chan, Markus Müschen, Vu N Ngo. Blood, The Journal of the American Society of Hematology 133 (4), 306-318, 2019.
  • A Non-genetic Mechanism for Chemoresistance in Lung Cancer: The Role of Integrin β4/Paxillin Axis. Atish Mohanty, Arin Nam, Alex Pozhitkov, Supriyo Bhattacharya, Lu Yang, Anusha Nathan, Xiwei Wu, Saumya Srivastava, Isa Mambetsariev, Michael Nelson, Rajendra Pangeni, Dan Raz, Yihong Chen, Yanan He, John Orban, AR Subbalakshmi, Linlin Guo, Mohd W Nasser, Marianna Koczywas, Surinder K Batra, Mohit Kumar Jolly, Prakash Kulkarni, Erminia Massarelli, Ravi Salgia. bioRxiv, 781807, 2019.
  • Cyclin D1 depletion induces DNA damage in mantle cell lymphoma line. S Mohanty, Suchismita Mohanty, Atish Mohanty, Natalie Sandoval, Thai Tran, Victoria Bedell, Jun Wu, Anna Scuto, Joyce Murata-Collins, Dennis D Weisenburger, Vu N Ngo. Leukemia & lymphoma 58 (3), 676-688, 2017.
  • CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma. Atish Mohanty, Natalie Sandoval, Manasi Das, Raju Pillai, Lu Chen, Robert W Chen, Hesham M Amin, Michael Wang, Guido Marcucci, Dennis D Weisenburger, Steven T Rosen, Lan V Pham, Vu N Ngo. Oncotarget 7 (45), 73558, 2016.
  • Genetic diversity and population structure of Indian golden silkmoth (Antheraea assama) Kallare P Arunkumar, Anup Kumar Sahu, Atish Ranjan Mohanty, Arvind K Awasthi, Appukuttannair R Pradeep, S Raje Urs, Javaregowda Nagaraju. PloS one 7 (8), 2012. 
  • Successive phosphorylation of p27KIP1 protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2. Atish R Mohanty, Qiuming Kan, Saumya Srivastava, Baasanjav Uranbileg, Shiho Arakawa-Takeuchi, Naoya Fujita, Hiroto Okayama. Journal of Biological Chemistry 287 (26), 21757-21764, 2012.
  • Prakash Kulkarni, Amita Behal, Atish Mohanty, Ravi Salgia, Aurora M. Nedelcu, Vladimir N. Uversky, Co-opting disorder into order: Intrinsically disordered proteins and the early evolution of complex multicellularity, International Journal of Biological Macromolecules, Volume 201, 2022, Pages 29-36.
  • Protein conformational dynamics and phenotypic switching. Kulkarni, P., Achuthan, S., Bhattacharya, S. Jolly MK, Kotnala S, Leite B.P. Vitor, Mohanty A, Orban J, Roy S, Rangarajan G, Salgia R, Biophys Rev (2021).
  • RLIP depletion induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells, Carcinogenesis. Sharad S Singhal, Atish Mohanty, Prakash Kulkarni, David Horne, Sanjay Awasthi, Ravi Salgia, Volume 42, Issue 5, May 2021, Pages 742–752.
  • Group Behavior and Emergence of Cancer Drug Resistance, Supriyo Bhattacharya, Atish Mohanty, Srisairam Achuthan, Sourabh Kotnala, Mohit Kumar Jolly, Prakash Kulkarni, Ravi Salgia, Trends in Cancer, Volume 7, Issue 4, 2021, Pages 323-334.
  • Targeting CA-125 Transcription by Development of a Conditionally Replicative Adenovirus for Ovarian Cancer Treatment. Yue, E.; Yang, G.; Yao, Y.; Wang, G.; Mohanty, A.; Fan, F.; Zhao, L.; Zhang, Y.; Mirzapoiazova, T.; Walser, T.C.; Rodriguez-Rodriguez, L.; Fong, Y.; Salgia, R.; Wang, E.W. Targeting CA-125 Cancers 2021, 13, 4265.
  • Acquired Resistance to PD-1/PD-L1 Blockade in Lung Cancer: Mechanisms and Patterns of Failure. Pathak, R., Pharaon, R.R.; Mohanty, A.; Villaflor, V.M.; Salgia, R.; Massarelli, E. Cancers 2020, 12, 3851.
  • Activation of EPHA2-ROBO1 Heterodimer by SLIT2 Attenuates Non-canonical Signaling and Proliferation in Squamous Cell Carcinomas, Saumya Srivastava, Ka Ming Pang, Mari Iida, Michael S. Nelson, Jiayi Liu, Arin Nam, Jiale Wang, Isa Mambetsariev, Raju Pillai, Atish Mohanty, Nellie McDaniel, Amita Behal, Prakash Kulkarni, Deric L. Wheeler, Ravi Salgia, iScience, Volume 23, Issue 11, 2020, 101692.
  • Biomarkers in immunotherapy: literature review and future directions. Pharaon R, Koczywas MA, Salgia S, Mohanty A, Massarelli E. J Thorac Dis. 2020;12(9):5119-5127. doi:10.21037/jtd.2020.04.15.
  • The Ephrin receptor A2 and Roundabout Guidance Receptor 1 heterodimer: A potential theranostic for squamous cell carcinomas. Ka M. Pang, Saumya Srivastava, Mari Iida, Michael Nelson, Jiayi Liu, Arin Nam, Jiale Wang, Isa Mambetsariev, Atish Mohanty, Nellie McDaniel, Amita Behal, Prakash Kulkarni, Deric L. Wheeler, Ravi Salgia, bioRxiv 2020.04.09.034405.
  • Cdc6 protein activates p27KIP1-bound Cdk2 protein only after the bound p27 protein undergoes C-terminal phosphorylation. Baasanjav Uranbileg, Hanako Yamamoto, Jung-ha Park, Atish R Mohanty, Shiho Arakawa-Takeuchi, Shigeki Jinno, Hiroto Okayama. Journal of Biological Chemistry 287 (9), 6275-6283, 2012.
  • Role of p27 [Kip1] phosphorylation in Cdc6-driven activation of p27-bound Cdk2. AR Mohanty, 2012.