City of Hope Cutaneous (Skin) Lymphoma Research
July 13, 2024
This page was reviewed under our medical and editorial policy by Alex Herrera, M.D., associate professor, division of lymphoma, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope® Cancer Center Duarte
Cutaneous lymphoma patients at City of Hope are just steps away from clinical research labs and scientists who are constantly developing potential new treatments. This means innovation may occur more quickly to help patients access new therapies, which are being developed and manufactured at our on-site labs.
Cutaneous Lymphoma Research and Clinical Trials
Cutaneous lymphoma research at City of Hope is focused on developing and discovering new treatments to improve prognosis and outcomes for our cutaneous lymphoma patients.
Clinical investigations we are leading include efforts to better understand the tumor microenvironment — the interaction between tumor and other cells that foster cancer growth — and finding new targets and developing new therapies aimed at finding a cure.
Current Cutaneous Lymphoma Trials
Our current open trials include those listed below.
IRB 15157: A Prospective, Observational, US-Based Study Assessing Outcomes, Adverse Events, Treatment Patterns, and Quality of Life in Patients Diagnosed with Mycosis Fungoides Cutaneous T-Cell Lymphoma and Treated with Valchlor®.
PHASE I
IRB 16273: A Dose Escalation Trial of Intratumoral Injections of TTI-621 in Subjects with Relapsed and Refractory Percutaneously-Accessible Solid Tumors and Mycosis Fungoides.
IRB 15270: A Dose-Ranging Study to Investigate the Safety, Tolerability, and Pharmacokinetics of MRG-106 Following Local Intratumoral and Subcutaneous Injection in Patients with Cutaneous T-Cell Lymphoma (CTCL), Mycosis Fungoides (MF) Sub-Type.
IRB 15165: A Study Evaluating Safety, Tolerability, and Pharmakinetics of Escalating Doses or AGS67E Given as Monotherapy in Subjects with Refractory or Relapsed Lymphoid Malignancies.
IRB 14349: A Study of Yttrium-90 Labeled Anti-CD25 Monoclonal Antibody Plus Standard BEAM Conditioning for Autologous Hematopoietic Cell Transplantation in Patients with Mature T-Cell Non-Hodgkin Lymphoma: the aTAC-BEAM Regimen.
PHASE I / IIA
IRB 16221: Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma.
IRB 16257: An Open-Label Study to Determine the Safety and Tolerability of ALRN-6924 in Patients with Advanced Solid Tumors of Lymphomas Expressing Wild-Type p53 Protein.
PHASE I / IB
IRB 15428: A Dose Escalation Study to Evaluate Safety and Efficacy of RP6530, a Dual P13K Delta/Gamma Inhibitor, in Patients with Relapsed or Refractory T-cell Lymphoma.
PHASE II
IRB 16042: A Trial of Intravenous Fenretinide (N-(4-hydroxyphenyl) Retinamide, 4-HPR) Emulsion for Patients with Relapsed/Refractory Peripheral T-cell Lymphomas (PTCL).
IRB 14321: A Single-Arm, Open-Label, Multicenter, Study of Folotyn® (Pralatrexate Injection) in Combination with Oral Leucovorin to Prevent or Reduce Mucositis in Patients with Relapsed or Refractory (R/R) Peripheral T-Cell Lymphoma (PTCL).
PHASE III
IRB 15122: A Multicenter, Randomized, Double-Blind, Placebo Controlled Study to Determine the Efficacy of Topical SGX301 (Synthetic Hypericin) and Fluorescent Bulb-Light Irradiation for the Treatment of Cutaneous T-Cell Lymphoma.
IRB 14338: A Randomized, Double-Blind, Placebo-Controlled Study of Brentuximab Vedotin and CHP (A+CHP) Versus CHOP in the Frontline Treatment of Patients with CD30-Positive Mature T-cell Lymphomas.
For more information on a specific clinical trial, please call 626-218-1133.