Liver Cancer Research

Liver cancer research and clinical trials

At City of Hope, liver cancer clinicians and researchers collaborate extensively to develop and evaluate new therapies for better survival and quality-of-life outcomes. Our patients have access to a wide variety of clinical trials including new chemotherapy and targeted therapies, hormone therapies, novel surgical techniques, innovative radiation approaches and new prevention strategies.
These trials give current patients access to promising, leading-edge therapies and improve overall care for future patients worldwide. Visit our clinical trials page to learn more about current studies and their eligibility criteria.

Here are some of our current liver cancer research projects:

  • A study of immunotherapy with durvalumab (MEDI4736) and tremelimumab following radioembolization liver-directed therapy in patients with locally advanced hepatocellular carcinoma
  • A study of immunotherapy with MK-1308A in combination with lenvatinib in participants with advanced hepatocellular carcinoma
  • A study evaluating multiple immunotherapy-based treatment combinations in patients with advanced liver cancers
  • A study of engineered ET140203 T-cells in adults with advanced hepatocellular carcinoma
  • A study investigating cancer attacking virus Voyager V1 (Vesicular Stomatitis Virus Expressing NIS and human interferon beta, VV1), in combination with immunotherapy cemiplimab in patients with hepatocellular carcinoma
  • A study of immune-modulatory IRX-2 regimen and nivolumab in advanced hepatocellular carcinoma