Melanoma
Melanocytes are the pigment-producing cells in your body. While most reside on your skin, they can also be found in your eyes, lips, nailbeds and internal organs. Melanoma originates in melanocytes.
There are many subtypes of melanoma — the main four being superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma and lentigo maligna melanoma — and rarer conditions like spitzoid melanoma, nevoid melanoma, desmoplastic melanoma, uveal melanoma or ocular melanoma, and mucosal melanoma.
According to the American Cancer Society, more than 100,000 new melanoma cases will be diagnosed this year (about 59,170 in men and 41,470 in women).
Skin cancer is the most prevalent of all cancers in the United States, and melanoma is the most severe skin cancer type. It also makes up just 1% of all skin cancer diagnoses. Early detection is critical, as survival rates worsen with later detection.
The five-year survival rate for Stage 1 melanoma is 98%, for Stage 3 melanoma is 63% and for Stage 4 is 17%.
City of Hope’s team of internationally trained dermatologists and dermatopathologists uses their clinical expertise and leading-edge technology to provide the most accurate diagnosis and effective treatment. This combination of experience and talent gives City of Hope its reputation for transforming melanoma patients with advanced disease and dire diagnoses into survivors.
City of Hope’s approach to treating skin cancer starts with a coordinated, multidisciplinary care team whose primary goal is offering you the best, most individualized treatment plan. Your plan includes the newest therapies — including immunotherapies — and innovative treatment combinations effective for even the most advanced melanoma patients.
Skin cancer is a disease that can appear in different ways in the body. Research at City of Hope — driven by patient-specific, individualized treatment strategies — is focused on those differences and on designing therapies that affect how skin cancer develops, progresses and spreads.
Getting treated for skin cancer at City of Hope means you are steps away from labs where new cancer treatments are being developed every day. That proximity means you benefit from something unique in cancer care — bench-to-bedside treatment.
When you come to City of Hope, you have access to a strong network of support services and staff to help you and your family along your skin cancer journey.
Our Expertise
City of Hope is internationally recognized for its research and breakthrough treatments, has been named one of America’s top cancer hospitals by U.S. News & World Report for more than a decade.
Our Commitment To Providing Exceptional Care Includes:
- Promising new therapies as part of our clinical trials program, including novel intralesional injection therapies. These include studying commercially approved agents such as TVEC, an oncolytic virus that directly targets melanoma tumors with other therapies.
- Collaboration with the Melanoma Research Foundation, National Clinical Trials Network, Cytokine Working Group, SWOG Cancer Research Network, and Cancer Immunotherapy Trials Network, providing quick access to the newest therapies and clinical trials
- Deep experience with immunotherapy-based treatments — including pivotal clinical trials for widely used drugs like ipilimumab, nivolumab and pembrolizumab
- Expertise with isolated limb infusion, a focused chemotherapy treatment unavailable at most other cancer centers
- Our internationally trained dermatopathologist combines clinical experience with leading-edge technology to provide the most accurate diagnosis.
- Tumor testing and customized drug therapy tailored to the molecular profile of specific skin cancers
- Expertise in advanced facial reconstructive and microvascular procedures for patients with complex skin cancers
- Survivorship clinics — including physical therapy for lymphedema-related side effects — provide support and monitoring throughout the disease.
Your care includes regular interaction and input from a team that includes oncologists, surgeons, radiation oncologists, dermatologists and pathologists, along with nurses, social workers and specially trained support staff.
City of Hope is one of only a few dozen centers in the U.S. using a comprehensive approach by a multidisciplinary team whose sole focus is treating skin cancer.
Our developments in the areas of breakthrough cancer drugs, bone marrow transplants and CAR T cell therapy are recognized internationally.
Our leadership in research and innovation continually enhances our ability to provide novel and differentiated approaches to cancer care.
