Heather Hampel, M.S., CGC

Recruited to the Department of Medical Oncology in November 2021 from The Ohio State University Comprehensive Cancer Center, Heather Hampel is an internationally-recognized cancer genetic counselor and researcher with a particular emphasis on universal tumor screening of all colorectal and endometrial cancer patients for Lynch Syndrome.

This work has changed the standard-of-care genetic screening practice for colorectal cancer patients. Her work includes over 170 publications on the prevalence of Lynch Syndrome along colorectal and endometrial cancer patients, the best testing protocols, cost-effectiveness, and referral guidelines for cancer genetics.

She completed her B.S. in Molecular Genetics at The Ohio State University and M.S. in Human Genetics from Sarah Lawrence College in New York. She has held several national leadership positions, including serving on the Board of Directors for the American Board of Genetic Counseling from 2006-2011, as well as serving as President in 2009 and 2010.

She is a past President for the Council of the Collaborative Group of the Americas on the Inherited Colorectal Cancer and recently served on the Steering Committee of the National Colorectal Cancer Roundtable. She was elected and recently began her term as Secretary/Treasurer of the National Society of Genetic Counselors.

• 2019, Jeremy Jass Memorial Lectureship, Familial Aspects of Cancer Research and Practice/KConFab annual meeting, Kingscliff, Australia
• 2018, AliveandKickn Blue Jeans Bash 2018 Honoree
• 2018, Niehaus, Southworth, Weissenbach Award and Visiting Professorship in Clinical Cancer Genetics, Memorial Sloan Kettering Cancer Center
• 2017, Kay Neale Lecturer at the International Society for Gastrointestinal Hereditary Tumors Annual Meeting in Florence, Italy
• 2013, Anne J. Krush Memorial Lecturer at the Collaborative Group of the Americas for Inherited Colorectal Cancer Annual Meeting in Anaheim, California
• 2006, Region IV Leadership Award, National Society of Genetic Counselors
• 1995, President, Graduate Student Steering Committee, Sarah Lawrence College
• 1995, Rigg Fellowship, Sarah Lawrence College
• 1993, Dean's List, multiple quarters, The Ohio State University

American Society of Human Genetics

• 1994 – Present, Member

National Society of Genetic Counselors

• 2002 – Present, Member, Education Committee, NSGC
• 2002 – Present, Chair, AEC Subcommittee  
• 1996 – Present, Cancer Special Interest Group  
• 2021 – 2022, Secretary/Treasurer Elect
• 2007 – 2008, Invited Member, Education Committee
• 2007, Invited Member, Nominating Committee  
• 2003 - Present, Invited Member, Rollnick Committee
• 2004, Co-Chair, Region IV AEC
• 2004, Chair, subcommittee of Cancer SIG to produce “Facts about Hereditary Colon Cancer” and “Facts about Hereditary Breast Ovarian Cancer” brochures printed by NSGC
• 2003 - 2004, Region IV Representative, NSGC Board of Directors
• 2002 - 2003, Member-at-large, Finance Committee
• 2002, Co-Chair, Planning Committee AEC 
• 2001, Co-Chair, Program Committee AEC 
• 2000, Co-Chair, Workshop Committee AEC 
• 1999, Co-Chair, Practice-based Symposia Committee AEC
• 1998 - 2000, Co-Chair, Education Committee of the Cancer Special Interest Group 
• 1998, Member, Program Committee AEC 
• 1997, Chair, Speakers Committee, Cancer Genetics Short Course
• 1997, Member, Practice-based Symposia Committee Annual Educational Conference (AEC) 
• 1994 - Present, Member

American Board of Genetic Counseling 

• 2018 – 2019, Member, Leadership taskforce     
• 2017 – 2018, Chair, American Board of Genetic Counseling Disciplinary Review Committee
• 2011, Chair, Credential Committee
• 2009 – 2010, President
• 2008, Chair, Practice Analysis Advisory Committee
• 2007 – 2011, Board of Directors, elected member
• 2005, Nominating Committee

Collaborative Group of the Americas for Inherited Colorectal Cancer

• 2017 – 2018, President
• 2015 – Present, Council Member
• 1997 – Present, Member

New York State Genetic Task Force

• 1995 – 1997, Member

National Colorectal Cancer Round Table

• 2018 – Present, Co-Chair, Family History and Early Onset Workgroup
• 2013 – Present, Invited representative of National Society of Genetic Counselors
• 2016 – 2020, Steering Committee

            
Ohio Genetic Counselors Association

• 2009 – 2013, Member, Ohio Genetic Counselors Licensure Committee
• 1997 – Present, Member

Ohio Department of Health Cancer Genetics Network

• 2006 – Present, Founding member
• 2006 – 2007, Chair, Colon Cancer Genetics Awareness committee

• Patel SG, Hampel H, Smith D, Gao D, Cockburn M, Kastrinos F. Advanced adenomas may be a red flag for hereditary cancer syndromes. Hered Cancer Clin Pract. 2021 Jan 12;19(1):8. PMID: 33436027.
• Hampel H, Pearlman R, de la Chapelle A, Pritchard CC, Zhao W, Jones D, Yilmaz A, Chen W, Frankel WL, Suarez AA, Cosgrove C, Backes F, Copeland L, Fowler J, O'Malley D, Salani R, McElroy JP, Stanich PP, Goodfellow P, Cohn DE. Double somatic mismatch repair gene pathogenic variants as common as Lynch syndrome among endometrial cancer patients. Gynecol Oncol. 2021 Jan;160(1):161-168. PMID: 33393477.
• Stanich PP, Pelstring KR, Hampel H, Pearlman R. A High Percentage of Early-Age Onset Colorectal Cancer is Potentially Preventable. Gastroenterology. 2020 Dec. Online ahead of print.PMID: 33310086.
• Nounu A, Greenhough A, Heesom KJ, Richmond RC, Zheng J, Weinstein SJ, Albanes D, Baron JA, Hopper JL, Figueiredo JC, Newcomb PA, Lindor NM, Casey G, Platz EA, Le Marchand L, Ulrich CM, Li CI, van Duijnhoven FJB, Gsur A, Campbell PT, Moreno V, Vodicka P, Vodickova L, Brenner H, Chang-Claude J, Hoffmeister M, Sakoda LC, Slattery ML, Schoen RE, Gunter MJ, Castellví-Bel S, Kim HR, Kweon SS, Chan AT, Li L, Zheng W, Bishop DT, Buchanan DD, Giles GG, Gruber SB, Rennert G, Stadler ZK, Harrison TA, Lin Y, Keku TO, Woods MO, Schafmayer C, Van Guelpen B, Gallinger S, Hampel H, Berndt SI, Pharoah PDP, Lindblom A, Wolk A, Wu AH, White E, Peters U, Drew DA, Scherer D, Bermejo JL, Williams AC, Relton CL. A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2020 Dec 14. PMID: 33318029. Online ahead of print.
• Bull CJ, Bell JA, Murphy N, Sanderson E, Davey Smith G, Timpson NJ, Banbury BL, Albanes D, Berndt SI, Bézieau S, Bishop DT, Brenner H, Buchanan DD, Burnett-Hartman A, Casey G, Castellví-Bel S, Chan AT, Chang-Claude J, Cross AJ, de la Chapelle A, Figueiredo JC, Gallinger SJ, Gapstur SM, Giles GG, Gruber SB, Gsur A, Hampe J, Hampel H, Harrison TA, Hoffmeister M, Hsu L, Huang WY, Huyghe JR, Jenkins MA, Joshu CE, Keku TO, Kühn T, Kweon SS, Le Marchand L, Li CI, Li L, Lindblom A, Martín V, May AM, Milne RL, Moreno V, Newcomb PA, Offit K, Ogino S, Phipps AI, Platz EA, Potter JD, Qu C, Quirós JR, Rennert G, Riboli E, Sakoda LC, Schafmayer C, Schoen RE, Slattery ML, Tangen CM, Tsilidis KK, Ulrich CM, van Duijnhoven FJB, van Guelpen B, Visvanathan K, Vodicka P, Vodickova L, Wang H, White E, Wolk A, Woods MO, Wu AH, Campbell PT, Zheng W, Peters U, Vincent EE, Gunter MJ. Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study. BMC Med. 2020 Dec 17;18(1):396. PMID: 33327948.
• Hidaka A, Harrison TA, Cao Y, Sakoda LC, Barfield R, Giannakis M, Song M, Phipps AI, Figueiredo JC, Zaidi SH, Toland AE, Amitay EL, Berndt SI, Borozan I, Chan AT, Gallinger S, Gunter MJ, Guinter MA, Harlid S, Hampel H, Jenkins MA, Lin Y, Moreno V, Newcomb PA, Nishihara R, Ogino S, Obón-Santacana M, Parfrey PS, Potter JD, Slattery ML, Steinfelder RS, Um CY, Wang X, Woods MO, Van Guelpen B, Thibodeau SN, Hoffmeister M, Sun W, Hsu L, Buchanan DD, Campbell PT, Peters U. Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies. Cancer Res. 2020 Oct 15;80(20):4578-4590. PMID: 32816852.
• Thomas M, Sakoda LC, Hoffmeister M, Rosenthal EA, Lee JK, van Duijnhoven FJB, Platz EA, Wu AH, Dampier CH, de la Chapelle A, Wolk A, Joshi AD, Burnett-Hartman A, Gsur A, Lindblom A, Castells A, Win AK, Namjou B, Van Guelpen B, Tangen CM, He Q, Li CI, Schafmayer C, Joshu CE, Ulrich CM, Bishop DT, Buchanan DD, Schaid D, Drew DA, Muller DC, Duggan D, Crosslin DR, Albanes D, Giovannucci EL, Larson E, Qu F, Mentch F, Giles GG, Hakonarson H, Hampel H, Stanaway IB, Figueiredo JC, Huyghe JR, Minnier J, Chang-Claude J, Hampe J, Harley JB, Visvanathan K, Curtis KR, Offit K, Li L, Le Marchand L, Vodickova L, Gunter MJ, Jenkins MA, Slattery ML, Lemire M, Woods MO, Song M, Murphy N, Lindor NM, Dikilitas O, Pharoah PDP, Campbell PT, Newcomb PA, Milne RL, MacInnis RJ, Castellví-Bel S, Ogino S, Berndt SI, Bézieau S, Thibodeau SN, Gallinger SJ, Zaidi SH, Harrison TA, Keku TO, Hudson TJ, Vymetalkova V, Moreno V, Martín V, Arndt V, Wei WQ, Chung W, Su YR, Hayes RB, White E, Vodicka P, Casey G, Gruber SB, Schoen RE, Chan AT, Potter JD, Brenner H, Jarvik GP, Corley DA, Peters U, Hsu L. 
  Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk. Am J Hum Genet. 2020 Sep 3;107(3):432-444. PMID: 32758450.
• Chen W, Hampel H, Pearlman R, Jones D, Zhao W, Alsomali M, Knight D, Frankel WL. Unexpected Expression of Mismatch Repair Protein Is More Commonly Seen with Pathogenic Missense than Other Mutations in Lynch Syndrome.  Hum Pathol. 2020 Sep;103:34-41. PMID: 32652087.
• Srinivasan S, Hampel H, Leeman J, Patel A, Rahm AK, Reuland DS, Roberts MC. Stakeholder perspectives on overcoming barriers to cascade testing in Lynch syndrome: A qualitative study. Cancer Prev Res (Phila). 2020 Dec;13(12):1037-1046. PMID: 32727822.
• Holowatyj AN, Washington KM, Salaria SN, Lieu CH, Idrees K, Eng C, Chandler PD, Hampel H, Martin RL, Lewis MA. Early-Onset Appendiceal Cancer Survival by Race or Ethnicity in the United States. Gastroenterology. 2020 Jun 12. Online ahead of print. PMID: 32540351.
• Heald B, Hampel H, Church J, Dudley B, Hall MJ, Mork ME, Singh A, Stoffel E, Stoll J, You YN, Yurgelun MB, Kupfer SS; Collaborative Group of the Americas on Inherited Gastrointestinal Cancer Position statement on multigene panel testing for patients with colorectal cancer and/or polyposis.  Fam Cancer. 2020 Jul;19(3):223-239. PMID: 32172433.
• Rahm AK, Bellcross C, Cragun D, Duquette D, Hampel H, Heald B. Implementing universal cancer screening programs can help sustain genomic medicine programs. Per Med. 2020 Jan;17(1):9-13. PMID: 31797715.
• Fauzi MFA, Chen W, Knight D, Hampel H, Frankel WL, Gurcan MN. Tumor Budding Detection System in Whole Slide Pathology Images. J Med Syst. 2019 Dec 18;44(2):38. PMID: 31853654.
• Archambault AN, Su YR, Jeon J, Thomas M, Lin Y, Conti DV, Win AK, Sakoda LC, Lansdorp-Vogelaar I, Peterse EFP, Zauber AG, Duggan D, Holowatyj AN, Huyghe JR, Brenner H, Cotterchio M, Bézieau S, Schmit SL, Edlund CK, Southey MC, MacInnis RJ, Campbell PT, Chang-Claude J, Slattery ML, Chan AT, Joshi AD, Song M, Cao Y, Woods MO, White E, Weinstein SJ, Ulrich CM, Hoffmeister M, Bien SA, Harrison TA, Hampe J, Li CI, Schafmayer C, Offit K, Pharoah PD, Moreno V, Lindblom A, Wolk A, Wu AH, Li L, Gunter MJ, Gsur A, Keku TO, Pearlman R, Bishop DT, Castellví-Bel S, Moreira L, Vodicka P, Kampman E, Giles GG, Albanes D, Baron JA, Berndt SI, Brezina S, Buch S, Buchanan DD, Trichopoulou A, Severi G, Chirlaque MD, Sánchez MJ, Palli D, Kühn T, Murphy N, Cross AJ, Burnett-Hartman AN, Chanock SJ, de la Chapelle A, Easton DF, Elliott F, English DR, Feskens EJM, FitzGerald LM, Goodman PJ, Hopper JL, Hudson TJ, Hunter DJ, Jacobs EJ, Joshu CE, Küry S, Markowitz SD, Milne RL, Platz EA, Rennert G, Rennert HS, Schumacher FR, Sandler RS, Seminara D, Tangen CM, Thibodeau SN, Toland AE, van Duijnhoven FJB, Visvanathan K, Vodickova L, Potter JD, Männistö S, Weigl K, Figueiredo J, Martín V, Larsson SC, Parfrey PS, Huang WY, Lenz HJ, Castelao JE, Gago-Dominguez M, Muñoz-Garzón V, Mancao C, Haiman CA, Wilkens LR, Siegel E, Barry E, Younghusband B, Van Guelpen B, Harlid S, Zeleniuch-Jacquotte A, Liang PS, Du M, Casey G, Lindor NM, Le Marchand L, Gallinger SJ, Jenkins MA, Newcomb PA, Gruber SB, Schoen RE, Hampel H, Corley DA, Hsu L, Peters U, Hayes RB. Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer. Gastroenterology. 2020 Apr;158(5):1274-1286. PMID: 31866242.
• Murphy N, Carreras-Torres R, Song M, Chan AT, Martin RM, Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Bradbury KE, Besevic J, Rinaldi S, Riboli E, Cross AJ, Travis RC, Agnoli C, Albanes D, Berndt SI, Bézieau S, Bishop DT, Brenner H, Buchanan DD, Onland-Moret NC, Burnett-Hartman A, Campbell PT, Casey G, Castellví-Bel S, Chang-Claude J, Chirlaque MD, de la Chapelle A, English D, Figueiredo JC, Gallinger SJ, Giles GG, Gruber SB, Gsur A, Hampe J, Hampel H, Harrison TA, Hoffmeister M, Hsu L, Huang WY, Huyghe JR, Jenkins MA, Keku TO, Kühn T, Kweon SS, Le Marchand L, Li CI, Li L, Lindblom A, Martín V, Milne RL, Moreno V, Newcomb PA, Offit K, Ogino S, Ose J, Perduca V, Phipps AI, Platz EA, Potter JD, Qu C, Rennert G, Sakoda LC, Schafmayer C, Schoen RE, Slattery ML, Tangen CM, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Wang H, White E, Wolk A, Woods MO, Wu AH, Zheng W, Peters U, Gunter MJ. Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses. Gastroenterology. 2020 Apr;158(5):1300-1312. PMID: 31884074.
• Chen W, Pearlman R, Hampel H, Pritchard CC, Markow M, Arnold C, Knight D, Frankel WL. Hum Pathol. MSH6 immunohistochemical heterogeneity in colorectal cancer: comparative sequencing from different tumor areas. 2020 Feb;96:104-111. PMID: 31783044.
• Paskett ED, Bernardo BM, Young GS, Katz ML, Reiter PL, Tatum CM, Oliveri JM, DeGraffinreid CR, Gray DM, Pearlman R, Hampel H. Comparative Effectiveness of Two Interventions to Increase Colorectal Cancer Screening for Those at Increased Risk Based on Family History: Results of a Randomized Trial. Cancer Epidemiol Biomarkers Prev. 2020 Jan;29(1):3-9. PMID: 31666284.
• Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, Kazmi N, Robinson TM, Albanes D, Aleksandrova K, Berndt SI, Timothy Bishop D, Brenner H, Buchanan DD, Bueno-de-Mesquita B, Campbell PT, Castellví-Bel S, Chan AT, Chang-Claude J, Ellingjord-Dale M, Figueiredo JC, Gallinger SJ, Giles GG, Giovannucci E, Gruber SB, Gsur A, Hampe J, Hampel H, Harlid S, Harrison TA, Hoffmeister M, Hopper JL, Hsu L, María Huerta J, Huyghe JR, Jenkins MA, Keku TO, Kühn T, La Vecchia C, Le Marchand L, Li CI, Li L, Lindblom A, Lindor NM, Lynch B, Markowitz SD, Masala G, May AM, Milne R, Monninkhof E, Moreno L, Moreno V, Newcomb PA, Offit K, Perduca V, Pharoah PDP, Platz EA, Potter JD, Rennert G, Riboli E, Sánchez MJ, Schmit SL, Schoen RE, Severi G, Sieri S, Slattery ML, Song M, Tangen CM, Thibodeau SN, Travis RC, Trichopoulou A, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Vodicka P, White E, Wolk A, Woods MO, Wu AH, Peters U, Gunter MJ, Murphy N. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. Nat Commun. 2020 Jan 30;11(1):597. PMID: 32001714.
• Stanich PP, Pearlman R, Hinton A, Gutierrez S, LaDuca H, Hampel H, Jasperson K. Prevalence of Germline Mutations in Polyposis and Colorectal Cancer-Associated Genes in Patients With Multiple Colorectal Polyps. Clin Gastroenterol Hepatol. 2019 Sep;17(10):2008-2015. PMID: 30557735.
• Gupta S, Provenzale D, Llor X, Halverson AL, Grady W, Chung DC, Haraldsdottir S, Markowitz AJ, Slavin TP Jr, Hampel H; CGC, Ness RM, Weiss JM, Ahnen DJ, Chen LM, Cooper G, Early DS, Giardiello FM, Hall MJ, Hamilton SR, Kanth P, Klapman JB, Lazenby AJ, Lynch PM, Mayer RJ, Mikkelson J; CGC, Peter S, Regenbogen SE, Dwyer MA; CGC, Ogba N. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019. J Natl Compr Canc Netw. 2019 Sep 1;17(9):1032-1041. PMID: 31487681.
• Hitchins MP, Vogelaar IP, Brennan K, Alvarez R, Zhou N, Martin B, Yuan X, Kim S, Haraldsdottir S, Kalady MF, De Vecchio J, Church J,de la Chapelle A, Hampel H, Pearlman R, Christensen M, Snyder C, Lanspa S, Haile RW, Lynch HT. Methylated SEPT9 plasma test may be applicable for the detection of colorectal cancer in patients with Lynch Syndrome. BMJ Open Gastroenterology 2019 May 28;6(1):e000299. PMID: 31275589.